Novel Kinase Inhibition Models and Their Uses

ABSTRACT

The present invention provides a c-Met inhibition model. The invention further provides a method to derive inhibition models for other kinases. The kinase inhibition models of the present invention can be used to design or screen for inhibitors for kinases.

RELATED APPLICATIONS

This application is a divisional application of U.S. Ser. No. 12/221,440, filed Jul. 31, 2008, which claims the benefit and priority to U.S. Ser. No. 60/962,881, filed Aug. 1, 2007. The contents of each of these applications are herein incorporated by reference in their entirety.

BACKGROUND OF THE INVENTION

Protein tyrosine kinases perform diverse functions ranging from stimulation of cell growth and differentiation to arrest of cell proliferation. They are either receptor tyrosine kinases (RTK) or intracellular tyrosine kinases. Inhibition of kinase activity is recognized as an effective way to control disease in humans.

The activation loop (A-loop) plays a key role in the activation of kinases. Many kinases switch on and off depending on the conformational state of the A-loop. The structural nature of these changes involves the phosphorylation of 1-3 residues in the A-loop, which, in turn, leads to the formation of salt bridges in the catalytic loop (C-loop) and the N-lobe. The N-lobe comprises residues from N1049 to M1160. Three important motifs are located in this lobe; the P-loop, the αC-helix and the Lys-Glu ionic pair. The precise alignment of which plays a critical role in the kinase catalytic activity. Other kinases do not require the phosphorylation of these A-loop residues to become active. It is thought that these kinases adopt a unique conformation and, as a result acidic residues in the A-loop, form a salt bridge with a conserved arginine residue in the C-loop. This allows access to the ATP binding pocket.

Upon tyrosine residue phosphorylation, the A-loop adopts a configuration optimized for substrate binding and catalysis. In many kinase structures resolved to date, the A-loop, in the phosphorylated form, adopts similar conformations to satisfy catalytic constraints and to provide a platform for substrate binding.

The activation loops in the unphosphorylated kinases exhibit a wide range of different conformations, which may explain their role in kinase activity regulation. In this unphosphorylated state, the A-loop can assume conformations ranging from fully open to completely closed (Huse, M. and Kuriyan, J. 2002. Cell 109:275-282). The open, autoinhibited, conformation has been observed in the crystal structures of fibroblast growth factor receptor (Mohammadi, M. et al. 1996. Cell, 86, 577-587) and c-Met (Wang, W. et al. 2006. Proc. Natl. Acad. Sci. USA 103:3563-3568). In this conformation of the fibroblast growth factor receptor, the A-loop is not suitable for substrate binding but does not obstruct the ATP binding site. In the closed, canonical, autoinhibited conformation, the activation loop folds as a pseudosubstrate, obstructing binding of both ATP and the peptide substrate.

The canonical, autoinhibited conformation has been detected in the unbound insulin receptor tyrosine kinase IRK, one of the most studied receptor tyrosine kinases (Hubbard, S. R. et al. 1994. Nature 372:746-754), c-Src kinase bound to the ATP analog AMP-PNP (Xu, W. et al. 1999. Molecular Cell 3:629-638), Hck bound to a small molecule inhibitor (Schindler, T. et al. 1999. Mol. Cell 3: 639-648), FLT3 receptor tyrosine kinase (Griffith, J. et al. 2004. Molecular Cell 13:69-178), c-Abl bound to Imatinib (Schindler, T. et al. 2000. Science 289, 1938-1942; Nagar, B. et al. 2002. Cancer Research 62:4236-4243), c-Kit tyrosine kinase receptor unbound and bound to Gleevec (Mol, C. D. et al. 2004. The Journal of Biological Chemistry 279:31655-31663), and more recently cFMS (colony stimulating factor receptor-1) bound to small molecule inhibitors (Schubert, C. et al. 2007. J. Biol. Chem. 282:4094-4101).

The majority of kinase inhibitors is believed to be interacting with the protein in a region which binds ATP. The conformation of the kinase, when bound by the inhibitors, is frequently very similar to the one in which ATP is bound, i.e., the active conformation of the kinase.

Typically, kinase inhibitors binding to the ATP pocket take advantage of limited sequence variations in the nucleotide binding site as well as conformational differences between phosphorylated and unphosphorylated forms of kinases. While phosphorylated forms may adopt similar conformations in different kinases, unphosphorylated, inactive conformations of kinases show great variability. Knowledge of these distinct kinase conformations allow rational drug design of high affinity, specific compounds.

A body of knowledge has given rise to the concept of ATP-competitive ligands and the use of X-ray crystallography to aid in their design. In such approaches it has become established that the ligand is required to at least in part to mimic the binding of ATP in the active site. The notion of these ligands competing for access to this site and on binding place the A-loop in a catalytically inactive conformation has been demonstrated by X-ray studies for the insulin-like receptor IGF1, IRK, cFMS, c-Abl, c-Kit, Flt3, MusK, etc.

More recently, a different type of kinase inhibitor has become known in the field. These new inhibitors appear to interact with an inactive form of the kinase in the ATP binding site. Stabilization of unphosphorylated inactive forms of RTKs provides a different approach to modulate signaling through kinases. It provides another mechanism to control over expression and non-ligand activation.

Controlling the position of the activation loop by use of small molecule inhibitors has been documented and shown by the use of X-ray crystallography. This technique provides a detailed structural insight into the mechanism by which the A-loop is prevented from achieving a catalytically active conformation. It is this technique which provides important and valuable information for the use of the design of more efficacious and selective kinase inhibitors.

In the case of the ATP-competitive ligand STI-571 binding to the inactive form of c-Abl, X-ray studies show that DFG is in the out conformation, and that the A-loop is held in an inactive conformation (Nagar, B. et al. 2002. Cancer Research 62:4236-4243).

Despite the identification of many agents which have been described to affect such control there remains a need for additional, novel and selective agents which offer the benefits of increased specificity and reduced side effects. Despite many reports, there remains a need to identify methods to inhibit the signaling through this important class of proteins.

The references cited herein are not admitted to be prior art to the claimed invention.

SUMMARY OF THE INVENTION

The invention provides a crystal structure including c-Met or c-Met kinase domain, and a ligand complexed thereto. In one aspect of the invention, the c-Met kinase domain comprises the amino acid sequence of cMet1 (SEQ ID NO: 1) from Table 1A or cMet2 (SEQ ID NO: 2) from Table 1B.

In certain embodiments of the invention, the ligand is a selective small molecule inhibitor of c-Met. In other embodiments of the invention, the inhibitor is (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl) pyrrolidine-2,5-dione, also known as “the selective c-Met inhibitor.”

The invention provides a process for constructing a c-Met inhibition model including the steps of crystallizing c-Met kinase domain bound to (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl) pyrrolidine-2,5-dione, resolving the x-ray crystallography of the c-Met kinase domain, applying the data generated from resolving the x-ray crystallography of the c-Met kinase domain to a computer algorithm, and generating from the computer algorithm a c-Met inhibition model suitable for screening or designing c-Met inhibitors. In one aspect of the invention, resolving the x-ray crystallography includes obtaining crystallographic coordinates for the c-Met kinase domain. The invention further provides a process for screening or designing c-Met inhibitors including using the c-Met inhibition model to screen or design c-Met inhibitors.

The invention provides a c-Met inhibition model including the crystallography coordinates of c-Met amino acids I_(—)1084, G_(—)1085, F_(—)1089, V_(—)1092, A_(—)1108, V_(—)1109, K_(—)1110, L_(—)1140, V_(—)1155, L_(—)1157, P_(—)1158, Y_(—)1159, M_(—)1160, K_(—)1161, H_(—)1162, G_(—)1163, D_(—)1164, M_(—)1211, A_(—)1221, D_(—)1222, F_(—)1223, A_(—)1226, and R_(—)1227 (SEQ ID NO: 11) which are within about a root mean square deviation of not more than about 1.5 Å from the backbone atoms of the amino acids according to Table 4. In one aspect of the invention, the crystallography coordinates contain coordinates of all the amino acids of c-Met that are within about a root mean square deviation of not more than about 1.5 Å from the backbone atoms of the amino acids according to Table 1A or Table 1B.

The invention provides a method for making an inhibition model for a kinase including the steps of performing sequence alignment between the amino acid sequences of the kinase and c-Met using four motifs: P-loop, salt-bridge, DFG-motif and the A-loop; identifying non-conserved residues between c-Met and the kinase, replacing the crystallography coordinates of the non-conserved residues in the c-Met inhibition model with those of the corresponding residues from the kinase, and refining the c-Met inhibition model with replaced crystallography coordinates to generate the inhibition model for the kinase. In one aspect of the invention, the method for making an inhibition model for a kinase further contains the step of evaluating the inhibition model for the kinase. In certain embodiments of the invention, the kinase is a tyrosine kinase. Alternatively, or in addition, the tyrosine kinase is a receptor tyrosine kinase. An exemplary receptor tyrosine kinase is selected from the group consisting of EGFR, VEGFR, FGFR, PDGFR, HER2, Kit, IRK, RET, AXL, FLT-3, EphB4, c-Met homologs, and c-Met mutants. In one embodiment of the invention, the receptor tyrosine kinase is FGFR-2. In another embodiment of the invention, the tyrosine kinase is a non-receptor tyrosine kinase. An exemplary non-receptor tyrosine kinase is selected from the group consisting of c-Abl, Src, Fyn, Lyn, and Yes. In one embodiment of the invention, the non-receptor tyrosine kinase is c-Abl. In one aspect of the invention, the kinase is a serine/threonine kinase. An exemplary serine/threonine kinase is selected from the group consisting of B-Raf, PIM, PAK, MEK, MAPK, AKT, and Aurora kinase.

The invention provides a c-Abl inhibition model including the crystallography coordinates of c-Abl amino acids L_(—)266, G_(—)267, Y_(—)271, V_(—)274, A_(—)287, V_(—)288, K_(—)289, V_(—)317, I_(—)331, T_(—)333, E_(—)334, F_(—)335, M_(—)336, T_(—)337, Y_(—)338, G_(—)339, N_(—)340, L_(—)388, A_(—)398, D_(—)399, F_(—)400, S_(—)403, and R_(—)404 (SEQ ID NO: 8) which are within about a root mean square deviation of not more than about 1.5 Å from the backbone atoms of the amino acids according to Table 5.

The invention also provides a method of similarity assessment including comparing the inhibition models of various kinases derived from the c-Met inhibition model. In one aspect of the invention, the models are compared applying a weighting system. In another aspect of the invention, the weighting system includes positive scores for residues critical for ligand binding, residues with side chain lining the inhibition model, and residues which are part of backbone of the inhibition model; and negative scores for additions, deletions and changes in backbone flexibility, or lack of residue alignment, and dramatic changes in size and/or polarity inside the inhibition model, lack of alignment of critical residues. In a further aspect of the invention, the positive score for residues critical for ligand binding is 2, for residues with side chain lining the inhibition model is 1, and for residues which are part of backbone of the inhibition model is 1; and the negative score for additions, deletions and changes in backbone flexibility, or lack of residue alignment is −1, and that for dramatic changes in size and/or polarity inside the inhibition model, lack of alignment of critical residues is −2. Alternatively, or in addition, conserved residue substitutions are assigned 1.

The invention provides a kinase inhibition model obtained by the method of making an inhibition model for a kinase as described above.

Finally, the invention provides a FGFR-2 inhibition model including the crystallography coordinates of FGFR-2 amino acids L_(—)487, G_(—)488, F_(—)492, V_(—)495, A_(—)515, V_(—)516, K_(—)517, I_(—)548, V 562, V 564, E_(—)565, Y 566, A 567, S 568, K 569, G_(—)570, N_(—)571, L_(—)633, A_(—)643, D_(—)644, F_(—)645, A 648, and R_(—)649 (SEQ ID NO: 10) which are within about a root mean square deviation of not more than about 1.5 Å from the backbone atoms of the amino acids according to Table 7.

Other features and advantages of the present invention are apparent from the additional descriptions provided herein including the different examples. The provided examples illustrate different components and methodology useful in practicing the present invention. The examples do not limit the claimed invention. Based on the present disclosure the skilled artisan can identify and employ other components and methodology useful for practicing the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic representation of the activation loop of unphosphorylated c-Met bound to the selective c-Met inhibitor (dark grey) superimposed with the peptide substrate (light grey) as seen in the phosphorylated insultin receptor IRK in complex with ATP and a peptide (Tyr residues are shown as sticks).

FIG. 2 is a schematic representation of the c-Met kinase domain, in which the activation loop is shown in the canonical, autoinhibitory, conformation forming a typical short anti-parallel strand.

FIG. 3 is a schematic representation of unphosphorylated c-Met bound to the selective c-Met inhibitor, in which Arg 1227 forms part of the inhibitor's binding site (dark grey).

FIG. 4 is a schematic representation of unphosphorylated c-Met bound to the selective c-Met inhibitor, in which a salt bridge, usually formed by the strictly conserved Lys (β3) and Glu (αC) residues that stabilize the phosphate group transfer, is disrupted as a result of the conformational changes of the A-loop and the helix αC.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to methods of designing and screening for kinase inhibitors. The present invention provides a c-Met inhibition model. The present invention further provides a method to derive an inhibition model for another kinase from the c-Met inhibition model. The present invention also provides a method to compare inhibition models derived from multiple kinases in order to determine the degree of similarity between inhibition models.

The receptor tyrosine kinase (RTK) c-Met belongs to the HGF receptor family, which includes tyrosine kinases encoded by three oncogenes: MET (mesenchymal-epithelial transition factor), RON (also known as MST1R, macrophage stimulating 1 receptor (c-met-related tyrosine kinase)), and SEA (S13 erythroblastosis oncogene homolog (avian)).

These RTKs share specific structural features: a heterodimeric α-β subunits, two neighboring tyrosine residues in the kinase domain responsible for the activation upon phosphorylation and two tyrosine docking sites in the C-terminal domain tail.

The extracellular α- and transmembrane-β chains are present after receptor proteolitic cleavage and linked together by disulfide bonds. The intracellular β-subunit (residues 956-1390) can be further divided into juxtamembrane (residues 956-1093), catalytic and C-terminal domains. The C-terminal docking sites mediate high affinity interactions with multiple SH2-containing transducers of several key signaling pathways, including Ras, MAPK, PI3K, Src and Stat3 which contribute to the malignant features of Met.

Ligand binding to the extracellular domain of the RTKs leads to dimerization of monomeric receptors resulting in autophosphorylation of specific tyrosine residues in the cytoplasmic domain. RTKs are subject to several auto regulatory mechanisms to limit ligand-independent activation. One of these mechanisms is the phosphorylation of the kinase activation loop. The tyrosine doublet is present at homologous locations in the A-loop in RON and SEA.

The structure of the unphosphorylated kinase domain of c-Met bound to the selective c-Met inhibitor is an example of how a small molecule can achieve specificity by recognizing and binding the canonical, autoinhibited form of the kinase. Herein we describe a novel mechanism of inhibition of the receptor tyrosine kinase (RTK) c-Met and its use to define an inhibition model of general application in the identification of novel kinase inhibitors.

1. The Structure of the c-Met Bound to the Selective c-Met Inhibitor

(−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione is a selective c-Met inhibitor (WO 2006/086484 A1).

A 2-Å resolution X-ray crystallographic shows that this compound binds to the unphosphorylated kinase domain of c-Met. This compound is referred to herein as “the selective c-Met inhibitor.”

The selective c-Met inhibitor is a single enantiomer that binds unphosphorylated c-Met at the highly conserved nucleotide-binding pocket. Overall the c-Met structure resembles the structures resolved for other tyrosine kinases in the presence of inhibitors such as Gleevec bound to c-Abl kinase and small molecules bound to cFMS. Structures of other receptor tyrosine kinases such as insulin receptor, cKit, Flt-3 in the absence of ligands also share a similar fold. In all these structures the activation loop is in the canonical, autoinhibitory conformation, blocking the access of ATP and the peptide substrate to the active site. In this particular conformation a tyrosine residue is in a pseudosubstrate conformation, buried deeply into the protein, making hydrogen bonds with important residues in the catalytic loop.

The structure of the c-Met bound to the selective c-Met inhibitor was compared with the inactive structure of c-Met in the public domain (PDB entry 2G15). In this structure, Tyr 1234 is not available for phosphorylation. The A-loop is in a different, open conformation. It is possible that the selective c-Met inhibitor recognizes and binds this particular, autoinhibitory conformation of c-Met, as it has been suggested for Gleevec bound to c-Abl and c-Kit kinases.

1.1. P-Loop Contains a Phenylalanine or a Similar Residue Able to Form Stacking Interaction with the Ligand

Another important structural motif of a kinase is the phosphate binding loop (P-loop). This loop contains a conserved glycine residue rich sequence (GXGXΦG), where Φ is usually a tyrosine or phenylalanine. The glycine residues allow the coordination of the ATP by well defined backbone interactions. In the absence of ATP, the P-loop is very flexible allowing the binding of small molecules. Some inhibitors stabilize this loop by interacting with the conserved aromatic residue, as is the case of crystal structures of Abl, FGFR in complex with inhibitors STI-571 (PDB entry 2HYY), SU-5402 (PDB entry 1FGI), and unphosphorylated c-Met bound to the selective c-Met inhibitor.

The nucleotide binding loop, the P-loop is well ordered in the structure of c-Met bound to the selective c-Met inhibitor, where residues 11084 to G1087 form part of the β1 strand. F1089 stabilizes the downfold of the loop by van de Waals contacts with the selective c-Met inhibitor.

1.2. A Tyrosine Residue in the A-Loop is Able to Interfere with the Peptide Substrate Binding

Autophosphorylation of key tyrosine residues in the catalytic core of the RTK enhances kinase activity. In the case of c-Met, Y1235 has been described as being the site of autophosphorylation and playing this regulatory role.

In the structure of c-Met bound to the selective c-Met inhibitor, the activation loop is in the canonical, autoinhibitory conformation with a short anti-parallel strand. Two tyrosine residues Y1234 and Y1235 located in the A-loop of the kinase domain are responsible for c-Met catalytic activity and in the structure of c-Met bound to the selective c-Met inhibitor, Y1234 is exposed. However, Y1235 is sequestered into the active site occupying the site of the substrate tyrosine. Un-phosphorylated Y1235 is held by a hydrogen bond network formed by catalytic loop (C-loop) D1204 and R1208. The arginine residue engages in hydrogen bonding interactions that orient asparagine ensuring the inaccessibility of Y1235.

1.3. Phenylalanine (of the DFG Motif which Consists of Residues D1222, F1223 and G1224 in the Activation Loop) Prevents the ATP Binding.

Most of our knowledge about RTK comes from structural and biochemical studies on the insulin receptor kinase IRK. Structures of IRK show that sequestration of the tyrosine residue in the active site is correlated with the movement away from the active site of a number of critical important residues. When the apo structure (DFG-out) is superposed with the phosphorylated IRK (DFG-in) in complex with ATP analog and a peptide substrate (PDB entry IRK3) the side chain of F1151 occupies the pocket of the adenine ring and the activation loop intersects the β- and γ-phosphate groups.

The positioning of phenylalanine from the DFG motif is critical for the proper orientation of the aspartic acid (DFG) which coordinates an essential Mg²⁺ and the ATP. Conformational changes of the DFG-motif are often linked to the conformation of the αC-helix, the only conserved helix in the β sheet-rich N terminal domain. An absolute conserved glutamic acid residue located in αC-helix forms an ion pair with another conserved lysine residue from the β3 sheet. This ion pair coordinates the α- and β-phosphates of the ATP.

In the structure of c-Met bound to the selective c-Met inhibitor, a ‘DFG-out’ conformation is present. The aspartic acid (of the DFG) points away from where the ATP would bind and phenylalanine is situated in the approximated position of the ATP adenine moiety. Stabilization of this portion of the A-loop is provided, in part, by the tricyclic group of the selective c-Met inhibitor, which makes van der Waals interactions with the phenylalanine residue from the DFG motif. In this way, although the hydroxyl group of Y1234 is in position for phospho-transfer, the DFG-out motif occludes the ATP binding site from interfering with phopho-transfer.

1.4. The Salt Bridge Between Lysine (N-Terminus) and Glutamic Acid (αC Helix) is Disrupted

The αC helix is a key regulatory element of protein kinases. Due to its proximity to the active site and its interactions with many conserved and essential kinase elements, the orientation of this helix is critical for catalytic activity. This helix contains a conserved glutamic acid residue that forms an ion pair with a lysine residue from the N-lobe. Glutamic acid is a strictly conserved feature in the kinase family and lysine is part of the protein kinase ATP binding region signature (PROSITE rule PS00107). The lysine residue coordinates the α- and the β-phosphates of ATP and is required for kinase activity. Moreover, the αC helix often interacts with the DFG motif of the activation loop.

In the structure of c-Met bound to the selective c-Met inhibitor, the alignment of the lysine-glutamic acid ion pair is disrupted, K1110 and E1127 are 16 Å apart, accentuating the inactive nature of the c-Met kinase conformation in the presence of the selective c-Met inhibitor.

When the αC helix of the complex formed by c-Met bound to the selective c-Met inhibitor is compared to the fully activated IRK structure bound to ATP and a peptide substrate, it is clear that the αC helix is partially disrupted and shifted away from the N-lobe. This movement, which is a combination of rotation and translation, results from the insertion of the activation loop deep between the P-loop and the αC helix.

In the structure formed by the complex formed when c-Met is bound to the selective c-Met inhibitor, the β3-αC loop has several contacts with the activation loop that are not observed in apo c-Met. R1114 from the β3-αC loop makes two contacts with the activation loop: R1114 forms salt bridges with G1224 from the DFG motif and with the carbonyl oxygen of R1227. In the structure of the apo c-Met kinase domain, the β3-αC loop adopts a more open conformation because the side chain of R1114 extends in the opposite direction towards the solvent.

An additional important feature of the activation loop is the conformation of R1227. It is hypothesized that R1227 plays a critical role in the stabilization of the activation loop by hydrogen bonding to the activated tyrosine upon phosphorylation (Johnson, L. M. and Noble, M. E. M. 1996. Cell, 85: 149-158). Three structures are often used to illustrate this interaction. First, the fully activated, triple phosphorylated insulin receptor kinase when bound to ATP and a peptide (1IR3). In this instance, the equivalent residue to R1227 in c-Met, residue R1155, makes hydrogen bonds with the phosphate group of Y1163. Second, a similar role has been described for R387 in the active form of the Hck tyrosine kinase (3LCK). With respect to Hck, R387 is making a hydrogen bond with the phosphorylated Y394. Finally, residue K189 of the serine/threonine kinase PKA bound to balanol (1BX6) fulfills a similar role. Using the foregoing examples as evidence, it is assumed that a critical role for R1227 is providing stabilization to the activation loop upon phosphorylation of c-Met.

The structures provided herein are contrary to published structures. For instance, in recently published structures of c-Met bound to small molecule inhibitors, the side chain of R1227 is missing (Bellon, S. F. ET AL. 2008. J. Biol. Chem. 283: 2675-2683; Albrecht, B. K. ET AL. 2008. J. Med. Chem. 51: 2879-2882). Similarly, in the structure of human Abl bound to Gleevec, the corresponding residue R386 is also missing (Cowan-Jacob, S. W. et al. 2007. ACTA CRYSTALLOGR., SECT. D 63: 80-93).

However, in the structure of the complex of c-Met bound to the selective c-Met inhibitor provided herein, R1227 is locked away from Y1234 and Y1235 through a direct hydrogen bond with N1209 and a water-mediated hydrogen bond to R1208, presenting the hydrophobic chain to the inhibitor. This van der Waals contact with the selective c-Met inhibitor restricts the movement of R1227 and prevents phosphate stabilization upon activation. Such a conformational change of this part of the activation loop, brought about by the selective c-Met inhibitor, is similar to that described for the activation loop containing R801 and a small molecule inhibitor of the autoinhibited cFMS (Schubert, C. ET AL. 2007. J. Biol. Chem. 282:4094-4101), the R815 residue of apo c-Kit bound to Gleevec (Mol, C. D. ET AL. 2004. The Journal of Biological Chemistry 279:31655-31663), and the R834 residue of apo Flt-3 (Griffith, J. ET AL. 2004. Molecular Cell 13:69-178).

1.5. A Small Molecule is Stabilizing 1-4, Preventing ATP and Peptide Binding

In the structure of c-Met bound to the selective c-Met inhibitor, the small molecule is placed in the interdomain cleft between the N (residues 1049-1160)- and C-lobes (residues 1161-1346). The carbonyl group from the succinamide ring forms hydrogen bond with the backbone amide of M1160 and the N—H group forms hydrogen bonds with the backbone carbonyl of P1158. The indole ring is close to the ATP binding site opening while the tricyclic ring is bound deep inside the hydrophobic pocket. The tricyclic moiety of the selective c-Met inhibitor forms van der Waals interactions with phenylalanine residues F1089 from the P-loop and F1223 from the DFG motif. European Patent Application No. EP1243596A2 (the contents of which are incorporated herein in their entirety) describes a small molecule bound to the kinase domain of c-Met. The structure of c-Met bound to the selective c-Met inhibitor differs significantly. Of particular note are differences in the P-loop and the A-loops. The selective c-Met inhibitor makes a van de Waals contact with the residue F1089 at the apex of the P-loop, F1089 of cMet (described in EP1243596A2, the contents of which are incorporated by reference in their entirety) is inserted towards the αC helix. Also of note are differences between the residue F1223. This residue is in the -out conformation while in the above mentioned patent it is in the -in conformation. The selective c-Met inhibitor prevents this residue from occupying a region close to the triphosphate binding site found when ATP binds the catalytic site.

European Patent Application No. EP1243596A2 provides the wild-type sequence of the c-Met kinase (SEQ ID NO: 12) shown below:

MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAE TPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPC QDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFP HNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFF VGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSY PIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEM PLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILF GVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGP NHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTS ISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEV IVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCG WCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDF GFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMS IIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGN SRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSI FSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGR NFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDL IYVHNPVFKPFEKPVMISMGNENVEIKGNDIDPEAVKGEVLKVGNKSCE NIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFT GLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLD RLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTD MSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEG IIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPT VKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLA RDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVVLWE LMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKA EMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSED NADDEVDTRPASFWETS

1.6. Computers, Computer Software, Computer Modeling

Computers are known in the art and may include a central processing unit (CPU), a working memory, which can be random-access memory, core memory, mass-storage memory, or combinations of all of the aforementioned.

The CPU may encode one or more programs. Computers may also include display, and input and output devices, such as one or more cathode-ray tube display terminals, keyboards, modems, input lines and output lines. Persons skilled in the computer art will understand that many variations of a computer exist in the art and all such variations are applicable to the present invention. Further, said computers may be networked to computer servers (the machine on which large calculations can be run in batch), and file servers (the main machine for all the centralized databases). Machine-readable media containing data, such as the crystal structure coordinates of the polypeptides of the invention may be inputted using various hardware, including modems, CD-ROM drives, disk drives, or keyboards

Output hardware, such as a CRT display terminal may be used for displaying a graphical representation of the HGFR polypeptide of the invention or the c-Met substrate-binding domain of these polypeptides using programs such as QUANTA. Output hardware may also include a printer, and disk drives.

The CPU coordinates the use of the various input and output devices, coordinates data accesses from storage and accesses to and from working memory, and determines the sequence of data processing steps. A number of programs may be used to process the machine-readable data of this invention. Such programs are discussed in reference to the computational methods of drug discovery as described herein.

Thus, one embodiment of the present invention includes X-ray coordinate data capable of being processed into a three dimensional graphical display of a molecule or molecular complex that comprises an c-Met-like substrate-binding pocket stored in a machine-readable storage medium. The three-dimensional structure of a molecule or molecular complex comprising an c-Met-like substrate-binding pocket may be used for a variety of purposes, including, but not limited to, drug discovery.

For example, the three-dimensional structure derived from the structure coordinate data may be computationally evaluated for its ability to associate with chemical entities. Such entities would be potential drug candidates and would be evaluated for their ability to inhibit or modulate the activity of c-Met.

As used herein, the term “three dimensional representation” refers to converting the lists of structure coordinates into structural models or graphical representation in three-dimensional space. The three dimensional structure may be displayed or used to perform computer modeling or fitting operations.

“Inhibition model”, refers to a region or regions of proteins that can associate with another chemical entity or compound. Such regions are of significant utility in fields such as drug discovery. These regions are formed by amino acid residues key for ligand binding or may be residues that are spatially related and define a three-dimensional shape of the binding pocket. The amino acid residues may be contiguous or non-contiguous in primary sequence. The region or regions may be embodied as a dataset (e.g. an array) recorded on computer readable media.

The term “motif” refers to a group of amino acid residues in proteins that defines a structural compartment or carries out a function in the protein, for example, catalysis, structural stabilization or phosphorylation. The motif may be conserved in sequence, structure and function. The motif can be contiguous in primary sequence or three-dimensional space. Examples of a motif include, but are not limited to, a binding pocket; activation loop, the glycine-rich or P-loop, and the DFG loop.

The term “homology model” refers to a set of coordinates derived from known three-dimensional structure used as a template. Generation of the homology model, termed “homology modeling”, involves sequence alignment, residue replacement, residue conformation adjustment through energy minimization

The term “part of the inhibition model” also referred as “part of a binding pocket” refers to less than all of the amino acid residues that define the binding pocket. The structure coordinates of amino acid residues that constitute part of a binding pocket may be specific for defining the chemical environment of the binding pocket, or useful in designing fragments of an inhibitor that may interact with those residues. Part of the inhibition model has at least five amino acid residues, preferably at least, ten to fourteen amino acid residues.

The term “chemical entity” refers to chemical compounds, complexes of at least two chemical compounds, and fragments of such compounds or complexes.

The “Chemical structure” term is applied to any atom or group of atoms that constitute a part of a molecule. Normally, chemical structures of a scaffold or ligand have a role in binding to a target molecule.

The term “associating with” or “binds to” or “binding affinity” refers to a condition of proximity between a chemical entity or compound, or portions thereof, and the inhibition model, or binding pocket or binding site on a protein. The association may be non-covalent, for example, wherein the juxtaposition is energetically favored by hydrogen bonding, van der Waals and/or electrostatic interactions

The term “interaction energy” refers to the energy determined for the interaction of a chemical entity and a binding pocket, domain, molecule or molecular complex or portion thereof, Interactions include but are not limited to one or more of covalent interactions, non-covalent interactions such as hydrogen bond, electrostatic, hydrophobic, aromatic, van der Waals interactions, and non-complementary electrostatic interactions such as repulsive charge-charge, dipole-dipole and charge-dipole interactions. As interaction energies are measured in negative values, the lower the value the more favorable the interaction.

For the purposes of this description and the following claims, the term “crystal structure” of a composition shall mean a computer readable medium in which is stored a representation of three dimensional positional information for atoms of the composition.

2.1 Construction of c-Met Inhibition Model

The model for the inhibition of c-Met kinase is constructed by the preparation of the 3-dimensional representation of the c-Met protein based on crystallographic structure of c-Met bound to the selective c-Met inhibitor complex.

An electronic representation of c-Met-ligand kinase domain structure was obtained from X-ray crystallographic data. Crystals of the ligand complexes of c-Met kinase can be grown by a number of techniques including batch crystallization, vapor diffusion (either by sitting drop or hanging drop) and by microdialysis. Seeding of the crystals in some instances is required to obtain X-ray quality crystals. Standard micro and/or macro seeding of crystals may therefore be used.

Once a crystal of the present invention is grown, X-ray diffraction data can be collected. X-ray diffraction data collection can be obtained using, for example, a MAR imaging plate detector. Crystals can be characterized by using X-rays produced in a conventional source (such as a sealed tube or a rotating anode) or using a synchrotron source.

Data processing and reduction can be carried out using programs such as HKL, DENZO, and SCALEPACK (Otwinowski and Minor, 1997, Meth. Enymol. 276:307-326 (1997)). In addition, X-PLOR, (Bruger, X-PLOR v.3.1 Manual, New Haven: Yale University, (1993)) or Heavy (T. Terwilliger, Los Alamos National Laboratory) may be utilized for bulk solvent correction and B-factor scaling. Electron density maps can be calculated using SHARP (La Fortelle, E. D. and Bricogne G., Meth. Enzymol. 276:472-494 (1997)) and SOLOMON. Molecular models can be built into this map using O (Jones, T. et al., ACTA Crystallogr. A47:110-119 (1991)), XTALVIEW (Scripps Research) or QUANTA96 (Accelrys, Inc. San Diego). Refinement can be done using XPLOR (Brunger, “X-PLOR:A System for X-ray Crystallography and NMR,” Yale University Press, New Haven, Conn.), using the free R-value to monitor the course of refinement. Molecular replacement involves using a known three-dimensional structure as a search model to determine the structure of an identical or closely related molecule or protein-ligand complex in a new crystal form. The measured X-ray diffraction properties of the new crystal are compared with those calculated from a search model structure to compute the position and orientation of the protein in the new crystal. Computer programs that can be used for this purpose include: X-PLOR, EPMR (Kissinger et al. Acta Cryst. D55:484-491 (1999)), ProLSQ and AMORE (J. Navaza, Acta Crystallographics ASO, 157-163 (1994)). Once the position and orientation are known an electron density map can be calculated using the search model to provide X-ray phases. Thereafter, the electron density is inspected for structural differences and the search model is modified to conform to the new structure. Other computer programs that can be used to solve the structures of kinase crystals include X-site, QUANTA, INSIGHT, ARP/wARP, and ICM.

The amino acids of the kinase domain of c-Met1 bound to the selective c-Met inhibitor are described herein and are defined by a set of structure coordinates set forth in Table 1A. The amino acids of the kinase domain of c-Met2 bound to the selective c-Met inhibitor are described herein and are defined by a set of structure coordinates set forth in Table 1B. The terms “structure coordinates” or “atomic coordinates” refer to Cartesian coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of X-rays by the atoms (scattering centers) of a protein or protein-ligand complex in crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are then used to establish the positions of the individual atoms of the enzyme or enzyme complex.

TABLE 1A (SEQ ID NO: 1) ATOM 1 CB LEU A1046 −12.128 23.172 12.578 56.91 C ATOM 2 CG LEU A1046 −10.61 22.897 12.417 57.12 C ATOM 3 CD1 LEU A1046 −10.172 21.715 13.29 57.11 C ATOM 4 CD2 LEU A1046 −10.196 22.666 10.944 56.48 C ATOM 5 C LEU A1046 −11.878 25.227 14.012 55.44 C ATOM 6 O LEU A1046 −11.778 26.019 13.032 55.74 O ATOM 7 N LEU A1046 −14.148 24.094 13.796 56.63 N ATOM 8 CA LEU A1046 −12.645 23.903 13.852 56.54 C ATOM 9 N LEU A1047 −11.331 25.48 15.21 53.3 N ATOM 10 CA LEU A1047 −10.406 26.598 15.301 50.4 C ATOM 11 CB LEU A1047 −10.5 27.402 16.574 51.71 C ATOM 12 CG LEU A1047 −10.362 28.806 15.979 51.83 C ATOM 13 CD1 LEU A1047 −11.47 28.957 14.891 53.47 C ATOM 14 CD2 LEU A1047 −10.363 29.918 17.042 52 C ATOM 15 C LEU A1047 −8.96 26.289 14.95 48.45 C ATOM 16 O LEU A1047 −8.275 25.497 15.594 48.01 O ATOM 17 N GLN A1048 −8.562 26.995 13.891 44.96 N ATOM 18 CA GLN A1048 −7.335 26.9 13.179 40.88 C ATOM 19 CB GLN A1048 −7.455 25.718 12.207 42.63 C ATOM 20 CG GLN A1048 −7.818 25.972 10.72 41.6 C ATOM 21 CD GLN A1048 −6.669 25.468 9.808 44.09 C ATOM 22 OE1 GLN A1048 −5.912 26.261 9.217 39.73 O ATOM 23 NE2 GLN A1048 −6.52 24.143 9.728 46.71 N ATOM 24 C GLN A1048 −7.28 28.319 12.517 38.85 C ATOM 25 O GLN A1048 −6.273 28.777 11.876 36.37 O ATOM 26 N ALA A1049 −8.408 29.017 12.748 35.35 N ATOM 27 CA ALA A1049 −8.506 30.471 12.686 31.97 C ATOM 28 CB ALA A1049 −9.981 30.902 12.748 31.67 C ATOM 29 C ALA A1049 −7.691 30.943 13.89 29.81 C ATOM 30 O ALA A1049 −7.868 32.004 14.431 29.2 O ATOM 31 N THR A1050 −6.732 30.11 14.251 27.92 N ATOM 32 CA THR A1050 −5.889 30.248 15.41 26.75 C ATOM 33 CB THR A1050 −6.401 29.283 16.498 27.8 C ATOM 34 OG1 THR A1050 −5.967 29.726 17.75 29.58 O ATOM 35 CG2 THR A1050 −5.908 27.822 16.32 31.14 C ATOM 36 C THR A1050 −4.448 29.924 15.044 24.25 C ATOM 37 O THR A1050 −3.59 30.157 15.797 24.4 O ATOM 38 N VAL A1051 −4.212 29.439 13.836 23.39 N ATOM 39 CA VAL A1051 −2.877 28.99 13.358 22.24 C ATOM 40 CB VAL A1051 −2.947 27.788 12.359 20.45 C ATOM 41 CG1 VAL A1051 −1.579 27.485 11.875 18.55 C ATOM 42 CG2 VAL A1051 −3.595 26.532 13.011 19.38 C ATOM 43 C VAL A1051 −2.1 30.118 12.657 22.8 C ATOM 44 O VAL A1051 −2.522 30.662 11.621 22.92 O ATOM 45 N HIS A1052 −0.978 30.488 13.223 22.7 N ATOM 46 CA HIS A1052 −0.228 31.494 12.584 23.68 C ATOM 47 CB HIS A1052 −0.265 32.834 13.364 22.38 C ATOM 48 CG HIS A1052 0.836 33.742 12.975 22.43 C ATOM 49 CD2 HIS A1052 2.061 33.943 13.536 27.19 C ATOM 50 ND1 HIS A1052 0.821 34.463 11.794 19.13 N ATOM 51 CE1 HIS A1052 1.969 35.092 11.658 24.7 C ATOM 52 NE2 HIS A1052 2.74 34.811 12.711 28.02 N ATOM 53 C HIS A1052 1.174 30.932 12.455 24.4 C ATOM 54 O HIS A1052 1.745 30.455 13.427 24.15 O ATOM 55 N ILE A1053 1.716 30.972 11.242 26.45 N ATOM 56 CA ILE A1053 3.121 30.613 11.024 27.16 C ATOM 57 CB ILE A1053 3.251 29.516 9.914 28.26 C ATOM 58 CG2 ILE A1053 4.734 29.093 9.685 26.49 C ATOM 59 CG1 ILE A1053 2.359 28.302 10.239 29.2 C ATOM 60 CD1 ILE A1053 2.763 27.523 11.503 29.05 C ATOM 61 C ILE A1053 3.87 31.843 10.573 27.98 C ATOM 62 O ILE A1053 3.477 32.505 9.609 28.95 O ATOM 63 N ASP A1054 4.961 32.165 11.241 29.63 N ATOM 64 CA ASP A1054 5.824 33.221 10.723 31.12 C ATOM 65 CB ASP A1054 6.616 33.903 11.853 31.79 C ATOM 66 CG ASP A1054 7.232 35.248 11.435 33.67 C ATOM 67 OD1 ASP A1054 7.123 35.707 10.245 31.69 O ATOM 68 OD2 ASP A1054 7.858 35.842 12.343 36.33 O ATOM 69 C ASP A1054 6.716 32.541 9.714 31.2 C ATOM 70 O ASP A1054 7.551 31.707 10.089 30.57 O ATOM 71 N LEU A1055 6.476 32.851 8.443 33.07 N ATOM 72 CA LEU A1055 7.198 32.223 7.316 35.79 C ATOM 73 CB LEU A1055 6.468 32.463 5.965 35.66 C ATOM 74 CG LEU A1055 5.094 31.724 5.872 35.17 C ATOM 75 CD1 LEU A1055 4.42 31.654 4.439 30.21 C ATOM 76 CD2 LEU A1055 5.19 30.345 6.57 30.42 C ATOM 77 C LEU A1055 8.702 32.622 7.259 37.77 C ATOM 78 O LEU A1055 9.593 31.826 6.823 38.16 O ATOM 79 N SER A1056 8.996 33.842 7.712 38.44 N ATOM 80 CA SER A1056 10.361 34.138 8.058 39.83 C ATOM 81 CB SER A1056 10.53 35.611 8.209 39.82 C ATOM 82 OG SER A1056 11.807 35.884 7.633 46.45 O ATOM 83 C SER A1056 10.692 33.399 9.366 39.54 C ATOM 84 O SER A1056 9.778 32.908 10.012 40.79 O ATOM 85 N ALA A1057 11.954 33.251 9.762 38.82 N ATOM 86 CA ALA A1057 12.222 32.456 10.987 38.37 C ATOM 87 CB ALA A1057 11.15 32.739 12.058 38.35 C ATOM 88 C ALA A1057 12.288 30.949 10.736 38.3 C ATOM 89 O ALA A1057 12.676 30.15 11.618 37.56 O ATOM 90 N LEU A1058 11.81 30.567 9.554 38.37 N ATOM 91 CA LEU A1058 11.986 29.242 9.036 38.18 C ATOM 92 CB LEU A1058 11.113 29.053 7.79 38.51 C ATOM 93 CG LEU A1058 9.756 28.341 7.928 37.27 C ATOM 94 CD1 LEU A1058 9.136 28.263 6.541 35.77 C ATOM 95 CD2 LEU A1058 9.864 26.954 8.632 34.79 C ATOM 96 C LEU A1058 13.445 29.182 8.652 38.37 C ATOM 97 O LEU A1058 13.942 30.156 8.091 36.78 O ATOM 98 N ASN A1059 14.11 28.051 8.952 39.31 N ATOM 99 CA ASN A1059 15.505 27.793 8.556 40.53 C ATOM 100 CB ASN A1059 15.835 26.343 8.802 41.11 C ATOM 101 CG ASN A1059 17.226 25.977 8.342 45.43 C ATOM 102 OD1 ASN A1059 17.992 25.369 9.092 51.44 O ATOM 103 ND2 ASN A1059 17.569 26.327 7.112 49.14 N ATOM 104 C ASN A1059 15.768 28.158 7.071 41.05 C ATOM 105 O ASN A1059 15.198 27.542 6.158 40.67 O ATOM 106 N PRO A1060 16.577 29.206 6.827 41.31 N ATOM 107 CD PRO A1060 17.241 30.03 7.84 41.79 C ATOM 108 CA PRO A1060 16.835 29.7 5.483 41.66 C ATOM 109 CB PRO A1060 17.753 30.888 5.721 42.18 C ATOM 110 CG PRO A1060 17.385 31.301 7.127 43.84 C ATOM 111 C PRO A1060 17.483 28.659 4.578 41.37 C ATOM 112 O PRO A1060 17.289 28.689 3.372 40.14 O ATOM 113 N GLU A1061 18.217 27.727 5.17 41.83 N ATOM 114 CA GLU A1061 18.738 26.625 4.399 42.84 C ATOM 115 CB GLU A1061 19.811 25.863 5.194 44.84 C ATOM 116 CG GLU A1061 21.075 25.53 4.347 48.59 C ATOM 117 CD GLU A1061 21.714 26.811 3.785 53.07 C ATOM 118 OE1 GLU A1061 21.973 27.726 4.605 55.39 O ATOM 119 OE2 GLU A1061 21.919 26.916 2.539 55.02 O ATOM 120 C GLU A1061 17.627 25.663 3.957 41.97 C ATOM 121 O GLU A1061 17.714 25.019 2.895 42.05 O ATOM 122 N LEU A1062 16.596 25.539 4.785 39.78 N ATOM 123 CA LEU A1062 15.602 24.545 4.529 37.71 C ATOM 124 CB LEU A1062 14.842 24.154 5.797 37.57 C ATOM 125 CG LEU A1062 13.492 23.442 5.605 38.39 C ATOM 126 CD1 LEU A1062 13.118 22.609 6.804 41.69 C ATOM 127 CD2 LEU A1062 12.386 24.433 5.387 38.42 C ATOM 128 C LEU A1062 14.701 25.111 3.449 36.6 C ATOM 129 O LEU A1062 14.26 24.355 2.556 35.41 O ATOM 130 N VAL A1063 14.492 26.43 3.493 34.92 N ATOM 131 CA VAL A1063 13.566 27.111 2.567 34.29 C ATOM 132 CB VAL A1063 13.244 28.526 3.087 34.3 C ATOM 133 CG1 VAL A1063 12.661 28.432 4.463 34.16 C ATOM 134 CG2 VAL A1063 14.486 29.41 3.087 33.47 C ATOM 135 C VAL A1063 14.005 27.153 1.079 34.81 C ATOM 136 O VAL A1063 13.196 27.221 0.151 33.36 O ATOM 137 N GLN A1064 15.317 27.136 0.839 36.44 N ATOM 138 CA GLN A1064 15.766 27.189 −0.531 36.8 C ATOM 139 CB GLN A1064 17.107 27.891 −0.714 37.34 C ATOM 140 CG GLN A1064 18.298 26.933 −0.903 42.24 C ATOM 141 CD GLN A1064 18.941 26.556 0.423 48.21 C ATOM 142 OE1 GLN A1064 19.424 25.401 0.631 46.84 O ATOM 143 NE2 GLN A1064 18.93 27.533 1.361 49.57 N ATOM 144 C GLN A1064 15.785 25.789 −1.019 35.4 C ATOM 145 O GLN A1064 15.745 25.572 −2.223 36.53 O ATOM 146 N ALA A1065 15.822 24.836 −0.102 34.9 N ATOM 147 CA ALA A1065 15.734 23.427 −0.484 34.73 C ATOM 148 CB ALA A1065 16.265 22.522 0.617 33.98 C ATOM 149 C ALA A1065 14.294 23.02 −0.867 35.39 C ATOM 150 O ALA A1065 14.084 21.938 −1.404 37.15 O ATOM 151 N VAL A1066 13.299 23.857 −0.567 34.68 N ATOM 152 CA VAL A1066 11.925 23.526 −0.857 33.72 C ATOM 153 CB VAL A1066 11.105 23.259 0.451 33.44 C ATOM 154 CG1 VAL A1066 11.819 22.214 1.276 35.84 C ATOM 155 CG2 VAL A1066 10.853 24.515 1.308 31.99 C ATOM 156 C VAL A1066 11.255 24.559 −1.73 34.18 C ATOM 157 O VAL A1066 10.05 24.555 −1.852 34.26 O ATOM 158 N GLN A1067 12.006 25.457 −2.355 34.69 N ATOM 159 CA GLN A1067 11.311 26.561 −3.041 35.45 C ATOM 160 CB GLN A1067 12.234 27.745 −3.342 35.7 C ATOM 161 CG GLN A1067 13.58 27.38 −4.01 39.46 C ATOM 162 CD GLN A1067 13.902 28.27 −5.218 41.67 C ATOM 163 OE1 GLN A1067 15.065 28.643 −5.421 40.43 O ATOM 164 NE2 GLN A1067 12.864 28.609 −6.03 41.3 N ATOM 165 C GLN A1067 10.592 26.046 −4.298 34.39 C ATOM 166 O GLN A1067 9.513 26.551 −4.704 33.28 O ATOM 167 N HIS A1068 11.184 24.999 −4.874 33.52 N ATOM 168 CA HIS A1068 10.604 24.326 −6.044 32.41 C ATOM 169 CB HIS A1068 11.598 23.345 −6.731 31.19 C ATOM 170 CG HIS A1068 11.982 22.16 −5.912 30.41 C ATOM 171 CD2 HIS A1068 11.716 20.828 −6.08 32.9 C ATOM 172 ND1 HIS A1068 12.762 22.256 −4.775 30.19 N ATOM 173 CE1 HIS A1068 12.951 21.041 −4.273 27.55 C ATOM 174 NE2 HIS A1068 12.318 20.159 −5.038 30.41 N ATOM 175 C HIS A1068 9.28 23.677 −5.688 31.32 C ATOM 176 O HIS A1068 8.382 23.674 −6.484 33.73 O ATOM 177 N VAL A1069 9.13 23.197 −4.467 30.56 N ATOM 178 CA VAL A1069 7.856 22.582 −3.983 29.15 C ATOM 179 CB VAL A1069 8.163 21.81 −2.733 29.55 C ATOM 180 CG1 VAL A1069 7.234 20.651 −2.639 31.08 C ATOM 181 CG2 VAL A1069 9.625 21.383 −2.751 30.94 C ATOM 182 C VAL A1069 6.711 23.542 −3.57 26.86 C ATOM 183 O VAL A1069 5.518 23.206 −3.653 25.45 O ATOM 184 N VAL A1070 7.105 24.72 −3.111 24.89 N ATOM 185 CA VAL A1070 6.187 25.716 −2.632 25.08 C ATOM 186 CB VAL A1070 6.875 26.794 −1.768 24.76 C ATOM 187 CG1 VAL A1070 5.823 27.937 −1.397 27.38 C ATOM 188 CG2 VAL A1070 7.398 26.161 −0.518 22.87 C ATOM 189 C VAL A1070 5.335 26.363 −3.725 24.92 C ATOM 190 O VAL A1070 5.866 26.883 −4.671 25.57 O ATOM 191 N ILE A1071 4.017 26.331 −3.539 24.9 N ATOM 192 CA ILE A1071 3.066 26.947 −4.426 25.41 C ATOM 193 CB ILE A1071 1.841 25.984 −4.658 26.26 C ATOM 194 CG2 ILE A1071 0.936 26.512 −5.742 25.59 C ATOM 195 CG1 ILE A1071 2.322 24.56 −5.002 27.15 C ATOM 196 CD1 ILE A1071 1.219 23.495 −5.119 24.77 C ATOM 197 C ILE A1071 2.552 28.291 −3.916 25.98 C ATOM 198 O ILE A1071 2.139 28.459 −2.744 25.3 O ATOM 199 N GLY A1072 2.475 29.24 −4.825 26.18 N ATOM 200 CA GLY A1072 1.98 30.52 −4.46 26.79 C ATOM 201 C GLY A1072 0.488 30.535 −4.409 27.83 C ATOM 202 O GLY A1072 −0.147 29.872 −5.205 26.82 O ATOM 203 N PRO A1073 −0.085 31.374 −3.509 29.78 N ATOM 204 CD PRO A1073 0.556 32.418 −2.675 30.6 C ATOM 205 CA PRO A1073 −1.515 31.335 −3.283 30.69 C ATOM 206 CB PRO A1073 −1.744 32.379 −2.15 31.44 C ATOM 207 CG PRO A1073 −0.627 33.301 −2.24 30.55 C ATOM 208 C PRO A1073 −2.233 31.821 −4.49 31.3 C ATOM 209 O PRO A1073 −3.436 31.784 −4.49 33.38 O ATOM 210 N SER A1074 −1.532 32.348 −5.49 30.64 N ATOM 211 CA SER A1074 −2.259 32.82 −6.665 29 C ATOM 212 CB SER A1074 −1.796 34.218 −7.058 28.51 C ATOM 213 OG SER A1074 −2.372 35.183 −6.185 26.91 O ATOM 214 C SER A1074 −2.124 31.81 −7.79 28.72 C ATOM 215 O SER A1074 −2.763 31.956 −8.833 28.82 O ATOM 216 N SER A1075 −1.311 30.771 −7.522 27.32 N ATOM 217 CA SER A1075 −1.055 29.665 −8.421 25.33 C ATOM 218 CB SER A1075 0.381 29.215 −8.266 25.63 C ATOM 219 OG SER A1075 1.239 30.134 −8.912 26.14 O ATOM 220 C SER A1075 −1.978 28.476 −8.173 25.13 C ATOM 221 O SER A1075 −1.868 27.453 −8.857 25.41 O ATOM 222 N LEU A1076 −2.879 28.615 −7.2 23.73 N ATOM 223 CA LEU A1076 −3.72 27.546 −6.762 21.91 C ATOM 224 CB LEU A1076 −3.187 26.898 −5.467 20.79 C ATOM 225 CG LEU A1076 −4.03 25.669 −5.036 20.11 C ATOM 226 CD1 LEU A1076 −3.951 24.503 −6.038 15.91 C ATOM 227 CD2 LEU A1076 −3.717 25.152 −3.646 19.98 C ATOM 228 C LEU A1076 −5.131 28.047 −6.533 22.97 C ATOM 229 O LEU A1076 −5.408 28.796 −5.548 24.03 O ATOM 230 N ILE A1077 −6.029 27.628 −7.42 22.57 N ATOM 231 CA ILE A1077 −7.439 27.868 −7.216 23.08 C ATOM 232 CB ILE A1077 −8.261 27.904 −8.53 24.06 C ATOM 233 CG2 ILE A1077 −9.65 28.526 −8.221 20.11 C ATOM 234 CG1 ILE A1077 −7.464 28.606 −9.652 22.13 C ATOM 235 CD1 ILE A1077 −7.14 30.062 −9.29 25.62 C ATOM 236 C ILE A1077 −8.061 26.798 −6.385 23.17 C ATOM 237 O ILE A1077 −7.874 25.639 −6.679 24.09 O ATOM 238 N VAL A1078 −8.804 27.195 −5.351 23.26 N ATOM 239 CA VAL A1078 −9.607 26.28 −4.572 23.02 C ATOM 240 CB VAL A1078 −8.916 25.876 −3.223 22.97 C ATOM 241 CG1 VAL A1078 −9.859 25.009 −2.365 22.11 C ATOM 242 CG2 VAL A1078 −7.658 25.173 −3.466 23.96 C ATOM 243 C VAL A1078 −10.893 26.989 −4.227 23.24 C ATOM 244 O VAL A1078 −10.877 27.922 −3.464 23.89 O ATOM 245 N HIS A1079 −12.003 26.51 −4.758 24.26 N ATOM 246 CA HIS A1079 −13.337 26.941 −4.381 24.97 C ATOM 247 CB HIS A1079 −14.21 26.807 −5.596 24.57 C ATOM 248 CG HIS A1079 −13.671 27.5 −6.804 24.97 C ATOM 249 CD2 HIS A1079 −13.2 27.014 −7.974 26.02 C ATOM 250 ND1 HIS A1079 −13.61 28.875 −6.909 24.64 N ATOM 251 CE1 HIS A1079 −13.12 29.202 −8.093 25.68 C ATOM 252 NE2 HIS A1079 −12.871 28.09 −8.763 25.4 N ATOM 253 C HIS A1079 −13.875 26.039 −3.251 27.07 C ATOM 254 O HIS A1079 −13.889 24.8 −3.387 26.98 O ATOM 255 N PHE A1080 −14.317 26.624 −2.137 28.58 N ATOM 256 CA PHE A1080 −14.61 25.778 −0.968 31.3 C ATOM 257 CB PHE A1080 −14.449 26.52 0.389 33.68 C ATOM 258 CG PHE A1080 −13.052 26.915 0.647 35.21 C ATOM 259 CD1 PHE A1080 −12.68 28.264 0.595 40.09 C ATOM 260 CD2 PHE A1080 −12.079 25.927 0.826 32.59 C ATOM 261 CE1 PHE A1080 −11.294 28.615 0.751 42.72 C ATOM 262 CE2 PHE A1080 −10.769 26.232 1 35.14 C ATOM 263 CZ PHE A1080 −10.341 27.577 0.966 40.38 C ATOM 264 C PHE A1080 −15.91 25.034 −0.977 30.93 C ATOM 265 O PHE A1080 −16.144 24.233 −0.073 31.9 O ATOM 266 N ASN A1081 −16.749 25.261 −1.98 29.99 N ATOM 267 CA ASN A1081 −17.951 24.477 −2.052 28.6 C ATOM 268 CB ASN A1081 −19.041 25.218 −2.808 29.48 C ATOM 269 CG ASN A1081 −18.671 25.483 −4.236 31.25 C ATOM 270 OD1 ASN A1081 −17.865 26.382 −4.541 29.24 O ATOM 271 ND2 ASN A1081 −19.204 24.643 −5.131 31.12 N ATOM 272 C ASN A1081 −17.608 23.185 −2.732 27.52 C ATOM 273 O ASN A1081 −18.403 22.229 −2.665 29.53 O ATOM 274 N GLU A1082 −16.414 23.124 −3.333 24.89 N ATOM 275 CA GLU A1082 −16.04 22.01 −4.213 22.44 C ATOM 276 CB GLU A1082 −15.32 22.481 −5.481 22.29 C ATOM 277 CG GLU A1082 −16.068 23.386 −6.341 22.97 C ATOM 278 CD GLU A1082 −15.26 23.767 −7.575 27.8 C ATOM 279 OE1 GLU A1082 −15.742 24.562 −8.432 28.49 O ATOM 280 OE2 GLU A1082 −14.136 23.253 −7.713 29.66 O ATOM 281 C GLU A1082 −15.21 20.951 −3.497 20.44 C ATOM 282 O GLU A1082 −14.018 21.015 −3.435 20.29 O ATOM 283 N VAL A1083 −15.888 19.932 −3.019 19.69 N ATOM 284 CA VAL A1083 −15.309 18.879 −2.201 16.58 C ATOM 285 CB VAL A1083 −16.098 18.697 −0.886 15.58 C ATOM 286 CG1 VAL A1083 −15.45 17.604 −0.042 12.74 C ATOM 287 CG2 VAL A1083 −16.132 20.05 −0.121 12.18 C ATOM 288 C VAL A1083 −15.236 17.566 −2.955 16.73 C ATOM 289 O VAL A1083 −16.201 17.105 −3.555 16.56 O ATOM 290 N ILE A1084 −14.054 16.977 −2.913 16.19 N ATOM 291 CA ILE A1084 −13.822 15.663 −3.494 15.78 C ATOM 292 CB ILE A1084 −12.32 15.465 −3.831 14.2 C ATOM 293 CG2 ILE A1084 −12.057 14.095 −4.192 12.01 C ATOM 294 CG1 ILE A1084 −11.939 16.363 −5.007 14.72 C ATOM 295 CD1 ILE A1084 −10.462 16.58 −5.098 12.82 C ATOM 296 C ILE A1084 −14.343 14.608 −2.533 15.45 C ATOM 297 O ILE A1084 −15.065 13.716 −2.937 15.82 O ATOM 298 N GLY A1085 −13.969 14.733 −1.273 14.58 N ATOM 299 CA GLY A1085 −14.324 13.76 −0.272 15.49 C ATOM 300 C GLY A1085 −14.158 14.328 1.144 16.4 C ATOM 301 O GLY A1085 −13.28 15.137 1.41 14.09 O ATOM 302 N ARG A1086 −15.036 13.887 2.039 18.79 N ATOM 303 CA ARG A1086 −14.945 14.135 3.466 20.86 C ATOM 304 CB ARG A1086 −16.251 14.676 3.989 21.21 C ATOM 305 CG ARG A1086 −16.373 16.172 3.885 23.45 C ATOM 306 CD ARG A1086 −17.9 16.646 3.969 26.42 C ATOM 307 NE ARG A1086 −18.001 18.021 3.466 27.6 N ATOM 308 CZ ARG A1086 −17.48 19.093 4.091 32.33 C ATOM 309 NH1 ARG A1086 −16.816 18.961 5.242 35.28 N ATOM 310 NH2 ARG A1086 −17.595 20.32 3.569 32.16 N ATOM 311 C ARG A1086 −14.682 12.807 4.096 20.17 C ATOM 312 O ARG A1086 −14.958 11.754 3.495 20.3 O ATOM 313 N GLY A1087 −14.079 12.823 5.28 20.64 N ATOM 314 CA GLY A1087 −13.973 11.578 6.063 20.22 C ATOM 315 C GLY A1087 −13.277 11.809 7.358 19.8 C ATOM 316 O GLY A1087 −13.267 12.898 7.864 20.95 O ATOM 317 N HIS A1088 −12.638 10.785 7.88 19.64 N ATOM 318 CA HIS A1088 −11.928 10.907 9.153 18.07 C ATOM 319 CB HIS A1088 −11.39 9.532 9.544 18.11 C ATOM 320 CG HIS A1088 −12.414 8.645 10.11 18.13 C ATOM 321 CD2 HIS A1088 −12.848 7.416 9.726 19.99 C ATOM 322 ND1 HIS A1088 −13.147 8.999 11.226 19.52 N ATOM 323 CE1 HIS A1088 −13.989 8.018 11.518 20.66 C ATOM 324 NE2 HIS A1088 −13.831 7.051 10.622 21.93 N ATOM 325 C HIS A1088 −10.732 11.749 8.888 16.52 C ATOM 326 O HIS A1088 −10.263 12.502 9.743 16.94 O ATOM 327 N PHE A1089 −10.193 11.522 7.698 14.83 N ATOM 328 CA PHE A1089 −9.003 12.234 7.244 13.7 C ATOM 329 CB PHE A1089 −8.494 11.675 5.925 11.64 C ATOM 330 CG PHE A1089 −9.525 11.593 4.91 10.95 C ATOM 331 CD1 PHE A1089 −9.965 12.794 4.219 13.52 C ATOM 332 CD2 PHE A1089 −10.09 10.376 4.612 8.32 C ATOM 333 CE1 PHE A1089 −10.956 12.734 3.249 10.64 C ATOM 334 CE2 PHE A1089 −11.079 10.261 3.648 10.05 C ATOM 335 CZ PHE A1089 −11.543 11.452 2.966 15.19 C ATOM 336 C PHE A1089 −9.287 13.746 7.164 12.68 C ATOM 337 O PHE A1089 −8.348 14.505 7.187 11.45 O ATOM 338 N GLY A1090 −10.577 14.126 7.178 11.98 N ATOM 339 CA GLY A1090 −11.019 15.513 7.028 13.34 C ATOM 340 C GLY A1090 −11.674 15.859 5.68 14 C ATOM 341 O GLY A1090 −12.487 15.12 5.127 14.32 O ATOM 342 N CYS A1091 −11.346 17.001 5.142 14.77 N ATOM 343 CA CYS A1091 −12.027 17.454 3.959 14.05 C ATOM 344 CB CYS A1091 −12.905 18.65 4.304 14.11 C ATOM 345 SG CYS A1091 −13.959 19.211 2.883 19.49 S ATOM 346 C CYS A1091 −11.019 17.769 2.824 13.5 C ATOM 347 O CYS A1091 −10.098 18.585 2.975 11.93 O ATOM 348 N VAL A1092 −11.215 17.09 1.711 12.32 N ATOM 349 CA VAL A1092 −10.36 17.217 0.573 12.75 C ATOM 350 CB VAL A1092 −9.928 15.823 0.058 12.83 C ATOM 351 CG1 VAL A1092 −9.089 15.986 −1.186 13.1 C ATOM 352 CG2 VAL A1092 −9.154 15.079 1.144 10.11 C ATOM 353 C VAL A1092 −11.092 17.993 −0.543 13.41 C ATOM 354 O VAL A1092 −12.196 17.644 −0.947 11.1 O ATOM 355 N TYR A1093 −10.405 19.012 −1.084 14.21 N ATOM 356 CA TYR A1093 −10.987 19.843 −2.087 13.01 C ATOM 357 CB TYR A1093 −10.838 21.298 −1.671 15.58 C ATOM 358 CG TYR A1093 −11.421 21.639 −0.338 16.74 C ATOM 359 CD1 TYR A1093 −10.62 21.582 0.8 20.27 C ATOM 360 CE1 TYR A1093 −11.131 21.931 2.072 24.42 C ATOM 361 CD2 TYR A1093 −12.767 22.025 −0.212 15.71 C ATOM 362 CE2 TYR A1093 −13.326 22.363 1.026 19.23 C ATOM 363 CZ TYR A1093 −12.491 22.327 2.2 24.72 C ATOM 364 OH TYR A1093 −12.946 22.676 3.505 25.2 O ATOM 365 C TYR A1093 −10.429 19.689 −3.461 13.15 C ATOM 366 O TYR A1093 −9.223 19.373 −3.67 10.61 O ATOM 367 N HIS A1094 −11.288 20.032 −4.413 13.11 N ATOM 368 CA HIS A1094 −10.809 20.226 −5.759 14.03 C ATOM 369 CB HIS A1094 −11.964 20.459 −6.695 13.93 C ATOM 370 CG HIS A1094 −12.696 19.219 −7.059 13.98 C ATOM 371 CD2 HIS A1094 −13.885 18.736 −6.647 15.38 C ATOM 372 ND1 HIS A1094 −12.217 18.329 −7.988 16.1 N ATOM 373 CE1 HIS A1094 −13.102 17.372 −8.161 19.29 C ATOM 374 NE2 HIS A1094 −14.106 17.58 −7.337 18.15 N ATOM 375 C HIS A1094 −9.891 21.425 −5.84 14.5 C ATOM 376 O HIS A1094 −10.192 22.432 −5.262 14.97 O ATOM 377 N GLY A1095 −8.78 21.306 −6.553 15.67 N ATOM 378 CA GLY A1095 −7.939 22.453 −6.806 17.79 C ATOM 379 C GLY A1095 −7.533 22.565 −8.27 18.77 C ATOM 380 O GLY A1095 −7.707 21.662 −9.049 17.49 O ATOM 381 N THR A1096 −7.015 23.715 −8.636 21.94 N ATOM 382 CA THR A1096 −6.45 23.941 −9.964 24.75 C ATOM 383 CB THR A1096 −7.362 24.783 −10.89 24.55 C ATOM 384 OG1 THR A1096 −8.54 24.038 −11.201 25.91 O ATOM 385 CG2 THR A1096 −6.679 25.036 −12.2 24.08 C ATOM 386 C THR A1096 −5.135 24.63 −9.743 26.07 C ATOM 387 O THR A1096 −5.071 25.709 −9.187 26.93 O ATOM 388 N LEU A1097 −4.081 23.94 −10.117 28.65 N ATOM 389 CA LEU A1097 −2.772 24.458 −10.032 31.8 C ATOM 390 CB LEU A1097 −1.85 23.345 −9.609 30.83 C ATOM 391 CG LEU A1097 −0.375 23.607 −9.399 32.94 C ATOM 392 CD1 LEU A1097 −0.234 24.57 −8.252 32.31 C ATOM 393 CD2 LEU A1097 0.493 22.298 −9.219 30.24 C ATOM 394 C LEU A1097 −2.449 25.09 −11.421 35.83 C ATOM 395 O LEU A1097 −2.405 24.415 −12.477 35.53 O ATOM 396 N LEU A1098 −2.31 26.421 −11.415 39.47 N ATOM 397 CA LEU A1098 −1.987 27.14 −12.619 43.37 C ATOM 398 CB LEU A1098 −2.541 28.54 −12.571 41.93 C ATOM 399 CG LEU A1098 −3.928 28.572 −11.927 43.36 C ATOM 400 CD1 LEU A1098 −4.141 29.836 −11.071 41.52 C ATOM 401 CD2 LEU A1098 −5.056 28.35 −12.955 42.76 C ATOM 402 C LEU A1098 −0.512 27.166 −12.525 47.12 C ATOM 403 O LEU A1098 0.04 27.78 −11.624 48.42 O ATOM 404 N ASP A1099 0.157 26.422 −13.379 51.62 N ATOM 405 CA ASP A1099 1.604 26.58 −13.384 56.85 C ATOM 406 CB ASP A1099 2.383 25.931 −12.186 57.68 C ATOM 407 CG ASP A1099 2.043 24.437 −11.941 63.37 C ATOM 408 OD1 ASP A1099 0.976 23.902 −12.415 70.78 O ATOM 409 OD2 ASP A1099 2.863 23.795 −11.226 65.81 O ATOM 410 C ASP A1099 2.297 26.411 −14.726 58.47 C ATOM 411 O ASP A1099 2.446 25.303 −15.282 59.18 O ATOM 412 N ASN A1100 2.591 27.597 −15.241 60.14 N ATOM 413 CA ASN A1100 3.733 27.913 −16.05 61.85 C ATOM 414 CB ASN A1100 5.058 27.881 −15.346 62.48 C ATOM 415 CG ASN A1100 5.207 29.074 −14.421 64.67 C ATOM 416 OD1 ASN A1100 4.493 30.084 −14.6 66.33 O ATOM 417 ND2 ASN A1100 6.098 28.973 −13.414 65.49 N ATOM 418 C ASN A1100 3.704 28.415 −17.45 61.64 C ATOM 419 O ASN A1100 3.76 27.649 −18.43 61.43 O ATOM 420 N ASP A1101 3.616 29.729 −17.532 61.13 N ATOM 421 CA ASP A1101 2.785 30.288 −18.571 61.44 C ATOM 422 CB ASP A1101 3.612 30.958 −19.687 62.05 C ATOM 423 CG ASP A1101 2.907 32.203 −20.251 63.68 C ATOM 424 OD1 ASP A1101 2.526 32.22 −21.452 62.73 O ATOM 425 OD2 ASP A1101 2.702 33.157 −19.455 66.21 O ATOM 426 C ASP A1101 1.805 29.22 −19.135 60.4 C ATOM 427 O ASP A1101 2.226 28.267 −19.83 60.81 O ATOM 428 N GLY A1102 0.516 29.356 −18.804 58.95 N ATOM 429 CA GLY A1102 −0.534 28.677 −19.573 56.58 C ATOM 430 C GLY A1102 −1.253 27.537 −18.885 54.7 C ATOM 431 O GLY A1102 −2.465 27.587 −18.683 53.95 O ATOM 432 N LYS A1103 −0.534 26.476 −18.542 53.24 N ATOM 433 CA LYS A1103 −1.278 25.235 −18.237 51.22 C ATOM 434 CB LYS A1103 −0.65 23.93 −18.814 51.58 C ATOM 435 CG LYS A1103 0.762 23.585 −18.409 54.34 C ATOM 436 CD LYS A1103 1.789 24.509 −19.112 57.47 C ATOM 437 CE LYS A1103 2.423 25.478 −18.11 55.46 C ATOM 438 NZ LYS A1103 3.733 24.994 −17.598 53.32 N ATOM 439 C LYS A1103 −1.924 25.068 −16.843 48.72 C ATOM 440 O LYS A1103 −1.492 25.647 −15.82 48.06 O ATOM 441 N LYS A1104 −3.032 24.329 −16.899 45.99 N ATOM 442 CA LYS A1104 −3.879 24.011 −15.771 43.3 C ATOM 443 CB LYS A1104 −5.317 24.45 −16.004 42.65 C ATOM 444 CG LYS A1104 −5.508 25.939 −15.923 41.8 C ATOM 445 CD LYS A1104 −6.917 26.243 −16.354 40.69 C ATOM 446 CE LYS A1104 −6.952 27.394 −17.336 40.81 C ATOM 447 NZ LYS A1104 −8.305 28.012 −17.239 41.64 N ATOM 448 C LYS A1104 −3.825 22.516 −15.436 41.44 C ATOM 449 O LYS A1104 −3.898 21.605 −16.313 40.97 O ATOM 450 N ILE A1105 −3.657 22.291 −14.142 37.97 N ATOM 451 CA ILE A1105 −3.705 20.976 −13.612 34.91 C ATOM 452 CB ILE A1105 −2.301 20.361 −13.454 35.61 C ATOM 453 CG2 ILE A1105 −1.135 21.401 −13.762 37.19 C ATOM 454 CG1 ILE A1105 −2.155 19.599 −12.139 36.65 C ATOM 455 CD1 ILE A1105 −0.883 18.749 −12.072 36.89 C ATOM 456 C ILE A1105 −4.701 20.852 −12.444 31.98 C ATOM 457 O ILE A1105 −4.608 21.565 −11.427 27.87 O ATOM 458 N HIS A1106 −5.686 19.967 −12.693 28.84 N ATOM 459 CA HIS A1106 −6.645 19.518 −11.728 26.8 C ATOM 460 CB HIS A1106 −7.622 18.551 −12.383 28.08 C ATOM 461 CG HIS A1106 −8.818 18.218 −11.543 30.25 C ATOM 462 CD2 HIS A1106 −9.146 18.556 −10.269 31.62 C ATOM 463 ND1 HIS A1106 −9.881 17.478 −12.03 33.44 N ATOM 464 CE1 HIS A1106 −10.804 17.357 −11.087 33.23 C ATOM 465 NE2 HIS A1106 −10.375 17.991 −10.003 35.32 N ATOM 466 C HIS A1106 −5.886 18.793 −10.631 24.68 C ATOM 467 O HIS A1106 −4.955 18.018 −10.904 25.45 O ATOM 468 N CYS A1107 −6.243 19.048 −9.386 21.07 N ATOM 469 CA CYS A1107 −5.523 18.458 −8.31 19.54 C ATOM 470 CB CYS A1107 −4.265 19.297 −8 20.32 C ATOM 471 SG CYS A1107 −4.67 21.059 −7.642 21.01 S ATOM 472 C CYS A1107 −6.454 18.368 −7.115 18.93 C ATOM 473 O CYS A1107 −7.648 18.819 −7.131 17.53 O ATOM 474 N ALA A1108 −5.915 17.78 −6.063 17.24 N ATOM 475 CA ALA A1108 −6.65 17.696 −4.829 15.77 C ATOM 476 CB ALA A1108 −6.865 16.206 −4.395 15.49 C ATOM 477 C ALA A1108 −5.856 18.437 −3.791 14.69 C ATOM 478 O ALA A1108 −4.645 18.317 −3.75 14.65 O ATOM 479 N VAL A1109 −6.559 19.158 −2.927 13.84 N ATOM 480 CA VAL A1109 −5.932 20.008 −1.939 12.57 C ATOM 481 CB VAL A1109 −6.094 21.513 −2.247 12.13 C ATOM 482 CG1 VAL A1109 −5.136 22.321 −1.227 11.45 C ATOM 483 CG2 VAL A1109 −5.762 21.768 −3.729 8.23 C ATOM 484 C VAL A1109 −6.49 19.734 −0.554 12.99 C ATOM 485 O VAL A1109 −7.719 19.469 −0.365 12.53 O ATOM 486 N LYS A1110 −5.587 19.781 0.41 12.17 N ATOM 487 CA LYS A1110 −5.977 19.552 1.81 14.24 C ATOM 488 CB LYS A1110 −5.985 18.063 2.167 13.99 C ATOM 489 CG LYS A1110 −6.46 17.861 3.594 21.03 C ATOM 490 CD LYS A1110 −6.867 16.451 3.838 23.19 C ATOM 491 CE LYS A1110 −7.619 16.316 5.141 25.85 C ATOM 492 NZ LYS A1110 −7.133 17.189 6.257 25.05 N ATOM 493 C LYS A1110 −5.123 20.326 2.802 13.07 C ATOM 494 O LYS A1110 −3.911 20.547 2.592 11.93 O ATOM 495 N SER A1111 −5.803 20.812 3.831 13.22 N ATOM 496 CA SER A1111 −5.157 21.588 4.925 13.91 C ATOM 497 CB SER A1111 −6.208 22.486 5.632 13.19 C ATOM 498 OG SER A1111 −5.588 23.295 6.645 16.46 O ATOM 499 C SER A1111 −4.531 20.633 5.894 12.91 C ATOM 500 O SER A1111 −5.173 19.691 6.345 13.35 O ATOM 501 N LEU A1112 −3.251 20.769 6.16 13.27 N ATOM 502 CA LEU A1112 −2.67 19.886 7.215 12.16 C ATOM 503 CB LEU A1112 −1.183 19.77 6.984 12.71 C ATOM 504 CG LEU A1112 −0.892 19.329 5.545 13.33 C ATOM 505 CD1 LEU A1112 0.556 19.371 5.272 10.72 C ATOM 506 CD2 LEU A1112 −1.401 17.897 5.255 16.22 C ATOM 507 C LEU A1112 −2.964 20.401 8.632 12.03 C ATOM 508 O LEU A1112 −2.145 21.009 9.264 11.5 O ATOM 509 N ASN A1113 −4.201 20.228 9.091 13.41 N ATOM 510 CA ASN A1113 −4.652 20.809 10.366 12.87 C ATOM 511 CB ASN A1113 −6.092 20.435 10.644 13.74 C ATOM 512 CG ASN A1113 −6.994 20.782 9.52 11.65 C ATOM 513 OD1 ASN A1113 −6.819 21.773 8.853 17.02 O ATOM 514 ND2 ASN A1113 −7.919 19.946 9.271 13.53 N ATOM 515 C ASN A1113 −3.822 20.364 11.556 12.79 C ATOM 516 O ASN A1113 −3.905 20.982 12.625 11.81 O ATOM 517 N ARG A1114 −2.993 19.335 11.362 11.67 N ATOM 518 CA ARG A1114 −2.192 18.838 12.447 11.69 C ATOM 519 CB ARG A1114 −1.872 17.402 12.26 12.4 C ATOM 520 CG ARG A1114 −3.031 16.474 12.672 15.55 C ATOM 521 CD ARG A1114 −2.856 15.116 12.074 19.31 C ATOM 522 NE ARG A1114 −1.941 14.212 12.787 25.78 N ATOM 523 CZ ARG A1114 −1.491 13.059 12.246 29.79 C ATOM 524 NH1 ARG A1114 −1.851 12.685 10.979 24.36 N ATOM 525 NH2 ARG A1114 −0.693 12.264 12.964 26.37 N ATOM 526 C ARG A1114 −0.933 19.587 12.57 12.08 C ATOM 527 O ARG A1114 −0.203 19.386 13.495 12.99 O ATOM 528 N ILE A1115 −0.645 20.425 11.59 13.44 N ATOM 529 CA ILE A1115 0.508 21.284 11.629 14.59 C ATOM 530 CB ILE A1115 1.202 21.342 10.297 14.68 C ATOM 531 CG2 ILE A1115 2.221 22.495 10.326 12.88 C ATOM 532 CG1 ILE A1115 1.808 19.959 9.988 12.83 C ATOM 533 CD1 ILE A1115 2.105 19.742 8.559 15.91 C ATOM 534 C ILE A1115 0.012 22.649 12.063 16.19 C ATOM 535 O ILE A1115 −0.616 23.356 11.311 15.61 O ATOM 536 N THR A1116 0.255 22.94 13.329 18.45 N ATOM 537 CA THR A1116 −0.373 24.035 14.047 20.84 C ATOM 538 CB THR A1116 −0.99 23.595 15.441 20 C ATOM 539 OG1 THR A1116 0.063 23.267 16.354 22.88 O ATOM 540 CG2 THR A1116 −1.914 22.399 15.325 19.02 C ATOM 541 C THR A1116 0.647 25.161 14.281 22.42 C ATOM 542 O THR A1116 0.262 26.269 14.657 24.01 O ATOM 543 N ASP A1117 1.925 24.884 14.072 24.01 N ATOM 544 CA ASP A1117 2.966 25.857 14.387 27.46 C ATOM 545 CB ASP A1117 3.215 25.998 15.919 28.91 C ATOM 546 CG ASP A1117 4.169 24.937 16.472 33.12 C ATOM 547 OD1 ASP A1117 5.406 25.172 16.513 42.43 O ATOM 548 OD2 ASP A1117 3.693 23.861 16.88 39.9 O ATOM 549 C ASP A1117 4.283 25.595 13.691 27.09 C ATOM 550 O ASP A1117 4.521 24.504 13.158 27.63 O ATOM 551 N ILE A1118 5.154 26.598 13.782 27.49 N ATOM 552 CA ILE A1118 6.42 26.628 13.014 28.72 C ATOM 553 CB ILE A1118 7.229 27.969 13.169 28.25 C ATOM 554 CG2 ILE A1118 7.455 28.31 14.587 28.16 C ATOM 555 CG1 ILE A1118 8.569 27.892 12.419 29.89 C ATOM 556 CD1 ILE A1118 8.654 28.76 11.192 26.9 C ATOM 557 C ILE A1118 7.296 25.38 13.127 28.67 C ATOM 558 O ILE A1118 7.848 24.949 12.137 29.24 O ATOM 559 N GLY A1119 7.361 24.755 14.293 28.57 N ATOM 560 CA GLY A1119 8.258 23.631 14.422 28.01 C ATOM 561 C GLY A1119 7.757 22.432 13.65 28.19 C ATOM 562 O GLY A1119 8.574 21.626 13.154 28.46 O ATOM 563 N GLU A1120 6.428 22.287 13.578 26.88 N ATOM 564 CA GLU A1120 5.838 21.15 12.906 26.64 C ATOM 565 CB GLU A1120 4.42 20.865 13.421 27.07 C ATOM 566 CG GLU A1120 4.269 20.751 14.884 27.63 C ATOM 567 CD GLU A1120 2.846 21.044 15.39 28.22 C ATOM 568 OE1 GLU A1120 2.099 21.807 14.783 28.44 O ATOM 569 OE2 GLU A1120 2.46 20.487 16.42 29.07 O ATOM 570 C GLU A1120 5.81 21.407 11.383 26.7 C ATOM 571 O GLU A1120 5.802 20.462 10.573 25.57 O ATOM 572 N VAL A1121 5.748 22.693 11.022 27.37 N ATOM 573 CA VAL A1121 5.922 23.13 9.647 27.71 C ATOM 574 CB VAL A1121 5.683 24.628 9.497 27.27 C ATOM 575 CG1 VAL A1121 6.097 25.15 8.094 23.83 C ATOM 576 CG2 VAL A1121 4.232 24.897 9.771 27.4 C ATOM 577 C VAL A1121 7.325 22.81 9.246 28.92 C ATOM 578 O VAL A1121 7.574 22.155 8.242 29.26 O ATOM 579 N SER A1122 8.239 23.273 10.055 29.93 N ATOM 580 CA SER A1122 9.619 23.092 9.773 32.48 C ATOM 581 CB SER A1122 10.424 23.719 10.877 32.29 C ATOM 582 OG SER A1122 11.749 23.285 10.758 38.18 O ATOM 583 C SER A1122 9.979 21.618 9.585 32.67 C ATOM 584 O SER A1122 10.711 21.274 8.654 32.69 O ATOM 585 N GLN A1123 9.433 20.778 10.459 33.88 N ATOM 586 CA GLN A1123 9.694 19.352 10.488 35.82 C ATOM 587 CB GLN A1123 9.422 18.731 11.856 36.63 C ATOM 588 CG GLN A1123 10.061 17.303 11.912 43.42 C ATOM 589 CD GLN A1123 9.12 16.204 12.492 51.27 C ATOM 590 OE1 GLN A1123 8.588 16.34 13.639 52.06 O ATOM 591 NE2 GLN A1123 8.934 15.093 11.713 49.85 N ATOM 592 C GLN A1123 8.86 18.583 9.502 35.76 C ATOM 593 O GLN A1123 9.02 17.389 9.395 36.26 O ATOM 594 N PHE A1124 7.937 19.267 8.837 35.73 N ATOM 595 CA PHE A1124 7.195 18.716 7.759 35.08 C ATOM 596 CB PHE A1124 5.78 19.251 7.763 34.12 C ATOM 597 CG PHE A1124 5.026 18.881 6.552 33.72 C ATOM 598 CD1 PHE A1124 4.905 17.538 6.189 33.01 C ATOM 599 CD2 PHE A1124 4.467 19.855 5.735 34.39 C ATOM 600 CE1 PHE A1124 4.217 17.146 5.019 35.69 C ATOM 601 CE2 PHE A1124 3.769 19.486 4.546 37.38 C ATOM 602 CZ PHE A1124 3.623 18.098 4.198 33.44 C ATOM 603 C PHE A1124 7.856 19.11 6.465 36.22 C ATOM 604 O PHE A1124 7.758 18.418 5.471 36.62 O ATOM 605 N LEU A1125 8.515 20.253 6.458 37.74 N ATOM 606 CA LEU A1125 9.041 20.818 5.213 38.87 C ATOM 607 CB LEU A1125 9.55 22.25 5.41 37.31 C ATOM 608 CG LEU A1125 8.45 23.306 5.26 31.73 C ATOM 609 CD1 LEU A1125 9.085 24.585 5.245 27.34 C ATOM 610 CD2 LEU A1125 7.633 23.113 4.006 29.13 C ATOM 611 C LEU A1125 10.118 19.936 4.675 41.71 C ATOM 612 O LEU A1125 10.5 20.024 3.508 43.58 O ATOM 613 N THR A1126 10.569 19.051 5.536 44.24 N ATOM 614 CA THR A1126 11.528 18.045 5.199 47.41 C ATOM 615 CB THR A1126 12.226 17.613 6.523 46.64 C ATOM 616 OG1 THR A1126 12.818 18.766 7.167 44.19 O ATOM 617 CG2 THR A1126 13.246 16.566 6.262 44.87 C ATOM 618 C THR A1126 10.862 16.834 4.43 49.62 C ATOM 619 O THR A1126 11.561 15.942 3.935 50.03 O ATOM 620 N GLU A1127 9.516 16.791 4.341 52.19 N ATOM 621 CA GLU A1127 8.783 15.674 3.645 52.2 C ATOM 622 CB GLU A1127 7.449 15.293 4.324 52.31 C ATOM 623 CG GLU A1127 7.501 15.199 5.841 53.81 C ATOM 624 CD GLU A1127 8.832 14.692 6.389 55.9 C ATOM 625 OE1 GLU A1127 9.174 15.026 7.545 57.21 O ATOM 626 OE2 GLU A1127 9.547 13.971 5.665 57.62 O ATOM 627 C GLU A1127 8.545 15.969 2.176 53.81 C ATOM 628 O GLU A1127 8.112 15.1 1.439 55.01 O ATOM 629 N GLY A1128 8.782 17.202 1.749 54.61 N ATOM 630 CA GLY A1128 9.106 17.403 0.357 55.06 C ATOM 631 C GLY A1128 10.488 16.749 0.176 55.64 C ATOM 632 O GLY A1128 10.614 15.726 −0.532 55.14 O ATOM 633 N ILE A1129 11.511 17.316 0.845 55.99 N ATOM 634 CA ILE A1129 12.95 16.959 0.641 56.67 C ATOM 635 CB ILE A1129 13.908 17.691 1.668 56.95 C ATOM 636 CG2 ILE A1129 13.492 19.182 1.83 55.72 C ATOM 637 CG1 ILE A1129 14.077 16.912 3.024 56.78 C ATOM 638 CD1 ILE A1129 15.422 16.113 3.3 53.37 C ATOM 639 C ILE A1129 13.277 15.432 0.541 57.46 C ATOM 640 O ILE A1129 14.386 15.035 0.094 58.01 O ATOM 641 N ILE A1130 12.309 14.597 0.965 57.33 N ATOM 642 CA ILE A1130 12.338 13.139 0.758 55.98 C ATOM 643 CB ILE A1130 12.578 12.337 2.059 55.97 C ATOM 644 CG2 ILE A1130 13.335 11.008 1.723 56.77 C ATOM 645 CG1 ILE A1130 13.265 13.188 3.132 55.59 C ATOM 646 CD1 ILE A1130 13.016 12.698 4.536 57.13 C ATOM 647 C ILE A1130 11.017 12.641 0.192 54.95 C ATOM 648 O ILE A1130 10.363 11.849 0.881 54.45 O ATOM 649 N MET A1131 10.628 13.064 −1.032 53.3 N ATOM 650 CA MET A1131 9.326 12.664 −1.518 52.51 C ATOM 651 CB MET A1131 8.386 12.568 −0.315 52.76 C ATOM 652 CG MET A1131 6.879 12.691 −0.612 55.76 C ATOM 653 SD MET A1131 5.963 12.687 0.939 55.65 S ATOM 654 CE MET A1131 6.21 10.987 1.559 53.64 C ATOM 655 C MET A1131 8.643 13.474 −2.611 51.28 C ATOM 656 O MET A1131 8.018 12.882 −3.51 51.1 O ATOM 657 N LYS A1132 8.644 14.809 −2.476 49.59 N ATOM 658 CA LYS A1132 8.324 15.729 −3.595 47.3 C ATOM 659 CB LYS A1132 8.789 17.164 −3.285 48.03 C ATOM 660 CG LYS A1132 10.293 17.164 −2.812 50.92 C ATOM 661 CD LYS A1132 11.15 18.336 −3.247 55.23 C ATOM 662 CE LYS A1132 12.093 18.78 −2.115 59.29 C ATOM 663 NZ LYS A1132 11.331 19.555 −1.032 62.84 N ATOM 664 C LYS A1132 9.143 15.254 −4.799 44.44 C ATOM 665 O LYS A1132 8.7 15.357 −5.954 44.56 O ATOM 666 N ASP A1133 10.318 14.71 −4.467 40.34 N ATOM 667 CA ASP A1133 11.375 14.342 −5.376 36.85 C ATOM 668 CB ASP A1133 12.709 14.419 −4.644 38.1 C ATOM 669 CG ASP A1133 13.169 15.86 −4.393 39.25 C ATOM 670 OD1 ASP A1133 12.747 16.789 −5.118 41.64 O ATOM 671 OD2 ASP A1133 13.953 16.054 −3.429 43.78 O ATOM 672 C ASP A1133 11.207 12.94 −5.944 34.05 C ATOM 673 O ASP A1133 11.739 12.66 −7.041 34.56 O ATOM 674 N PHE A1134 10.49 12.067 −5.218 28.41 N ATOM 675 CA PHE A1134 10.146 10.735 −5.744 24.7 C ATOM 676 CB PHE A1134 9.28 9.939 −4.749 23.35 C ATOM 677 CG PHE A1134 10.06 9.444 −3.583 22.72 C ATOM 678 CD1 PHE A1134 9.434 8.928 −2.485 22.8 C ATOM 679 CD2 PHE A1134 11.454 9.545 −3.574 22.21 C ATOM 680 CE1 PHE A1134 10.225 8.477 −1.407 26.8 C ATOM 681 CE2 PHE A1134 12.231 9.132 −2.522 23.45 C ATOM 682 CZ PHE A1134 11.652 8.565 −1.446 22.5 C ATOM 683 C PHE A1134 9.473 10.818 −7.109 22.06 C ATOM 684 O PHE A1134 8.578 11.597 −7.275 21.7 O ATOM 685 N SER A1135 9.928 10.048 −8.079 19.56 N ATOM 686 CA SER A1135 9.24 10.001 −9.339 18.42 C ATOM 687 CB SER A1135 10.033 10.836 −10.349 19.51 C ATOM 688 OG SER A1135 9.252 11.189 −11.487 19.35 O ATOM 689 C SER A1135 9.127 8.538 −9.816 17.14 C ATOM 690 O SER A1135 10.052 7.971 −10.389 16.98 O ATOM 691 N HIS A1136 8.002 7.906 −9.564 15.18 N ATOM 692 CA HIS A1136 7.775 6.589 −10.15 12.41 C ATOM 693 CB HIS A1136 8.12 5.487 −9.143 11.98 C ATOM 694 CG HIS A1136 8.054 4.111 −9.726 12.38 C ATOM 695 CD2 HIS A1136 9.014 3.342 −10.296 12.91 C ATOM 696 ND1 HIS A1136 6.887 3.402 −9.823 10.71 N ATOM 697 CE1 HIS A1136 7.124 2.27 −10.449 14.23 C ATOM 698 NE2 HIS A1136 8.415 2.198 −10.725 8.48 N ATOM 699 C HIS A1136 6.306 6.582 −10.556 11.29 C ATOM 700 O HIS A1136 5.478 7.238 −9.9 10.24 O ATOM 701 N PRO A1137 5.981 5.977 −11.708 10.16 N ATOM 702 CD PRO A1137 6.95 5.593 −12.754 10.83 C ATOM 703 CA PRO A1137 4.582 5.808 −12.11 9.53 C ATOM 704 CB PRO A1137 4.65 5.004 −13.437 10.43 C ATOM 705 CG PRO A1137 6.114 4.696 −13.672 11.57 C ATOM 706 C PRO A1137 3.648 5.099 −11.124 9.5 C ATOM 707 O PRO A1137 2.46 5.254 −11.205 11.49 O ATOM 708 N ASN A1138 4.153 4.305 −10.205 9.85 N ATOM 709 CA ASN A1138 3.317 3.68 −9.221 9.77 C ATOM 710 CB ASN A1138 3.543 2.164 −9.193 9.54 C ATOM 711 CG ASN A1138 3.25 1.539 −10.487 9.02 C ATOM 712 OD1 ASN A1138 4.175 0.982 −11.148 10.24 O ATOM 713 ND2 ASN A1138 1.987 1.653 −10.932 9.34 N ATOM 714 C ASN A1138 3.502 4.246 −7.809 10.27 C ATOM 715 O ASN A1138 3.104 3.638 −6.837 9.17 O ATOM 716 N VAL A1139 4.045 5.448 −7.727 11.2 N ATOM 717 CA VAL A1139 4.147 6.196 −6.473 11.12 C ATOM 718 CB VAL A1139 5.614 6.467 −6.114 10.21 C ATOM 719 CG1 VAL A1139 5.682 7.242 −4.755 9.07 C ATOM 720 CG2 VAL A1139 6.356 5.132 −6.068 5.79 C ATOM 721 C VAL A1139 3.411 7.492 −6.689 11.77 C ATOM 722 O VAL A1139 3.647 8.158 −7.713 10.94 O ATOM 723 N LEU A1140 2.522 7.823 −5.745 13.02 N ATOM 724 CA LEU A1140 1.71 9.03 −5.83 15.05 C ATOM 725 CB LEU A1140 0.503 8.927 −4.925 15.32 C ATOM 726 CG LEU A1140 −0.733 9.865 −4.978 14.43 C ATOM 727 CD1 LEU A1140 −0.669 10.86 −3.921 17.59 C ATOM 728 CD2 LEU A1140 −0.925 10.507 −6.316 12.71 C ATOM 729 C LEU A1140 2.641 10.14 −5.355 17.56 C ATOM 730 O LEU A1140 3.161 10.068 −4.248 18.36 O ATOM 731 N SER A1141 2.944 11.121 −6.193 18.73 N ATOM 732 CA SER A1141 3.834 12.13 −5.697 21.1 C ATOM 733 CB SER A1141 5.055 12.328 −6.649 24.1 C ATOM 734 OG SER A1141 6.3 11.941 −6.014 26.54 O ATOM 735 C SER A1141 3.144 13.464 −5.374 20.71 C ATOM 736 O SER A1141 2.13 13.815 −5.93 19.98 O ATOM 737 N LEU A1142 3.752 14.182 −4.45 20.91 N ATOM 738 CA LEU A1142 3.323 15.505 −4.03 22.16 C ATOM 739 CB LEU A1142 4.34 15.894 −2.937 23.71 C ATOM 740 CG LEU A1142 4.041 16.699 −1.689 23.78 C ATOM 741 CD1 LEU A1142 3.912 18.061 −2.193 27.43 C ATOM 742 CD2 LEU A1142 2.719 16.18 −1.182 26.21 C ATOM 743 C LEU A1142 3.373 16.496 −5.235 21.52 C ATOM 744 O LEU A1142 4.395 16.47 −5.96 19.46 O ATOM 745 N LEU A1143 2.31 17.314 −5.498 19.99 N ATOM 746 CA LEU A1143 2.485 18.436 −6.495 19.13 C ATOM 747 CB LEU A1143 1.204 18.79 −7.251 18.43 C ATOM 748 CG LEU A1143 0.689 17.786 −8.297 18.69 C ATOM 749 CD1 LEU A1143 −0.597 18.167 −8.903 12.55 C ATOM 750 CD2 LEU A1143 1.731 17.452 −9.369 14.52 C ATOM 751 C LEU A1143 3.082 19.719 −5.899 18.63 C ATOM 752 O LEU A1143 3.836 20.444 −6.547 17.14 O ATOM 753 N GLY A1144 2.692 20.033 −4.675 18.45 N ATOM 754 CA GLY A1144 3.367 21.071 −3.916 18.59 C ATOM 755 C GLY A1144 2.707 21.3 −2.586 19.82 C ATOM 756 O GLY A1144 1.828 20.563 −2.135 19.78 O ATOM 757 N ILE A1145 3.144 22.371 −1.964 22.33 N ATOM 758 CA ILE A1145 2.663 22.855 −0.703 22.29 C ATOM 759 CB ILE A1145 3.805 22.853 0.339 23.4 C ATOM 760 CG2 ILE A1145 3.223 22.796 1.739 22.81 C ATOM 761 CG1 ILE A1145 4.753 21.695 0.117 23.81 C ATOM 762 CD1 ILE A1145 4.176 20.356 0.659 27.04 C ATOM 763 C ILE A1145 2.325 24.302 −0.914 22.87 C ATOM 764 O ILE A1145 3.085 24.998 −1.56 22.95 O ATOM 765 N CYS A1146 1.213 24.758 −0.345 24.26 N ATOM 766 CA CYS A1146 1.049 26.164 −0.048 27.33 C ATOM 767 CB CYS A1146 −0.335 26.706 −0.453 27.93 C ATOM 768 SG CYS A1146 −0.799 25.936 −2.042 40.01 S ATOM 769 C CYS A1146 1.314 26.435 1.413 26.36 C ATOM 770 O CYS A1146 0.576 26.017 2.263 26.54 O ATOM 771 N LEU A1147 2.381 27.169 1.681 26.97 N ATOM 772 CA LEU A1147 2.702 27.677 3.028 26.84 C ATOM 773 CB LEU A1147 4.215 27.96 3.13 25.24 C ATOM 774 CG LEU A1147 5.124 26.744 3.04 23.65 C ATOM 775 CD1 LEU A1147 6.564 27.203 3.331 22.66 C ATOM 776 CD2 LEU A1147 4.686 25.628 4.009 22.26 C ATOM 777 C LEU A1147 1.92 28.956 3.281 27.19 C ATOM 778 O LEU A1147 2.092 29.949 2.592 27.3 O ATOM 779 N ARG A1148 1.034 28.926 4.254 29.23 N ATOM 780 CA ARG A1148 0.26 30.107 4.572 30.63 C ATOM 781 CB ARG A1148 −1.216 29.77 4.627 29.46 C ATOM 782 CG ARG A1148 −1.673 29.076 3.423 29.26 C ATOM 783 CD ARG A1148 −3.153 29.009 3.391 24.3 C ATOM 784 NE ARG A1148 −3.536 28.04 4.382 23.08 N ATOM 785 CZ ARG A1148 −4.774 27.756 4.699 22.68 C ATOM 786 NH1 ARG A1148 −5.728 28.404 4.05 25.32 N ATOM 787 NH2 ARG A1148 −5.034 26.805 5.596 19.48 N ATOM 788 C ARG A1148 0.772 30.687 5.885 32.3 C ATOM 789 O ARG A1148 1.33 29.934 6.749 32.98 O ATOM 790 N SER A1149 0.656 32.013 6.005 33.88 N ATOM 791 CA SER A1149 0.938 32.721 7.301 35.81 C ATOM 792 CB SER A1149 1.614 34.074 7.063 36.19 C ATOM 793 OG SER A1149 3.02 34.017 7.166 40.64 O ATOM 794 C SER A1149 −0.398 33.008 7.919 35.4 C ATOM 795 O SER A1149 −0.839 34.149 7.871 38.1 O ATOM 796 N GLU A1150 −1.06 31.972 8.401 33.94 N ATOM 797 CA GLU A1150 −2.447 31.964 8.87 33.33 C ATOM 798 CB GLU A1150 −3.232 33.244 8.587 33.3 C ATOM 799 CG GLU A1150 −2.992 34.371 9.613 35.05 C ATOM 800 CD GLU A1150 −3.965 35.531 9.472 36.72 C ATOM 801 OE1 GLU A1150 −3.696 36.603 10.093 41.98 O ATOM 802 OE2 GLU A1150 −5.026 35.391 8.789 41.29 O ATOM 803 C GLU A1150 −3.119 30.737 8.235 30.98 C ATOM 804 O GLU A1150 −3.349 30.674 7.024 29.7 O ATOM 805 N GLY A1151 −3.385 29.744 9.066 28.12 N ATOM 806 CA GLY A1151 −3.827 28.45 8.559 24.41 C ATOM 807 C GLY A1151 −2.653 27.52 8.348 21.21 C ATOM 808 O GLY A1151 −1.513 27.918 8.1 20.6 O ATOM 809 N SER A1152 −2.965 26.243 8.455 19.89 N ATOM 810 CA SER A1152 −2.038 25.175 8.252 16.36 C ATOM 811 CB SER A1152 −2.709 23.894 8.687 16.61 C ATOM 812 OG SER A1152 −2.738 23.798 10.107 17.18 O ATOM 813 C SER A1152 −1.604 25.15 6.792 15.1 C ATOM 814 O SER A1152 −2.313 25.628 5.915 16.63 O ATOM 815 N PRO A1153 −0.426 24.621 6.515 13.76 N ATOM 816 CD PRO A1153 0.58 24.139 7.483 13.56 C ATOM 817 CA PRO A1153 −0.015 24.444 5.132 13.75 C ATOM 818 CB PRO A1153 1.3 23.722 5.273 13.97 C ATOM 819 CG PRO A1153 1.807 24.225 6.721 13.45 C ATOM 820 C PRO A1153 −0.982 23.58 4.363 14.15 C ATOM 821 O PRO A1153 −1.705 22.739 4.935 15.18 O ATOM 822 N LEU A1154 −1.04 23.84 3.079 14.16 N ATOM 823 CA LEU A1154 −1.901 23.118 2.192 15.42 C ATOM 824 CB LEU A1154 −2.525 24.029 1.175 14.91 C ATOM 825 CG LEU A1154 −3.898 24.572 1.467 19.4 C ATOM 826 CD1 LEU A1154 −4.454 24.434 2.886 17.68 C ATOM 827 CD2 LEU A1154 −3.97 25.964 0.981 16.05 C ATOM 828 C LEU A1154 −0.996 22.156 1.485 14.7 C ATOM 829 O LEU A1154 0.175 22.461 1.248 15.04 O ATOM 830 N VAL A1155 −1.527 20.973 1.215 13.24 N ATOM 831 CA VAL A1155 −0.806 20.022 0.444 12.27 C ATOM 832 CB VAL A1155 −0.535 18.73 1.26 12.93 C ATOM 833 CG1 VAL A1155 −1.88 17.94 1.51 11.63 C ATOM 834 CG2 VAL A1155 0.462 17.886 0.543 13.81 C ATOM 835 C VAL A1155 −1.622 19.8 −0.827 10.87 C ATOM 836 O VAL A1155 −2.762 19.527 −0.794 12.07 O ATOM 837 N VAL A1156 −0.977 19.902 −1.962 12.01 N ATOM 838 CA VAL A1156 −1.583 19.681 −3.277 11.31 C ATOM 839 CB VAL A1156 −1.229 20.937 −4.185 10.29 C ATOM 840 CG1 VAL A1156 −1.952 20.883 −5.456 11.18 C ATOM 841 CG2 VAL A1156 −1.469 22.212 −3.418 6.3 C ATOM 842 C VAL A1156 −1.103 18.318 −3.926 11.26 C ATOM 843 O VAL A1156 0.103 18.047 −4.127 11.04 O ATOM 844 N LEU A1157 −2.064 17.505 −4.295 11.75 N ATOM 845 CA LEU A1157 −1.796 16.193 −4.836 13.19 C ATOM 846 CB LEU A1157 −2.393 15.103 −3.892 14.39 C ATOM 847 CG LEU A1157 −1.414 14.668 −2.797 14.11 C ATOM 848 CD1 LEU A1157 −1.38 15.742 −1.819 18.43 C ATOM 849 CD2 LEU A1157 −1.93 13.478 −2.133 20.54 C ATOM 850 C LEU A1157 −2.435 16.028 −6.195 14 C ATOM 851 O LEU A1157 −3.476 16.716 −6.456 14.03 O ATOM 852 N PRO A1158 −1.868 15.084 −7.043 13.2 N ATOM 853 CD PRO A1158 −0.643 14.268 −6.906 11.65 C ATOM 854 CA PRO A1158 −2.582 14.75 −8.303 13.36 C ATOM 855 CB PRO A1158 −1.725 13.611 −8.951 11.42 C ATOM 856 CG PRO A1158 −0.418 13.751 −8.253 10.64 C ATOM 857 C PRO A1158 −4.015 14.35 −8.05 12.86 C ATOM 858 O PRO A1158 −4.261 13.651 −7.092 14.24 O ATOM 859 N TYR A1159 −4.932 14.859 −8.858 13.23 N ATOM 860 CA TYR A1159 −6.252 14.393 −8.865 13.78 C ATOM 861 CB TYR A1159 −7.058 15.142 −9.93 15.01 C ATOM 862 CG TYR A1159 −8.481 14.649 −9.961 12.86 C ATOM 863 CD1 TYR A1159 −9.297 14.773 −8.806 12.4 C ATOM 864 CE1 TYR A1159 −10.556 14.308 −8.758 11.04 C ATOM 865 CD2 TYR A1159 −8.985 13.989 −11.08 13.73 C ATOM 866 CE2 TYR A1159 −10.307 13.454 −11.037 13.1 C ATOM 867 CZ TYR A1159 −11.07 13.657 −9.875 13.4 C ATOM 868 OH TYR A1159 −12.355 13.191 −9.804 16.89 O ATOM 869 C TYR A1159 −6.2 12.948 −9.211 15.49 C ATOM 870 O TYR A1159 −5.444 12.519 −10.099 16.43 O ATOM 871 N MET A1160 −6.991 12.165 −8.506 16.74 N ATOM 872 CA MET A1160 −6.931 10.714 −8.614 16.11 C ATOM 873 CB MET A1160 −6.311 10.119 −7.325 17.37 C ATOM 874 CG MET A1160 −5.161 9.13 −7.551 19.28 C ATOM 875 SD MET A1160 −3.813 9.522 −8.699 23.59 S ATOM 876 CE MET A1160 −3.543 7.869 −9.241 22.32 C ATOM 877 C MET A1160 −8.355 10.257 −8.795 16.51 C ATOM 878 O MET A1160 −9.082 9.992 −7.822 14.78 O ATOM 879 N LYS A1161 −8.752 10.184 −10.066 16.45 N ATOM 880 CA LYS A1161 −10.146 9.947 −10.418 17.31 C ATOM 881 CB LYS A1161 −10.245 9.711 −11.902 17.73 C ATOM 882 CG LYS A1161 −11.664 9.683 −12.341 20.77 C ATOM 883 CD LYS A1161 −11.705 9.365 −13.814 24.83 C ATOM 884 CE LYS A1161 −13.144 9.363 −14.295 25.08 C ATOM 885 NZ LYS A1161 −13.025 9.002 −15.7 26.92 N ATOM 886 C LYS A1161 −10.867 8.77 −9.707 16.89 C ATOM 887 O LYS A1161 −12.07 8.888 −9.275 17.09 O ATOM 888 N HIS A1162 −10.193 7.624 −9.613 15.69 N ATOM 889 CA HIS A1162 −10.88 6.482 −8.989 15.59 C ATOM 890 CB HIS A1162 −10.72 5.207 −9.789 14.21 C ATOM 891 CG HIS A1162 −11.262 5.341 −11.169 13.81 C ATOM 892 CD2 HIS A1162 −10.65 5.378 −12.376 15.14 C ATOM 893 ND1 HIS A1162 −12.602 5.556 −11.41 14.06 N ATOM 894 CE1 HIS A1162 −12.797 5.689 −12.713 16.19 C ATOM 895 NE2 HIS A1162 −11.631 5.557 −13.328 16.34 N ATOM 896 C HIS A1162 −10.631 6.293 −7.505 15.76 C ATOM 897 O HIS A1162 −11.07 5.273 −6.918 17.54 O ATOM 898 N GLY A1163 −9.981 7.281 −6.891 14.54 N ATOM 899 CA GLY A1163 −9.797 7.311 −5.446 13.69 C ATOM 900 C GLY A1163 −8.933 6.175 −4.992 13.15 C ATOM 901 O GLY A1163 −8.07 5.685 −5.752 12.3 O ATOM 902 N ASP A1164 −9.204 5.721 −3.784 13.21 N ATOM 903 CA ASP A1164 −8.424 4.633 −3.228 15.24 C ATOM 904 CB ASP A1164 −8.358 4.621 −1.67 15.61 C ATOM 905 CG ASP A1164 −9.602 3.98 −0.995 20.21 C ATOM 906 OD1 ASP A1164 −10.69 4.556 −0.969 25.32 O ATOM 907 OD2 ASP A1164 −9.498 2.888 −0.421 27.01 O ATOM 908 C ASP A1164 −8.831 3.266 −3.739 15.25 C ATOM 909 O ASP A1164 −9.991 2.932 −3.954 14.63 O ATOM 910 N LEU A1165 −7.802 2.456 −3.823 16.8 N ATOM 911 CA LEU A1165 −7.867 1.131 −4.346 18.15 C ATOM 912 CB LEU A1165 −6.471 0.555 −4.155 18.15 C ATOM 913 CG LEU A1165 −6.254 −0.82 −4.745 18.98 C ATOM 914 CD1 LEU A1165 −6.799 −0.956 −6.187 19.58 C ATOM 915 CD2 LEU A1165 −4.782 −0.942 −4.773 23.5 C ATOM 916 C LEU A1165 −8.88 0.262 −3.617 18.36 C ATOM 917 O LEU A1165 −9.566 −0.575 −4.2 17.43 O ATOM 918 O GLN A1166 −11.809 −1.243 −1.678 23.09 O ATOM 919 N GLN A1166 −8.781 0.307 −2.284 20 ATOM 920 CA GLN A1166 −9.693 −0.321 −1.354 20 ATOM 921 C GLN A1166 −11.177 −0.243 −1.617 20 ATOM 922 CB GLN A1166 −9.303 −0.104 0.131 20 ATOM 923 CG GLN A1166 −9.599 −1.201 1.163 20 ATOM 924 CD GLN A1166 −11.008 −1.183 1.711 20 ATOM 925 OE1 GLN A1166 −11.667 −0.191 1.668 20 ATOM 926 NE2 GLN A1166 −11.455 −2.294 2.208 20 ATOM 927 N ASN A1167 −11.721 0.971 −1.76 22.82 N ATOM 928 CA ASN A1167 −13.142 1.243 −2.091 22.98 C ATOM 929 CB ASN A1167 −13.482 2.739 −1.849 23.61 C ATOM 930 CG ASN A1167 −13.721 3.05 −0.404 24.86 C ATOM 931 OD1 ASN A1167 −14.747 2.681 0.17 29.97 O ATOM 932 ND2 ASN A1167 −12.777 3.729 0.201 24.59 N ATOM 933 C ASN A1167 −13.365 0.97 −3.554 22.09 C ATOM 934 O ASN A1167 −14.472 0.568 −3.972 22.42 O ATOM 935 N PHE A1168 −12.336 1.214 −4.352 20.93 N ATOM 936 CA PHE A1168 −12.444 0.801 −5.741 21.8 C ATOM 937 CB PHE A1168 −11.238 1.267 −6.545 22.22 C ATOM 938 CG PHE A1168 −11.36 1.012 −7.966 23.93 C ATOM 939 CD1 PHE A1168 −12.022 1.922 −8.777 28.08 C ATOM 940 CD2 PHE A1168 −10.854 −0.18 −8.513 28.78 C ATOM 941 CE1 PHE A1168 −12.208 1.659 −10.153 31.38 C ATOM 942 CE2 PHE A1168 −11.014 −0.482 −9.875 30.49 C ATOM 943 CZ PHE A1168 −11.688 0.438 −10.709 29.96 C ATOM 944 C PHE A1168 −12.742 −0.711 −5.906 20.84 C ATOM 945 O PHE A1168 −13.71 −1.104 −6.509 21.8 O ATOM 946 N ILE A1169 −11.932 −1.557 −5.318 21.69 N ATOM 947 CA ILE A1169 −12.101 −3.02 −5.434 21.21 C ATOM 948 CB ILE A1169 −10.79 −3.818 −4.97 20.88 C ATOM 949 CG2 ILE A1169 −9.584 −3.379 −5.84 16.89 C ATOM 950 CG1 ILE A1169 −10.53 −3.655 −3.444 20.13 C ATOM 951 CD1 ILE A1169 −9.219 −4.284 −2.912 17.66 C ATOM 952 C ILE A1169 −13.327 −3.475 −4.699 22.65 C ATOM 953 O ILE A1169 −13.956 −4.433 −5.044 24.92 O ATOM 954 N ARG A1170 −13.696 −2.769 −3.675 24.78 N ATOM 955 CA ARG A1170 −14.841 −3.173 −2.895 27.45 C ATOM 956 CB ARG A1170 −14.573 −2.797 −1.471 26.7 C ATOM 957 CG ARG A1170 −15.698 −2.707 −0.613 29.73 C ATOM 958 CD ARG A1170 −15.338 −1.544 0.225 36.17 C ATOM 959 NE ARG A1170 −15.115 −1.902 1.627 43.74 N ATOM 960 CZ ARG A1170 −14.896 −0.989 2.59 45.61 C ATOM 961 NH1 ARG A1170 −14.837 0.324 2.25 37.76 N ATOM 962 NH2 ARG A1170 −14.718 −1.399 3.877 43.16 N ATOM 963 C ARG A1170 −16.198 −2.692 −3.43 29.47 C ATOM 964 O ARG A1170 −17.234 −3.059 −2.907 31.36 O ATOM 965 N ASN A1171 −16.217 −1.936 −4.522 32.08 N ATOM 966 CA ASN A1171 −17.475 −1.556 −5.177 33.39 C ATOM 967 CB ASN A1171 −17.367 −0.142 −5.702 34.28 C ATOM 968 CG ASN A1171 −18.728 0.484 −5.977 34.85 C ATOM 969 OD1 ASN A1171 −18.83 1.706 −6.129 32.84 O ATOM 970 ND2 ASN A1171 −19.779 −0.34 −6.017 34.99 N ATOM 971 C ASN A1171 −17.889 −2.476 −6.327 33.85 C ATOM 972 O ASN A1171 −17.171 −2.562 −7.326 32.39 O ATOM 973 N GLU A1172 −19.046 −3.143 −6.172 35.59 N ATOM 974 CA GLU A1172 −19.548 −4.089 −7.207 37.83 C ATOM 975 CB GLU A1172 −20.558 −5.143 −6.681 38.24 C ATOM 976 CG GLU A1172 −20.166 −5.831 −5.304 42.55 C ATOM 977 CD GLU A1172 −18.806 −6.659 −5.293 48.09 C ATOM 978 OE1 GLU A1172 −18.827 −7.858 −5.695 49.77 O ATOM 979 OE2 GLU A1172 −17.727 −6.153 −4.82 48.47 O ATOM 980 C GLU A1172 −20.001 −3.393 −8.499 37.62 C ATOM 981 O GLU A1172 −20.113 −4.038 −9.537 38.48 O ATOM 982 N THR A1173 −20.151 −2.072 −8.448 37.81 N ATOM 983 CA THR A1173 −20.229 −1.225 −9.646 38.22 C ATOM 984 CB THR A1173 −20.255 0.238 −9.247 38.54 C ATOM 985 OG1 THR A1173 −21.41 0.471 −8.421 42.46 O ATOM 986 CG2 THR A1173 −20.294 1.169 −10.489 39.4 C ATOM 987 C THR A1173 −19.051 −1.353 −10.595 37.94 C ATOM 988 O THR A1173 −19.151 −0.997 −11.783 39.05 O ATOM 989 N HIS A1174 −17.913 −1.768 −10.058 36.95 N ATOM 990 CA HIS A1174 −16.674 −1.912 −10.826 36.02 C ATOM 991 CB HIS A1174 −15.462 −1.363 −10.036 37.52 C ATOM 992 CG HIS A1174 −15.661 −0.004 −9.393 41.68 C ATOM 993 CD2 HIS A1174 −14.856 1.087 −9.375 42.46 C ATOM 994 ND1 HIS A1174 −16.769 0.337 −8.635 47.13 N ATOM 995 CE1 HIS A1174 −16.646 1.581 −8.205 44.27 C ATOM 996 NE2 HIS A1174 −15.493 2.056 −8.641 44.18 N ATOM 997 C HIS A1174 −16.519 −3.437 −11 33.97 C ATOM 998 O HIS A1174 −17.201 −4.25 −10.316 33.49 O ATOM 999 N ASN A1175 −15.63 −3.856 −11.89 31.33 N ATOM 1000 CA ASN A1175 −15.406 −5.303 −12.013 28.29 C ATOM 1001 CB ASN A1175 −16.401 −5.944 −13.003 26.81 C ATOM 1002 CG ASN A1175 −16.56 −7.457 −12.797 27.33 C ATOM 1003 OD1 ASN A1175 −16.965 −7.914 −11.714 25.48 O ATOM 1004 ND2 ASN A1175 −16.234 −8.25 −13.846 23.69 N ATOM 1005 C ASN A1175 −13.967 −5.677 −12.35 26.55 C ATOM 1006 O ASN A1175 −13.708 −6.266 −13.408 26.61 O ATOM 1007 N PRO A1176 −13.036 −5.42 −11.418 25.23 N ATOM 1008 CD PRO A1176 −13.117 −4.731 −10.105 24.47 C ATOM 1009 CA PRO A1176 −11.683 −5.913 −11.71 24.16 C ATOM 1010 CB PRO A1176 −10.826 −5.27 −10.581 24.13 C ATOM 1011 CG PRO A1176 −11.784 −5.014 −9.455 23.25 C ATOM 1012 C PRO A1176 −11.63 −7.463 −11.712 22.75 C ATOM 1013 O PRO A1176 −12.121 −8.118 −10.79 23.37 O ATOM 1014 N THR A1177 −11.114 −8.04 −12.784 21.08 N ATOM 1015 CA THR A1177 −10.898 −9.469 −12.874 18.85 C ATOM 1016 CB THR A1177 −10.494 −9.914 −14.3 18.88 C ATOM 1017 OG1 THR A1177 −9.242 −9.28 −14.634 19.84 O ATOM 1018 CG2 THR A1177 −11.598 −9.527 −15.347 18.87 C ATOM 1019 C THR A1177 −9.757 −9.846 −11.899 17.26 C ATOM 1020 O THR A1177 −9.065 −9.003 −11.348 15.8 O ATOM 1021 N VAL A1178 −9.607 −11.133 −11.684 15.8 N ATOM 1022 CA VAL A1178 −8.509 −11.651 −10.904 16.14 C ATOM 1023 CB VAL A1178 −8.5 −13.223 −10.915 15.53 C ATOM 1024 CG1 VAL A1178 −7.309 −13.705 −10.261 15.69 C ATOM 1025 CG2 VAL A1178 −9.747 −13.793 −10.221 15.73 C ATOM 1026 C VAL A1178 −7.219 −11.17 −11.532 14.86 C ATOM 1027 O VAL A1178 −6.359 −10.704 −10.845 15.18 O ATOM 1028 N LYS A1179 −7.085 −11.347 −12.847 15.44 N ATOM 1029 CA LYS A1179 −5.966 −10.765 −13.584 16.04 C ATOM 1030 CB LYS A1179 −6.177 −10.988 −15.109 16.98 C ATOM 1031 CG LYS A1179 −5.079 −10.35 −16.015 18.66 C ATOM 1032 CD LYS A1179 −4.147 −11.355 −16.683 18.04 C ATOM 1033 CE LYS A1179 −3.388 −10.723 −17.929 20.93 C ATOM 1034 NZ LYS A1179 −2.56 −11.797 −18.707 22.94 N ATOM 1035 C LYS A1179 −5.727 −9.246 −13.248 14.25 C ATOM 1036 O LYS A1179 −4.607 −8.793 −13.141 11.31 O ATOM 1037 N ASP A1180 −6.812 −8.495 −13.133 14.79 N ATOM 1038 CA ASP A1180 −6.788 −7.03 −12.867 15.14 C ATOM 1039 CB ASP A1180 −8.224 −6.451 −13.001 15.66 C ATOM 1040 CG ASP A1180 −8.624 −6.138 −14.446 21.29 C ATOM 1041 OD1 ASP A1180 −9.866 −5.915 −14.763 24.01 O ATOM 1042 OD2 ASP A1180 −7.679 −6.095 −15.281 27.62 O ATOM 1043 C ASP A1180 −6.25 −6.82 −11.46 13.2 C ATOM 1044 O ASP A1180 −5.379 −5.979 −11.212 13.36 O ATOM 1045 N LEU A1181 −6.756 −7.615 −10.527 11.47 N ATOM 1046 CA LEU A1181 −6.303 −7.517 −9.13 9.77 C ATOM 1047 CB LEU A1181 −7.187 −8.413 −8.305 9.68 C ATOM 1048 CG LEU A1181 −8.476 −7.975 −7.638 7.92 C ATOM 1049 CD1 LEU A1181 −8.865 −6.576 −7.944 8.74 C ATOM 1050 CD2 LEU A1181 −9.58 −9 −7.905 3.42 C ATOM 1051 C LEU A1181 −4.848 −7.876 −8.912 8.81 C ATOM 1052 O LEU A1181 −4.104 −7.223 −8.163 8.69 O ATOM 1053 N ILE A1182 −4.408 −8.927 −9.57 8.8 N ATOM 1054 CA ILE A1182 −2.986 −9.267 −9.562 8.84 C ATOM 1055 CB ILE A1182 −2.76 −10.613 −10.313 10.68 C ATOM 1056 CG2 ILE A1182 −1.247 −11.036 −10.247 7.66 C ATOM 1057 CG1 ILE A1182 −3.664 −11.715 −9.681 10.62 C ATOM 1058 CD1 ILE A1182 −3.664 −13.062 −10.422 12.08 C ATOM 1059 C ILE A1182 −2.176 −8.16 −10.181 8.2 C ATOM 1060 O ILE A1182 −1.12 −7.817 −9.686 8.72 O ATOM 1061 N GLY A1183 −2.646 −7.59 −11.278 7.96 N ATOM 1062 CA GLY A1183 −2.02 −6.43 −11.836 8.15 C ATOM 1063 C GLY A1183 −1.877 −5.284 −10.854 9.46 C ATOM 1064 O GLY A1183 −0.836 −4.71 −10.786 9.11 O ATOM 1065 N PHE A1184 −2.966 −4.912 −10.133 11.34 N ATOM 1066 CA PHE A1184 −2.919 −3.923 −9.065 10.26 C ATOM 1067 CB PHE A1184 −4.239 −3.763 −8.316 9.89 C ATOM 1068 CG PHE A1184 −5.4 −3.275 −9.179 11.92 C ATOM 1069 CD1 PHE A1184 −5.194 −2.497 −10.285 14.53 C ATOM 1070 CD2 PHE A1184 −6.724 −3.591 −8.847 14.63 C ATOM 1071 CE1 PHE A1184 −6.273 −2.09 −11.091 15.48 C ATOM 1072 CE2 PHE A1184 −7.779 −3.188 −9.636 14.52 C ATOM 1073 CZ PHE A1184 −7.539 −2.445 −10.775 12.06 C ATOM 1074 C PHE A1184 −1.799 −4.254 −8.124 10.46 C ATOM 1075 O PHE A1184 −0.991 −3.356 −7.809 10.91 O ATOM 1076 N GLY A1185 −1.732 −5.534 −7.687 10.44 N ATOM 1077 CA GLY A1185 −0.685 −6.022 −6.776 7.06 C ATOM 1078 C GLY A1185 0.675 −5.808 −7.442 7.98 C ATOM 1079 O GLY A1185 1.649 −5.263 −6.834 8.85 O ATOM 1080 N LEU A1186 0.788 −6.237 −8.698 7.09 N ATOM 1081 CA LEU A1186 2.034 −5.966 −9.473 6.15 C ATOM 1082 CB LEU A1186 1.97 −6.564 −10.864 3.48 C ATOM 1083 CG LEU A1186 3.21 −6.47 −11.81 7.84 C ATOM 1084 CD1 LEU A1186 4.5 −6.921 −11.173 10.47 C ATOM 1085 CD2 LEU A1186 2.965 −7.238 −13.117 5.94 C ATOM 1086 C LEU A1186 2.456 −4.469 −9.46 6.45 C ATOM 1087 O LEU A1186 3.646 −4.159 −9.149 8.35 O ATOM 1088 N GLN A1187 1.518 −3.556 −9.706 4.69 N ATOM 1089 CA GLN A1187 1.827 −2.119 −9.774 7.07 C ATOM 1090 CB GLN A1187 0.559 −1.336 −10.225 7.15 C ATOM 1091 CG GLN A1187 0.145 −1.578 −11.706 9.39 C ATOM 1092 CD GLN A1187 −1.053 −0.767 −12.136 9.26 C ATOM 1093 OE1 GLN A1187 −1.039 0.462 −12.092 11.28 O ATOM 1094 NE2 GLN A1187 −2.08 −1.441 −12.595 10.28 N ATOM 1095 C GLN A1187 2.328 −1.586 −8.435 7.09 C ATOM 1096 O GLN A1187 3.262 −0.835 −8.35 8.11 O ATOM 1097 N VAL A1188 1.657 −1.962 −7.355 8.62 N ATOM 1098 CA VAL A1188 2.069 −1.609 −6.017 7.25 C ATOM 1099 CB VAL A1188 1.029 −2.178 −4.976 7.78 C ATOM 1100 CG1 VAL A1188 1.56 −1.976 −3.526 6.03 C ATOM 1101 CG2 VAL A1188 −0.316 −1.492 −5.103 6.83 C ATOM 1102 C VAL A1188 3.452 −2.217 −5.683 7.86 C ATOM 1103 O VAL A1188 4.251 −1.56 −5.06 9.73 O ATOM 1104 N ALA A1189 3.692 −3.491 −5.993 6.51 N ATOM 1105 CA ALA A1189 5.007 −4.053 −5.813 6.67 C ATOM 1106 CB ALA A1189 5.075 −5.504 −6.374 5.44 C ATOM 1107 C ALA A1189 6.071 −3.189 −6.516 7.79 C ATOM 1108 O ALA A1189 7.194 −3.024 −5.945 7.89 O ATOM 1109 N LYS A1190 5.787 −2.67 −7.758 6.25 N ATOM 1110 CA LYS A1190 6.796 −1.834 −8.454 4.83 C ATOM 1111 CB LYS A1190 6.361 −1.573 −9.894 5.09 C ATOM 1112 CG LYS A1190 6.426 −2.867 −10.641 6.53 C ATOM 1113 CD LYS A1190 5.901 −2.797 −12.039 11.48 C ATOM 1114 CE LYS A1190 6.178 −4.122 −12.805 10.35 C ATOM 1115 NZ LYS A1190 5.376 −4.012 −14.119 5.13 N ATOM 1116 C LYS A1190 7.025 −0.52 −7.774 5.07 C ATOM 1117 O LYS A1190 8.171 −0.069 −7.643 6.03 O ATOM 1118 N GLY A1191 5.919 0.157 −7.41 5.61 N ATOM 1119 CA GLY A1191 5.97 1.325 −6.513 5.95 C ATOM 1120 C GLY A1191 6.781 1.045 −5.299 6.41 C ATOM 1121 O GLY A1191 7.707 1.773 −4.994 7.75 O ATOM 1122 N MET A1192 6.487 −0.048 −4.587 7.71 N ATOM 1123 CA MET A1192 7.236 −0.323 −3.339 8.41 C ATOM 1124 CB MET A1192 6.577 −1.482 −2.653 10.35 C ATOM 1125 CG MET A1192 5.282 −1.115 −1.963 9.89 C ATOM 1126 SD MET A1192 5.581 0.263 −0.802 14.47 S ATOM 1127 CE MET A1192 6.863 −0.345 0.254 11.37 C ATOM 1128 C MET A1192 8.718 −0.659 −3.568 9.94 C ATOM 1129 O MET A1192 9.61 −0.216 −2.828 9.3 O ATOM 1130 N LYS A1193 9.004 −1.42 −4.634 9.24 N ATOM 1131 CA LYS A1193 10.367 −1.654 −5.007 8.67 C ATOM 1132 CB LYS A1193 10.443 −2.536 −6.202 8.81 C ATOM 1133 CG LYS A1193 11.81 −3.023 −6.484 10.02 C ATOM 1134 CD LYS A1193 11.979 −3.575 −7.901 8.96 C ATOM 1135 CE LYS A1193 13.498 −3.572 −8.277 9.49 C ATOM 1136 NZ LYS A1193 13.743 −4.27 −9.513 15.27 N ATOM 1137 C LYS A1193 11.12 −0.367 −5.26 9.78 C ATOM 1138 O LYS A1193 12.272 −0.228 −4.873 9.11 O ATOM 1139 N TYR A1194 10.451 0.594 −5.896 10.85 N ATOM 1140 CA TYR A1194 11.023 1.904 −6.061 10.32 C ATOM 1141 CB TYR A1194 10.051 2.76 −6.851 11.52 C ATOM 1142 CG TYR A1194 10.526 4.172 −6.973 11.52 C ATOM 1143 CD1 TYR A1194 11.52 4.483 −7.857 9.72 C ATOM 1144 CE1 TYR A1194 11.998 5.785 −7.936 16.28 C ATOM 1145 CD2 TYR A1194 9.963 5.196 −6.179 12.54 C ATOM 1146 CE2 TYR A1194 10.407 6.485 −6.224 14.38 C ATOM 1147 CZ TYR A1194 11.42 6.793 −7.129 18.51 C ATOM 1148 OH TYR A1194 11.878 8.103 −7.25 19.47 O ATOM 1149 C TYR A1194 11.39 2.561 −4.701 10.21 C ATOM 1150 O TYR A1194 12.564 2.975 −4.43 9.3 O ATOM 1151 N LEU A1195 10.378 2.622 −3.829 10.8 N ATOM 1152 CA LEU A1195 10.464 3.313 −2.54 10.49 C ATOM 1153 CB LEU A1195 9.125 3.189 −1.851 11.47 C ATOM 1154 CG LEU A1195 8.115 4.35 −1.972 9.95 C ATOM 1155 CD1 LEU A1195 7.944 4.563 −3.323 16.01 C ATOM 1156 CD2 LEU A1195 6.792 3.895 −1.414 10.13 C ATOM 1157 C LEU A1195 11.53 2.694 −1.692 10.23 C ATOM 1158 O LEU A1195 12.311 3.368 −1.107 11.31 O ATOM 1159 N ALA A1196 11.587 1.377 −1.681 11.66 N ATOM 1160 CA ALA A1196 12.606 0.636 −0.935 12.04 C ATOM 1161 CB ALA A1196 12.259 −0.832 −0.918 14.25 C ATOM 1162 C ALA A1196 14.031 0.83 −1.442 11.92 C ATOM 1163 O ALA A1196 14.956 0.679 −0.685 10.62 O ATOM 1164 N SER A1197 14.196 1.198 −2.704 12.53 N ATOM 1165 CA SER A1197 15.516 1.523 −3.258 14.34 C ATOM 1166 CB SER A1197 15.512 1.502 −4.809 12.95 C ATOM 1167 OG SER A1197 14.768 2.609 −5.335 18.14 O ATOM 1168 C SER A1197 15.982 2.872 −2.776 15.31 C ATOM 1169 O SER A1197 17.151 3.148 −2.812 15.58 O ATOM 1170 N LYS A1198 15.038 3.733 −2.368 17.2 N ATOM 1171 CA LYS A1198 15.335 5.058 −1.872 17.87 C ATOM 1172 CB LYS A1198 14.182 5.996 −2.238 18.38 C ATOM 1173 CG LYS A1198 13.869 6.115 −3.698 20.26 C ATOM 1174 CD LYS A1198 15.011 6.846 −4.464 25.11 C ATOM 1175 CE LYS A1198 14.913 6.593 −6.028 30.26 C ATOM 1176 NZ LYS A1198 16.214 6.552 −6.827 23.87 N ATOM 1177 C LYS A1198 15.376 4.861 −0.383 19 C ATOM 1178 O LYS A1198 15.387 5.808 0.383 20.3 O ATOM 1179 N LYS A1199 15.344 3.605 0.022 18.71 N ATOM 1180 CA LYS A1199 15.19 3.22 1.411 20.01 C ATOM 1181 CB LYS A1199 16.523 3.188 2.164 20.74 C ATOM 1182 CG LYS A1199 17.471 4.222 1.788 21.64 C ATOM 1183 CD LYS A1199 18.294 3.84 0.543 31.5 C ATOM 1184 CE LYS A1199 19.039 2.467 0.574 29.62 C ATOM 1185 NZ LYS A1199 18.412 1.599 1.567 28.43 N ATOM 1186 C LYS A1199 14.135 4.038 2.147 19.36 C ATOM 1187 O LYS A1199 14.377 4.557 3.212 19.28 O ATOM 1188 N PHE A1200 12.961 4.151 1.547 18.79 N ATOM 1189 CA PHE A1200 11.834 4.788 2.197 17.86 C ATOM 1190 CB PHE A1200 11.029 5.568 1.14 17.17 C ATOM 1191 CG PHE A1200 9.743 6.111 1.664 18.38 C ATOM 1192 CD1 PHE A1200 8.571 5.39 1.535 12.53 C ATOM 1193 CD2 PHE A1200 9.718 7.361 2.338 17 C ATOM 1194 CE1 PHE A1200 7.385 5.872 2.071 15.8 C ATOM 1195 CE2 PHE A1200 8.535 7.851 2.811 14.97 C ATOM 1196 CZ PHE A1200 7.349 7.091 2.689 13.81 C ATOM 1197 C PHE A1200 11.01 3.658 2.786 16.62 C ATOM 1198 O PHE A1200 10.479 2.841 2.025 16.28 O ATOM 1199 N VAL A1201 10.893 3.612 4.107 16.06 N ATOM 1200 CA VAL A1201 9.965 2.684 4.803 14.92 C ATOM 1201 CB VAL A1201 10.506 2.167 6.16 14.85 C ATOM 1202 CG1 VAL A1201 9.448 1.315 6.839 14.19 C ATOM 1203 CG2 VAL A1201 11.84 1.313 5.982 12.79 C ATOM 1204 C VAL A1201 8.575 3.318 4.939 15.98 C ATOM 1205 O VAL A1201 8.428 4.412 5.475 18.87 O ATOM 1206 N HIS A1202 7.552 2.661 4.405 15.17 N ATOM 1207 CA HIS A1202 6.283 3.264 4.251 14.89 C ATOM 1208 CB HIS A1202 5.491 2.509 3.135 15.35 C ATOM 1209 CG HIS A1202 4.164 3.144 2.826 17.55 C ATOM 1210 CD2 HIS A1202 3.75 3.885 1.765 20.15 C ATOM 1211 ND1 HIS A1202 3.118 3.161 3.736 15.04 N ATOM 1212 CE1 HIS A1202 2.11 3.845 3.218 17.84 C ATOM 1213 NE2 HIS A1202 2.462 4.291 2.023 17.78 N ATOM 1214 C HIS A1202 5.505 3.343 5.591 14.91 C ATOM 1215 O HIS A1202 4.95 4.386 5.964 12.58 O ATOM 1216 N ARG A1203 5.426 2.179 6.266 16.87 N ATOM 1217 CA ARG A1203 4.83 1.98 7.621 17.09 C ATOM 1218 CB ARG A1203 5.296 3.035 8.654 16.92 C ATOM 1219 CG ARG A1203 6.843 3.146 8.598 25.55 C ATOM 1220 CD ARG A1203 7.385 3.934 9.684 35.04 C ATOM 1221 NE ARG A1203 6.647 5.198 9.715 46.62 N ATOM 1222 CZ ARG A1203 7.231 6.397 9.8 50.6 C ATOM 1223 NH1 ARG A1203 6.485 7.493 9.835 51.11 N ATOM 1224 NH2 ARG A1203 8.569 6.492 9.91 52.32 N ATOM 1225 C ARG A1203 3.316 1.808 7.598 15.31 C ATOM 1226 O ARG A1203 2.804 1.194 8.459 16.7 O ATOM 1227 N ASP A1204 2.634 2.256 6.567 14.71 N ATOM 1228 CA ASP A1204 1.216 2.108 6.521 13.7 C ATOM 1229 CB ASP A1204 0.457 3.387 6.964 12.97 C ATOM 1230 CG ASP A1204 −1.043 3.076 7.256 14.25 C ATOM 1231 OD1 ASP A1204 −1.836 4.044 7.394 15.49 O ATOM 1232 OD2 ASP A1204 −1.44 1.858 7.263 9.66 O ATOM 1233 C ASP A1204 0.774 1.643 5.141 12.88 C ATOM 1234 O ASP A1204 −0.186 2.174 4.56 14.12 O ATOM 1235 N LEU A1205 1.478 0.646 4.609 11.34 N ATOM 1236 CA LEU A1205 1.112 0.108 3.321 8.79 C ATOM 1237 CB LEU A1205 2.258 −0.744 2.749 8.43 C ATOM 1238 CG LEU A1205 1.935 −1.463 1.458 10.04 C ATOM 1239 CD1 LEU A1205 1.684 −0.398 0.27 13.53 C ATOM 1240 CD2 LEU A1205 3.076 −2.419 1.125 13.6 C ATOM 1241 C LEU A1205 −0.146 −0.673 3.471 7.99 C ATOM 1242 O LEU A1205 −0.17 −1.624 4.263 8.8 O ATOM 1243 N ALA A1206 −1.204 −0.28 2.738 7.11 N ATOM 1244 CA ALA A1206 −2.522 −0.922 2.824 5.5 C ATOM 1245 CB ALA A1206 −3.232 −0.459 4.063 4.27 C ATOM 1246 C ALA A1206 −3.265 −0.446 1.584 6.81 C ATOM 1247 O ALA A1206 −2.838 0.581 1.02 8.33 O ATOM 1248 N ALA A1207 −4.313 −1.167 1.132 5.92 N ATOM 1249 CA ALA A1207 −5.061 −0.819 −0.065 6.86 C ATOM 1250 CB ALA A1207 −6.198 −1.931 −0.465 6.56 C ATOM 1251 C ALA A1207 −5.664 0.575 −0.007 6.43 C ATOM 1252 O ALA A1207 −5.717 1.282 −0.997 7.31 O ATOM 1253 N ARG A1208 −6.118 0.96 1.163 8.2 N ATOM 1254 CA ARG A1208 −6.685 2.317 1.469 7.4 C ATOM 1255 CB ARG A1208 −7.153 2.406 2.935 5.83 C ATOM 1256 CG ARG A1208 −6.069 2.35 3.935 6.41 C ATOM 1257 CD ARG A1208 −6.516 2.624 5.392 7.75 C ATOM 1258 NE ARG A1208 −5.463 2.178 6.312 9.76 N ATOM 1259 CZ ARG A1208 −5.268 0.92 6.703 10.11 C ATOM 1260 NH1 ARG A1208 −6.079 −0.022 6.275 11.92 N ATOM 1261 NH2 ARG A1208 −4.249 0.595 7.505 10.73 N ATOM 1262 C ARG A1208 −5.723 3.419 1.17 8.21 C ATOM 1263 O ARG A1208 −6.139 4.544 0.915 9.68 O ATOM 1264 N ASN A1209 −4.444 3.09 1.145 8.68 N ATOM 1265 CA ASN A1209 −3.399 4.061 0.811 11.82 C ATOM 1266 CB ASN A1209 −2.244 4.061 1.85 11.24 C ATOM 1267 CG ASN A1209 −2.656 4.697 3.119 14.87 C ATOM 1268 OD1 ASN A1209 −3.234 5.806 3.092 17.92 O ATOM 1269 ND2 ASN A1209 −2.404 4.018 4.255 12.83 N ATOM 1270 C ASN A1209 −2.83 3.996 −0.638 11.91 C ATOM 1271 O ASN A1209 −1.844 4.607 −0.923 11.85 O ATOM 1272 N CYS A1210 −3.491 3.295 −1.537 12.5 N ATOM 1273 CA CYS A1210 −3.014 3.254 −2.893 12.98 C ATOM 1274 CB CYS A1210 −2.797 1.789 −3.34 14.54 C ATOM 1275 SG CYS A1210 −1.63 0.848 −2.296 12.02 S ATOM 1276 C CYS A1210 −4.108 3.876 −3.657 13.31 C ATOM 1277 O CYS A1210 −5.28 3.55 −3.418 13.93 O ATOM 1278 N MET A1211 −3.749 4.745 −4.594 13.69 N ATOM 1279 CA MET A1211 −4.737 5.583 −5.243 14.05 C ATOM 1280 CB MET A1211 −4.318 7.044 −5.221 13.18 C ATOM 1281 CG MET A1211 −4.372 7.766 −3.853 14.65 C ATOM 1282 SD MET A1211 −6.007 7.72 −3.108 19.96 S ATOM 1283 CE MET A1211 −5.754 6.684 −1.674 18.93 C ATOM 1284 C MET A1211 −4.793 5.093 −6.651 15.42 C ATOM 1285 O MET A1211 −3.861 4.454 −7.062 17.43 O ATOM 1286 N LEU A1212 −5.844 5.432 −7.405 15.97 N ATOM 1287 CA LEU A1212 −6.055 4.901 −8.741 16.16 C ATOM 1288 CB LEU A1212 −7.151 3.801 −8.617 16.56 C ATOM 1289 CG LEU A1212 −7.139 2.614 −9.573 17.65 C ATOM 1290 CD1 LEU A1212 −5.859 1.949 −9.639 23.51 C ATOM 1291 CD2 LEU A1212 −8.148 1.645 −9.272 19.13 C ATOM 1292 C LEU A1212 −6.465 6.014 −9.699 16.21 C ATOM 1293 O LEU A1212 −7.471 6.687 −9.487 14.42 O ATOM 1294 N ASP A1213 −5.64 6.267 −10.72 17.29 N ATOM 1295 CA ASP A1213 −5.966 7.277 −11.686 17.98 C ATOM 1296 CB ASP A1213 −4.714 7.942 −12.234 17.61 C ATOM 1297 CG ASP A1213 −4.057 7.162 −13.362 21.66 C ATOM 1298 OD1 ASP A1213 −4.672 6.193 −13.876 24.08 O ATOM 1299 OD2 ASP A1213 −2.912 7.535 −13.769 20.5 O ATOM 1300 C ASP A1213 −6.965 6.79 −12.774 20.22 C ATOM 1301 O ASP A1213 −7.448 5.629 −12.725 19.55 O ATOM 1302 N GLU A1214 −7.314 7.705 −13.703 21.62 N ATOM 1303 CA GLU A1214 −8.236 7.449 −14.83 23.37 C ATOM 1304 CB GLU A1214 −8.604 8.755 −15.616 23.66 C ATOM 1305 CG GLU A1214 −7.572 9.41 −16.542 26.65 C ATOM 1306 CD GLU A1214 −6.209 9.664 −15.865 35.32 C ATOM 1307 OE1 GLU A1214 −5.163 9.62 −16.55 34.94 O ATOM 1308 OE2 GLU A1214 −6.161 9.901 −14.619 42.76 O ATOM 1309 C GLU A1214 −7.781 6.309 −15.745 23.4 C ATOM 1310 O GLU A1214 −8.61 5.643 −16.379 24.55 O ATOM 1311 N LYS A1215 −6.481 6.04 −15.762 22.3 N ATOM 1312 CA LYS A1215 −6.01 4.85 −16.476 22.72 C ATOM 1313 CB LYS A1215 −4.601 5.007 −17.096 23.86 C ATOM 1314 CG LYS A1215 −4.485 6.167 −18.063 27.17 C ATOM 1315 CD LYS A1215 −5.679 6.128 −19.019 38.23 C ATOM 1316 CE LYS A1215 −5.745 7.422 −19.897 43.79 C ATOM 1317 NZ LYS A1215 −7.201 7.763 −20.262 43.62 N ATOM 1318 C LYS A1215 −5.995 3.604 −15.657 20.86 C ATOM 1319 O LYS A1215 −5.58 2.607 −16.183 20.64 O ATOM 1320 N PHE A1216 −6.37 3.659 −14.377 18.46 N ATOM 1321 CA PHE A1216 −6.214 2.522 −13.522 17.8 C ATOM 1322 CB PHE A1216 −6.913 1.295 −14.107 17.25 C ATOM 1323 CG PHE A1216 −8.348 1.556 −14.511 20.05 C ATOM 1324 CD1 PHE A1216 −8.761 1.389 −15.824 22.43 C ATOM 1325 CD2 PHE A1216 −9.284 2.024 −13.58 22.9 C ATOM 1326 CE1 PHE A1216 −10.076 1.681 −16.183 24.6 C ATOM 1327 CE2 PHE A1216 −10.624 2.314 −13.951 23.53 C ATOM 1328 CZ PHE A1216 −11.008 2.147 −15.237 22.85 C ATOM 1329 C PHE A1216 −4.741 2.253 −13.216 17.5 C ATOM 1330 O PHE A1216 −4.304 1.15 −13.082 18.14 O ATOM 1331 N THR A1217 −3.957 3.298 −13.18 17.79 N ATOM 1332 CA THR A1217 −2.607 3.219 −12.693 17.79 C ATOM 1333 CB THR A1217 −1.804 4.287 −13.327 18.38 C ATOM 1334 OG1 THR A1217 −1.948 4.137 −14.748 21.49 O ATOM 1335 CG2 THR A1217 −0.354 4.224 −12.873 13.71 C ATOM 1336 C THR A1217 −2.699 3.462 −11.183 17.99 C ATOM 1337 O THR A1217 −3.245 4.477 −10.67 16.42 O ATOM 1338 N VAL A1218 −2.215 2.44 −10.491 18.2 N ATOM 1339 CA VAL A1218 −2.219 2.359 −9.016 15.99 C ATOM 1340 CB VAL A1218 −2.161 0.864 −8.566 15.74 C ATOM 1341 CG1 VAL A1218 −2.229 0.783 −7.046 16.54 C ATOM 1342 CG2 VAL A1218 −3.25 0.032 −9.306 10.74 C ATOM 1343 C VAL A1218 −0.991 3.132 −8.554 14.73 C ATOM 1344 O VAL A1218 0.099 2.884 −9.049 13.83 O ATOM 1345 N LYS A1219 −1.17 4.075 −7.639 14.58 N ATOM 1346 CA LYS A1219 −0.015 4.811 −7.058 13.67 C ATOM 1347 CB LYS A1219 −0.099 6.274 −7.451 15.2 C ATOM 1348 CG LYS A1219 −0.59 6.535 −8.83 12.87 C ATOM 1349 CD LYS A1219 0.553 7.063 −9.626 17.61 C ATOM 1350 CE LYS A1219 0.129 8.243 −10.531 17.38 C ATOM 1351 NZ LYS A1219 0.955 8.178 −11.791 20.39 N ATOM 1352 C LYS A1219 0.04 4.726 −5.535 12.93 C ATOM 1353 O LYS A1219 −0.889 5.08 −4.853 12.69 O ATOM 1354 N VAL A1220 1.133 4.22 −5.006 13.18 N ATOM 1355 CA VAL A1220 1.295 4.11 −3.584 14.16 C ATOM 1356 CB VAL A1220 2.612 3.296 −3.195 15.1 C ATOM 1357 CG1 VAL A1220 2.647 2.973 −1.626 10.24 C ATOM 1358 CG2 VAL A1220 2.803 2.046 −4.12 13.42 C ATOM 1359 C VAL A1220 1.368 5.516 −2.973 13.35 C ATOM 1360 O VAL A1220 2.135 6.359 −3.443 12.9 O ATOM 1361 N ALA A1221 0.59 5.731 −1.934 13.13 N ATOM 1362 CA ALA A1221 0.477 7.015 −1.251 15.47 C ATOM 1363 CB ALA A1221 −0.897 7.657 −1.458 14.33 C ATOM 1364 C ALA A1221 0.767 6.868 0.204 17.59 C ATOM 1365 O ALA A1221 0.471 5.839 0.824 17.38 O ATOM 1366 N ASP A1222 1.379 7.919 0.731 22.48 N ATOM 1367 CA ASP A1222 1.684 8.106 2.149 25.6 C ATOM 1368 CB ASP A1222 3.192 8.125 2.428 27.07 C ATOM 1369 CG ASP A1222 3.493 8.453 3.94 32.14 C ATOM 1370 OD1 ASP A1222 2.699 7.951 4.822 33.77 O ATOM 1371 OD2 ASP A1222 4.486 9.212 4.217 33.87 O ATOM 1372 C ASP A1222 1.168 9.469 2.525 26.89 C ATOM 1373 O ASP A1222 1.8 10.507 2.234 27.25 O ATOM 1374 N PHE A1223 0.002 9.486 3.138 28.9 N ATOM 1375 CA PHE A1223 −0.585 10.751 3.509 29.85 C ATOM 1376 CB PHE A1223 −2.098 10.611 3.545 29.09 C ATOM 1377 CG PHE A1223 −2.653 10.334 2.195 27.66 C ATOM 1378 CD1 PHE A1223 −2.643 11.317 1.22 26.86 C ATOM 1379 CD2 PHE A1223 −3.137 9.056 1.86 30.65 C ATOM 1380 CE1 PHE A1223 −3.089 11.039 −0.071 24.73 C ATOM 1381 CE2 PHE A1223 −3.645 8.786 0.589 25.98 C ATOM 1382 CZ PHE A1223 −3.582 9.774 −0.378 26.39 C ATOM 1383 C PHE A1223 0.116 11.46 4.721 31.22 C ATOM 1384 O PHE A1223 0.264 12.703 4.723 29.93 O ATOM 1385 N GLY A1224 0.646 10.652 5.659 32.26 N ATOM 1386 CA GLY A1224 1.429 11.172 6.793 32.77 C ATOM 1387 C GLY A1224 1.115 12.632 7.186 32.9 C ATOM 1388 O GLY A1224 1.627 13.595 6.547 34.83 O ATOM 1389 N LEU A1225 0.298 12.814 8.224 30.34 N ATOM 1390 CA LEU A1225 −0.024 14.15 8.732 28.57 C ATOM 1391 CB LEU A1225 1.211 15.102 8.77 29.79 C ATOM 1392 CG LEU A1225 1.929 15.448 10.104 30.95 C ATOM 1393 CD1 LEU A1225 3.437 15.355 10.005 34.31 C ATOM 1394 CD2 LEU A1225 1.597 16.811 10.571 30.73 C ATOM 1395 C LEU A1225 −1.205 14.74 7.982 25.9 C ATOM 1396 O LEU A1225 −1.955 15.535 8.544 24.79 O ATOM 1397 N ALA A1226 −1.367 14.336 6.721 24.64 N ATOM 1398 CA ALA A1226 −2.529 14.746 5.877 23.24 C ATOM 1399 CB ALA A1226 −2.28 14.5 4.418 22.44 C ATOM 1400 C ALA A1226 −3.874 14.179 6.293 22.93 C ATOM 1401 O ALA A1226 −4.884 14.705 5.881 25.88 O ATOM 1402 N ARG A1227 −3.899 13.13 7.111 21.9 N ATOM 1403 CA ARG A1227 −5.103 12.644 7.801 20.66 C ATOM 1404 CB ARG A1227 −5.072 11.105 8.016 20.71 C ATOM 1405 CG ARG A1227 −4.785 10.271 6.78 21.21 C ATOM 1406 CD ARG A1227 −4.87 8.73 7.056 25.36 C ATOM 1407 NE ARG A1227 −4.892 7.917 5.827 26.96 N ATOM 1408 CZ ARG A1227 −5.974 7.695 5.082 27.88 C ATOM 1409 NH1 ARG A1227 −7.16 8.212 5.416 26.34 N ATOM 1410 NH2 ARG A1227 −5.871 6.976 3.966 28.15 N ATOM 1411 C ARG A1227 −5.291 13.342 9.152 18.83 C ATOM 1412 O ARG A1227 −4.498 13.203 10.087 17.34 O ATOM 1413 N ASP A1228 −6.334 14.138 9.243 18.68 N ATOM 1414 CA ASP A1228 −6.686 14.721 10.519 18.91 C ATOM 1415 CB ASP A1228 −7.921 15.575 10.374 17.57 C ATOM 1416 CG ASP A1228 −7.668 16.824 9.579 19.31 C ATOM 1417 OD1 ASP A1228 −6.496 17.218 9.34 19.72 O ATOM 1418 OD2 ASP A1228 −8.671 17.429 9.178 20.69 O ATOM 1419 C ASP A1228 −6.912 13.643 11.584 19.75 C ATOM 1420 O ASP A1228 −6.289 13.678 12.62 19.14 O ATOM 1421 N MET A1229 −7.813 12.698 11.298 21.88 N ATOM 1422 CA MET A1229 −8.063 11.56 12.135 25.64 C ATOM 1423 CB MET A1229 −9.439 11.661 12.693 24.99 C ATOM 1424 CG MET A1229 −9.704 12.994 13.452 30.42 C ATOM 1425 SD MET A1229 −11.278 12.878 14.395 36.16 S ATOM 1426 CE MET A1229 −12.571 12.228 13.252 35.24 C ATOM 1427 C MET A1229 −7.998 10.279 11.382 24.56 C ATOM 1428 O MET A1229 −8.016 10.252 10.174 24.7 O ATOM 1429 N TYR A1230 −7.966 9.201 12.145 26.77 N ATOM 1430 CA TYR A1230 −7.921 7.806 11.669 26.42 C ATOM 1431 CB TYR A1230 −6.702 7.141 12.275 27.51 C ATOM 1432 CG TYR A1230 −5.446 7.784 11.808 28.23 C ATOM 1433 CD1 TYR A1230 −5.082 9.065 12.25 29.43 C ATOM 1434 CE1 TYR A1230 −3.974 9.693 11.788 28.12 C ATOM 1435 CD2 TYR A1230 −4.679 7.176 10.867 28.14 C ATOM 1436 CE2 TYR A1230 −3.527 7.772 10.422 32.14 C ATOM 1437 CZ TYR A1230 −3.187 9.036 10.871 30.68 C ATOM 1438 OH TYR A1230 −2.021 9.609 10.379 32.92 O ATOM 1439 C TYR A1230 −9.133 7.062 12.158 27.27 C ATOM 1440 O TYR A1230 −9.575 7.242 13.318 28.05 O ATOM 1441 N ASP A1231 −9.672 6.224 11.281 27.51 N ATOM 1442 CA ASP A1231 −10.722 5.291 11.618 27.33 C ATOM 1443 CB ASP A1231 −11.113 4.53 10.355 28.35 C ATOM 1444 CG ASP A1231 −12.533 3.939 10.428 30.8 C ATOM 1445 OD1 ASP A1231 −12.904 3.368 11.506 27.15 O ATOM 1446 OD2 ASP A1231 −13.254 4.051 9.374 32.11 O ATOM 1447 C ASP A1231 −10.189 4.316 12.672 26.73 C ATOM 1448 O ASP A1231 −9.124 3.73 12.492 26.31 O ATOM 1449 N LYS A1232 −10.921 4.162 13.772 26.23 N ATOM 1450 CA LYS A1232 −10.512 3.29 14.858 26.77 C ATOM 1451 CB LYS A1232 −11.386 3.552 16.076 27.66 C ATOM 1452 CG LYS A1232 −12.866 3.335 15.895 29.64 C ATOM 1453 CD LYS A1232 −13.584 3.778 17.234 33.88 C ATOM 1454 CE LYS A1232 −15.158 3.919 17.075 37.98 C ATOM 1455 NZ LYS A1232 −15.727 5.229 17.684 37.47 N ATOM 1456 C LYS A1232 −10.572 1.803 14.483 26.25 C ATOM 1457 O LYS A1232 −10.143 0.931 15.234 25.01 O ATOM 1458 N GLU A1233 −11.11 1.547 13.299 25.77 N ATOM 1459 CA GLU A1233 −11.279 0.232 12.787 25.68 C ATOM 1460 CB GLU A1233 −12.34 0.277 11.688 26.68 C ATOM 1461 CG GLU A1233 −13.789 −0.168 12.099 33.83 C ATOM 1462 CD GLU A1233 −14.499 0.709 13.208 42.96 C ATOM 1463 OE1 GLU A1233 −14.86 0.117 14.302 42.59 O ATOM 1464 OE2 GLU A1233 −14.717 1.954 12.977 42.71 O ATOM 1465 C GLU A1233 −9.963 −0.242 12.227 24.54 C ATOM 1466 O GLU A1233 −9.769 −1.414 12.19 24.6 O ATOM 1467 N TYR A1234 −9.048 0.655 11.801 23.56 N ATOM 1468 CA TYR A1234 −7.777 0.205 11.19 22.08 C ATOM 1469 CB TYR A1234 −7.554 0.688 9.75 24.83 C ATOM 1470 CG TYR A1234 −8.779 0.596 8.908 27.05 C ATOM 1471 CD1 TYR A1234 −9.405 1.764 8.447 32.67 C ATOM 1472 CE1 TYR A1234 −10.59 1.71 7.702 34.74 C ATOM 1473 CD2 TYR A1234 −9.363 −0.637 8.628 28.02 C ATOM 1474 CE2 TYR A1234 −10.562 −0.729 7.895 30.43 C ATOM 1475 CZ TYR A1234 −11.173 0.445 7.448 33.92 C ATOM 1476 OH TYR A1234 −12.348 0.376 6.709 35.91 O ATOM 1477 C TYR A1234 −6.604 0.532 12.054 19.79 C ATOM 1478 O TYR A1234 −5.57 −0.125 11.991 19.58 O ATOM 1479 N TYR A1235 −6.787 1.532 12.906 17.81 N ATOM 1480 CA TYR A1235 −5.682 1.997 13.724 14.18 C ATOM 1481 CB TYR A1235 −5.331 3.388 13.366 13.99 C ATOM 1482 CG TYR A1235 −5.008 3.583 11.916 12.91 C ATOM 1483 CD1 TYR A1235 −3.681 3.405 11.449 8.54 C ATOM 1484 CE1 TYR A1235 −3.357 3.532 10.153 6.16 C ATOM 1485 CD2 TYR A1235 −6.053 3.895 10.984 12.53 C ATOM 1486 CE2 TYR A1235 −5.743 4.111 9.651 14.2 C ATOM 1487 CZ TYR A1235 −4.38 3.917 9.229 14.55 C ATOM 1488 OH TYR A1235 −4.077 4.129 7.868 15.24 O ATOM 1489 C TYR A1235 −5.972 1.952 15.171 13.04 C ATOM 1490 O TYR A1235 −7.039 2.27 15.597 12.41 O ATOM 1491 N SER A1236 −4.999 1.454 15.887 12.87 N ATOM 1492 CA SER A1236 −4.921 1.538 17.288 13.9 C ATOM 1493 CB SER A1236 −4.209 0.295 17.817 13.75 C ATOM 1494 OG SER A1236 −5.074 −0.828 17.649 14.05 O ATOM 1495 C SER A1236 −4.083 2.768 17.579 15.02 C ATOM 1496 O SER A1236 −3.273 3.238 16.72 13.02 O ATOM 1497 N VAL A1237 −4.271 3.257 18.8 15.2 N ATOM 1498 CA VAL A1237 −3.669 4.477 19.233 15.62 C ATOM 1499 CB VAL A1237 −4.713 5.574 19.68 16.92 C ATOM 1500 CG1 VAL A1237 −3.991 6.947 19.977 14.81 C ATOM 1501 CG2 VAL A1237 −5.918 5.75 18.643 14.15 C ATOM 1502 C VAL A1237 −2.757 4.186 20.391 17.2 C ATOM 1503 O VAL A1237 −3.164 3.555 21.401 17.99 O ATOM 1504 N HIS A1238 −1.532 4.675 20.285 16.58 N ATOM 1505 CA HIS A1238 −0.63 4.538 21.372 16.6 C ATOM 1506 CB HIS A1238 0.79 4.641 20.897 14.86 C ATOM 1507 CG HIS A1238 1.781 4.197 21.91 18.5 C ATOM 1508 CD2 HIS A1238 2.607 3.122 21.943 22.35 C ATOM 1509 ND1 HIS A1238 2.023 4.899 23.075 21.05 N ATOM 1510 CE1 HIS A1238 2.961 4.28 23.78 23.43 C ATOM 1511 NE2 HIS A1238 3.336 3.197 23.116 23.63 N ATOM 1512 C HIS A1238 −0.941 5.544 22.475 17.59 C ATOM 1513 O HIS A1238 −0.965 6.753 22.219 16.29 O ATOM 1514 N ASN A1239 −1.161 5.013 23.705 19.38 N ATOM 1515 CA ASN A1239 −1.566 5.784 24.887 20.91 C ATOM 1516 CB ASN A1239 −1.67 4.904 26.147 19.93 C ATOM 1517 CG ASN A1239 −2.929 4.038 26.166 18.41 C ATOM 1518 OD1 ASN A1239 −2.947 2.919 26.751 13.41 O ATOM 1519 ND2 ASN A1239 −3.987 4.536 25.513 13.83 N ATOM 1520 C ASN A1239 −0.63 6.964 25.164 23.6 C ATOM 1521 O ASN A1239 −1.11 8.123 25.292 24.04 O ATOM 1522 N LYS A1240 0.679 6.679 25.225 25.19 N ATOM 1523 CA LYS A1240 1.674 7.662 25.602 27.16 C ATOM 1524 CB LYS A1240 2.949 6.948 25.947 27.24 C ATOM 1525 CG LYS A1240 2.753 5.852 27.025 31.39 C ATOM 1526 CD LYS A1240 2.092 6.44 28.311 33.31 C ATOM 1527 CE LYS A1240 1.02 5.512 28.908 35.74 C ATOM 1528 NZ LYS A1240 0.389 6.132 30.138 33.11 N ATOM 1529 C LYS A1240 1.924 8.663 24.477 29.32 C ATOM 1530 O LYS A1240 1.67 9.871 24.627 30.53 O ATOM 1531 N THR A1241 2.43 8.188 23.337 29.79 N ATOM 1532 CA THR A1241 2.509 9.073 22.222 29.89 C ATOM 1533 CB THR A1241 3.467 8.616 21.201 30.25 C ATOM 1534 OG1 THR A1241 3.185 9.403 20.037 33.35 O ATOM 1535 CG2 THR A1241 3.344 7.112 20.901 28.34 C ATOM 1536 C THR A1241 1.096 9.212 21.643 30.22 C ATOM 1537 O THR A1241 0.134 9.339 22.39 32.12 O ATOM 1538 N GLY A1242 0.921 9.192 20.345 27.97 N ATOM 1539 CA GLY A1242 −0.442 9.02 19.841 25.59 C ATOM 1540 C GLY A1242 −0.261 8.357 18.492 23.61 C ATOM 1541 O GLY A1242 −1.07 8.496 17.614 23.73 O ATOM 1542 N ALA A1243 0.859 7.673 18.364 22.33 N ATOM 1543 CA ALA A1243 1.246 6.956 17.18 21.48 C ATOM 1544 CB ALA A1243 2.497 6.121 17.461 19.16 C ATOM 1545 C ALA A1243 0.044 6.081 16.798 20.06 C ATOM 1546 O ALA A1243 −0.532 5.452 17.648 18.79 O ATOM 1547 N LYS A1244 −0.377 6.218 15.54 19.98 N ATOM 1548 CA LYS A1244 −1.313 5.355 14.829 20.6 C ATOM 1549 CB LYS A1244 −1.695 5.942 13.468 21.8 C ATOM 1550 CG LYS A1244 −2.614 7.095 13.557 24.9 C ATOM 1551 CD LYS A1244 −2.3 7.965 14.744 29.39 C ATOM 1552 CE LYS A1244 −3.596 8.051 15.56 37.57 C ATOM 1553 NZ LYS A1244 −4.284 6.676 15.714 36.7 N ATOM 1554 C LYS A1244 −0.646 4.085 14.508 19.2 C ATOM 1555 O LYS A1244 0.49 4.124 14.123 19.11 O ATOM 1556 N LEU A1245 −1.368 2.966 14.627 18.63 N ATOM 1557 CA LEU A1245 −0.791 1.644 14.347 17.18 C ATOM 1558 CB LEU A1245 −0.369 0.954 15.664 16.59 C ATOM 1559 CG LEU A1245 0.56 1.802 16.567 19.65 C ATOM 1560 CD1 LEU A1245 0.157 1.66 18.01 17.13 C ATOM 1561 CD2 LEU A1245 2.037 1.413 16.357 21.7 C ATOM 1562 C LEU A1245 −1.757 0.774 13.587 14.78 C ATOM 1563 O LEU A1245 −2.652 0.238 14.189 15 O ATOM 1564 N PRO A1246 −1.545 0.587 12.279 13.51 N ATOM 1565 CD PRO A1246 −0.403 1.159 11.572 14.89 C ATOM 1566 CA PRO A1246 −2.353 −0.239 11.366 13.3 C ATOM 1567 CB PRO A1246 −1.767 0.072 9.956 12.09 C ATOM 1568 CG PRO A1246 −0.694 0.867 10.104 11.81 C ATOM 1569 C PRO A1246 −2.172 −1.735 11.687 13.12 C ATOM 1570 O PRO A1246 −1.721 −2.584 10.83 12.05 O ATOM 1571 N VAL A1247 −2.472 −2.017 12.935 11.59 N ATOM 1572 CA VAL A1247 −2.334 −3.363 13.565 12.32 C ATOM 1573 CB VAL A1247 −3.255 −3.391 14.805 10.84 C ATOM 1574 CG1 VAL A1247 −3.524 −4.818 15.249 15.86 C ATOM 1575 CG2 VAL A1247 −2.617 −2.612 15.917 6.8 C ATOM 1576 C VAL A1247 −2.446 −4.663 12.667 11.2 C ATOM 1577 O VAL A1247 −1.546 −5.488 12.665 11.23 O ATOM 1578 N LYS A1248 −3.525 −4.804 11.918 10.8 N ATOM 1579 CA LYS A1248 −3.743 −5.957 11.027 12.03 C ATOM 1580 CB LYS A1248 −5.177 −5.964 10.572 13.05 C ATOM 1581 CG LYS A1248 −6.152 −5.331 11.58 19.76 C ATOM 1582 CD LYS A1248 −7.062 −6.387 12.249 23.58 C ATOM 1583 CE LYS A1248 −8.534 −5.932 12.134 30.55 C ATOM 1584 NZ LYS A1248 −9.463 −6.69 13.084 34.02 N ATOM 1585 C LYS A1248 −2.883 −6.023 9.745 10.65 C ATOM 1586 O LYS A1248 −2.959 −6.994 8.999 9.86 O ATOM 1587 N TRP A1249 −2.086 −4.981 9.491 10.31 N ATOM 1588 CA TRP A1249 −1.18 −4.913 8.351 8.47 C ATOM 1589 CB TRP A1249 −1.359 −3.605 7.607 8.12 C ATOM 1590 CG TRP A1249 −2.504 −3.633 6.747 7.42 C ATOM 1591 CD2 TRP A1249 −3.871 −3.47 7.156 5.46 C ATOM 1592 CE2 TRP A1249 −4.665 −3.607 5.983 5.77 C ATOM 1593 CE3 TRP A1249 −4.494 −3.162 8.381 6 C ATOM 1594 CD1 TRP A1249 −2.526 −3.943 5.372 4.82 C ATOM 1595 NE1 TRP A1249 −3.811 −3.91 4.929 5.43 N ATOM 1596 CZ2 TRP A1249 −6.098 −3.459 6.001 6.63 C ATOM 1597 CZ3 TRP A1249 −5.928 −2.947 8.392 4.82 C ATOM 1598 CH2 TRP A1249 −6.698 −3.109 7.2 7.88 C ATOM 1599 C TRP A1249 0.225 −5.008 8.863 8.81 C ATOM 1600 O TRP A1249 1.186 −5.191 8.069 8.2 O ATOM 1601 N MET A1250 0.346 −4.956 10.201 9.07 N ATOM 1602 CA MET A1250 1.668 −4.953 10.821 10.3 C ATOM 1603 CB MET A1250 1.62 −4.238 12.155 8.96 C ATOM 1604 CG MET A1250 1.667 −2.721 12.005 10.76 C ATOM 1605 SD MET A1250 1.131 −1.902 13.583 11.56 S ATOM 1606 CE MET A1250 2.534 −2.069 14.536 12.6 C ATOM 1607 C MET A1250 2.295 −6.361 10.962 12.06 C ATOM 1608 O MET A1250 1.611 −7.327 11.333 11.13 O ATOM 1609 N ALA A1251 3.614 −6.434 10.703 13.83 N ATOM 1610 CA ALA A1251 4.46 −7.603 11.026 14.52 C ATOM 1611 CB ALA A1251 5.94 −7.409 10.539 11.9 C ATOM 1612 C ALA A1251 4.402 −7.944 12.522 16.24 C ATOM 1613 O ALA A1251 4.346 −7.052 13.376 16.66 O ATOM 1614 N LEU A1252 4.438 −9.232 12.86 18.73 N ATOM 1615 CA LEU A1252 4.276 −9.537 14.27 21.52 C ATOM 1616 CB LEU A1252 3.851 −10.996 14.594 21.72 C ATOM 1617 CG LEU A1252 4.851 −12.116 14.433 23.21 C ATOM 1618 CD1 LEU A1252 5.321 −12.497 15.742 28.6 C ATOM 1619 CD2 LEU A1252 4.261 −13.324 13.792 24.47 C ATOM 1620 C LEU A1252 5.478 −9.077 15.042 21.57 C ATOM 1621 O LEU A1252 5.406 −8.936 16.224 23.8 O ATOM 1622 N GLU A1253 6.569 −8.764 14.386 22.36 N ATOM 1623 CA GLU A1253 7.621 −8.143 15.118 23.04 C ATOM 1624 CB GLU A1253 9.001 −8.442 14.545 22.64 C ATOM 1625 CG GLU A1253 9.349 −7.787 13.254 25.77 C ATOM 1626 CD GLU A1253 8.924 −8.608 12.003 31.65 C ATOM 1627 OE1 GLU A1253 8.158 −9.631 12.111 30.46 O ATOM 1628 OE2 GLU A1253 9.38 −8.206 10.895 34.18 O ATOM 1629 C GLU A1253 7.37 −6.682 15.304 24.06 C ATOM 1630 O GLU A1253 7.937 −6.101 16.209 25.96 O ATOM 1631 N SER A1254 6.544 −6.048 14.464 25.72 N ATOM 1632 CA SER A1254 6.234 −4.615 14.679 26.4 C ATOM 1633 CB SER A1254 5.766 −3.88 13.427 25.25 C ATOM 1634 OG SER A1254 6.77 −3.938 12.44 25.06 O ATOM 1635 C SER A1254 5.177 −4.542 15.769 27.38 C ATOM 1636 O SER A1254 5.149 −3.604 16.568 26.76 O ATOM 1637 N LEU A1255 4.311 −5.555 15.81 28.96 N ATOM 1638 CA LEU A1255 3.313 −5.671 16.904 30.09 C ATOM 1639 CB LEU A1255 2.445 −6.892 16.682 28.19 C ATOM 1640 CG LEU A1255 1.457 −6.67 15.571 25.9 C ATOM 1641 CD1 LEU A1255 0.648 −7.916 15.545 21.2 C ATOM 1642 CD2 LEU A1255 0.623 −5.462 15.862 22.34 C ATOM 1643 C LEU A1255 4.029 −5.854 18.256 31.71 C ATOM 1644 O LEU A1255 3.438 −5.765 19.341 32.56 O ATOM 1645 N GLN A1256 5.315 −6.125 18.161 32.58 N ATOM 1646 CA GLN A1256 6.02 −6.599 19.279 34.23 C ATOM 1647 CB GLN A1256 6.598 −7.935 18.872 34.77 C ATOM 1648 CG GLN A1256 6.603 −9.017 19.89 37.62 C ATOM 1649 CD GLN A1256 6.165 −10.365 19.269 41.02 C ATOM 1650 OE1 GLN A1256 4.976 −10.64 19.236 42.75 O ATOM 1651 NE2 GLN A1256 7.116 −11.184 18.775 39.8 N ATOM 1652 C GLN A1256 7.164 −5.65 19.573 33.79 C ATOM 1653 O GLN A1256 8.044 −5.999 20.347 35.8 O ATOM 1654 N THR A1257 7.218 −4.49 18.945 32.41 N ATOM 1655 CA THR A1257 8.397 −3.635 19.143 31.17 C ATOM 1656 CB THR A1257 9.718 −4.095 18.392 31.52 C ATOM 1657 OG1 THR A1257 9.638 −3.809 16.969 30.13 O ATOM 1658 CG2 THR A1257 10.112 −5.605 18.665 30.26 C ATOM 1659 C THR A1257 8.147 −2.263 18.645 30.43 C ATOM 1660 O THR A1257 8.877 −1.356 19.008 30.95 O ATOM 1661 N GLN A1258 7.193 −2.138 17.734 29.57 N ATOM 1662 CA GLN A1258 6.735 −0.853 17.219 30.28 C ATOM 1663 CB GLN A1258 6.459 0.13 18.384 31.08 C ATOM 1664 CG GLN A1258 5.144 0.893 18.275 33.11 C ATOM 1665 CD GLN A1258 5.061 2.095 19.274 33.27 C ATOM 1666 OE1 GLN A1258 5.397 1.939 20.463 39.41 O ATOM 1667 NE2 GLN A1258 4.584 3.27 18.798 29.74 N ATOM 1668 C GLN A1258 7.729 −0.263 16.224 28.93 C ATOM 1669 O GLN A1258 7.637 0.916 15.872 29.28 O ATOM 1670 N LYS A1259 8.64 −1.096 15.742 28.14 N ATOM 1671 CA LYS A1259 9.582 −0.677 14.701 28.14 C ATOM 1672 CB LYS A1259 11.05 −0.984 15.129 30.57 C ATOM 1673 CG LYS A1259 11.648 0.003 16.193 31.76 C ATOM 1674 CD LYS A1259 12.782 −0.73 16.978 32.91 C ATOM 1675 CE LYS A1259 13.536 0.295 17.915 37.06 C ATOM 1676 NZ LYS A1259 14.494 −0.291 18.924 32.88 N ATOM 1677 C LYS A1259 9.293 −1.259 13.316 24.48 C ATOM 1678 O LYS A1259 8.873 −2.411 13.2 21.83 O ATOM 1679 N PHE A1260 9.596 −0.455 12.288 21.57 N ATOM 1680 CA PHE A1260 9.234 −0.778 10.91 19.9 C ATOM 1681 CB PHE A1260 8.242 0.249 10.37 18.27 C ATOM 1682 CG PHE A1260 7 0.392 11.208 16.53 C ATOM 1683 CD1 PHE A1260 6.991 1.259 12.353 17.28 C ATOM 1684 CD2 PHE A1260 5.851 −0.336 10.909 14.62 C ATOM 1685 CE1 PHE A1260 5.874 1.39 13.158 14.55 C ATOM 1686 CE2 PHE A1260 4.706 −0.221 11.702 16.06 C ATOM 1687 CZ PHE A1260 4.698 0.646 12.807 18.96 C ATOM 1688 C PHE A1260 10.446 −0.912 9.984 20.79 C ATOM 1689 O PHE A1260 11.497 −0.282 10.19 22.74 O ATOM 1690 N THR A1261 10.319 −1.739 8.958 19.25 N ATOM 1691 CA THR A1261 11.369 −1.894 7.99 17.76 C ATOM 1692 CB THR A1261 12.358 −3.043 8.369 18.7 C ATOM 1693 OG1 THR A1261 11.668 −4.302 8.396 18.46 O ATOM 1694 CG2 THR A1261 13 −2.793 9.746 19.38 C ATOM 1695 C THR A1261 10.726 −2.181 6.637 16.24 C ATOM 1696 O THR A1261 9.519 −2.344 6.549 15.68 O ATOM 1697 N THR A1262 11.542 −2.225 5.581 13.6 N ATOM 1698 CA THR A1262 11.063 −2.608 4.321 12.49 C ATOM 1699 CB THR A1262 12.175 −2.541 3.221 14.06 C ATOM 1700 OG1 THR A1262 12.656 −1.212 3.086 11.22 O ATOM 1701 CG2 THR A1262 11.636 −2.914 1.843 14.36 C ATOM 1702 C THR A1262 10.525 −3.996 4.475 11.49 C ATOM 1703 O THR A1262 9.629 −4.349 3.817 11.81 O ATOM 1704 N LYS A1263 11.132 −4.822 5.318 12.87 N ATOM 1705 CA LYS A1263 10.597 −6.177 5.595 12.76 C ATOM 1706 CB LYS A1263 11.604 −6.976 6.408 13.32 C ATOM 1707 CG LYS A1263 12.832 −7.445 5.589 14.58 C ATOM 1708 CD LYS A1263 12.449 −8.002 4.24 10.3 C ATOM 1709 CE LYS A1263 13.641 −8.874 3.828 14.06 C ATOM 1710 NZ LYS A1263 13.635 −9.233 2.408 10.78 N ATOM 1711 C LYS A1263 9.235 −6.256 6.256 10.99 C ATOM 1712 O LYS A1263 8.509 −7.228 6.056 10.11 O ATOM 1713 N SER A1264 8.925 −5.263 7.076 10.36 N ATOM 1714 CA SER A1264 7.575 −5.162 7.644 11.41 C ATOM 1715 CB SER A1264 7.54 −4.346 8.93 11.47 C ATOM 1716 OG SER A1264 7.752 −2.984 8.714 14.16 O ATOM 1717 C SER A1264 6.633 −4.601 6.598 11.2 C ATOM 1718 O SER A1264 5.43 −4.992 6.553 11.68 O ATOM 1719 N ASP A1265 7.204 −3.819 5.679 9.67 N ATOM 1720 CA ASP A1265 6.45 −3.364 4.538 11.37 C ATOM 1721 CB ASP A1265 7.171 −2.28 3.753 10.45 C ATOM 1722 CG ASP A1265 6.956 −0.879 4.332 14.18 C ATOM 1723 OD1 ASP A1265 7.593 0.032 3.753 14.77 O ATOM 1724 OD2 ASP A1265 6.163 −0.667 5.331 16.48 O ATOM 1725 C ASP A1265 6.041 −4.533 3.618 11.53 C ATOM 1726 O ASP A1265 4.944 −4.545 3.046 14.2 O ATOM 1727 N VAL A1266 6.856 −5.549 3.576 10.63 N ATOM 1728 CA VAL A1266 6.602 −6.704 2.752 11.03 C ATOM 1729 CB VAL A1266 7.949 −7.558 2.57 10.66 C ATOM 1730 CG1 VAL A1266 7.661 −9.023 2.243 8.73 C ATOM 1731 CG2 VAL A1266 8.825 −6.919 1.505 8.25 C ATOM 1732 C VAL A1266 5.475 −7.515 3.393 10.47 C ATOM 1733 O VAL A1266 4.63 −8.017 2.669 12.51 O ATOM 1734 N TRP A1267 5.455 −7.602 4.728 9.37 N ATOM 1735 CA TRP A1267 4.375 −8.239 5.466 8.82 C ATOM 1736 CB TRP A1267 4.633 −8.156 7 8.16 C ATOM 1737 CG TRP A1267 3.559 −8.824 7.849 10.92 C ATOM 1738 CD2 TRP A1267 3.665 −10.046 8.612 9.89 C ATOM 1739 CE2 TRP A1267 2.394 −10.3 9.176 9.5 C ATOM 1740 CE3 TRP A1267 4.712 −10.904 8.911 8.75 C ATOM 1741 CD1 TRP A1267 2.232 −8.433 7.972 10.68 C ATOM 1742 NE1 TRP A1267 1.552 −9.29 8.779 6.35 N ATOM 1743 CZ2 TRP A1267 2.156 −11.378 10.068 8.31 C ATOM 1744 CZ3 TRP A1267 4.465 −11.994 9.747 10.23 C ATOM 1745 CH2 TRP A1267 3.187 −12.215 10.325 8.98 C ATOM 1746 C TRP A1267 3.041 −7.557 5.104 8.67 C ATOM 1747 O TRP A1267 2.055 −8.236 4.836 9.65 O ATOM 1748 N SER A1268 3 −6.206 5.109 9.54 N ATOM 1749 CA SER A1268 1.746 −5.456 4.795 7.78 C ATOM 1750 CB SER A1268 1.913 −3.967 5.045 7.03 C ATOM 1751 OG SER A1268 2.513 −3.772 6.256 8.59 O ATOM 1752 C SER A1268 1.365 −5.634 3.342 7.8 C ATOM 1753 O SER A1268 0.17 −5.677 3.001 7.51 O ATOM 1754 N PHE A1269 2.387 −5.73 2.479 8.59 N ATOM 1755 CA PHE A1269 2.169 −5.956 1.088 9.1 C ATOM 1756 CB PHE A1269 3.473 −5.888 0.338 8.27 C ATOM 1757 CG PHE A1269 3.314 −6.245 −1.096 8.45 C ATOM 1758 CD1 PHE A1269 2.619 −5.363 −1.972 9.17 C ATOM 1759 CD2 PHE A1269 3.719 −7.495 −1.559 8.51 C ATOM 1760 CE1 PHE A1269 2.369 −5.68 −3.271 7.04 C ATOM 1761 CE2 PHE A1269 3.495 −7.836 −2.88 8.56 C ATOM 1762 CZ PHE A1269 2.784 −6.942 −3.728 9.89 C ATOM 1763 C PHE A1269 1.442 −7.323 0.919 10.64 C ATOM 1764 O PHE A1269 0.49 −7.477 0.111 11.13 O ATOM 1765 N GLY A1270 1.857 −8.317 1.702 11.64 N ATOM 1766 CA GLY A1270 1.14 −9.587 1.648 11.42 C ATOM 1767 C GLY A1270 −0.332 −9.417 2.029 10.97 C ATOM 1768 O GLY A1270 −1.199 −10.04 1.413 11.25 O ATOM 1769 N VAL A1271 −0.613 −8.596 3.059 9.54 N ATOM 1770 CA VAL A1271 −2.01 −8.356 3.569 8.57 C ATOM 1771 CB VAL A1271 −2.033 −7.621 4.946 8.56 C ATOM 1772 CG1 VAL A1271 −3.47 −7.359 5.392 7 C ATOM 1773 CG2 VAL A1271 −1.271 −8.389 6.08 3.23 C ATOM 1774 C VAL A1271 −2.833 −7.584 2.516 9.92 C ATOM 1775 O VAL A1271 −4.001 −7.95 2.211 10.22 O ATOM 1776 N LEU A1272 −2.175 −6.593 1.899 10.19 N ATOM 1777 CA LEU A1272 −2.68 −5.873 0.716 11.37 C ATOM 1778 CB LEU A1272 −1.764 −4.681 0.411 11.24 C ATOM 1779 CG LEU A1272 −1.525 −3.908 −0.905 14.03 C ATOM 1780 CD1 LEU A1272 −2.293 −4.472 −2.089 13.62 C ATOM 1781 CD2 LEU A1272 −1.645 −2.378 −0.821 13.61 C ATOM 1782 C LEU A1272 −3.038 −6.764 −0.501 11.35 C ATOM 1783 O LEU A1272 −4.086 −6.613 −1.146 11.16 O ATOM 1784 N LEU A1273 −2.208 −7.748 −0.75 10.97 N ATOM 1785 CA LEU A1273 −2.507 −8.766 −1.748 10.03 C ATOM 1786 CB LEU A1273 −1.341 −9.755 −1.831 9.71 C ATOM 1787 CG LEU A1273 −0.17 −9.307 −2.652 12.95 C ATOM 1788 CD1 LEU A1273 0.852 −10.401 −2.848 13.19 C ATOM 1789 CD2 LEU A1273 −0.706 −8.847 −3.99 16.74 C ATOM 1790 C LEU A1273 −3.716 −9.555 −1.395 8.67 C ATOM 1791 O LEU A1273 −4.436 −9.945 −2.273 7.96 O ATOM 1792 N TRP A1274 −3.86 −9.879 −0.092 9.8 N ATOM 1793 CA TRP A1274 −5.031 −10.602 0.426 8.39 C ATOM 1794 CB TRP A1274 −4.81 −11.063 1.856 7.65 C ATOM 1795 CG TRP A1274 −5.841 −11.888 2.417 3.72 C ATOM 1796 CD2 TRP A1274 −7.005 −11.445 3.132 4.89 C ATOM 1797 CE2 TRP A1274 −7.731 −12.617 3.507 2 C ATOM 1798 CE3 TRP A1274 −7.48 −10.181 3.54 4.57 C ATOM 1799 CD1 TRP A1274 −5.909 −13.249 2.383 4.08 C ATOM 1800 NE1 TRP A1274 −7.037 −13.694 3.025 2.01 N ATOM 1801 CZ2 TRP A1274 −8.903 −12.574 4.242 2.67 C ATOM 1802 CZ3 TRP A1274 −8.727 −10.127 4.267 8.33 C ATOM 1803 CH2 TRP A1274 −9.417 −11.329 4.607 3.57 C ATOM 1804 C TRP A1274 −6.228 −9.715 0.277 9.2 C ATOM 1805 O TRP A1274 −7.31 −10.183 −0.178 10.85 O ATOM 1806 N GLU A1275 −6.053 −8.426 0.596 9.74 N ATOM 1807 CA GLU A1275 −7.159 −7.458 0.406 10.36 C ATOM 1808 CB GLU A1275 −6.761 −6.009 0.771 9.95 C ATOM 1809 CG GLU A1275 −6.544 −5.683 2.246 11 C ATOM 1810 CD GLU A1275 −6.205 −4.183 2.392 12.14 C ATOM 1811 OE1 GLU A1275 −5.043 −3.754 2.104 12.7 O ATOM 1812 OE2 GLU A1275 −7.131 −3.392 2.7 11.37 O ATOM 1813 C GLU A1275 −7.61 −7.445 −1.028 10.04 C ATOM 1814 O GLU A1275 −8.794 −7.315 −1.306 10.34 O ATOM 1815 N LEU A1276 −6.641 −7.421 −1.934 11.02 N ATOM 1816 CA LEU A1276 −6.883 −7.423 −3.355 11.94 C ATOM 1817 CB LEU A1276 −5.549 −7.374 −4.068 11.7 C ATOM 1818 CG LEU A1276 −5.098 −6.161 −4.878 13.84 C ATOM 1819 CD1 LEU A1276 −5.77 −4.882 −4.59 15.07 C ATOM 1820 CD2 LEU A1276 −3.588 −6.017 −4.794 14.8 C ATOM 1821 C LEU A1276 −7.649 −8.691 −3.79 12.76 C ATOM 1822 O LEU A1276 −8.688 −8.584 −4.439 14.11 O ATOM 1823 N MET A1277 −7.181 −9.872 −3.387 12.53 N ATOM 1824 CA MET A1277 −7.783 −11.114 −3.844 13.7 C ATOM 1825 CB MET A1277 −6.838 −12.32 −3.715 11.99 C ATOM 1826 CG MET A1277 −5.573 −12.151 −4.52 16.79 C ATOM 1827 SD MET A1277 −5.667 −11.426 −6.22 25.77 S ATOM 1828 CE MET A1277 −6.432 −12.816 −7.071 17.04 C ATOM 1829 C MET A1277 −9.1 −11.424 −3.185 14.22 C ATOM 1830 O MET A1277 −9.877 −12.227 −3.727 15.37 O ATOM 1831 N THR A1278 −9.345 −10.845 −2.007 14.32 N ATOM 1832 CA THR A1278 −10.683 −10.929 −1.389 12.59 C ATOM 1833 CB THR A1278 −10.597 −10.94 0.12 13.16 C ATOM 1834 OG1 THR A1278 −10.167 −9.64 0.627 9.42 O ATOM 1835 CG2 THR A1278 −9.611 −12.04 0.543 8.23 C ATOM 1836 C THR A1278 −11.582 −9.779 −1.809 13.58 C ATOM 1837 O THR A1278 −12.71 −9.661 −1.286 14.22 O ATOM 1838 N ARG A1279 −11.094 −8.931 −2.726 12.97 N ATOM 1839 CA ARG A1279 −11.853 −7.804 −3.23 15.57 C ATOM 1840 CB ARG A1279 −13.12 −8.298 −3.949 14.48 C ATOM 1841 CG ARG A1279 −13.201 −7.815 −5.354 20.35 C ATOM 1842 CD ARG A1279 −14.28 −8.526 −6.25 20.34 C ATOM 1843 NE ARG A1279 −13.757 −9.783 −6.773 27.23 N ATOM 1844 CZ ARG A1279 −13.268 −10.03 −8.019 29.48 C ATOM 1845 NH1 ARG A1279 −13.237 −9.082 −8.967 19.95 N ATOM 1846 NH2 ARG A1279 −12.773 −11.281 −8.296 29.36 N ATOM 1847 C ARG A1279 −12.252 −6.851 −2.08 15.31 C ATOM 1848 O ARG A1279 −13.412 −6.454 −1.997 16.43 O ATOM 1849 N GLY A1280 −11.316 −6.472 −1.202 14.52 N ATOM 1850 CA GLY A1280 −11.607 −5.431 −0.235 14.65 C ATOM 1851 C GLY A1280 −12.149 −5.991 1.088 15.17 C ATOM 1852 O GLY A1280 −12.617 −5.233 1.934 13.6 O ATOM 1853 N ALA A1281 −12.066 −7.311 1.31 14.02 N ATOM 1854 CA ALA A1281 −12.479 −7.784 2.644 14.68 C ATOM 1855 CB ALA A1281 −12.698 −9.349 2.709 13.99 C ATOM 1856 C ALA A1281 −11.512 −7.29 3.732 14.17 C ATOM 1857 O ALA A1281 −10.291 −7.095 3.428 13.46 O ATOM 1858 N PRO A1282 −12.025 −7.152 4.989 13.83 N ATOM 1859 CD PRO A1282 −13.426 −7.463 5.268 15.14 C ATOM 1860 CA PRO A1282 −11.327 −6.761 6.233 15.61 C ATOM 1861 CB PRO A1282 −12.477 −6.518 7.241 16.49 C ATOM 1862 CG PRO A1282 −13.805 −6.384 6.27 16.92 C ATOM 1863 C PRO A1282 −10.542 −7.972 6.721 16.94 C ATOM 1864 O PRO A1282 −11.135 −9.035 6.958 17.36 O ATOM 1865 N PRO A1283 −9.212 −7.829 6.868 17.68 N ATOM 1866 CD PRO A1283 −8.431 −6.615 6.538 17.72 C ATOM 1867 CA PRO A1283 −8.407 −8.909 7.458 17.23 C ATOM 1868 CB PRO A1283 −6.978 −8.369 7.397 17.46 C ATOM 1869 CG PRO A1283 −7.01 −6.992 6.83 17.37 C ATOM 1870 C PRO A1283 −8.809 −9.139 8.924 17.48 C ATOM 1871 O PRO A1283 −9.079 −8.155 9.671 17.71 O ATOM 1872 N TYR A1284 −8.86 −10.402 9.336 16.72 N ATOM 1873 CA TYR A1284 −9.106 −10.759 10.742 17.3 C ATOM 1874 CB TYR A1284 −7.938 −10.382 11.624 16.01 C ATOM 1875 CG TYR A1284 −6.551 −10.698 11.111 17.42 C ATOM 1876 CD1 TYR A1284 −5.946 −11.957 11.312 15.84 C ATOM 1877 CE1 TYR A1284 −4.631 −12.201 10.876 14.8 C ATOM 1878 CD2 TYR A1284 −5.809 −9.724 10.468 16.16 C ATOM 1879 CE2 TYR A1284 −4.539 −9.98 10.008 16.45 C ATOM 1880 CZ TYR A1284 −3.932 −11.185 10.22 16.76 C ATOM 1881 OH TYR A1284 −2.656 −11.326 9.687 16.71 O ATOM 1882 C TYR A1284 −10.342 −10.136 11.365 18.43 C ATOM 1883 O TYR A1284 −10.225 −9.475 12.388 18.85 O ATOM 1884 N PRO A1285 −11.519 −10.319 10.758 20.37 N ATOM 1885 CD PRO A1285 −11.84 −11.196 9.635 20.13 C ATOM 1886 CA PRO A1285 −12.689 −9.555 11.184 23.29 C ATOM 1887 CB PRO A1285 −13.739 −9.907 10.135 22.39 C ATOM 1888 CG PRO A1285 −13.326 −11.24 9.66 21.13 C ATOM 1889 C PRO A1285 −13.166 −9.872 12.61 26.8 C ATOM 1890 O PRO A1285 −13.433 −8.936 13.408 25.99 O ATOM 1891 N ASP A1286 −13.265 −11.154 12.972 30.65 N ATOM 1892 CA ASP A1286 −13.848 −11.408 14.323 35.35 C ATOM 1893 CB ASP A1286 −14.553 −12.807 14.453 37.22 C ATOM 1894 CG ASP A1286 −15.524 −13.112 13.255 43.19 C ATOM 1895 OD1 ASP A1286 −14.994 −13.477 12.169 46.45 O ATOM 1896 OD2 ASP A1286 −16.782 −12.965 13.391 46.26 O ATOM 1897 C ASP A1286 −12.895 −11.155 15.535 35.1 C ATOM 1898 O ASP A1286 −13.065 −11.858 16.549 36.23 O ATOM 1899 N VAL A1287 −11.959 −10.172 15.481 32.52 N ATOM 1900 CA VAL A1287 −10.802 −10.275 16.39 29.97 C ATOM 1901 CB VAL A1287 −9.744 −11.371 15.935 29.53 C ATOM 1902 CG1 VAL A1287 −9.59 −11.36 14.514 30.14 C ATOM 1903 CG2 VAL A1287 −8.408 −11.176 16.544 30.07 C ATOM 1904 C VAL A1287 −10.145 −9.032 16.83 28.88 C ATOM 1905 O VAL A1287 −9.891 −8.145 16.02 29.31 O ATOM 1906 N ASN A1288 −9.858 −8.968 18.137 26.64 N ATOM 1907 CA ASN A1288 −9.176 −7.828 18.689 24.13 C ATOM 1908 CB ASN A1288 −9.554 −7.638 20.164 25 C ATOM 1909 CG ASN A1288 −9.045 −8.774 21.085 25.21 C ATOM 1910 OD1 ASN A1288 −7.878 −9.281 20.965 21.19 O ATOM 1911 ND2 ASN A1288 −9.928 −9.165 22.048 22.42 N ATOM 1912 C ASN A1288 −7.678 −7.882 18.51 23.31 C ATOM 1913 O ASN A1288 −7.145 −8.852 18.011 22.44 O ATOM 1914 N THR A1289 −7.008 −6.829 18.966 23.16 N ATOM 1915 CA THR A1289 −5.58 −6.648 18.82 22.72 C ATOM 1916 CB THR A1289 −5.102 −5.234 19.26 23.85 C ATOM 1917 OG1 THR A1289 −5.823 −4.741 20.416 26.46 O ATOM 1918 CG2 THR A1289 −5.304 −4.207 18.143 25.64 C ATOM 1919 C THR A1289 −4.739 −7.686 19.517 22.02 C ATOM 1920 O THR A1289 −3.619 −8.007 19.065 23 O ATOM 1921 N PHE A1290 −5.251 −8.222 20.614 20.54 N ATOM 1922 CA PHE A1290 −4.486 −9.215 21.359 19.45 C ATOM 1923 CB PHE A1290 −4.935 −9.309 22.861 19.8 C ATOM 1924 CG PHE A1290 −4.062 −10.269 23.708 18.62 C ATOM 1925 CD1 PHE A1290 −2.808 −9.855 24.201 16.3 C ATOM 1926 CD2 PHE A1290 −4.466 −11.598 23.931 20.15 C ATOM 1927 CE1 PHE A1290 −1.999 −10.702 24.984 19.55 C ATOM 1928 CE2 PHE A1290 −3.661 −12.486 24.692 18.86 C ATOM 1929 CZ PHE A1290 −2.404 −12.053 25.206 20.06 C ATOM 1930 C PHE A1290 −4.587 −10.609 20.684 18.03 C ATOM 1931 O PHE A1290 −3.605 −11.325 20.562 16.43 O ATOM 1932 N ASP A1291 −5.793 −10.996 20.303 17.58 N ATOM 1933 CA ASP A1291 −5.964 −12.302 19.726 19.32 C ATOM 1934 CB ASP A1291 −7.414 −12.688 19.644 18.53 C ATOM 1935 CG ASP A1291 −8.056 −12.83 20.984 21.78 C ATOM 1936 OD1 ASP A1291 −7.39 −13.29 21.98 19.49 O ATOM 1937 OD2 ASP A1291 −9.277 −12.483 21.039 24.79 O ATOM 1938 C ASP A1291 −5.301 −12.414 18.338 20.96 C ATOM 1939 O ASP A1291 −4.776 −13.486 17.993 21.73 O ATOM 1940 N ILE A1292 −5.313 −11.32 17.569 20.88 N ATOM 1941 CA ILE A1292 −4.576 −11.26 16.303 21.43 C ATOM 1942 CB ILE A1292 −4.718 −9.857 15.559 20.9 C ATOM 1943 CG2 ILE A1292 −3.601 −9.658 14.6 22.73 C ATOM 1944 CG1 ILE A1292 −5.981 −9.858 14.679 22.1 C ATOM 1945 CD1 ILE A1292 −6.854 −8.575 14.742 27.9 C ATOM 1946 C ILE A1292 −3.153 −11.697 16.529 20.67 C ATOM 1947 O ILE A1292 −2.569 −12.403 15.728 21.89 O ATOM 1948 N THR A1293 −2.591 −11.277 17.633 20.67 N ATOM 1949 CA THR A1293 −1.187 −11.53 17.92 21.87 C ATOM 1950 CB THR A1293 −0.769 −10.598 19.089 22.47 C ATOM 1951 OG1 THR A1293 −0.81 −9.23 18.606 25.62 O ATOM 1952 CG2 THR A1293 0.571 −10.944 19.614 20.56 C ATOM 1953 C THR A1293 −0.949 −13.006 18.292 22.24 C ATOM 1954 O THR A1293 0.01 −13.642 17.844 22.94 O ATOM 1955 N VAL A1294 −1.844 −13.548 19.105 22.43 N ATOM 1956 CA VAL A1294 −1.887 −14.965 19.401 22.79 C ATOM 1957 CB VAL A1294 −3.039 −15.316 20.484 24.33 C ATOM 1958 CG1 VAL A1294 −2.905 −16.703 20.93 21.06 C ATOM 1959 CG2 VAL A1294 −3.012 −14.34 21.698 22.9 C ATOM 1960 C VAL A1294 −2.137 −15.775 18.156 22.04 C ATOM 1961 O VAL A1294 −1.472 −16.737 17.979 23.52 O ATOM 1962 N TYR A1295 −3.127 −15.42 17.336 21.11 N ATOM 1963 CA TYR A1295 −3.378 −16.062 16.036 21.27 C ATOM 1964 CB TYR A1295 −4.387 −15.233 15.215 21.55 C ATOM 1965 CG TYR A1295 −4.827 −15.809 13.847 22.76 C ATOM 1966 CD1 TYR A1295 −5.852 −16.772 13.788 24.13 C ATOM 1967 CE1 TYR A1295 −6.251 −17.347 12.586 22.48 C ATOM 1968 CD2 TYR A1295 −4.24 −15.406 12.639 18.86 C ATOM 1969 CE2 TYR A1295 −4.647 −15.975 11.44 19.4 C ATOM 1970 CZ TYR A1295 −5.662 −16.957 11.412 22 C ATOM 1971 OH TYR A1295 −6.157 −17.572 10.245 15.34 O ATOM 1972 C TYR A1295 −2.05 −16.149 15.285 21.71 C ATOM 1973 O TYR A1295 −1.72 −17.214 14.76 23.7 O ATOM 1974 N LEU A1296 −1.278 −15.061 15.253 20.06 N ATOM 1975 CA LEU A1296 −0.1 −15.031 14.463 19.72 C ATOM 1976 CB LEU A1296 0.315 −13.583 14.173 18.7 C ATOM 1977 CG LEU A1296 −0.563 −12.717 13.227 17.29 C ATOM 1978 CD1 LEU A1296 −0.108 −11.231 13.155 14.74 C ATOM 1979 CD2 LEU A1296 −0.67 −13.32 11.866 13.27 C ATOM 1980 C LEU A1296 1.069 −15.809 15.034 21.48 C ATOM 1981 O LEU A1296 1.891 −16.348 14.288 20.81 O ATOM 1982 N LEU A1297 1.202 −15.8 16.367 23.54 N ATOM 1983 CA LEU A1297 2.303 −16.527 17.031 23.91 C ATOM 1984 CB LEU A1297 2.543 −16.042 18.472 23.89 C ATOM 1985 CG LEU A1297 3.38 −14.752 18.474 27.22 C ATOM 1986 CD1 LEU A1297 3.407 −13.97 19.768 28.81 C ATOM 1987 CD2 LEU A1297 4.763 −15.022 18.017 31.47 C ATOM 1988 C LEU A1297 2.053 −18.024 17.018 24.35 C ATOM 1989 O LEU A1297 2.956 −18.785 17.371 26.26 O ATOM 1990 N GLN A1298 0.865 −18.444 16.598 23.07 N ATOM 1991 CA GLN A1298 0.509 −19.839 16.478 23.56 C ATOM 1992 CB GLN A1298 −0.975 −20.019 16.765 23.4 C ATOM 1993 CG GLN A1298 −1.185 −20.016 18.319 29.5 C ATOM 1994 CD GLN A1298 −2.609 −20.215 18.746 33.61 C ATOM 1995 OE1 GLN A1298 −3.551 −19.932 17.988 33.3 O ATOM 1996 NE2 GLN A1298 −2.79 −20.662 20.004 36.42 N ATOM 1997 C GLN A1298 0.813 −20.336 15.092 23.28 C ATOM 1998 O GLN A1298 0.486 −21.504 14.767 23.77 O ATOM 1999 N GLY A1299 1.427 −19.453 14.293 21.11 N ATOM 2000 CA GLY A1299 1.761 −19.705 12.913 19.57 C ATOM 2001 C GLY A1299 0.552 −19.613 11.985 19.57 C ATOM 2002 O GLY A1299 0.69 −19.848 10.779 19.65 O ATOM 2003 N ARG A1300 −0.642 −19.294 12.519 17.34 N ATOM 2004 CA ARG A1300 −1.791 −19.147 11.663 15.11 C ATOM 2005 CB ARG A1300 −3.068 −19.072 12.496 15.35 C ATOM 2006 CG ARG A1300 −3.227 −20.162 13.511 17.32 C ATOM 2007 CD ARG A1300 −4.385 −19.878 14.443 19 C ATOM 2008 NE ARG A1300 −5.495 −20.632 13.951 26.17 N ATOM 2009 CZ ARG A1300 −5.943 −21.75 14.51 26.18 C ATOM 2010 NH1 ARG A1300 −5.407 −22.226 15.639 26.4 N ATOM 2011 NH2 ARG A1300 −6.947 −22.383 13.935 28.78 N ATOM 2012 C ARG A1300 −1.625 −17.896 10.789 13.95 C ATOM 2013 O ARG A1300 −0.906 −16.952 11.167 11.48 O ATOM 2014 N ARG A1301 −2.292 −17.914 9.62 12.59 N ATOM 2015 CA ARG A1301 −2.296 −16.803 8.679 10.68 C ATOM 2016 CB ARG A1301 −1.227 −17.008 7.66 9.76 C ATOM 2017 CG ARG A1301 0.201 −17.075 8.265 9.66 C ATOM 2018 CD ARG A1301 0.732 −15.697 8.706 10.28 C ATOM 2019 NE ARG A1301 2.117 −15.7 9.169 7.99 N ATOM 2020 CZ ARG A1301 2.433 −16.002 10.423 11.74 C ATOM 2021 NH1 ARG A1301 1.466 −16.398 11.307 6.97 N ATOM 2022 NH2 ARG A1301 3.713 −15.986 10.777 11.06 N ATOM 2023 C ARG A1301 −3.668 −16.6 8.022 11.29 C ATOM 2024 O ARG A1301 −4.596 −17.417 8.188 10.02 O ATOM 2025 N LEU A1302 −3.83 −15.488 7.303 11.13 N ATOM 2026 CA LEU A1302 −5.106 −15.197 6.609 10.8 C ATOM 2027 CB LEU A1302 −5.014 −13.85 5.963 9.1 C ATOM 2028 CG LEU A1302 −4.833 −12.681 6.864 6.48 C ATOM 2029 CD1 LEU A1302 −4.307 −11.511 6.008 9.35 C ATOM 2030 CD2 LEU A1302 −6.153 −12.358 7.484 4.82 C ATOM 2031 C LEU A1302 −5.312 −16.286 5.57 12.1 C ATOM 2032 O LEU A1302 −4.346 −16.769 5.013 13.45 O ATOM 2033 N LEU A1303 −6.537 −16.737 5.331 14.81 N ATOM 2034 CA LEU A1303 −6.711 −18 4.542 15.67 C ATOM 2035 CB LEU A1303 −8.023 −18.684 4.826 14.95 C ATOM 2036 CG LEU A1303 −8.178 −19.581 6.054 18.31 C ATOM 2037 CD1 LEU A1303 −6.996 −19.498 6.984 20.03 C ATOM 2038 CD2 LEU A1303 −9.492 −19.163 6.791 15.76 C ATOM 2039 C LEU A1303 −6.66 −17.616 3.1 16.46 C ATOM 2040 O LEU A1303 −6.816 −16.433 2.806 17.16 O ATOM 2041 N GLN A1304 −6.44 −18.594 2.224 16.59 N ATOM 2042 CA GLN A1304 −6.3 −18.347 0.838 16.9 C ATOM 2043 CB GLN A1304 −5.86 −19.567 0.157 15.65 C ATOM 2044 CG GLN A1304 −5.653 −19.308 −1.266 15.99 C ATOM 2045 CD GLN A1304 −5.059 −20.498 −2.033 18.57 C ATOM 2046 OE1 GLN A1304 −4.449 −21.434 −1.479 14.91 O ATOM 2047 NE2 GLN A1304 −5.186 −20.415 −3.343 19.66 N ATOM 2048 C GLN A1304 −7.665 −17.96 0.305 20.07 C ATOM 2049 O GLN A1304 −8.661 −18.688 0.48 21.65 O ATOM 2050 N PRO A1305 −7.758 −16.779 −0.303 20.86 N ATOM 2051 CD PRO A1305 −6.779 −15.677 −0.48 21.62 C ATOM 2052 CA PRO A1305 −9.075 −16.464 −0.792 21.48 C ATOM 2053 CB PRO A1305 −8.959 −14.995 −1.167 20.75 C ATOM 2054 CG PRO A1305 −7.643 −14.505 −0.558 21.05 C ATOM 2055 C PRO A1305 −9.462 −17.375 −1.955 23.17 C ATOM 2056 O PRO A1305 −8.602 −18.053 −2.505 22.48 O ATOM 2057 N GLU A1306 −10.761 −17.436 −2.283 26 N ATOM 2058 CA GLU A1306 −11.26 −18.192 −3.458 28.18 C ATOM 2059 CB GLU A1306 −12.763 −18.089 −3.506 29.06 C ATOM 2060 CG GLU A1306 −13.503 −19.357 −3.241 32.62 C ATOM 2061 CD GLU A1306 −15.012 −19.072 −3.204 38.95 C ATOM 2062 OE1 GLU A1306 −15.586 −18.781 −4.279 38.36 O ATOM 2063 OE2 GLU A1306 −15.613 −19.109 −2.096 42.58 O ATOM 2064 C GLU A1306 −10.727 −17.481 −4.699 29.17 C ATOM 2065 O GLU A1306 −10.623 −16.223 −4.716 28.95 O ATOM 2066 N TYR A1307 −10.373 −18.239 −5.733 29.22 N ATOM 2067 CA TYR A1307 −9.876 −17.566 −6.982 29.91 C ATOM 2068 CB TYR A1307 −10.817 −16.438 −7.467 31.22 C ATOM 2069 CG TYR A1307 −12.238 −16.847 −7.415 34.72 C ATOM 2070 CD1 TYR A1307 −12.651 −17.996 −8.093 37.5 C ATOM 2071 CE1 TYR A1307 −13.982 −18.423 −8.057 37.34 C ATOM 2072 CD2 TYR A1307 −13.183 −16.105 −6.674 37.26 C ATOM 2073 CE2 TYR A1307 −14.515 −16.517 −6.635 38.36 C ATOM 2074 CZ TYR A1307 −14.896 −17.692 −7.347 37.41 C ATOM 2075 OH TYR A1307 −16.196 −18.158 −7.348 37.73 O ATOM 2076 C TYR A1307 −8.469 −16.946 −6.918 27.27 C ATOM 2077 O TYR A1307 −8.005 −16.415 −7.922 28.16 O ATOM 2078 N CYS A1308 −7.836 −16.986 −5.76 24.33 N ATOM 2079 CA CYS A1308 −6.448 −16.581 −5.609 22.31 C ATOM 2080 CB CYS A1308 −6.179 −16.264 −4.155 21.21 C ATOM 2081 SG CYS A1308 −4.524 −15.866 −3.835 21.98 S ATOM 2082 C CYS A1308 −5.63 −17.792 −5.972 21.69 C ATOM 2083 O CYS A1308 −5.657 −18.776 −5.197 21.71 O ATOM 2084 N PRO A1309 −4.895 −17.737 −7.136 20.38 N ATOM 2085 CD PRO A1309 −4.914 −16.66 −8.151 20.39 C ATOM 2086 CA PRO A1309 −3.952 −18.758 −7.524 18.95 C ATOM 2087 CB PRO A1309 −3.177 −18.102 −8.703 18.71 C ATOM 2088 CG PRO A1309 −3.54 −16.76 −8.732 21.17 C ATOM 2089 C PRO A1309 −2.999 −19.167 −6.393 17.95 C ATOM 2090 O PRO A1309 −2.449 −18.309 −5.682 16.25 O ATOM 2091 N ASP A1310 −2.831 −20.485 −6.258 17.69 N ATOM 2092 CA ASP A1310 −1.936 −21.129 −5.289 18.08 C ATOM 2093 CB ASP A1310 −1.805 −22.64 −5.628 17.94 C ATOM 2094 CG ASP A1310 −3.062 −23.451 −5.251 26.79 C ATOM 2095 OD1 ASP A1310 −4.071 −22.782 −4.899 31.89 O ATOM 2096 OD2 ASP A1310 −3.076 −24.745 −5.262 29.15 O ATOM 2097 C ASP A1310 −0.53 −20.464 −5.191 17.75 C ATOM 2098 O ASP A1310 −0.043 −20.203 −4.067 18.85 O ATOM 2099 N PRO A1311 0.177 −20.268 −6.356 17.25 N ATOM 2100 CD PRO A1311 −0.102 −20.803 −7.725 16.88 C ATOM 2101 CA PRO A1311 1.465 −19.559 −6.343 15.19 C ATOM 2102 CB PRO A1311 1.82 −19.434 −7.84 13.7 C ATOM 2103 CG PRO A1311 1.293 −20.726 −8.404 14.93 C ATOM 2104 C PRO A1311 1.351 −18.218 −5.741 15.13 C ATOM 2105 O PRO A1311 2.274 −17.853 −5.016 15.93 O ATOM 2106 N LEU A1312 0.248 −17.498 −5.99 13.68 N ATOM 2107 CA LEU A1312 0.124 −16.184 −5.399 14.9 C ATOM 2108 CB LEU A1312 −1.102 −15.427 −5.875 15.12 C ATOM 2109 CG LEU A1312 −1.007 −13.901 −6.065 16.16 C ATOM 2110 CD1 LEU A1312 −2.415 −13.27 −6.038 17.09 C ATOM 2111 CD2 LEU A1312 −0.203 −13.323 −5.007 22.34 C ATOM 2112 C LEU A1312 0.05 −16.301 −3.88 15.48 C ATOM 2113 O LEU A1312 0.695 −15.523 −3.154 14.57 O ATOM 2114 N TYR A1313 −0.724 −17.288 −3.406 15.42 N ATOM 2115 CA TYR A1313 −0.859 −17.479 −1.998 15.15 C ATOM 2116 CB TYR A1313 −1.893 −18.528 −1.643 15.52 C ATOM 2117 CG TYR A1313 −2.23 −18.548 −0.145 16.45 C ATOM 2118 CD1 TYR A1313 −2.56 −17.358 0.54 15.64 C ATOM 2119 CE1 TYR A1313 −2.936 −17.372 1.926 16.19 C ATOM 2120 CD2 TYR A1313 −2.212 −19.754 0.591 15.35 C ATOM 2121 CE2 TYR A1313 −2.591 −19.791 1.956 15.48 C ATOM 2122 CZ TYR A1313 −2.936 −18.585 2.613 17.43 C ATOM 2123 OH TYR A1313 −3.289 −18.608 3.927 14.53 O ATOM 2124 C TYR A1313 0.474 −17.838 −1.447 15.35 C ATOM 2125 O TYR A1313 0.814 −17.353 −0.375 14.4 O ATOM 2126 N GLU A1314 1.256 −18.633 −2.188 15.71 N ATOM 2127 CA GLU A1314 2.582 −18.991 −1.697 18.23 C ATOM 2128 CB GLU A1314 3.388 −19.844 −2.715 18.61 C ATOM 2129 CG GLU A1314 2.698 −21.155 −3.256 25.52 C ATOM 2130 CD GLU A1314 3.287 −21.719 −4.675 29.14 C ATOM 2131 OE1 GLU A1314 4.453 −21.269 −5.127 32.9 O ATOM 2132 OE2 GLU A1314 2.545 −22.601 −5.337 34.86 O ATOM 2133 C GLU A1314 3.328 −17.677 −1.454 15.23 C ATOM 2134 O GLU A1314 4.172 −17.576 −0.566 14.59 O ATOM 2135 N VAL A1315 3.088 −16.69 −2.301 13.92 N ATOM 2136 CA VAL A1315 3.813 −15.431 −2.161 13.5 C ATOM 2137 CB VAL A1315 3.785 −14.546 −3.475 14.69 C ATOM 2138 CG1 VAL A1315 4.069 −13.078 −3.177 14.19 C ATOM 2139 CG2 VAL A1315 4.77 −15.107 −4.591 12.06 C ATOM 2140 C VAL A1315 3.327 −14.682 −0.917 12.08 C ATOM 2141 O VAL A1315 4.137 −14.155 −0.228 10.73 O ATOM 2142 N MET A1316 2.033 −14.671 −0.63 11.53 N ATOM 2143 CA MET A1316 1.517 −13.987 0.538 13.7 C ATOM 2144 CB MET A1316 −0.01 −13.976 0.634 12.56 C ATOM 2145 CG MET A1316 −0.722 −13.524 −0.618 15.54 C ATOM 2146 SD MET A1316 −2.547 −13.416 −0.347 20.85 S ATOM 2147 CE MET A1316 −3.235 −14.193 −1.73 19.52 C ATOM 2148 C MET A1316 2.079 −14.643 1.748 13.01 C ATOM 2149 O MET A1316 2.561 −13.971 2.65 15.31 O ATOM 2150 N LEU A1317 2.056 −15.963 1.801 12.31 N ATOM 2151 CA LEU A1317 2.673 −16.625 2.935 11.49 C ATOM 2152 CB LEU A1317 2.497 −18.127 2.873 9.86 C ATOM 2153 CG LEU A1317 1.111 −18.695 2.882 7.48 C ATOM 2154 CD1 LEU A1317 1.176 −20.143 2.433 7.53 C ATOM 2155 CD2 LEU A1317 0.443 −18.515 4.217 3.61 C ATOM 2156 C LEU A1317 4.115 −16.342 3.052 11.01 C ATOM 2157 O LEU A1317 4.637 −16.294 4.137 14.42 O ATOM 2158 N LYS A1318 4.837 −16.313 1.961 12.75 N ATOM 2159 CA LYS A1318 6.254 −15.938 2.056 15.07 C ATOM 2160 CB LYS A1318 6.876 −15.918 0.675 15.17 C ATOM 2161 CG LYS A1318 7.096 −17.29 0.083 24.05 C ATOM 2162 CD LYS A1318 8.157 −18.097 0.911 34.28 C ATOM 2163 CE LYS A1318 9.463 −17.244 1.089 35.3 C ATOM 2164 NZ LYS A1318 10.632 −18.122 0.888 37.08 N ATOM 2165 C LYS A1318 6.414 −14.497 2.746 14.84 C ATOM 2166 O LYS A1318 7.365 −14.269 3.513 15.47 O ATOM 2167 N CYS A1319 5.472 −13.595 2.467 12.45 N ATOM 2168 CA CYS A1319 5.395 −12.258 3.016 13.65 C ATOM 2169 CB CYS A1319 4.184 −11.562 2.396 13.17 C ATOM 2170 SG CYS A1319 4.626 −11.089 0.668 17.23 S ATOM 2171 C CYS A1319 5.242 −12.206 4.498 11.7 C ATOM 2172 O CYS A1319 5.657 −11.255 5.129 11.48 O ATOM 2173 N TRP A1320 4.674 −13.272 5.038 11.74 N ATOM 2174 CA TRP A1320 4.364 −13.378 6.418 11.21 C ATOM 2175 CB TRP A1320 2.956 −13.816 6.577 10.12 C ATOM 2176 CG TRP A1320 1.981 −12.93 5.933 8.99 C ATOM 2177 CD2 TRP A1320 0.794 −13.355 5.289 8.09 C ATOM 2178 CE2 TRP A1320 0.173 −12.196 4.77 6.13 C ATOM 2179 CE3 TRP A1320 0.152 −14.624 5.15 10.88 C ATOM 2180 CD1 TRP A1320 2.052 −11.549 5.778 7.31 C ATOM 2181 NE1 TRP A1320 0.971 −11.113 5.077 5.04 N ATOM 2182 CZ2 TRP A1320 −1.05 −12.246 4.139 5.59 C ATOM 2183 CZ3 TRP A1320 −1.066 −14.693 4.483 7.31 C ATOM 2184 CH2 TRP A1320 −1.641 −13.517 3.956 8.66 C ATOM 2185 C TRP A1320 5.244 −14.353 7.147 13.67 C ATOM 2186 O TRP A1320 4.827 −14.909 8.143 14.64 O ATOM 2187 N HIS A1321 6.471 −14.547 6.666 15.52 N ATOM 2188 CA HIS A1321 7.441 −15.283 7.387 15.52 C ATOM 2189 CB HIS A1321 8.71 −15.494 6.566 15.45 C ATOM 2190 CG HIS A1321 9.52 −16.676 7.019 19.13 C ATOM 2191 CD2 HIS A1321 9.627 −17.924 6.509 18.26 C ATOM 2192 ND1 HIS A1321 10.327 −16.649 8.147 17.94 N ATOM 2193 CE1 HIS A1321 10.873 −17.836 8.318 19.05 C ATOM 2194 NE2 HIS A1321 10.487 −18.617 7.323 21 N ATOM 2195 C HIS A1321 7.723 −14.594 8.724 16.55 C ATOM 2196 O HIS A1321 7.91 −13.367 8.798 14.69 O ATOM 2197 N PRO A1322 7.719 −15.401 9.805 18.27 N ATOM 2198 CD PRO A1322 7.45 −16.846 9.725 17.64 C ATOM 2199 CA PRO A1322 8.004 −14.959 11.159 20.5 C ATOM 2200 CB PRO A1322 8.069 −16.273 11.949 20.57 C ATOM 2201 CG PRO A1322 7.257 −17.255 11.109 20.2 C ATOM 2202 C PRO A1322 9.373 −14.272 11.183 22.28 C ATOM 2203 O PRO A1322 9.553 −13.274 11.887 24.17 O ATOM 2204 N LYS A1323 10.32 −14.818 10.441 23.53 N ATOM 2205 CA LYS A1323 11.644 −14.265 10.317 26.14 C ATOM 2206 CB LYS A1323 12.676 −15.384 10.057 26.85 C ATOM 2207 CG LYS A1323 13.098 −16.183 11.289 32.8 C ATOM 2208 CD LYS A1323 14.653 −16.203 11.372 40.5 C ATOM 2209 CE LYS A1323 15.207 −14.739 11.543 40.83 C ATOM 2210 NZ LYS A1323 16.672 −14.663 11.818 38.1 N ATOM 2211 C LYS A1323 11.736 −13.231 9.224 26.02 C ATOM 2212 O LYS A1323 11.931 −13.568 8.042 27.17 O ATOM 2213 N ALA A1324 11.669 −11.973 9.63 27.03 N ATOM 2214 CA ALA A1324 11.753 −10.83 8.711 27.52 C ATOM 2215 CB ALA A1324 12.013 −9.546 9.448 27.19 C ATOM 2216 C ALA A1324 12.743 −10.992 7.585 28.21 C ATOM 2217 O ALA A1324 12.55 −10.353 6.541 29.23 O ATOM 2218 N GLU A1325 13.758 −11.855 7.76 28.16 N ATOM 2219 CA GLU A1325 14.848 −11.996 6.775 28.45 C ATOM 2220 CB GLU A1325 16.188 −12.172 7.469 30.57 C ATOM 2221 CG GLU A1325 16.132 −13.059 8.745 36.13 C ATOM 2222 CD GLU A1325 17.211 −14.16 8.711 44.36 C ATOM 2223 OE1 GLU A1325 16.858 −15.364 8.463 44.39 O ATOM 2224 OE2 GLU A1325 18.411 −13.803 8.91 45.7 O ATOM 2225 C GLU A1325 14.615 −13.104 5.73 26.67 C ATOM 2226 O GLU A1325 15.22 −13.121 4.643 24.01 O ATOM 2227 N MET A1326 13.683 −13.99 6.047 25.01 N ATOM 2228 CA MET A1326 13.262 −14.975 5.077 24.44 C ATOM 2229 CB MET A1326 12.799 −16.21 5.822 25.54 C ATOM 2230 CG MET A1326 13.81 −16.689 6.838 30.66 C ATOM 2231 SD MET A1326 15.391 −17.066 6.07 39.12 S ATOM 2232 CE MET A1326 15.057 −18.795 5.656 38.1 C ATOM 2233 C MET A1326 12.146 −14.455 4.17 22.62 C ATOM 2234 O MET A1326 11.629 −15.161 3.301 22.3 O ATOM 2235 N ARG A1327 11.718 −13.218 4.398 20.92 N ATOM 2236 CA ARG A1327 10.72 −12.616 3.544 17.8 C ATOM 2237 CB ARG A1327 10.117 −11.425 4.234 16.42 C ATOM 2238 CG ARG A1327 9.313 −11.875 5.335 17.54 C ATOM 2239 CD ARG A1327 8.503 −10.757 5.939 16.7 C ATOM 2240 NE ARG A1327 8.293 −11.1 7.326 18.93 N ATOM 2241 CZ ARG A1327 8.294 −10.232 8.337 12.34 C ATOM 2242 NH1 ARG A1327 8.497 −8.965 8.137 8.64 N ATOM 2243 NH2 ARG A1327 8.151 −10.678 9.537 12.79 N ATOM 2244 C ARG A1327 11.36 −12.196 2.213 15.89 C ATOM 2245 O ARG A1327 12.484 −11.73 2.175 14.94 O ATOM 2246 N PRO A1328 10.609 −12.309 1.126 14.58 N ATOM 2247 CD PRO A1328 9.266 −12.869 1.009 12.52 C ATOM 2248 CA PRO A1328 11.167 −11.836 −0.146 13.78 C ATOM 2249 CB PRO A1328 10.127 −12.248 −1.161 12.76 C ATOM 2250 CG PRO A1328 8.86 −12.432 −0.349 15.33 C ATOM 2251 C PRO A1328 11.328 −10.322 −0.181 14.39 C ATOM 2252 O PRO A1328 10.566 −9.595 0.486 14.86 O ATOM 2253 N SER A1329 12.302 −9.858 −0.972 14.35 N ATOM 2254 CA SER A1329 12.494 −8.429 −1.282 14.19 C ATOM 2255 CB SER A1329 13.904 −8.201 −1.891 13.44 C ATOM 2256 OG SER A1329 13.89 −8.853 −3.18 15.17 O ATOM 2257 C SER A1329 11.481 −8.011 −2.31 11.85 C ATOM 2258 O SER A1329 11 −8.862 −3.097 14.08 O ATOM 2259 N PHE A1330 11.222 −6.713 −2.389 10.58 N ATOM 2260 CA PHE A1330 10.322 −6.24 −3.391 12.2 C ATOM 2261 CB PHE A1330 9.996 −4.758 −3.212 11.92 C ATOM 2262 CG PHE A1330 9.043 −4.493 −2.073 10.86 C ATOM 2263 CD1 PHE A1330 7.729 −4.902 −2.161 6 C ATOM 2264 CD2 PHE A1330 9.494 −3.884 −0.896 6.99 C ATOM 2265 CE1 PHE A1330 6.91 −4.709 −1.126 6.91 C ATOM 2266 CE2 PHE A1330 8.643 −3.633 0.136 9.1 C ATOM 2267 CZ PHE A1330 7.349 −4.088 0.049 8.01 C ATOM 2268 C PHE A1330 10.798 −6.542 −4.805 13.02 C ATOM 2269 O PHE A1330 10 −6.6 −5.692 14.88 O ATOM 2270 N SER A1331 12.086 −6.71 −5.022 14.67 N ATOM 2271 CA SER A1331 12.609 −7.117 −6.325 16.24 C ATOM 2272 CB SER A1331 14.109 −7.298 −6.207 17.17 C ATOM 2273 OG SER A1331 14.734 −6.176 −6.688 18.61 O ATOM 2274 C SER A1331 12.083 −8.473 −6.71 17.27 C ATOM 2275 O SER A1331 11.591 −8.652 −7.857 18.02 O ATOM 2276 N GLU A1332 12.201 −9.432 −5.777 17.22 N ATOM 2277 CA GLU A1332 11.72 −10.756 −6.074 18.79 C ATOM 2278 CB GLU A1332 12.302 −11.826 −5.205 19.77 C ATOM 2279 CG GLU A1332 11.983 −13.29 −5.763 28.13 C ATOM 2280 CD GLU A1332 12.543 −13.635 −7.25 32 C ATOM 2281 OE1 GLU A1332 12.099 −14.666 −7.872 28.88 O ATOM 2282 OE2 GLU A1332 13.401 −12.879 −7.778 32.58 O ATOM 2283 C GLU A1332 10.214 −10.791 −6.033 18.26 C ATOM 2284 O GLU A1332 9.584 −11.529 −6.828 18.92 O ATOM 2285 N LEU A1333 9.602 −9.984 −5.174 16.87 N ATOM 2286 CA LEU A1333 8.122 −9.956 −5.252 16.38 C ATOM 2287 CB LEU A1333 7.522 −9.018 −4.227 16.3 C ATOM 2288 CG LEU A1333 6.986 −9.505 −2.882 16.8 C ATOM 2289 CD1 LEU A1333 6.727 −11.004 −2.852 14.42 C ATOM 2290 CD2 LEU A1333 7.787 −9.07 −1.725 11.65 C ATOM 2291 C LEU A1333 7.685 −9.55 −6.66 16 C ATOM 2292 O LEU A1333 6.84 −10.217 −7.241 14.65 O ATOM 2293 N VAL A1334 8.31 −8.508 −7.243 15.24 N ATOM 2294 CA VAL A1334 7.993 −8.138 −8.648 14.36 C ATOM 2295 CB VAL A1334 8.677 −6.82 −9.026 14.96 C ATOM 2296 CG1 VAL A1334 8.585 −6.5 −10.556 10.22 C ATOM 2297 CG2 VAL A1334 8.057 −5.675 −8.214 14.56 C ATOM 2298 C VAL A1334 8.255 −9.218 −9.724 13.55 C ATOM 2299 O VAL A1334 7.422 −9.446 −10.626 12.74 O ATOM 2300 N SER A1335 9.399 −9.865 −9.634 13.77 N ATOM 2301 CA SER A1335 9.72 −10.93 −10.566 14.73 C ATOM 2302 CB SER A1335 11.063 −11.566 −10.217 14.19 C ATOM 2303 OG SER A1335 12.091 −10.61 −10.426 16.15 O ATOM 2304 C SER A1335 8.633 −11.994 −10.579 15.13 C ATOM 2305 O SER A1335 8.096 −12.389 −11.628 14.15 O ATOM 2306 N ARG A1336 8.282 −12.397 −9.376 15.11 N ATOM 2307 CA ARG A1336 7.33 −13.462 −9.19 16.04 C ATOM 2308 CB ARG A1336 7.326 −13.919 −7.745 15 C ATOM 2309 CG ARG A1336 8.714 −14.435 −7.37 18.51 C ATOM 2310 CD ARG A1336 8.656 −14.946 −5.887 31.61 C ATOM 2311 NE ARG A1336 8.945 −16.391 −5.826 37.59 N ATOM 2312 CZ ARG A1336 8.352 −17.326 −5.074 35.7 C ATOM 2313 NH1 ARG A1336 7.332 −17.055 −4.267 33.74 N ATOM 2314 NH2 ARG A1336 8.82 −18.576 −5.162 35.74 N ATOM 2315 C ARG A1336 5.961 −13.09 −9.649 14.98 C ATOM 2316 O ARG A1336 5.399 −13.775 −10.522 16.44 O ATOM 2317 N ILE A1337 5.422 −12.005 −9.104 14.66 N ATOM 2318 CA ILE A1337 4.113 −11.611 −9.481 16.19 C ATOM 2319 CB ILE A1337 3.342 −10.739 −8.46 16.11 C ATOM 2320 CG2 ILE A1337 4.17 −9.721 −7.791 20.81 C ATOM 2321 CG1 ILE A1337 2.252 −9.97 −9.195 20.46 C ATOM 2322 CD1 ILE A1337 1.345 −9.167 −8.18 23.81 C ATOM 2323 C ILE A1337 4.012 −11.191 −10.902 12.25 C ATOM 2324 O ILE A1337 3.022 −11.435 −11.54 14.02 O ATOM 2325 N SER A1338 5.028 −10.58 −11.446 11.38 N ATOM 2326 CA SER A1338 5.013 −10.42 −12.924 10.49 C ATOM 2327 CB SER A1338 6.354 −9.854 −13.388 10.85 C ATOM 2328 OG SER A1338 6.152 −9.131 −14.566 10.54 O ATOM 2329 C SER A1338 4.757 −11.755 −13.658 10 C ATOM 2330 O SER A1338 4.007 −11.788 −14.661 10.17 O ATOM 2331 N ALA A1339 5.416 −12.836 −13.207 8.72 N ATOM 2332 CA ALA A1339 5.326 −14.152 −13.868 7.99 C ATOM 2333 CB ALA A1339 6.29 −15.077 −13.294 5.14 C ATOM 2334 C ALA A1339 3.925 −14.703 −13.758 9.66 C ATOM 2335 O ALA A1339 3.353 −15.213 −14.736 9.27 O ATOM 2336 N ILE A1340 3.359 −14.594 −12.542 11.06 N ATOM 2337 CA ILE A1340 1.997 −14.976 −12.258 10.27 C ATOM 2338 CB ILE A1340 1.733 −14.767 −10.76 10.82 C ATOM 2339 CG2 ILE A1340 0.282 −14.868 −10.418 8.31 C ATOM 2340 CG1 ILE A1340 2.558 −15.733 −9.91 10.31 C ATOM 2341 CD1 ILE A1340 2.557 −15.363 −8.468 8.49 C ATOM 2342 C ILE A1340 1.016 −14.125 −13.086 11.55 C ATOM 2343 O ILE A1340 0.04 −14.636 −13.667 12.6 O ATOM 2344 N PHE A1341 1.239 −12.82 −13.094 11.83 N ATOM 2345 CA PHE A1341 0.472 −11.93 −13.942 12.83 C ATOM 2346 CB PHE A1341 0.933 −10.462 −13.794 11.93 C ATOM 2347 CG PHE A1341 0.097 −9.488 −14.628 10.99 C ATOM 2348 CD1 PHE A1341 −1.227 −9.222 −14.264 7.52 C ATOM 2349 CD2 PHE A1341 0.627 −8.868 −15.775 8.04 C ATOM 2350 CE1 PHE A1341 −2.058 −8.307 −15.048 11.01 C ATOM 2351 CE2 PHE A1341 −0.177 −7.999 −16.562 11.88 C ATOM 2352 CZ PHE A1341 −1.556 −7.711 −16.174 9.93 C ATOM 2353 C PHE A1341 0.463 −12.325 −15.397 12.79 C ATOM 2354 O PHE A1341 −0.587 −12.401 −15.997 14.47 O ATOM 2355 N SER A1342 1.638 −12.488 −15.974 15.32 N ATOM 2356 CA SER A1342 1.824 −12.793 −17.415 17.78 C ATOM 2357 CB SER A1342 3.315 −12.827 −17.797 16.79 C ATOM 2358 OG SER A1342 3.831 −11.526 −17.777 21.88 O ATOM 2359 C SER A1342 1.264 −14.123 −17.826 18.08 C ATOM 2360 O SER A1342 0.703 −14.274 −18.9 17.24 O ATOM 2361 N THR A1343 1.455 −15.104 −16.971 19.94 N ATOM 2362 CA THR A1343 1.061 −16.422 −17.358 22.37 C ATOM 2363 CB THR A1343 2.005 −17.478 −16.806 21.44 C ATOM 2364 OG1 THR A1343 2.055 −17.379 −15.369 21.47 O ATOM 2365 CG2 THR A1343 3.42 −17.315 −17.408 20.58 C ATOM 2366 C THR A1343 −0.371 −16.659 −16.921 25.51 C ATOM 2367 O THR A1343 −0.857 −17.769 −17.004 26.88 O ATOM 2368 N PHE A1344 −1.054 −15.641 −16.409 28.5 N ATOM 2369 CA PHE A1344 −2.33 −15.953 −15.798 30.95 C ATOM 2370 CB PHE A1344 −2.881 −14.847 −14.904 30.06 C ATOM 2371 CG PHE A1344 −4.151 −15.235 −14.222 27 C ATOM 2372 CD1 PHE A1344 −4.119 −16.097 −13.114 24.24 C ATOM 2373 CD2 PHE A1344 −5.368 −14.795 −14.711 23.57 C ATOM 2374 CE1 PHE A1344 −5.268 −16.519 −12.49 25.54 C ATOM 2375 CE2 PHE A1344 −6.539 −15.163 −14.084 27.12 C ATOM 2376 CZ PHE A1344 −6.52 −16.033 −12.955 27.52 C ATOM 2377 C PHE A1344 −3.35 −16.303 −16.855 33.54 C ATOM 2378 O PHE A1344 −3.642 −15.49 −17.717 34.12 O ATOM 2379 N ILE A1345 −3.911 −17.508 −16.715 37.1 N ATOM 2380 CA ILE A1345 −4.975 −18.047 −17.583 40.92 C ATOM 2381 CB ILE A1345 −6.372 −17.424 −17.281 40.56 C ATOM 2382 CG2 ILE A1345 −7.344 −17.479 −18.492 43.36 C ATOM 2383 CG1 ILE A1345 −6.946 −18.152 −16.051 43.45 C ATOM 2384 CD1 ILE A1345 −6.095 −19.438 −15.574 42.93 C ATOM 2385 C ILE A1345 −4.582 −18.074 −19.053 42.84 C ATOM 2386 O ILE A1345 −4.93 −17.184 −19.846 43.44 O ATOM 2387 N GLY A1346 −3.853 −19.135 −19.387 44.61 N ATOM 2388 CA GLY A1346 −3.191 −19.289 −20.675 47.27 C ATOM 2389 C GLY A1346 −1.718 −19.513 −20.354 49.35 C ATOM 2390 O GLY A1346 −0.836 −18.874 −20.993 50.37 O ATOM 2391 OXT GLY A1346 −1.376 −20.327 −19.436 49.81 O ATOM 2392 CB LEU B1046 −19.47 −2.928 −35.925 40.32 C ATOM 2393 CG LEU B1046 −19.758 −3.718 −34.616 42.01 C ATOM 2394 CD1 LEU B1046 −20.832 −2.953 −33.779 43.06 C ATOM 2395 CD2 LEU B1046 −20.105 −5.302 −34.77 43.57 C ATOM 2396 C LEU B1046 −21.81 −3.071 −37.017 38.8 C ATOM 2397 O LEU B1046 −22.337 −1.936 −36.888 38.58 O ATOM 2398 N LEU B1046 −19.683 −2.665 −38.453 39.51 N ATOM 2399 CA LEU B1046 −20.269 −3.271 −37.199 39.72 C ATOM 2400 N LEU B1047 −22.5 −4.219 −37.024 36.75 N ATOM 2401 CA LEU B1047 −23.938 −4.27 −37.208 35 C ATOM 2402 CB LEU B1047 −24.394 −5.715 −37.47 35.39 C ATOM 2403 CG LEU B1047 −23.713 −6.205 −38.741 35.87 C ATOM 2404 CD1 LEU B1047 −23.788 −7.735 −38.824 37.42 C ATOM 2405 CD2 LEU B1047 −24.313 −5.475 −39.975 37.06 C ATOM 2406 C LEU B1047 −24.768 −3.645 −36.094 34.09 C ATOM 2407 O LEU B1047 −25.941 −3.357 −36.318 34.1 O ATOM 2408 N GLN B1048 −24.173 −3.443 −34.92 32.01 N ATOM 2409 CA GLN B1048 −24.918 −2.908 −33.804 31.29 C ATOM 2410 CB GLN B1048 −24.251 −3.227 −32.485 32.27 C ATOM 2411 CG GLN B1048 −25.255 −3.176 −31.342 33.61 C ATOM 2412 CD GLN B1048 −26.259 −4.273 −31.386 32.27 C ATOM 2413 OE1 GLN B1048 −27.227 −4.221 −30.635 33.78 O ATOM 2414 NE2 GLN B1048 −26.062 −5.279 −32.267 31.81 N ATOM 2415 C GLN B1048 −25.025 −1.417 −33.875 29.15 C ATOM 2416 O GLN B1048 −25.992 −0.848 −33.361 27.54 O ATOM 2417 N ASN B1049 −24.017 −0.83 −34.532 26.05 N ATOM 2418 CA ASN B1049 −23.931 0.576 −34.716 23.59 C ATOM 2419 CB ASN B1049 −22.482 1.001 −34.97 24.38 C ATOM 2420 CG ASN B1049 −21.622 0.973 −33.648 24.85 C ATOM 2421 OD1 ASN B1049 −22.107 1.324 −32.587 26.09 O ATOM 2422 ND2 ASN B1049 −20.402 0.522 −33.731 21.98 N ATOM 2423 C ASN B1049 −24.868 1.003 −35.796 22.45 C ATOM 2424 O ASN B1049 −24.841 2.144 −36.211 23.31 O ATOM 2425 N THR B1050 −25.734 0.094 −36.206 20.21 N ATOM 2426 CA THR B1050 −26.721 0.383 −37.195 20.27 C ATOM 2427 CB THR B1050 −26.531 −0.463 −38.515 21.41 C ATOM 2428 OG1 THR B1050 −26.525 −1.886 −38.239 19.46 O ATOM 2429 CG2 THR B1050 −25.199 −0.064 −39.193 19.7 C ATOM 2430 C THR B1050 −28.101 0.169 −36.592 20.15 C ATOM 2431 O THR B1050 −29.095 0.325 −37.282 21.67 O ATOM 2432 N VAL B1051 −28.179 −0.187 −35.313 18.2 N ATOM 2433 CA VAL B1051 −29.469 −0.378 −34.68 16.02 C ATOM 2434 CB VAL B1051 −29.476 −1.635 −33.802 15.07 C ATOM 2435 CG1 VAL B1051 −30.907 −1.929 −33.219 13 C ATOM 2436 CG2 VAL B1051 −28.978 −2.812 −34.622 14.4 C ATOM 2437 C VAL B1051 −29.942 0.86 −33.933 15.78 C ATOM 2438 O VAL B1051 −29.384 1.279 −32.964 16.31 O ATOM 2439 N HIS B1052 −31.027 1.411 −34.394 16.59 N ATOM 2440 CA HIS B1052 −31.618 2.529 −33.778 18.42 C ATOM 2441 CB HIS B1052 −31.387 3.822 −34.557 18.24 C ATOM 2442 CG HIS B1052 −32.216 4.963 −34.042 19.56 C ATOM 2443 CD2 HIS B1052 −33.382 5.5 −34.497 21.3 C ATOM 2444 ND1 HIS B1052 −31.871 5.688 −32.909 18.28 N ATOM 2445 CE1 HIS B1052 −32.789 6.613 −32.687 21.03 C ATOM 2446 NE2 HIS B1052 −33.717 6.522 −33.639 22.99 N ATOM 2447 C HIS B1052 −33.121 2.309 −33.659 19.7 C ATOM 2448 O HIS B1052 −33.795 2.169 −34.623 17.97 O ATOM 2449 N ILE B1053 −33.613 2.326 −32.421 22.55 N ATOM 2450 CA ILE B1053 −35.034 2.208 −32.114 23.12 C ATOM 2451 CB ILE B1053 −35.285 0.984 −31.134 23.12 C ATOM 2452 CG2 ILE B1053 −36.733 0.925 −30.644 24.87 C ATOM 2453 CG1 ILE B1053 −35.093 −0.36 −31.88 25.79 C ATOM 2454 CD1 ILE B1053 −33.685 −0.82 −31.891 25.97 C ATOM 2455 C ILE B1053 −35.501 3.595 −31.605 22.88 C ATOM 2456 O ILE B1053 −34.884 4.229 −30.723 21.71 O ATOM 2457 N ASP B1054 −36.547 4.089 −32.257 23.62 N ATOM 2458 CA ASP B1054 −37.259 5.279 −31.796 22.76 C ATOM 2459 CB ASP B1054 −37.853 6.041 −32.94 21.73 C ATOM 2460 CG ASP B1054 −38.49 7.376 −32.487 25.42 C ATOM 2461 OD1 ASP B1054 −38.42 7.74 −31.259 22.46 O ATOM 2462 OD2 ASP B1054 −39.062 8.047 −33.389 24.97 O ATOM 2463 C ASP B1054 −38.321 4.895 −30.767 22.65 C ATOM 2464 O ASP B1054 −39.403 4.347 −31.071 21.94 O ATOM 2465 N LEU B1055 −37.966 5.172 −29.529 22.61 N ATOM 2466 CA LEU B1055 −38.7 4.625 −28.442 22.29 C ATOM 2467 CB LEU B1055 −37.762 4.498 −27.224 22.09 C ATOM 2468 CG LEU B1055 −36.525 3.601 −27.266 18 C ATOM 2469 CD1 LEU B1055 −35.705 4.088 −26.122 12.81 C ATOM 2470 CD2 LEU B1055 −36.869 2.13 −27.07 13.43 C ATOM 2471 C LEU B1055 −39.982 5.424 −28.134 22.75 C ATOM 2472 O LEU B1055 −40.843 4.978 −27.358 23.67 O ATOM 2473 N SER B1056 −40.102 6.61 −28.713 22.3 N ATOM 2474 CA SER B1056 −41.315 7.386 −28.546 22.63 C ATOM 2475 CB SER B1056 −41.038 8.903 −28.703 22.8 C ATOM 2476 OG SER B1056 −41.157 9.337 −30.088 27.69 O ATOM 2477 C SER B1056 −42.349 6.877 −29.561 21.86 C ATOM 2478 O SER B1056 −43.533 7.151 −29.427 21.84 O ATOM 2479 N ALA B1057 −41.879 6.157 −30.584 20.99 N ATOM 2480 CA ALA B1057 −42.734 5.647 −31.616 20.22 C ATOM 2481 CB ALA B1057 −41.99 5.632 −32.978 18.95 C ATOM 2482 C ALA B1057 −43.307 4.264 −31.229 21.18 C ATOM 2483 O ALA B1057 −44.219 3.778 −31.926 20.6 O ATOM 2484 N ILE B1058 −42.83 3.636 −30.124 21.64 N ATOM 2485 CA ILE B1058 −43.436 2.342 −29.748 24.04 C ATOM 2486 CB ILE B1058 −42.458 1.292 −28.981 25.07 C ATOM 2487 CG2 ILE B1058 −42.049 0.035 −29.832 24.86 C ATOM 2488 CG1 ILE B1058 −41.062 1.827 −28.705 27.45 C ATOM 2489 CD1 ILE B1058 −40.264 0.856 −27.838 24.61 C ATOM 2490 C ILE B1058 −44.831 2.573 −29.065 24.88 C ATOM 2491 O ILE B1058 −45.074 3.592 −28.422 23.85 O ATOM 2492 N ASP B1059 −45.751 1.635 −29.243 25.65 N ATOM 2493 CA ASP B1059 −47.12 1.761 −28.726 27.02 C ATOM 2494 CB ASP B1059 −47.874 0.466 −29.066 27.56 C ATOM 2495 CG ASP B1059 −49.325 0.485 −28.635 30.75 C ATOM 2496 OD1 ASP B1059 −49.705 1.293 −27.785 40.3 O ATOM 2497 OD2 ASP B1059 −50.123 −0.314 −29.14 31.86 O ATOM 2498 C ASP B1059 −47.181 2.078 −27.208 26.95 C ATOM 2499 O ASP B1059 −46.646 1.356 −26.4 26.36 O ATOM 2500 N PRO B1060 −47.829 3.179 −26.83 27.49 N ATOM 2501 CD PRO B1060 −48.573 4.133 −27.673 27.27 C ATOM 2502 CA PRO B1060 −47.769 3.579 −25.41 28.26 C ATOM 2503 CB PRO B1060 −48.521 4.909 −25.366 27.9 C ATOM 2504 CG PRO B1060 −48.629 5.373 −26.822 28.06 C ATOM 2505 C PRO B1060 −48.32 2.587 −24.385 29.45 C ATOM 2506 O PRO B1060 −47.748 2.415 −23.307 30.22 O ATOM 2507 N GLU B1061 −49.408 1.942 −24.706 30.74 N ATOM 2508 CA GLU B1061 −49.959 0.958 −23.839 33.13 C ATOM 2509 CB GLU B1061 −51.478 0.826 −24.17 34.78 C ATOM 2510 CG GLU B1061 −51.864 −0.178 −25.282 40.8 C ATOM 2511 CD GLU B1061 −52.775 0.432 −26.428 49.08 C ATOM 2512 OE1 GLU B1061 −52.827 1.704 −26.613 48.2 O ATOM 2513 OE2 GLU B1061 −53.38 −0.394 −27.2 48.8 O ATOM 2514 C GLU B1061 −49.165 −0.372 −23.908 33.24 C ATOM 2515 O GLU B1061 −49.181 −1.18 −22.979 34.27 O ATOM 2516 N LEU B1062 −48.453 −0.62 −25.007 32.69 N ATOM 2517 CA LEU B1062 −47.536 −1.766 −25.044 30.44 C ATOM 2518 CB LEU B1062 −47.052 −2.023 −26.48 29.15 C ATOM 2519 CG LEU B1062 −45.923 −2.999 −26.687 27.13 C ATOM 2520 CD1 LEU B1062 −46.297 −4.408 −26.216 31.15 C ATOM 2521 CD2 LEU B1062 −45.616 −3.05 −28.073 27.14 C ATOM 2522 C LEU B1062 −46.37 −1.497 −24.1 30 C ATOM 2523 O LEU B1062 −45.786 −2.41 −23.486 30.93 O ATOM 2524 N VAL B1063 −46.038 −0.227 −23.992 29.06 N ATOM 2525 CA VAL B1063 −44.925 0.206 −23.206 29 C ATOM 2526 CB VAL B1063 −44.365 1.581 −23.717 29.34 C ATOM 2527 CG1 VAL B1063 −43.551 2.311 −22.617 29.44 C ATOM 2528 CG2 VAL B1063 −43.511 1.386 −24.988 28.58 C ATOM 2529 C VAL B1063 −45.321 0.238 −21.745 29.41 C ATOM 2530 O VAL B1063 −44.469 0.028 −20.86 30.22 O ATOM 2531 N GLN B1064 −46.6 0.454 −21.467 29.08 N ATOM 2532 CA GLN B1064 −47.005 0.512 −20.079 30.44 C ATOM 2533 CB GLN B1064 −48.222 1.421 −19.809 30.98 C ATOM 2534 CG GLN B1064 −49.62 0.775 −19.89 33.87 C ATOM 2535 CD GLN B1064 −50.761 1.864 −19.961 35.5 C ATOM 2536 OE1 GLN B1064 −50.849 2.665 −20.92 36.93 O ATOM 2537 NE2 GLN B1064 −51.619 1.884 −18.929 38.37 N ATOM 2538 C GLN B1064 −47.189 −0.853 −19.531 28.49 C ATOM 2539 O GLN B1064 −46.973 −1.035 −18.366 29.12 O ATOM 2540 N ALA B1065 −47.533 −1.823 −20.37 27.57 N ATOM 2541 CA ALA B1065 −47.577 −3.233 −19.945 26.74 C ATOM 2542 CB ALA B1065 −48.221 −4.172 −21.041 25.84 C ATOM 2543 C ALA B1065 −46.183 −3.745 −19.532 25.79 C ATOM 2544 O ALA B1065 −46.007 −4.275 −18.419 27.1 O ATOM 2545 N VAL B1066 −45.179 −3.577 −20.408 24.07 N ATOM 2546 CA VAL B1066 −43.793 −3.985 −20.037 20.35 C ATOM 2547 CB VAL B1066 −42.881 −4.179 −21.255 19.59 C ATOM 2548 CG1 VAL B1066 −43.498 −5.217 −22.2 21.58 C ATOM 2549 CG2 VAL B1066 −42.557 −2.906 −21.898 16.39 C ATOM 2550 C VAL B1066 −43.041 −3.122 −19.037 18.35 C ATOM 2551 O VAL B1066 −42.011 −3.581 −18.522 15.66 O ATOM 2552 N GLN B1067 −43.518 −1.892 −18.781 17.6 N ATOM 2553 CA GLN B1067 −42.692 −0.943 −18.001 18.58 C ATOM 2554 CB GLN B1067 −43.438 0.308 −17.614 19.35 C ATOM 2555 CG GLN B1067 −42.496 1.426 −17.248 21.19 C ATOM 2556 CD GLN B1067 −42.009 2.22 −18.529 28.66 C ATOM 2557 OE1 GLN B1067 −42.801 2.91 −19.19 34.61 O ATOM 2558 NE2 GLN B1067 −40.715 2.116 −18.857 29.45 N ATOM 2559 C GLN B1067 −42.037 −1.527 −16.752 18.71 C ATOM 2560 O GLN B1067 −40.856 −1.297 −16.503 18.11 O ATOM 2561 N HIS B1068 −42.803 −2.315 −15.979 18.98 N ATOM 2562 CA HIS B1068 −42.268 −2.956 −14.767 17.95 C ATOM 2563 CB HIS B1068 −43.383 −3.675 −13.987 17.82 C ATOM 2564 CG HIS B1068 −43.839 −4.954 −14.606 17.17 C ATOM 2565 CD2 HIS B1068 −43.713 −6.237 −14.176 14.13 C ATOM 2566 ND1 HIS B1068 −44.53 −5.009 −15.811 17.44 N ATOM 2567 CE1 HIS B1068 −44.793 −6.274 −16.089 13.01 C ATOM 2568 NE2 HIS B1068 −44.304 −7.033 −15.111 8.61 N ATOM 2569 C HIS B1068 −41.102 −3.933 −15.002 18.08 C ATOM 2570 O HIS B1068 −40.532 −4.395 −14.033 18.66 O ATOM 2571 N VAL B1069 −40.726 −4.255 −16.243 16.48 N ATOM 2572 CA VAL B1069 −39.549 −5.075 −16.433 16.15 C ATOM 2573 CB VAL B1069 −39.863 −6.453 −17.109 16.83 C ATOM 2574 CG1 VAL B1069 −41.014 −7.1 −16.412 19.33 C ATOM 2575 CG2 VAL B1069 −40.229 −6.338 −18.559 14.34 C ATOM 2576 C VAL B1069 −38.471 −4.345 −17.176 17.86 C ATOM 2577 O VAL B1069 −37.419 −4.952 −17.516 16.09 O ATOM 2578 N VAL B1070 −38.712 −3.044 −17.429 18.48 N ATOM 2579 CA VAL B1070 −37.723 −2.234 −18.045 20.54 C ATOM 2580 CB VAL B1070 −38.351 −1.049 −18.735 20.78 C ATOM 2581 CG1 VAL B1070 −37.268 0.109 −19.063 18.98 C ATOM 2582 CG2 VAL B1070 −39.005 −1.533 −19.984 18.5 C ATOM 2583 C VAL B1070 −36.728 −1.82 −16.945 24.51 C ATOM 2584 O VAL B1070 −37.163 −1.379 −15.872 24.82 O ATOM 2585 N ILE B1071 −35.412 −1.965 −17.193 26.55 N ATOM 2586 CA ILE B1071 −34.446 −1.77 −16.119 30.01 C ATOM 2587 CB ILE B1071 −33.245 −2.653 −16.216 30.69 C ATOM 2588 CG2 ILE B1071 −32.383 −2.125 −17.338 33.43 C ATOM 2589 CG1 ILE B1071 −32.445 −2.495 −14.932 33.59 C ATOM 2590 CD1 ILE B1071 −31.103 −3.292 −14.886 40.65 C ATOM 2591 C ILE B1071 −33.891 −0.359 −15.933 30.56 C ATOM 2592 O ILE B1071 −33.696 0.101 −14.761 34.27 O ATOM 2593 N GLY B1072 −33.597 0.356 −17.004 29.37 N ATOM 2594 CA GLY B1072 −33.137 1.712 −16.772 26.85 C ATOM 2595 C GLY B1072 −31.662 1.57 −16.679 26.99 C ATOM 2596 O GLY B1072 −31.176 0.816 −15.851 25.3 O ATOM 2597 N PRO B1073 −30.927 2.277 −17.567 27.71 N ATOM 2598 CD PRO B1073 −31.427 3.359 −18.434 27.61 C ATOM 2599 CA PRO B1073 −29.496 2.058 −17.766 27.02 C ATOM 2600 CB PRO B1073 −29.153 3.005 −18.892 27.25 C ATOM 2601 CG PRO B1073 −30.131 4.068 −18.823 28.49 C ATOM 2602 C PRO B1073 −28.623 2.277 −16.545 27.4 C ATOM 2603 O PRO B1073 −27.721 1.477 −16.282 29 O ATOM 2604 N SER B1074 −28.896 3.3 −15.759 26.53 N ATOM 2605 CA SER B1074 −28.106 3.497 −14.564 25.63 C ATOM 2606 CB SER B1074 −28.601 4.769 −13.836 27.59 C ATOM 2607 OG SER B1074 −29.856 4.546 −13.133 31.65 O ATOM 2608 C SER B1074 −28.251 2.296 −13.622 23.1 C ATOM 2609 O SER B1074 −27.384 2.065 −12.768 23.98 O ATOM 2610 N SER B1075 −29.357 1.574 −13.71 18.79 N ATOM 2611 CA SER B1075 −29.571 0.456 −12.794 18.39 C ATOM 2612 CB SER B1075 −31.059 0.086 −12.656 17.77 C ATOM 2613 OG SER B1075 −31.839 1.212 −12.351 19.47 O ATOM 2614 C SER B1075 −28.779 −0.81 −13.213 17.24 C ATOM 2615 O SER B1075 −28.733 −1.788 −12.462 16.14 O ATOM 2616 N LEU B1076 −28.205 −0.789 −14.42 16.22 N ATOM 2617 CA LEU B1076 −27.525 −1.956 −14.919 17.04 C ATOM 2618 CB LEU B1076 −28.278 −2.618 −16.083 15.02 C ATOM 2619 CG LEU B1076 −27.488 −3.894 −16.519 13.13 C ATOM 2620 CD1 LEU B1076 −27.606 −5.133 −15.543 7.07 C ATOM 2621 CD2 LEU B1076 −27.827 −4.35 −17.936 8.37 C ATOM 2622 C LEU B1076 −26.094 −1.653 −15.374 18 C ATOM 2623 O LEU B1076 −25.845 −0.71 −16.155 18.86 O ATOM 2624 N ILE B1077 −25.169 −2.464 −14.871 18.31 N ATOM 2625 CA ILE B1077 −23.807 −2.441 −15.319 18.16 C ATOM 2626 CB ILE B1077 −22.839 −2.115 −14.189 19.53 C ATOM 2627 CG2 ILE B1077 −22.56 −3.33 −13.34 22.33 C ATOM 2628 CG1 ILE B1077 −21.569 −1.492 −14.799 21.29 C ATOM 2629 CD1 ILE B1077 −21.712 0.173 −14.883 24.57 C ATOM 2630 C ILE B1077 −23.434 −3.727 −16.041 16.53 C ATOM 2631 O ILE B1077 −23.573 −4.818 −15.513 15.15 O ATOM 2632 N VAL B1078 −23.04 −3.586 −17.297 15.26 N ATOM 2633 CA VAL B1078 −22.6 −4.742 −18.049 15.42 C ATOM 2634 CB VAL B1078 −23.043 −4.673 −19.544 16.36 C ATOM 2635 CG1 VAL B1078 −22.471 −5.905 −20.285 14.87 C ATOM 2636 CG2 VAL B1078 −24.636 −4.51 −19.726 11.11 C ATOM 2637 C VAL B1078 −21.104 −4.807 −17.967 15.76 C ATOM 2638 O VAL B1078 −20.415 −3.899 −18.399 16.11 O ATOM 2639 N HIS B1079 −20.585 −5.882 −17.405 17.22 N ATOM 2640 CA HIS B1079 −19.151 −6.04 −17.273 17.57 C ATOM 2641 CB HIS B1079 −18.811 −6.974 −16.077 16.84 C ATOM 2642 CG HIS B1079 −19.364 −6.485 −14.776 17.03 C ATOM 2643 CD2 HIS B1079 −20.056 −7.12 −13.793 21.02 C ATOM 2644 ND1 HIS B1079 −19.275 −5.165 −14.389 16.77 N ATOM 2645 CE1 HIS B1079 −19.92 −5 −13.24 19.8 C ATOM 2646 NE2 HIS B1079 −20.386 −6.173 −12.847 20.06 N ATOM 2647 C HIS B1079 −18.635 −6.581 −18.64 18.29 C ATOM 2648 O HIS B1079 −18.643 −7.789 −18.891 19.18 O ATOM 2649 N PHE B1080 −18.201 −5.68 −19.514 18.22 N ATOM 2650 CA PHE B1080 −17.706 −6.073 −20.82 19.57 C ATOM 2651 CB PHE B1080 −17.608 −4.889 −21.759 19.74 C ATOM 2652 CG PHE B1080 −18.942 −4.432 −22.233 19.46 C ATOM 2653 CD1 PHE B1080 −19.751 −5.295 −22.93 23.85 C ATOM 2654 CD2 PHE B1080 −19.403 −3.179 −21.925 22.05 C ATOM 2655 CE1 PHE B1080 −21.015 −4.902 −23.356 26.81 C ATOM 2656 CE2 PHE B1080 −20.663 −2.732 −22.313 21.69 C ATOM 2657 CZ PHE B1080 −21.491 −3.592 −23.037 25.84 C ATOM 2658 C PHE B1080 −16.419 −6.756 −20.781 20.12 C ATOM 2659 O PHE B1080 −15.98 −7.259 −21.786 21.86 O ATOM 2660 N ASN B1081 −15.811 −6.815 −19.61 20.99 N ATOM 2661 CA ASN B1081 −14.49 −7.401 −19.465 21.84 C ATOM 2662 CB ASN B1081 −13.673 −6.529 −18.514 21.63 C ATOM 2663 CG ASN B1081 −14.274 −6.49 −17.069 20.2 C ATOM 2664 OD1 ASN B1081 −15.501 −6.616 −16.867 16.99 O ATOM 2665 ND2 ASN B1081 −13.405 −6.322 −16.085 15.89 N ATOM 2666 C ASN B1081 −14.606 −8.795 −18.867 23.39 C ATOM 2667 O ASN B1081 −13.604 −9.426 −18.54 24.79 O ATOM 2668 N GLU B1082 −15.829 −9.267 −18.702 24.64 N ATOM 2669 CA GLU B1082 −16.084 −10.518 −18.036 26.06 C ATOM 2670 CB GLU B1082 −16.522 −10.215 −16.577 29.29 C ATOM 2671 CG GLU B1082 −16.231 −11.268 −15.473 34.27 C ATOM 2672 CD GLU B1082 −14.907 −11.959 −15.704 44.49 C ATOM 2673 OE1 GLU B1082 −14.676 −13.031 −15.057 45.75 O ATOM 2674 OE2 GLU B1082 −14.119 −11.43 −16.551 46.68 O ATOM 2675 C GLU B1082 −17.217 −11.233 −18.766 24.39 C ATOM 2676 O GLU B1082 −18.366 −11.067 −18.417 23.91 O ATOM 2677 N VAL B1083 −16.87 −12.048 −19.745 22.94 N ATOM 2678 CA VAL B1083 −17.822 −12.922 −20.483 21.14 C ATOM 2679 CB VAL B1083 −17.234 −13.339 −21.91 20.22 C ATOM 2680 CG1 VAL B1083 −18.168 −14.113 −22.678 20.65 C ATOM 2681 CG2 VAL B1083 −16.972 −12.155 −22.701 20.7 C ATOM 2682 C VAL B1083 −18.119 −14.182 −19.678 19.57 C ATOM 2683 O VAL B1083 −17.216 −14.89 −19.278 20.67 O ATOM 2684 N ILE B1084 −19.388 −14.495 −19.475 18.67 N ATOM 2685 CA ILE B1084 −19.753 −15.742 −18.846 16.22 C ATOM 2686 CB ILE B1084 −21.28 −15.711 −18.512 17.63 C ATOM 2687 CG2 ILE B1084 −21.768 −17.038 −17.916 17.14 C ATOM 2688 CG1 ILE B1084 −21.664 −14.544 −17.596 17.65 C ATOM 2689 CD1 ILE B1084 −23.067 −14.626 −17.029 11.56 C ATOM 2690 C ILE B1084 −19.458 −16.902 −19.867 16.46 C ATOM 2691 O ILE B1084 −18.887 −17.914 −19.53 15.12 O ATOM 2692 N GLY B1085 −19.893 −16.739 −21.118 16.34 N ATOM 2693 CA GLY B1085 −19.514 −17.614 −22.216 16.79 C ATOM 2694 C GLY B1085 −19.858 −17.033 −23.558 18.48 C ATOM 2695 O GLY B1085 −20.736 −16.182 −23.688 17.84 O ATOM 2696 N ARG B1086 −19.122 −17.454 −24.572 21.62 N ATOM 2697 CA ARG B1086 −19.513 −17.188 −25.976 24.64 C ATOM 2698 CB ARG B1086 −18.458 −16.397 −26.721 24.78 C ATOM 2699 CG ARG B1086 −17.073 −16.877 −26.491 31.15 C ATOM 2700 CD ARG B1086 −16.223 −15.631 −26.219 35.05 C ATOM 2701 NE ARG B1086 −16.505 −14.628 −27.228 34.79 N ATOM 2702 CZ ARG B1086 −16.196 −13.337 −27.146 39.83 C ATOM 2703 NH1 ARG B1086 −15.603 −12.816 −26.057 37.31 N ATOM 2704 NH2 ARG B1086 −16.52 −12.555 −28.176 42.02 N ATOM 2705 C ARG B1086 −19.868 −18.464 −26.719 24.15 C ATOM 2706 O ARG B1086 −19.849 −19.536 −26.129 25.44 O ATOM 2707 N GLY B1087 −20.246 −18.354 −27.988 24.14 N ATOM 2708 CA GLY B1087 −20.613 −19.541 −28.764 22.48 C ATOM 2709 C GLY B1087 −21.557 −19.128 −29.866 22.96 C ATOM 2710 O GLY B1087 −21.668 −17.947 −30.179 22.52 O ATOM 2711 N HIS B1088 −22.276 −20.087 −30.435 22.87 N ATOM 2712 CA HIS B1088 −23.123 −19.797 −31.547 23.11 C ATOM 2713 CB HIS B1088 −23.739 −21.099 −32.06 23.86 C ATOM 2714 CG HIS B1088 −22.764 −22.012 −32.747 29.02 C ATOM 2715 CD2 HIS B1088 −21.826 −21.771 −33.703 33.46 C ATOM 2716 ND1 HIS B1088 −22.688 −23.375 −32.471 31.16 N ATOM 2717 CE1 HIS B1088 −21.741 −23.927 −33.216 31.77 C ATOM 2718 NE2 HIS B1088 −21.198 −22.979 −33.969 35.52 N ATOM 2719 C HIS B1088 −24.199 −18.805 −31.131 22.73 C ATOM 2720 O HIS B1088 −24.67 −18.004 −31.946 23.01 O ATOM 2721 N PHE B1089 −24.611 −18.88 −29.856 21.15 N ATOM 2722 CA PHE B1089 −25.64 −17.965 −29.292 19.41 C ATOM 2723 CB PHE B1089 −26.116 −18.361 −27.851 17.09 C ATOM 2724 CG PHE B1089 −24.998 −18.644 −26.906 15.09 C ATOM 2725 CD1 PHE B1089 −24.57 −19.945 −26.708 10.23 C ATOM 2726 CD2 PHE B1089 −24.337 −17.606 −26.235 15.28 C ATOM 2727 CE1 PHE B1089 −23.533 −20.227 −25.91 12.01 C ATOM 2728 CE2 PHE B1089 −23.256 −17.882 −25.376 11.78 C ATOM 2729 CZ PHE B1089 −22.833 −19.17 −25.219 12.66 C ATOM 2730 C PHE B1089 −25.193 −16.546 −29.29 18.49 C ATOM 2731 O PHE B1089 −26.008 −15.624 −29.268 19.76 O ATOM 2732 N GLY B1090 −23.888 −16.375 −29.266 18.92 N ATOM 2733 CA GLY B1090 −23.269 −15.059 −29.181 18.6 C ATOM 2734 C GLY B1090 −22.421 −14.958 −27.952 19.37 C ATOM 2735 O GLY B1090 −21.628 −15.857 −27.601 19.8 O ATOM 2736 N CYS B1091 −22.632 −13.863 −27.246 20.89 N ATOM 2737 CA CYS B1091 −21.784 −13.532 −26.131 18.73 C ATOM 2738 CB CYS B1091 −20.765 −12.491 −26.582 17.69 C ATOM 2739 SG CYS B1091 −19.599 −12.191 −25.292 25.76 S ATOM 2740 C CYS B1091 −22.658 −13.055 −24.95 16.84 C ATOM 2741 O CYS B1091 −23.368 −12.093 −25.073 16.87 O ATOM 2742 N VAL B1092 −22.606 −13.784 −23.821 15.9 N ATOM 2743 CA VAL B1092 −23.285 −13.453 −22.564 13.08 C ATOM 2744 CB VAL B1092 −23.925 −14.71 −22.003 13.11 C ATOM 2745 CG1 VAL B1092 −24.666 −14.416 −20.667 11.81 C ATOM 2746 CG2 VAL B1092 −24.849 −15.318 −23.044 9.74 C ATOM 2747 C VAL B1092 −22.28 −12.846 −21.558 13.31 C ATOM 2748 O VAL B1092 −21.195 −13.45 −21.285 12.97 O ATOM 2749 N TYR B1093 −22.614 −11.675 −21.01 12.17 N ATOM 2750 CA TYR B1093 −21.69 −11.008 −20.081 12.63 C ATOM 2751 CB TYR B1093 −21.487 −9.535 −20.455 15.65 C ATOM 2752 CG TYR B1093 −20.841 −9.296 −21.779 19.09 C ATOM 2753 CD1 TYR B1093 −21.625 −9.162 −22.952 23.98 C ATOM 2754 CE1 TYR B1093 −21.015 −8.929 −24.224 24.21 C ATOM 2755 CD2 TYR B1093 −19.438 −9.231 −21.89 23.44 C ATOM 2756 CE2 TYR B1093 −18.811 −9.033 −23.136 22.72 C ATOM 2757 CZ TYR B1093 −19.613 −8.866 −24.294 24.32 C ATOM 2758 OH TYR B1093 −19.014 −8.678 −25.537 26.39 O ATOM 2759 C TYR B1093 −22.208 −11.057 −18.669 11.68 C ATOM 2760 O TYR B1093 −23.387 −11.169 −18.415 10.89 O ATOM 2761 N HIS B1094 −21.299 −10.925 −17.749 12.3 N ATOM 2762 CA HIS B1094 −21.586 −10.755 −16.356 13.94 C ATOM 2763 CB HIS B1094 −20.262 −10.865 −15.54 14.31 C ATOM 2764 CG HIS B1094 −19.78 −12.281 −15.292 17.39 C ATOM 2765 CD2 HIS B1094 −18.702 −12.953 −15.769 16.61 C ATOM 2766 ND1 HIS B1094 −20.423 −13.158 −14.434 19.34 N ATOM 2767 CE1 HIS B1094 −19.751 −14.297 −14.387 17.95 C ATOM 2768 NE2 HIS B1094 −18.701 −14.196 −15.185 16.9 N ATOM 2769 C HIS B1094 −22.193 −9.334 −16.234 14.54 C ATOM 2770 O HIS B1094 −21.766 −8.464 −16.954 14.33 O ATOM 2771 N GLY B1095 −23.174 −9.125 −15.343 15.33 N ATOM 2772 CA GLY B1095 −23.679 −7.799 −15.024 17.33 C ATOM 2773 C GLY B1095 −24.024 −7.644 −13.537 19.43 C ATOM 2774 O GLY B1095 −24.178 −8.645 −12.821 20.21 O ATOM 2775 N THR B1096 −24.127 −6.395 −13.075 19.44 N ATOM 2776 CA THR B1096 −24.62 −6.053 −11.77 20.54 C ATOM 2777 CB THR B1096 −23.533 −5.296 −10.884 22.73 C ATOM 2778 OG1 THR B1096 −22.325 −6.063 −10.81 24.87 O ATOM 2779 CG2 THR B1096 −23.999 −4.975 −9.458 21.73 C ATOM 2780 C THR B1096 −25.899 −5.216 −11.944 20.08 C ATOM 2781 O THR B1096 −25.953 −4.19 −12.614 18.92 O ATOM 2782 N LEU B1097 −26.939 −5.68 −11.29 20.8 N ATOM 2783 CA LEU B1097 −28.208 −5.019 −11.339 21.12 C ATOM 2784 CB LEU B1097 −29.271 −6.052 −11.687 20.87 C ATOM 2785 CG LEU B1097 −30.728 −5.667 −11.808 20.41 C ATOM 2786 CD1 LEU B1097 −30.878 −4.58 −12.837 16.06 C ATOM 2787 CD2 LEU B1097 −31.543 −6.919 −12.214 21.59 C ATOM 2788 C LEU B1097 −28.466 −4.378 −9.989 21.74 C ATOM 2789 O LEU B1097 −28.114 −4.932 −8.956 21.45 O ATOM 2790 N LEU B1098 −29.026 −3.183 −10.009 22.86 N ATOM 2791 CA LEU B1098 −29.656 −2.633 −8.818 25.58 C ATOM 2792 CB LEU B1098 −29.714 −1.129 −8.928 27.1 C ATOM 2793 CG LEU B1098 −28.506 −0.437 −8.287 32.12 C ATOM 2794 CD1 LEU B1098 −28.999 0.999 −7.909 35.01 C ATOM 2795 CD2 LEU B1098 −27.972 −1.212 −7.019 32.02 C ATOM 2796 C LEU B1098 −31.076 −3.162 −8.549 26.01 C ATOM 2797 O LEU B1098 −32.028 −2.912 −9.356 25.42 O ATOM 2798 N ASP B1099 −31.232 −3.895 −7.445 25.81 N ATOM 2799 CA ASP B1099 −32.545 −4.391 −7.105 27.24 C ATOM 2800 CB ASP B1099 −32.484 −5.6 −6.116 28.47 C ATOM 2801 CG ASP B1099 −32.237 −5.18 −4.638 30.23 C ATOM 2802 OD1 ASP B1099 −32.055 −6.081 −3.819 34.88 O ATOM 2803 OD2 ASP B1099 −32.207 −3.984 −4.275 32.44 O ATOM 2804 C ASP B1099 −33.44 −3.248 −6.602 27.3 C ATOM 2805 O ASP B1099 −32.963 −2.101 −6.454 25.57 O ATOM 2806 N ASN B1100 −34.724 −3.579 −6.33 28.29 N ATOM 2807 CA ASN B1100 −35.721 −2.609 −5.847 28.31 C ATOM 2808 CB ASN B1100 −37.072 −3.219 −5.631 26.71 C ATOM 2809 CG ASN B1100 −38.145 −2.143 −5.454 26.73 C ATOM 2810 OD1 ASN B1100 −38.8 −2.068 −4.398 20.33 O ATOM 2811 ND2 ASN B1100 −38.335 −1.282 −6.52 26.17 N ATOM 2812 C ASN B1100 −35.348 −1.864 −4.576 29.84 C ATOM 2813 O ASN B1100 −35.804 −0.737 −4.363 29.24 O ATOM 2814 N ASP B1101 −34.554 −2.538 −3.74 31.72 N ATOM 2815 CA ASP B1101 −33.82 −1.927 −2.64 34.59 C ATOM 2816 CB ASP B1101 −33.808 −2.889 −1.481 33.48 C ATOM 2817 CG ASP B1101 −35.207 −2.991 −0.827 39.38 C ATOM 2818 OD1 ASP B1101 −35.775 −1.921 −0.349 45.14 O ATOM 2819 OD2 ASP B1101 −35.761 −4.108 −0.813 36.72 O ATOM 2820 C ASP B1101 −32.413 −1.465 −3.077 36.69 C ATOM 2821 O ASP B1101 −32.127 −1.237 −4.265 36.88 O ATOM 2822 N GLY B1102 −31.498 −1.305 −2.143 39.09 N ATOM 2823 CA GLY B1102 −30.124 −0.924 −2.613 40.88 C ATOM 2824 C GLY B1102 −29.297 −2.014 −3.32 39.37 C ATOM 2825 O GLY B1102 −28.518 −1.73 −4.196 39.26 O ATOM 2826 N LYS B1103 −29.521 −3.246 −2.908 38.65 N ATOM 2827 CA LYS B1103 −28.754 −4.403 −3.272 38.51 C ATOM 2828 CB LYS B1103 −29.56 −5.646 −2.852 39.63 C ATOM 2829 CG LYS B1103 −28.778 −6.767 −2.134 44.66 C ATOM 2830 CD LYS B1103 −29.167 −6.92 −0.629 52.43 C ATOM 2831 CE LYS B1103 −30.716 −6.764 −0.3 54.14 C ATOM 2832 NZ LYS B1103 −31.134 −5.32 0.054 55.6 N ATOM 2833 C LYS B1103 −28.243 −4.509 −4.736 36.26 C ATOM 2834 O LYS B1103 −28.98 −4.338 −5.686 35.57 O ATOM 2835 N LYS B1104 −26.964 −4.828 −4.861 34.09 N ATOM 2836 CA LYS B1104 −26.323 −5.12 −6.123 34.17 C ATOM 2837 CB LYS B1104 −24.868 −4.601 −6.109 34.35 C ATOM 2838 CG LYS B1104 −24.593 −3.486 −5.057 36.56 C ATOM 2839 CD LYS B1104 −23.171 −2.909 −5.185 38.62 C ATOM 2840 CE LYS B1104 −23.128 −1.452 −5.724 43.22 C ATOM 2841 NZ LYS B1104 −23.341 −1.512 −7.206 46.31 N ATOM 2842 C LYS B1104 −26.402 −6.652 −6.38 31.81 C ATOM 2843 O LYS B1104 −25.87 −7.441 −5.616 31.44 O ATOM 2844 N ILE B1105 −27.149 −7.033 −7.414 29.56 N ATOM 2845 CA ILE B1105 −27.428 −8.426 −7.813 27.18 C ATOM 2846 CB ILE B1105 −28.907 −8.58 −8.179 27.2 C ATOM 2847 CG2 ILE B1105 −29.283 −9.993 −8.613 26.76 C ATOM 2848 CG1 ILE B1105 −29.777 −8.168 −6.994 29.84 C ATOM 2849 CD1 ILE B1105 −29.216 −8.504 −5.573 31.01 C ATOM 2850 C ILE B1105 −26.605 −8.859 −9.06 26.17 C ATOM 2851 O ILE B1105 −26.553 −8.178 −10.122 24.06 O ATOM 2852 N HIS B1106 −26.01 −10.031 −8.905 24.12 N ATOM 2853 CA HIS B1106 −25.326 −10.679 −9.971 23.11 C ATOM 2854 CB HIS B1106 −24.395 −11.738 −9.411 22.82 C ATOM 2855 CG HIS B1106 −23.467 −12.292 −10.441 26.43 C ATOM 2856 CD2 HIS B1106 −23.107 −11.797 −11.66 26.36 C ATOM 2857 ND1 HIS B1106 −22.832 −13.509 −10.306 25.2 N ATOM 2858 CE1 HIS B1106 −22.083 −13.705 −11.374 29.25 C ATOM 2859 NE2 HIS B1106 −22.239 −12.687 −12.212 25.17 N ATOM 2860 C HIS B1106 −26.274 −11.204 −11.077 21.62 C ATOM 2861 O HIS B1106 −27.227 −11.865 −10.811 22.59 O ATOM 2862 N CYS B1107 −26.007 −10.883 −12.33 19.48 N ATOM 2863 CA CYS B1107 −26.835 −11.388 −13.385 17.55 C ATOM 2864 CB CYS B1107 −27.965 −10.384 −13.666 18.07 C ATOM 2865 SG CYS B1107 −27.227 −8.718 −14.16 18.42 S ATOM 2866 C CYS B1107 −26 −11.588 −14.661 16.17 C ATOM 2867 O CYS B1107 −24.815 −11.264 −14.744 15.08 O ATOM 2868 N ALA B1108 −26.695 −12.123 −15.666 15.55 N ATOM 2869 CA ALA B1108 −26.16 −12.448 −16.975 11.19 C ATOM 2870 CB ALA B1108 −26.452 −13.869 −17.222 10.83 C ATOM 2871 C ALA B1108 −26.894 −11.561 −17.972 9.92 C ATOM 2872 O ALA B1108 −28.124 −11.399 −17.883 6.01 O ATOM 2873 N VAL B1109 −26.136 −10.926 −18.872 8.97 N ATOM 2874 CA VAL B1109 −26.774 −10.01 −19.843 9.33 C ATOM 2875 CB VAL B1109 −26.807 −8.391 −19.481 9.45 C ATOM 2876 CG1 VAL B1109 −26.032 −8.005 −18.3 8.25 C ATOM 2877 CG2 VAL B1109 −26.452 −7.547 −20.668 8.77 C ATOM 2878 C VAL B1109 −26.389 −10.338 −21.304 9.24 C ATOM 2879 O VAL B1109 −25.3 −10.815 −21.579 7.3 O ATOM 2880 N LYS B1110 −27.33 −10.08 −22.194 9.22 N ATOM 2881 CA LYS B1110 −27.189 −10.462 −23.567 11.63 C ATOM 2882 CB LYS B1110 −27.786 −11.887 −23.756 12.52 C ATOM 2883 CG LYS B1110 −27.781 −12.443 −25.149 13.32 C ATOM 2884 CD LYS B1110 −26.441 −13.135 −25.377 11.87 C ATOM 2885 CE LYS B1110 −26.107 −13.203 −26.846 21 C ATOM 2886 NZ LYS B1110 −27.201 −13.071 −27.897 14.68 N ATOM 2887 C LYS B1110 −27.941 −9.431 −24.432 11.11 C ATOM 2888 O LYS B1110 −29.071 −9.075 −24.095 8.61 O ATOM 2889 N SER B1111 −27.245 −8.907 −25.467 11.93 N ATOM 2890 CA SER B1111 −27.887 −8.092 −26.53 13.48 C ATOM 2891 CB SER B1111 −26.851 −7.147 −27.199 14.94 C ATOM 2892 OG SER B1111 −27.026 −7.007 −28.604 13.55 O ATOM 2893 C SER B1111 −28.647 −8.977 −27.532 13.17 C ATOM 2894 O SER B1111 −28.147 −10.014 −27.985 11.98 O ATOM 2895 N LEU B1112 −29.896 −8.608 −27.816 14.3 N ATOM 2896 CA LEU B1112 −30.675 −9.407 −28.783 14.87 C ATOM 2897 CB LEU B1112 −32.192 −9.38 −28.546 15.11 C ATOM 2898 CG LEU B1112 −32.469 −9.532 −27.068 12.54 C ATOM 2899 CD1 LEU B1112 −33.858 −9.321 −26.935 11.61 C ATOM 2900 CD2 LEU B1112 −32.111 −10.95 −26.66 12.26 C ATOM 2901 C LEU B1112 −30.323 −8.969 −30.187 14.57 C ATOM 2902 O LEU B1112 −31.054 −8.269 −30.824 13.73 O ATOM 2903 N ASN B1113 −29.169 −9.435 −30.641 15.7 N ATOM 2904 CA ASN B1113 −28.644 −9.036 −31.913 17.23 C ATOM 2905 CB ASN B1113 −27.293 −9.678 −32.137 16.16 C ATOM 2906 CG ASN B1113 −26.265 −9.178 −31.126 15.4 C ATOM 2907 OD1 ASN B1113 −26.097 −7.984 −30.918 15.23 O ATOM 2908 ND2 ASN B1113 −25.602 −10.073 −30.507 16.3 N ATOM 2909 C ASN B1113 −29.569 −9.245 −33.104 18.32 C ATOM 2910 O ASN B1113 −29.219 −8.847 −34.181 21.69 O ATOM 2911 N ARG B1114 −30.765 −9.776 −32.907 16.84 N ATOM 2912 CA ARG B1114 −31.561 −10.105 −34.016 16.33 C ATOM 2913 CB ARG B1114 −32.027 −11.553 −33.914 17.05 C ATOM 2914 CG ARG B1114 −30.88 −12.544 −34.163 19.42 C ATOM 2915 CD ARG B1114 −31.261 −13.954 −33.837 22.69 C ATOM 2916 NE ARG B1114 −32.327 −14.399 −34.716 29.67 N ATOM 2917 CZ ARG B1114 −33.248 −15.305 −34.369 37.44 C ATOM 2918 NH1 ARG B1114 −33.236 −15.907 −33.125 34.6 N ATOM 2919 NH2 ARG B1114 −34.174 −15.635 −35.285 34.77 N ATOM 2920 C ARG B1114 −32.719 −9.186 −34.121 16.57 C ATOM 2921 O ARG B1114 −33.455 −9.265 −35.114 15.8 O ATOM 2922 N ILE B1115 −32.923 −8.377 −33.064 16.18 N ATOM 2923 CA ILE B1115 −33.885 −7.318 −33.061 15.66 C ATOM 2924 CB ILE B1115 −34.432 −6.958 −31.659 16.8 C ATOM 2925 CG2 ILE B1115 −35.521 −5.899 −31.741 14.64 C ATOM 2926 CG1 ILE B1115 −34.762 −8.167 −30.74 19.85 C ATOM 2927 CD1 ILE B1115 −35.743 −9.11 −31.195 21.64 C ATOM 2928 C ILE B1115 −33.133 −6.119 −33.611 15.81 C ATOM 2929 O ILE B1115 −32.31 −5.46 −32.89 15.75 O ATOM 2930 N THR B1116 −33.362 −5.856 −34.901 15.82 N ATOM 2931 CA THR B1116 −32.576 −4.842 −35.64 16.62 C ATOM 2932 CB THR B1116 −32.017 −5.435 −36.928 15.6 C ATOM 2933 OG1 THR B1116 −33.084 −5.709 −37.85 15.48 O ATOM 2934 CG2 THR B1116 −31.311 −6.728 −36.622 14.81 C ATOM 2935 C THR B1116 −33.361 −3.528 −35.902 18 C ATOM 2936 O THR B1116 −32.808 −2.563 −36.384 19.97 O ATOM 2937 N ASP B1117 −34.652 −3.498 −35.583 18.89 N ATOM 2938 CA ASP B1117 −35.485 −2.31 −35.723 18.62 C ATOM 2939 CB ASP B1117 −35.95 −2.156 −37.175 20.27 C ATOM 2940 CG ASP B1117 −36.778 −3.349 −37.646 23.06 C ATOM 2941 OD1 ASP B1117 −37.751 −3.729 −36.981 29.38 O ATOM 2942 OD2 ASP B1117 −36.46 −3.945 −38.686 32.03 O ATOM 2943 C ASP B1117 −36.701 −2.351 −34.8 17.98 C ATOM 2944 O ASP B1117 −36.942 −3.363 −34.138 18.33 O ATOM 2945 N ILE B1118 −37.435 −1.232 −34.758 17.89 N ATOM 2946 CA ILE B1118 −38.546 −1.012 −33.845 18.34 C ATOM 2947 CB ILE B1118 −39.083 0.396 −33.961 19.06 C ATOM 2948 CG2 ILE B1118 −39.857 0.592 −35.276 18.01 C ATOM 2949 CG1 ILE B1118 −39.932 0.715 −32.733 20.21 C ATOM 2950 CD1 ILE B1118 −40.595 2.106 −32.764 20.59 C ATOM 2951 C ILE B1118 −39.722 −1.987 −34.056 18.2 C ATOM 2952 O ILE B1118 −40.434 −2.352 −33.116 16.36 O ATOM 2953 N GLY B1119 −39.912 −2.41 −35.296 18.21 N ATOM 2954 CA GLY B1119 −40.961 −3.359 −35.567 19.58 C ATOM 2955 C GLY B1119 −40.705 −4.683 −34.836 20.43 C ATOM 2956 O GLY B1119 −41.653 −5.29 −34.339 19.99 O ATOM 2957 N GLU B1120 −39.423 −5.094 −34.794 19.5 N ATOM 2958 CA GLU B1120 −38.965 −6.307 −34.155 20.69 C ATOM 2959 CB GLU B1120 −37.588 −6.722 −34.711 20.04 C ATOM 2960 CG GLU B1120 −37.682 −6.969 −36.176 23 C ATOM 2961 CD GLU B1120 −36.343 −7.215 −36.859 26.75 C ATOM 2962 OE1 GLU B1120 −35.262 −6.975 −36.243 25.12 O ATOM 2963 OE2 GLU B1120 −36.4 −7.619 −38.049 28.35 O ATOM 2964 C GLU B1120 −38.938 −6.188 −32.6 20.23 C ATOM 2965 O GLU B1120 −39.085 −7.197 −31.923 18.33 O ATOM 2966 N VAL B1121 −38.754 −4.954 −32.08 20.43 N ATOM 2967 CA VAL B1121 −38.787 −4.699 −30.651 20.56 C ATOM 2968 CB VAL B1121 −38.324 −3.278 −30.303 20.8 C ATOM 2969 CG1 VAL B1121 −38.445 −3.064 −28.833 20.21 C ATOM 2970 CG2 VAL B1121 −36.884 −3.082 −30.672 19.6 C ATOM 2971 C VAL B1121 −40.217 −4.911 −30.185 21.33 C ATOM 2972 O VAL B1121 −40.487 −5.678 −29.252 23.1 O ATOM 2973 N SER B1122 −41.141 −4.252 −30.869 21.22 N ATOM 2974 CA SER B1122 −42.512 −4.24 −30.503 20.16 C ATOM 2975 CB SER B1122 −43.213 −3.315 −31.468 20.41 C ATOM 2976 OG SER B1122 −44.646 −3.36 −31.284 27.62 O ATOM 2977 C SER B1122 −43.054 −5.679 −30.533 20.02 C ATOM 2978 O SER B1122 −43.856 −6.091 −29.659 16.24 O ATOM 2979 N GLN B1123 −42.557 −6.467 −31.517 20.28 N ATOM 2980 CA GLN B1123 −42.983 −7.86 −31.617 20.71 C ATOM 2981 CB GLN B1123 −42.579 −8.467 −32.959 21.57 C ATOM 2982 CG GLN B1123 −42.542 −9.975 −32.88 26.83 C ATOM 2983 CD GLN B1123 −42.828 −10.698 −34.188 34.81 C ATOM 2984 OE1 GLN B1123 −41.885 −11.107 −34.907 30.93 O ATOM 2985 NE2 GLN B1123 −44.141 −10.923 −34.478 34.08 N ATOM 2986 C GLN B1123 −42.472 −8.71 −30.43 19.33 C ATOM 2987 O GLN B1123 −43.164 −9.598 −29.906 18.63 O ATOM 2988 N PHE B1124 −41.245 −8.416 −30.046 18.92 N ATOM 2989 CA PHE B1124 −40.593 −8.976 −28.889 19.21 C ATOM 2990 CB PHE B1124 −39.17 −8.464 −28.855 19.71 C ATOM 2991 CG PHE B1124 −38.487 −8.783 −27.6 20.88 C ATOM 2992 CD1 PHE B1124 −38.26 −10.104 −27.248 23.63 C ATOM 2993 CD2 PHE B1124 −38.134 −7.77 −26.724 20.85 C ATOM 2994 CE1 PHE B1124 −37.659 −10.407 −26.031 24.95 C ATOM 2995 CE2 PHE B1124 −37.538 −8.052 −25.524 20.74 C ATOM 2996 CZ PHE B1124 −37.297 −9.35 −25.178 23.67 C ATOM 2997 C PHE B1124 −41.296 −8.611 −27.564 18.85 C ATOM 2998 O PHE B1124 −41.446 −9.435 −26.68 18.31 O ATOM 2999 N LEU B1125 −41.75 −7.369 −27.439 18.95 N ATOM 3000 CA LEU B1125 −42.379 −6.957 −26.208 19.31 C ATOM 3001 CB LEU B1125 −42.611 −5.444 −26.14 18.61 C ATOM 3002 CG LEU B1125 −41.395 −4.544 −26.055 17.81 C ATOM 3003 CD1 LEU B1125 −41.888 −3.154 −25.953 13.16 C ATOM 3004 CD2 LEU B1125 −40.476 −4.981 −24.911 14.76 C ATOM 3005 C LEU B1125 −43.664 −7.693 −26.029 20.43 C ATOM 3006 O LEU B1125 −43.999 −8.102 −24.885 19.8 O ATOM 3007 N THR B1126 −44.346 −7.892 −27.165 21.81 N ATOM 3008 CA THR B1126 −45.593 −8.636 −27.203 24.27 C ATOM 3009 CB THR B1126 −46.294 −8.457 −28.491 25.04 C ATOM 3010 OG1 THR B1126 −46.77 −7.12 −28.565 27.43 O ATOM 3011 CG2 THR B1126 −47.491 −9.396 −28.593 27.15 C ATOM 3012 C THR B1126 −45.397 −10.114 −26.995 25.94 C ATOM 3013 O THR B1126 −45.977 −10.651 −26.074 25.49 O ATOM 3014 N GLU B1127 −44.56 −10.747 −27.849 28.18 N ATOM 3015 CA GLU B1127 −44.342 −12.216 −27.902 29.09 C ATOM 3016 CB GLU B1127 −43.6 −12.615 −29.212 29.43 C ATOM 3017 CG GLU B1127 −44.366 −12.433 −30.585 34.63 C ATOM 3018 CD GLU B1127 −43.93 −13.447 −31.739 36.34 C ATOM 3019 OE1 GLU B1127 −42.932 −14.233 −31.583 42.77 O ATOM 3020 OE2 GLU B1127 −44.616 −13.46 −32.813 43.01 O ATOM 3021 C GLU B1127 −43.509 −12.73 −26.759 27.06 C ATOM 3022 O GLU B1127 −43.782 −13.746 −26.167 28.65 O ATOM 3023 N GLY B1128 −42.419 −12.061 −26.507 25.65 N ATOM 3024 CA GLY B1128 −41.409 −12.606 −25.676 23.56 C ATOM 3025 C GLY B1128 −41.495 −12.108 −24.259 22.44 C ATOM 3026 O GLY B1128 −40.861 −12.688 −23.385 23.01 O ATOM 3027 N ILE B1129 −42.313 −11.087 −23.994 21.65 N ATOM 3028 CA ILE B1129 −42.452 −10.613 −22.605 20.71 C ATOM 3029 CB ILE B1129 −41.976 −9.163 −22.398 20.57 C ATOM 3030 CG2 ILE B1129 −42.295 −8.632 −20.984 16.98 C ATOM 3031 CG1 ILE B1129 −40.527 −8.996 −22.884 22.44 C ATOM 3032 CD1 ILE B1129 −39.511 −8.768 −21.844 27.47 C ATOM 3033 C ILE B1129 −43.868 −10.773 −22.116 21.37 C ATOM 3034 O ILE B1129 −44.074 −11.484 −21.141 22.91 O ATOM 3035 N ILE B1130 −44.83 −10.116 −22.768 21.42 N ATOM 3036 CA ILE B1130 −46.225 −10.12 −22.373 21.54 C ATOM 3037 CB ILE B1130 −46.963 −8.979 −23.165 23.73 C ATOM 3038 CG2 ILE B1130 −48.557 −9.195 −23.349 23.9 C ATOM 3039 CG1 ILE B1130 −46.652 −7.612 −22.528 22.28 C ATOM 3040 CD1 ILE B1130 −46.984 −6.542 −23.431 29.63 C ATOM 3041 C ILE B1130 −46.9 −11.48 −22.593 21.67 C ATOM 3042 O ILE B1130 −47.808 −11.858 −21.875 20.59 O ATOM 3043 N MET B1131 −46.453 −12.211 −23.587 21.62 N ATOM 3044 CA MET B1131 −47.003 −13.489 −23.86 25.06 C ATOM 3045 CB MET B1131 −46.974 −13.796 −25.365 25.52 C ATOM 3046 CG MET B1131 −48.265 −13.463 −26.138 28.21 C ATOM 3047 SD MET B1131 −47.881 −13.85 −27.932 37.9 S ATOM 3048 CE MET B1131 −48.83 −12.507 −28.735 33.81 C ATOM 3049 C MET B1131 −46.236 −14.575 −23.133 23.04 C ATOM 3050 O MET B1131 −46.56 −15.74 −23.305 22.39 O ATOM 3051 N LYS B1132 −45.22 −14.212 −22.347 22.43 N ATOM 3052 CA LYS B1132 −44.486 −15.183 −21.513 21.49 C ATOM 3053 CB LYS B1132 −43.145 −15.617 −22.13 21.65 C ATOM 3054 CG LYS B1132 −43.284 −16.095 −23.534 24.27 C ATOM 3055 CD LYS B1132 −41.954 −16.295 −24.221 26.68 C ATOM 3056 CE LYS B1132 −42.215 −17.072 −25.529 31.37 C ATOM 3057 NZ LYS B1132 −40.981 −17.343 −26.409 30.29 N ATOM 3058 C LYS B1132 −44.264 −14.664 −20.109 19.94 C ATOM 3059 O LYS B1132 −43.142 −14.619 −19.637 18.91 O ATOM 3060 N ASP B1133 −45.356 −14.262 −19.461 19.36 N ATOM 3061 CA ASP B1133 −45.318 −13.836 −18.068 18.25 C ATOM 3062 CB ASP B1133 −46.394 −12.803 −17.826 19.04 C ATOM 3063 CG ASP B1133 −46.025 −11.787 −16.716 25.02 C ATOM 3064 OD1 ASP B1133 −46.678 −10.734 −16.677 32.68 O ATOM 3065 OD2 ASP B1133 −45.12 −11.971 −15.874 27.29 O ATOM 3066 C ASP B1133 −45.459 −15.042 −17.07 16.25 C ATOM 3067 O ASP B1133 −46.575 −15.418 −16.702 15.72 O ATOM 3068 N PHE B1134 −44.334 −15.661 −16.703 13.2 N ATOM 3069 CA PHE B1134 −44.371 −16.847 −15.908 13.49 C ATOM 3070 CB PHE B1134 −43.749 −18.062 −16.681 13.84 C ATOM 3071 CG PHE B1134 −44.392 −18.326 −17.977 12.66 C ATOM 3072 CD1 PHE B1134 −43.665 −18.247 −19.149 8.62 C ATOM 3073 CD2 PHE B1134 −45.74 −18.598 −18.038 13.15 C ATOM 3074 CE1 PHE B1134 −44.24 −18.472 −20.344 9.63 C ATOM 3075 CE2 PHE B1134 −46.381 −18.775 −19.284 11.64 C ATOM 3076 CZ PHE B1134 −45.626 −18.693 −20.441 12.7 C ATOM 3077 C PHE B1134 −43.658 −16.664 −14.532 12.63 C ATOM 3078 O PHE B1134 −42.758 −15.847 −14.405 12.68 O ATOM 3079 N SER B1135 −44.032 −17.467 −13.554 11.18 N ATOM 3080 CA SER B1135 −43.437 −17.455 −12.292 12.48 C ATOM 3081 CB SER B1135 −44.072 −16.389 −11.376 13.66 C ATOM 3082 OG SER B1135 −43.358 −16.274 −10.114 19.22 O ATOM 3083 C SER B1135 −43.606 −18.843 −11.714 11.96 C ATOM 3084 O SER B1135 −44.722 −19.284 −11.4 10.34 O ATOM 3085 N HIS B1136 −42.453 −19.496 −11.574 10.83 N ATOM 3086 CA HIS B1136 −42.306 −20.857 −11.158 9.03 C ATOM 3087 CB HIS B1136 −42.855 −21.851 −12.194 7.78 C ATOM 3088 CG HIS B1136 −42.977 −23.233 −11.645 7.34 C ATOM 3089 CD2 HIS B1136 −44.027 −23.881 −11.077 7.24 C ATOM 3090 ND1 HIS B1136 −41.892 −24.076 −11.5 8.84 N ATOM 3091 CE1 HIS B1136 −42.293 −25.22 −10.952 7.21 C ATOM 3092 NE2 HIS B1136 −43.589 −25.13 −10.706 4.2 N ATOM 3093 C HIS B1136 −40.833 −21.147 −10.873 9.44 C ATOM 3094 O HIS B1136 −39.956 −20.823 −11.676 8.14 O ATOM 3095 N PRO B1137 −40.546 −21.776 −9.716 9.87 N ATOM 3096 CD PRO B1137 −41.499 −22.126 −8.63 10.69 C ATOM 3097 CA PRO B1137 −39.187 −22.146 −9.357 10.54 C ATOM 3098 CB PRO B1137 −39.406 −23.019 −8.096 11.7 C ATOM 3099 CG PRO B1137 −40.94 −23.414 −8.112 11.22 C ATOM 3100 C PRO B1137 −38.38 −22.924 −10.41 10.67 C ATOM 3101 O PRO B1137 −37.14 −22.846 −10.452 11.71 O ATOM 3102 N ASN B1138 −39.037 −23.703 −11.254 10.13 N ATOM 3103 CA ASN B1138 −38.29 −24.439 −12.246 9.9 C ATOM 3104 CB ASN B1138 −38.763 −25.865 −12.216 9.42 C ATOM 3105 CG ASN B1138 −38.553 −26.473 −10.929 8.48 C ATOM 3106 OD1 ASN B1138 −39.522 −26.863 −10.251 15.21 O ATOM 3107 ND2 ASN B1138 −37.308 −26.552 −10.52 8.93 N ATOM 3108 C ASN B1138 −38.452 −23.889 −13.678 10.14 C ATOM 3109 O ASN B1138 −38.23 −24.616 −14.664 8.96 O ATOM 3110 N VAL B1139 −38.924 −22.657 −13.754 9.25 N ATOM 3111 CA VAL B1139 −39.065 −21.923 −15.004 10.14 C ATOM 3112 CB VAL B1139 −40.54 −21.427 −15.265 8.36 C ATOM 3113 CG1 VAL B1139 −40.555 −20.35 −16.371 8.76 C ATOM 3114 CG2 VAL B1139 −41.434 −22.588 −15.597 5.54 C ATOM 3115 C VAL B1139 −38.13 −20.705 −14.944 10.69 C ATOM 3116 O VAL B1139 −38.19 −19.885 −14.027 10.15 O ATOM 3117 N LEU B1140 −37.28 −20.593 −15.945 12.82 N ATOM 3118 CA LEU B1140 −36.349 −19.437 −16.033 13.46 C ATOM 3119 CB LEU B1140 −35.175 −19.772 −16.941 12.15 C ATOM 3120 CG LEU B1140 −34.135 −18.663 −17.089 15.4 C ATOM 3121 CD1 LEU B1140 −33.713 −18.075 −15.707 18.65 C ATOM 3122 CD2 LEU B1140 −32.907 −19.173 −17.841 12.12 C ATOM 3123 C LEU B1140 −37.037 −18.175 −16.586 13.98 C ATOM 3124 O LEU B1140 −37.475 −18.138 −17.745 13.7 O ATOM 3125 N SER B1141 −37.085 −17.129 −15.779 14.05 N ATOM 3126 CA SER B1141 −37.655 −15.877 −16.224 14.32 C ATOM 3127 CB SER B1141 −38.768 −15.484 −15.25 13.42 C ATOM 3128 OG SER B1141 −39.906 −16.321 −15.411 13.02 O ATOM 3129 C SER B1141 −36.596 −14.766 −16.233 15.85 C ATOM 3130 O SER B1141 −35.669 −14.739 −15.377 15.5 O ATOM 3131 N LEU B1142 −36.725 −13.818 −17.152 16.95 N ATOM 3132 CA LEU B1142 −35.742 −12.734 −17.138 18.29 C ATOM 3133 CB LEU B1142 −35.65 −12.031 −18.472 20.03 C ATOM 3134 CG LEU B1142 −36.683 −11.192 −19.185 24.65 C ATOM 3135 CD1 LEU B1142 −36.465 −11.506 −20.665 29.86 C ATOM 3136 CD2 LEU B1142 −38.054 −11.563 −18.827 32.52 C ATOM 3137 C LEU B1142 −35.978 −11.764 −15.999 17.94 C ATOM 3138 O LEU B1142 −37.135 −11.543 −15.618 17.46 O ATOM 3139 N LEU B1143 −34.899 −11.216 −15.437 16.77 N ATOM 3140 CA LEU B1143 −35.012 −10.281 −14.378 16.17 C ATOM 3141 CB LEU B1143 −33.665 −9.964 −13.809 16.58 C ATOM 3142 CG LEU B1143 −32.949 −11.007 −12.956 20.56 C ATOM 3143 CD1 LEU B1143 −31.483 −10.458 −12.607 16.47 C ATOM 3144 CD2 LEU B1143 −33.812 −11.432 −11.674 18.65 C ATOM 3145 C LEU B1143 −35.629 −9.006 −14.915 17.22 C ATOM 3146 O LEU B1143 −36.534 −8.435 −14.265 18.1 O ATOM 3147 N GLY B1144 −35.191 −8.583 −16.1 15.71 N ATOM 3148 CA GLY B1144 −35.812 −7.492 −16.747 17.55 C ATOM 3149 C GLY B1144 −35.253 −7.37 −18.15 20.81 C ATOM 3150 O GLY B1144 −34.589 −8.28 −18.639 19.87 O ATOM 3151 N ILE B1145 −35.47 −6.183 −18.749 23.32 N ATOM 3152 CA ILE B1145 −35.234 −5.948 −20.142 25.4 C ATOM 3153 CB ILE B1145 −36.486 −6.088 −21.066 25.54 C ATOM 3154 CG2 ILE B1145 −37.502 −4.876 −21.036 24.37 C ATOM 3155 CG1 ILE B1145 −36.033 −6.509 −22.437 26.57 C ATOM 3156 CD1 ILE B1145 −35.844 −5.401 −23.399 27.64 C ATOM 3157 C ILE B1145 −34.341 −4.823 −20.522 26.94 C ATOM 3158 O ILE B1145 −33.335 −5.104 −21.145 31.01 O ATOM 3159 N CYS B1146 −34.585 −3.572 −20.255 26.18 N ATOM 3160 CA CYS B1146 −33.589 −2.676 −20.911 27.81 C ATOM 3161 CB CYS B1146 −32.206 −3.307 −20.8 28.25 C ATOM 3162 SG CYS B1146 −30.968 −2.29 −20.084 39.86 S ATOM 3163 C CYS B1146 −33.773 −2.264 −22.392 25.44 C ATOM 3164 O CYS B1146 −33.198 −2.858 −23.32 23.13 O ATOM 3165 N LEU B1147 −34.518 −1.171 −22.583 25.47 N ATOM 3166 CA LEU B1147 −34.844 −0.701 −23.923 24.48 C ATOM 3167 CB LEU B1147 −36.316 −0.258 −23.981 25.28 C ATOM 3168 CG LEU B1147 −37.558 −1.097 −24.228 25.29 C ATOM 3169 CD1 LEU B1147 −37.319 −2.1 −25.298 27.97 C ATOM 3170 CD2 LEU B1147 −37.919 −1.835 −23.005 29.1 C ATOM 3171 C LEU B1147 −33.936 0.474 −24.325 24.42 C ATOM 3172 O LEU B1147 −34.008 1.556 −23.735 23.15 O ATOM 3173 N ARG B1148 −33.121 0.273 −25.353 23.32 N ATOM 3174 CA ARG B1148 −32.146 1.268 −25.796 21.75 C ATOM 3175 CB ARG B1148 −30.787 0.593 −25.999 20.87 C ATOM 3176 CG ARG B1148 −30.383 −0.248 −24.849 19.8 C ATOM 3177 CD ARG B1148 −28.89 −0.531 −24.978 18.29 C ATOM 3178 NE ARG B1148 −28.626 −1.545 −25.976 13.37 N ATOM 3179 CZ ARG B1148 −27.407 −1.955 −26.323 16.93 C ATOM 3180 NH1 ARG B1148 −26.329 −1.435 −25.77 16.14 N ATOM 3181 NH2 ARG B1148 −27.271 −2.924 −27.214 14.69 N ATOM 3182 C ARG B1148 −32.559 1.823 −27.148 21.36 C ATOM 3183 O ARG B1148 −33.208 1.153 −27.92 20.58 O ATOM 3184 N SER B1149 −32.145 3.03 −27.46 20.94 N ATOM 3185 CA SER B1149 −32.415 3.529 −28.803 23.03 C ATOM 3186 CB SER B1149 −32.81 5 −28.785 23.52 C ATOM 3187 OG SER B1149 −32.164 5.688 −27.735 27.64 O ATOM 3188 C SER B1149 −31.197 3.354 −29.678 22.72 C ATOM 3189 O SER B1149 −31.312 3.299 −30.88 24.19 O ATOM 3190 N GLU B1150 −30.026 3.218 −29.085 22.05 N ATOM 3191 CA GLU B1150 −28.968 2.623 −29.868 22.66 C ATOM 3192 CB GLU B1150 −27.718 3.501 −29.894 23.8 C ATOM 3193 CG GLU B1150 −28.005 4.95 −30.295 30 C ATOM 3194 CD GLU B1150 −26.698 5.665 −30.456 40.1 C ATOM 3195 OE1 GLU B1150 −25.743 5.351 −29.649 44.42 O ATOM 3196 OE2 GLU B1150 −26.6 6.507 −31.39 41.6 O ATOM 3197 C GLU B1150 −28.647 1.196 −29.458 20.41 C ATOM 3198 O GLU B1150 −28.415 0.889 −28.303 18.54 O ATOM 3199 N GLY B1151 −28.638 0.337 −30.449 18.5 N ATOM 3200 CA GLY B1151 −28.221 −1.006 −30.23 17.16 C ATOM 3201 C GLY B1151 −29.443 −1.827 −29.963 16.88 C ATOM 3202 O GLY B1151 −30.511 −1.283 −29.731 17.89 O ATOM 3203 N SER B1152 −29.291 −3.138 −30.001 16.38 N ATOM 3204 CA SER B1152 −30.385 −4.035 −29.793 15.73 C ATOM 3205 CB SER B1152 −29.973 −5.418 −30.296 16.22 C ATOM 3206 OG SER B1152 −29.949 −5.455 −31.709 17.36 O ATOM 3207 C SER B1152 −30.776 −4.049 −28.296 15.34 C ATOM 3208 O SER B1152 −29.979 −3.74 −27.395 14.35 O ATOM 3209 N PRO B1153 −32.021 −4.399 −28.026 15.04 N ATOM 3210 CD PRO B1153 −33.116 −4.774 −28.945 13.23 C ATOM 3211 CA PRO B1153 −32.397 −4.431 −26.604 15.68 C ATOM 3212 CB PRO B1153 −33.902 −4.764 −26.616 14.25 C ATOM 3213 CG PRO B1153 −34.335 −4.63 −28.038 14.42 C ATOM 3214 C PRO B1153 −31.597 −5.479 −25.808 16.25 C ATOM 3215 O PRO B1153 −31.076 −6.412 −26.374 18.1 O ATOM 3216 N LEU B1154 −31.453 −5.274 −24.505 16.93 N ATOM 3217 CA LEU B1154 −30.681 −6.147 −23.64 15.03 C ATOM 3218 CB LEU B1154 −29.958 −5.32 −22.638 15.08 C ATOM 3219 CG LEU B1154 −28.563 −4.899 −23.086 18.21 C ATOM 3220 CD1 LEU B1154 −28.269 −5.2 −24.556 12.75 C ATOM 3221 CD2 LEU B1154 −28.33 −3.462 −22.734 14.99 C ATOM 3222 C LEU B1154 −31.623 −7.012 −22.876 14.73 C ATOM 3223 O LEU B1154 −32.705 −6.607 −22.574 13.4 O ATOM 3224 N VAL B1155 −31.199 −8.227 −22.585 13.87 N ATOM 3225 CA VAL B1155 −32.019 −9.147 −21.863 13.52 C ATOM 3226 CB VAL B1155 −32.349 −10.322 −22.832 14.55 C ATOM 3227 CG1 VAL B1155 −31.496 −11.534 −22.58 14.03 C ATOM 3228 CG2 VAL B1155 −33.823 −10.609 −22.785 18.15 C ATOM 3229 C VAL B1155 −31.204 −9.502 −20.622 11.35 C ATOM 3230 O VAL B1155 −30.018 −9.713 −20.715 11.04 O ATOM 3231 N VAL B1156 −31.81 −9.371 −19.455 11.53 N ATOM 3232 CA VAL B1156 −31.118 −9.533 −18.172 11.14 C ATOM 3233 CB VAL B1156 −31.192 −8.245 −17.256 12.17 C ATOM 3234 CG1 VAL B1156 −30.313 −8.371 −15.994 10.66 C ATOM 3235 CG2 VAL B1156 −30.748 −6.969 −18.047 10.76 C ATOM 3236 C VAL B1156 −31.722 −10.771 −17.483 12.56 C ATOM 3237 O VAL B1156 −32.97 −10.885 −17.293 12.88 O ATOM 3238 N LEU B1157 −30.847 −11.733 −17.187 11.87 N ATOM 3239 CA LEU B1157 −31.252 −12.933 −16.52 10.49 C ATOM 3240 CB LEU B1157 −31.067 −14.103 −17.467 11.83 C ATOM 3241 CG LEU B1157 −32.163 −14.083 −18.539 10.1 C ATOM 3242 CD1 LEU B1157 −31.622 −13.381 −19.796 10.35 C ATOM 3243 CD2 LEU B1157 −32.674 −15.419 −18.81 8.6 C ATOM 3244 C LEU B1157 −30.496 −13.192 −15.263 10.83 C ATOM 3245 O LEU B1157 −29.321 −12.728 −15.103 11.75 O ATOM 3246 N PRO B1158 −31.122 −13.969 −14.366 10.41 N ATOM 3247 CD PRO B1158 −32.504 −14.489 −14.459 9.43 C ATOM 3248 CA PRO B1158 −30.416 −14.389 −13.147 9.97 C ATOM 3249 CB PRO B1158 −31.426 −15.321 −12.386 8.9 C ATOM 3250 CG PRO B1158 −32.711 −15.132 −13.099 11.26 C ATOM 3251 C PRO B1158 −29.15 −15.139 −13.487 10.1 C ATOM 3252 O PRO B1158 −29.076 −15.847 −14.493 9.14 O ATOM 3253 N TYR B1159 −28.138 −14.912 −12.675 11.58 N ATOM 3254 CA TYR B1159 −26.951 −15.703 −12.742 13.59 C ATOM 3255 CB TYR B1159 −25.849 −15.174 −11.787 13.68 C ATOM 3256 CG TYR B1159 −24.551 −15.855 −12.053 11.81 C ATOM 3257 CD1 TYR B1159 −24.019 −15.89 −13.372 10.98 C ATOM 3258 CE1 TYR B1159 −22.863 −16.554 −13.655 13.01 C ATOM 3259 CD2 TYR B1159 −23.877 −16.487 −11.057 9.14 C ATOM 3260 CE2 TYR B1159 −22.661 −17.182 −11.319 13.66 C ATOM 3261 CZ TYR B1159 −22.136 −17.193 −12.616 14.72 C ATOM 3262 OH TYR B1159 −20.946 −17.909 −12.902 14.73 O ATOM 3263 C TYR B1159 −27.242 −17.175 −12.476 15.39 C ATOM 3264 O TYR B1159 −27.802 −17.531 −11.415 15.7 O ATOM 3265 N MET B1160 −26.915 −18.017 −13.469 16.37 N ATOM 3266 CA MET B1160 −27.146 −19.454 −13.38 17.49 C ATOM 3267 CB MET B1160 −27.924 −20.031 −14.581 16.46 C ATOM 3268 CG MET B1160 −29.345 −19.722 −14.506 18.94 C ATOM 3269 SD MET B1160 −30.35 −20.465 −13.143 24.07 S ATOM 3270 CE MET B1160 −30.719 −19.019 −12.29 18.12 C ATOM 3271 C MET B1160 −25.792 −20.045 −13.308 17.29 C ATOM 3272 O MET B1160 −25.206 −20.378 −14.31 18 O ATOM 3273 N LYS B1161 −25.318 −20.191 −12.09 18.45 N ATOM 3274 CA LYS B1161 −23.951 −20.603 −11.824 18.74 C ATOM 3275 CB LYS B1161 −23.776 −20.791 −10.319 19.72 C ATOM 3276 CG LYS B1161 −22.35 −21.047 −9.981 23.56 C ATOM 3277 CD LYS B1161 −22.224 −21.793 −8.725 29.41 C ATOM 3278 CE LYS B1161 −20.946 −22.585 −8.754 30.13 C ATOM 3279 NZ LYS B1161 −20.265 −22.285 −7.519 27.21 N ATOM 3280 C LYS B1161 −23.5 −21.856 −12.55 18.52 C ATOM 3281 O LYS B1161 −22.321 −21.926 −12.981 18.11 O ATOM 3282 N HIS B1162 −24.405 −22.857 −12.644 17.41 N ATOM 3283 CA HIS B1162 −24.078 −24.115 −13.34 16.48 C ATOM 3284 CB HIS B1162 −24.523 −25.36 −12.589 16.27 C ATOM 3285 CG HIS B1162 −23.83 −25.477 −11.266 16.91 C ATOM 3286 CD2 HIS B1162 −24.284 −25.341 −10.003 16.13 C ATOM 3287 ND1 HIS B1162 −22.46 −25.683 −11.166 17.49 N ATOM 3288 CE1 HIS B1162 −22.101 −25.672 −9.901 14.86 C ATOM 3289 NE2 HIS B1162 −23.179 −25.435 −9.173 20.15 N ATOM 3290 C HIS B1162 −24.306 −24.198 −14.829 15.43 C ATOM 3291 O HIS B1162 −23.91 −25.177 −15.453 16.77 O ATOM 3292 N GLY B1163 −24.847 −23.142 −15.4 14.23 N ATOM 3293 CA GLY B1163 −25.038 −23.084 −16.822 14.76 C ATOM 3294 C GLY B1163 −26.047 −24.096 −17.255 15.34 C ATOM 3295 O GLY B1163 −26.976 −24.428 −16.501 16.36 O ATOM 3296 N ASP B1164 −25.917 −24.588 −18.48 16.34 N ATOM 3297 CA ASP B1164 −26.945 −25.538 −18.957 18.41 C ATOM 3298 CB ASP B1164 −27.121 −25.598 −20.496 18.9 C ATOM 3299 CG ASP B1164 −25.891 −26.048 −21.199 21.41 C ATOM 3300 OD1 ASP B1164 −24.914 −25.301 −21.18 28.55 O ATOM 3301 OD2 ASP B1164 −25.853 −27.138 −21.785 29.67 O ATOM 3302 C ASP B1164 −26.682 −26.928 −18.37 17.3 C ATOM 3303 O ASP B1164 −25.566 −27.291 −18.054 16 O ATOM 3304 N LEU B1165 −27.774 −27.648 −18.211 17.7 N ATOM 3305 CA LEU B1165 −27.81 −28.965 −17.592 18.17 C ATOM 3306 CB LEU B1165 −29.266 −29.359 −17.491 17.68 C ATOM 3307 CG LEU B1165 −29.707 −30.465 −16.606 19.62 C ATOM 3308 CD1 LEU B1165 −29.32 −30.147 −15.204 16.24 C ATOM 3309 CD2 LEU B1165 −31.247 −30.479 −16.754 18.87 C ATOM 3310 C LEU B1165 −27.036 −29.93 −18.463 18.24 C ATOM 3311 O LEU B1165 −26.37 −30.857 −17.984 19.49 O ATOM 3312 O GLN B1166 −24.217 −31.36 −20.284 19.01 O ATOM 3313 N GLN B1166 −27.018 −29.582 −19.74 20 ATOM 3314 CA GLN B1166 −26.241 −30.315 −20.685 20 ATOM 3315 C GLN B1166 −24.776 −30.339 −20.427 20 ATOM 3316 CB GLN B1166 −26.63 −30.114 −22.143 20 ATOM 3317 CG GLN B1166 −26.508 −31.277 −22.946 20 ATOM 3318 CD GLN B1166 −25.18 −31.389 −23.537 20 ATOM 3319 OE1 GLN B1166 −24.559 −30.388 −23.785 20 ATOM 3320 NE2 GLN B1166 −24.739 −32.604 −23.846 20 ATOM 3321 N ASN B1167 −24.187 −29.18 −20.32 17.24 N ATOM 3322 CA ASN B1167 −22.791 −29.026 −20.108 16.95 C ATOM 3323 CB ASN B1167 −22.376 −27.567 −20.263 20.74 C ATOM 3324 CG ASN B1167 −22.142 −27.188 −21.735 27.08 C ATOM 3325 OD1 ASN B1167 −22.25 −26.022 −22.133 31.53 O ATOM 3326 ND2 ASN B1167 −21.845 −28.203 −22.554 33.46 N ATOM 3327 C ASN B1167 −22.438 −29.459 −18.73 15.8 C ATOM 3328 O ASN B1167 −21.324 −29.908 −18.491 15.55 O ATOM 3329 N PHE B1168 −23.407 −29.357 −17.815 13.95 N ATOM 3330 CA PHE B1168 −23.214 −29.806 −16.451 10.88 C ATOM 3331 CB PHE B1168 −24.361 −29.366 −15.595 11.09 C ATOM 3332 CG PHE B1168 −24.158 −29.635 −14.117 11.13 C ATOM 3333 CD1 PHE B1168 −23.363 −28.811 −13.353 10.57 C ATOM 3334 CD2 PHE B1168 −24.695 −30.78 −13.517 12.93 C ATOM 3335 CE1 PHE B1168 −23.163 −29.081 −11.984 10.74 C ATOM 3336 CE2 PHE B1168 −24.481 −31.042 −12.106 11.1 C ATOM 3337 CZ PHE B1168 −23.755 −30.167 −11.369 8.04 C ATOM 3338 C PHE B1168 −22.949 −31.297 −16.311 10.98 C ATOM 3339 O PHE B1168 −21.953 −31.673 −15.737 11.29 O ATOM 3340 N ILE B1169 −23.815 −32.144 −16.851 11.3 N ATOM 3341 CA ILE B1169 −23.729 −33.567 −16.649 12.11 C ATOM 3342 CB ILE B1169 −25.098 −34.24 −16.912 12.31 C ATOM 3343 CG2 ILE B1169 −26.225 −33.639 −16.073 10.67 C ATOM 3344 CG1 ILE B1169 −25.46 −34.188 −18.407 13.38 C ATOM 3345 CD1 ILE B1169 −26.855 −34.265 −18.702 10.53 C ATOM 3346 C ILE B1169 −22.594 −34.162 −17.527 15.08 C ATOM 3347 O ILE B1169 −22.133 −35.264 −17.321 15.78 O ATOM 3348 N ARG B1170 −22.087 −33.403 −18.478 18.02 N ATOM 3349 CA ARG B1170 −20.955 −33.871 −19.3 20.11 C ATOM 3350 CB ARG B1170 −20.93 −33.178 −20.633 20.14 C ATOM 3351 CG ARG B1170 −21.93 −33.631 −21.507 25.59 C ATOM 3352 CD ARG B1170 −21.717 −32.821 −22.713 37.19 C ATOM 3353 NE ARG B1170 −20.989 −33.521 −23.777 45.62 N ATOM 3354 CZ ARG B1170 −20.98 −34.84 −23.999 48.56 C ATOM 3355 NH1 ARG B1170 −21.656 −35.705 −23.257 49.01 N ATOM 3356 NH2 ARG B1170 −20.276 −35.287 −25.009 53.39 N ATOM 3357 C ARG B1170 −19.646 −33.526 −18.713 19.84 C ATOM 3358 O ARG B1170 −18.677 −34.145 −19.024 20.06 O ATOM 3359 N ASN B1171 −19.618 −32.485 −17.907 21.49 N ATOM 3360 CA ASN B1171 −18.43 −32.106 −17.182 22.67 C ATOM 3361 CB ASN B1171 −18.795 −30.932 −16.286 23.22 C ATOM 3362 CG ASN B1171 −17.572 −30.201 −15.733 23.88 C ATOM 3363 OD1 ASN B1171 −16.55 −30.813 −15.4 20.38 O ATOM 3364 ND2 ASN B1171 −17.694 −28.874 −15.624 20.34 N ATOM 3365 C ASN B1171 −17.885 −33.289 −16.354 24.16 C ATOM 3366 O ASN B1171 −18.536 −33.819 −15.452 22.97 O ATOM 3367 N GLU B1172 −16.678 −33.712 −16.71 26.75 N ATOM 3368 CA GLU B1172 −16.009 −34.843 −16.074 28.61 C ATOM 3369 CB GLU B1172 −14.887 −35.381 −16.95 29.06 C ATOM 3370 CG GLU B1172 −15.267 −35.539 −18.398 35.59 C ATOM 3371 CD GLU B1172 −14.865 −34.295 −19.239 43.46 C ATOM 3372 OE1 GLU B1172 −15.514 −33.222 −19.077 43.38 O ATOM 3373 OE2 GLU B1172 −13.887 −34.403 −20.063 47.72 O ATOM 3374 C GLU B1172 −15.483 −34.444 −14.708 27.92 C ATOM 3375 O GLU B1172 −15.003 −35.266 −13.956 29.83 O ATOM 3376 N THR B1173 −15.636 −33.183 −14.372 27.32 N ATOM 3377 CA THR B1173 −15.43 −32.68 −13.012 26.3 C ATOM 3378 CB THR B1173 −15.075 −31.202 −13.127 26.43 C ATOM 3379 OG1 THR B1173 −13.63 −31.125 −13.229 30.48 O ATOM 3380 CG2 THR B1173 −15.66 −30.328 −12.025 23.88 C ATOM 3381 C THR B1173 −16.558 −32.937 −11.996 24.95 C ATOM 3382 O THR B1173 −16.435 −32.607 −10.82 24.21 O ATOM 3383 N HIS B1174 −17.62 −33.571 −12.472 24.38 N ATOM 3384 CA HIS B1174 −18.893 −33.624 −11.786 25.17 C ATOM 3385 CB HIS B1174 −20.018 −32.862 −12.503 25.48 C ATOM 3386 CG HIS B1174 −19.887 −31.375 −12.444 29.5 C ATOM 3387 CD2 HIS B1174 −19.494 −30.546 −11.44 31.51 C ATOM 3388 ND1 HIS B1174 −20.152 −30.563 −13.535 33.78 N ATOM 3389 CE1 HIS B1174 −19.929 −29.297 −13.204 33.6 C ATOM 3390 NE2 HIS B1174 −19.518 −29.261 −11.942 33.57 N ATOM 3391 C HIS B1174 −19.237 −35.06 −11.806 24.6 C ATOM 3392 O HIS B1174 −19.048 −35.739 −12.822 25 O ATOM 3393 N ASN B1175 −19.709 −35.531 −10.662 23.47 N ATOM 3394 CA ASN B1175 −20.013 −36.93 −10.504 22.28 C ATOM 3395 CB ASN B1175 −18.961 −37.601 −9.664 20.86 C ATOM 3396 CG ASN B1175 −17.621 −37.656 −10.387 19.89 C ATOM 3397 OD1 ASN B1175 −17.519 −38.384 −11.343 22.05 O ATOM 3398 ND2 ASN B1175 −16.619 −36.852 −9.971 16.3 N ATOM 3399 C ASN B1175 −21.423 −37.021 −9.946 23.32 C ATOM 3400 O ASN B1175 −21.635 −37.437 −8.785 24.86 O ATOM 3401 N PRO B1176 −22.414 −36.616 −10.773 22.41 N ATOM 3402 CD PRO B1176 −22.338 −36.215 −12.177 22.32 C ATOM 3403 CA PRO B1176 −23.771 −36.663 −10.305 23.02 C ATOM 3404 CB PRO B1176 −24.534 −35.94 −11.415 22.38 C ATOM 3405 CG PRO B1176 −23.765 −36.251 −12.623 22.63 C ATOM 3406 C PRO B1176 −24.193 −38.161 −10.156 23.36 C ATOM 3407 O PRO B1176 −23.874 −38.971 −11.045 23.72 O ATOM 3408 N THR B1177 −24.891 −38.522 −9.066 22.41 N ATOM 3409 CA THR B1177 −25.329 −39.894 −8.913 22.82 C ATOM 3410 CB THR B1177 −25.906 −40.189 −7.496 23.27 C ATOM 3411 OG1 THR B1177 −26.923 −39.244 −7.205 25.75 O ATOM 3412 CG2 THR B1177 −24.846 −40.122 −6.402 24.8 C ATOM 3413 C THR B1177 −26.445 −40.103 −9.907 21.38 C ATOM 3414 O THR B1177 −27.015 −39.122 −10.377 22.43 O ATOM 3415 N VAL B1178 −26.814 −41.362 −10.162 20.22 N ATOM 3416 CA VAL B1178 −28.127 −41.672 −10.826 18.98 C ATOM 3417 CB VAL B1178 −28.384 −43.198 −10.992 18.34 C ATOM 3418 CG1 VAL B1178 −29.81 −43.489 −11.15 15.54 C ATOM 3419 CG2 VAL B1178 −27.665 −43.704 −12.223 21.1 C ATOM 3420 C VAL B1178 −29.339 −40.965 −10.181 17.51 C ATOM 3421 O VAL B1178 −30.123 −40.409 −10.878 18.57 O ATOM 3422 N LYS B1179 −29.475 −40.98 −8.856 17.04 N ATOM 3423 CA LYS B1179 −30.533 −40.228 −8.217 16.95 C ATOM 3424 CB LYS B1179 −30.434 −40.373 −6.733 17.15 C ATOM 3425 CG LYS B1179 −31.75 −40.037 −6.122 20.25 C ATOM 3426 CD LYS B1179 −31.633 −39.315 −4.835 21.96 C ATOM 3427 CE LYS B1179 −32.453 −40.04 −3.77 20.85 C ATOM 3428 NZ LYS B1179 −33.846 −39.761 −3.562 19.21 N ATOM 3429 C LYS B1179 −30.573 −38.71 −8.511 16.1 C ATOM 3430 O LYS B1179 −31.638 −38.131 −8.72 14.21 O ATOM 3431 N ASP B1180 −29.418 −38.055 −8.42 16.12 N ATOM 3432 CA ASP B1180 −29.33 −36.644 −8.707 16.31 C ATOM 3433 CB ASP B1180 −27.843 −36.248 −8.692 19.77 C ATOM 3434 CG ASP B1180 −27.216 −36.236 −7.291 22.65 C ATOM 3435 OD1 ASP B1180 −25.969 −36.124 −7.281 24.69 O ATOM 3436 OD2 ASP B1180 −27.935 −36.383 −6.262 27.87 O ATOM 3437 C ASP B1180 −29.828 −36.325 −10.131 14.91 C ATOM 3438 O ASP B1180 −30.496 −35.363 −10.344 13.63 O ATOM 3439 N LEU B1181 −29.413 −37.128 −11.104 13.93 N ATOM 3440 CA LEU B1181 −29.865 −36.965 −12.49 13.81 C ATOM 3441 CB LEU B1181 −29.123 −37.972 −13.366 13.28 C ATOM 3442 CG LEU B1181 −27.901 −37.653 −14.197 9.73 C ATOM 3443 CD1 LEU B1181 −27.341 −36.303 −14.092 9.56 C ATOM 3444 CD2 LEU B1181 −26.891 −38.75 −13.897 10.5 C ATOM 3445 C LEU B1181 −31.377 −37.123 −12.681 13.36 C ATOM 3446 O LEU B1181 −32.047 −36.419 −13.479 14.36 O ATOM 3447 N ILE B1182 −31.922 −38.037 −11.915 13.26 N ATOM 3448 CA ILE B1182 −33.364 −38.243 −11.922 14.38 C ATOM 3449 CB ILE B1182 −33.811 −39.543 −11.232 14.16 C ATOM 3450 CG2 ILE B1182 −35.3 −39.644 −11.367 14.28 C ATOM 3451 CG1 ILE B1182 −33.124 −40.796 −11.852 16.35 C ATOM 3452 CD1 ILE B1182 −33.51 −42.162 −11.15 13.84 C ATOM 3453 C ILE B1182 −34.013 −37.034 −11.248 12.99 C ATOM 3454 O ILE B1182 −35.112 −36.592 −11.651 13.57 O ATOM 3455 N GLY B1183 −33.296 −36.464 −10.297 11.14 N ATOM 3456 CA GLY B1183 −33.788 −35.294 −9.552 11.95 C ATOM 3457 C GLY B1183 −33.881 −34.082 −10.45 11.52 C ATOM 3458 O GLY B1183 −34.842 −33.342 −10.372 12.52 O ATOM 3459 N PHE B1184 −32.878 −33.895 −11.321 11.73 N ATOM 3460 CA PHE B1184 −32.913 −32.822 −12.365 11.3 C ATOM 3461 CB PHE B1184 −31.571 −32.746 −13.138 10.96 C ATOM 3462 CG PHE B1184 −30.39 −32.459 −12.273 11.49 C ATOM 3463 CD1 PHE B1184 −30.525 −31.643 −11.109 13.87 C ATOM 3464 CD2 PHE B1184 −29.157 −32.957 −12.595 11.09 C ATOM 3465 CE1 PHE B1184 −29.436 −31.36 −10.293 9.36 C ATOM 3466 CE2 PHE B1184 −28.055 −32.649 −11.827 13.76 C ATOM 3467 CZ PHE B1184 −28.201 −31.849 −10.646 13.97 C ATOM 3468 C PHE B1184 −34.078 −33.017 −13.34 10.31 C ATOM 3469 O PHE B1184 −34.762 −32.09 −13.67 9.73 O ATOM 3470 N GLY B1185 −34.284 −34.259 −13.786 11.17 N ATOM 3471 CA GLY B1185 −35.405 −34.585 −14.702 10.09 C ATOM 3472 C GLY B1185 −36.727 −34.315 −14.063 9.24 C ATOM 3473 O GLY B1185 −37.591 −33.763 −14.709 10.87 O ATOM 3474 N LEU B1186 −36.874 −34.646 −12.779 8.52 N ATOM 3475 CA LEU B1186 −38.075 −34.268 −11.99 7.28 C ATOM 3476 CB LEU B1186 −38.072 −34.915 −10.56 6.85 C ATOM 3477 CG LEU B1186 −39.207 −34.583 −9.582 5.42 C ATOM 3478 CD1 LEU B1186 −40.59 −34.846 −10.16 2 C ATOM 3479 CD2 LEU B1186 −38.918 −35.353 −8.286 3.95 C ATOM 3480 C LEU B1186 −38.308 −32.767 −11.899 8.57 C ATOM 3481 O LEU B1186 −39.442 −32.313 −12.096 12.45 O ATOM 3482 N GLN B1187 −37.292 −31.971 −11.621 8.71 N ATOM 3483 CA GLN B1187 −37.472 −30.518 −11.66 10.1 C ATOM 3484 CB GLN B1187 −36.18 −29.843 −11.25 11.08 C ATOM 3485 CG GLN B1187 −35.743 −30.165 −9.871 11.17 C ATOM 3486 CD GLN B1187 −34.601 −29.239 −9.455 13.84 C ATOM 3487 OE1 GLN B1187 −34.721 −28.008 −9.538 14.08 O ATOM 3488 NE2 GLN B1187 −33.476 −29.829 −9.045 15.84 N ATOM 3489 C GLN B1187 −37.887 −29.991 −13.027 9.54 C ATOM 3490 O GLN B1187 −38.666 −29.035 −13.151 11.12 O ATOM 3491 N VAL B1188 −37.347 −30.555 −14.079 7.7 N ATOM 3492 CA VAL B1188 −37.784 −30.081 −15.428 7.36 C ATOM 3493 CB VAL B1188 −36.91 −30.734 −16.527 6.86 C ATOM 3494 CG1 VAL B1188 −37.338 −30.385 −17.939 3.33 C ATOM 3495 CG2 VAL B1188 −35.458 −30.404 −16.278 2 C ATOM 3496 C VAL B1188 −39.245 −30.414 −15.687 8.4 C ATOM 3497 O VAL B1188 −39.952 −29.679 −16.346 9.43 O ATOM 3498 N ALA B1189 −39.704 −31.547 −15.173 9.65 N ATOM 3499 CA ALA B1189 −41.041 −31.997 −15.446 9.84 C ATOM 3500 CB ALA B1189 −41.181 −33.479 −15.04 9.75 C ATOM 3501 C ALA B1189 −41.986 −31.113 −14.676 10.41 C ATOM 3502 O ALA B1189 −43.117 −30.837 −15.14 11.55 O ATOM 3503 N LYS B1190 −41.51 −30.588 −13.543 10.99 N ATOM 3504 CA LYS B1190 −42.341 −29.679 −12.721 12.28 C ATOM 3505 CB LYS B1190 −41.775 −29.502 −11.359 12.77 C ATOM 3506 CG LYS B1190 −41.7 −30.717 −10.574 12.61 C ATOM 3507 CD LYS B1190 −41.08 −30.362 −9.251 15.08 C ATOM 3508 CE LYS B1190 −41.464 −31.401 −8.288 19.04 C ATOM 3509 NZ LYS B1190 −40.942 −30.924 −6.946 25.19 N ATOM 3510 C LYS B1190 −42.506 −28.293 −13.3 11.94 C ATOM 3511 O LYS B1190 −43.611 −27.659 −13.176 14.36 O ATOM 3512 N GLY B1191 −41.439 −27.806 −13.918 10.85 N ATOM 3513 CA GLY B1191 −41.463 −26.55 −14.72 8.71 C ATOM 3514 C GLY B1191 −42.34 −26.777 −15.935 8 C ATOM 3515 O GLY B1191 −43.19 −25.951 −16.236 8.54 O ATOM 3516 N MET B1192 −42.205 −27.936 −16.602 7.97 N ATOM 3517 CA MET B1192 −42.971 −28.222 −17.854 8.25 C ATOM 3518 CB MET B1192 −42.501 −29.543 −18.507 8.8 C ATOM 3519 CG MET B1192 −41.361 −29.451 −19.436 11.12 C ATOM 3520 SD MET B1192 −41.314 −27.838 −20.283 18 S ATOM 3521 CE MET B1192 −42.181 −27.995 −21.823 11.46 C ATOM 3522 C MET B1192 −44.437 −28.371 −17.563 7.29 C ATOM 3523 O MET B1192 −45.335 −27.941 −18.337 7.17 O ATOM 3524 N LYS B1193 −44.691 −29.027 −16.451 7.48 N ATOM 3525 CA LYS B1193 −46.097 −29.193 −15.988 9.21 C ATOM 3526 CB LYS B1193 −46.127 −30.004 −14.713 7.62 C ATOM 3527 CG LYS B1193 −47.429 −30.099 −14.098 7.45 C ATOM 3528 CD LYS B1193 −47.198 −30.498 −12.681 10.42 C ATOM 3529 CE LYS B1193 −48.442 −30.778 −12.021 14.83 C ATOM 3530 NZ LYS B1193 −48.088 −30.966 −10.58 22.35 N ATOM 3531 C LYS B1193 −46.75 −27.808 −15.773 8.79 C ATOM 3532 O LYS B1193 −47.911 −27.589 −16.18 9.23 O ATOM 3533 N TYR B1194 −45.974 −26.879 −15.186 9.48 N ATOM 3534 CA TYR B1194 −46.435 −25.503 −15.04 10.02 C ATOM 3535 CB TYR B1194 −45.485 −24.704 −14.143 10.13 C ATOM 3536 CG TYR B1194 −45.798 −23.213 −14.084 9.08 C ATOM 3537 CD1 TYR B1194 −46.675 −22.706 −13.116 7.43 C ATOM 3538 CE1 TYR B1194 −46.958 −21.357 −13.076 9.59 C ATOM 3539 CD2 TYR B1194 −45.186 −22.323 −14.971 5.88 C ATOM 3540 CE2 TYR B1194 −45.424 −20.998 −14.942 7.13 C ATOM 3541 CZ TYR B1194 −46.329 −20.48 −14.019 12.26 C ATOM 3542 OH TYR B1194 −46.625 −19.107 −14.038 11.64 O ATOM 3543 C TYR B1194 −46.645 −24.811 −16.41 10.44 C ATOM 3544 O TYR B1194 −47.777 −24.356 −16.745 11.5 O ATOM 3545 N LEU B1195 −45.606 −24.771 −17.235 9.91 N ATOM 3546 CA LEU B1195 −45.724 −24.136 −18.545 10.18 C ATOM 3547 CB LEU B1195 −44.469 −24.386 −19.357 11.31 C ATOM 3548 CG LEU B1195 −43.235 −23.478 −19.274 8.14 C ATOM 3549 CD1 LEU B1195 −43.559 −22.302 −18.412 11.05 C ATOM 3550 CD2 LEU B1195 −42.091 −24.231 −18.759 11.77 C ATOM 3551 C LEU B1195 −46.878 −24.77 −19.256 12.15 C ATOM 3552 O LEU B1195 −47.733 −24.094 −19.829 12.53 O ATOM 3553 N ALA B1196 −46.971 −26.096 −19.173 12.77 N ATOM 3554 CA ALA B1196 −48.058 −26.765 −19.89 13.11 C ATOM 3555 CB ALA B1196 −47.874 −28.244 −19.778 14.13 C ATOM 3556 C ALA B1196 −49.452 −26.395 −19.441 13.63 C ATOM 3557 O ALA B1196 −50.383 −26.608 −20.204 15.78 O ATOM 3558 N SER B1197 −49.639 −25.911 −18.196 14.48 N ATOM 3559 CA SER B1197 −50.99 −25.572 −17.664 12.95 C ATOM 3560 CB SER B1197 −51.017 −25.758 −16.192 12.98 C ATOM 3561 OG SER B1197 −50.055 −24.902 −15.565 17.5 O ATOM 3562 C SER B1197 −51.308 −24.121 −18.035 12.58 C ATOM 3563 O SER B1197 −52.442 −23.652 −17.985 12.68 O ATOM 3564 N LYS B1198 −50.286 −23.398 −18.441 13.13 N ATOM 3565 CA LYS B1198 −50.489 −22.056 −18.999 13.05 C ATOM 3566 CB LYS B1198 −49.29 −21.187 −18.707 12.52 C ATOM 3567 CG LYS B1198 −48.959 −21.126 −17.249 12.04 C ATOM 3568 CD LYS B1198 −50.273 −20.967 −16.457 13.08 C ATOM 3569 CE LYS B1198 −49.936 −21.012 −14.985 17.36 C ATOM 3570 NZ LYS B1198 −51.129 −20.589 −14.245 21.98 N ATOM 3571 C LYS B1198 −50.649 −22.161 −20.484 13.41 C ATOM 3572 O LYS B1198 −50.651 −21.132 −21.155 13.33 O ATOM 3573 N LYS B1199 −50.755 −23.418 −20.98 13.76 N ATOM 3574 CA LYS B1199 −50.809 −23.725 −22.414 14.88 C ATOM 3575 CB LYS B1199 −52.085 −23.141 −23.005 14.84 C ATOM 3576 CG LYS B1199 −53.317 −23.86 −22.454 21.78 C ATOM 3577 CD LYS B1199 −54.523 −22.873 −22.192 33.81 C ATOM 3578 CE LYS B1199 −55.034 −22.06 −23.489 35.48 C ATOM 3579 NZ LYS B1199 −55.173 −22.933 −24.757 39.92 N ATOM 3580 C LYS B1199 −49.553 −23.275 −23.214 14.93 C ATOM 3581 O LYS B1199 −49.62 −22.835 −24.357 14.95 O ATOM 3582 N PHE B1200 −48.393 −23.358 −22.585 14.67 N ATOM 3583 CA PHE B1200 −47.225 −22.929 −23.253 14.24 C ATOM 3584 CB PHE B1200 −46.337 −22.153 −22.308 12.15 C ATOM 3585 CG PHE B1200 −45.039 −21.734 −22.94 11.68 C ATOM 3586 CD1 PHE B1200 −43.852 −22.502 −22.753 12.56 C ATOM 3587 CD2 PHE B1200 −44.986 −20.629 −23.723 7.4 C ATOM 3588 CE1 PHE B1200 −42.662 −22.101 −23.342 11.48 C ATOM 3589 CE2 PHE B1200 −43.803 −20.209 −24.297 10.2 C ATOM 3590 CZ PHE B1200 −42.657 −20.938 −24.138 10.48 C ATOM 3591 C PHE B1200 −46.522 −24.127 −23.913 14.52 C ATOM 3592 O PHE B1200 −46.239 −25.117 −23.274 14.04 O ATOM 3593 N VAL B1201 −46.278 −24.026 −25.212 15.61 N ATOM 3594 CA VAL B1201 −45.552 −25.077 −25.937 16.14 C ATOM 3595 CB VAL B1201 −46.223 −25.368 −27.276 16.14 C ATOM 3596 CG1 VAL B1201 −45.37 −26.28 −28.169 14.77 C ATOM 3597 CG2 VAL B1201 −47.68 −25.93 −27.046 16.33 C ATOM 3598 C VAL B1201 −44.093 −24.6 −26.108 16.79 C ATOM 3599 O VAL B1201 −43.794 −23.635 −26.791 17.87 O ATOM 3600 N HIS B1202 −43.185 −25.274 −25.451 15.99 N ATOM 3601 CA HIS B1202 −41.85 −24.848 −25.49 17.06 C ATOM 3602 CB HIS B1202 −41.108 −25.639 −24.44 16.49 C ATOM 3603 CG HIS B1202 −39.733 −25.142 −24.188 15.87 C ATOM 3604 CD2 HIS B1202 −39.216 −24.479 −23.131 13.61 C ATOM 3605 ND1 HIS B1202 −38.697 −25.338 −25.084 16.33 N ATOM 3606 CE1 HIS B1202 −37.596 −24.822 −24.575 15.98 C ATOM 3607 NE2 HIS B1202 −37.887 −24.287 −23.392 16.78 N ATOM 3608 C HIS B1202 −41.223 −25.044 −26.903 18.23 C ATOM 3609 O HIS B1202 −40.688 −24.086 −27.441 18.63 O ATOM 3610 N ARG B1203 −41.276 −26.276 −27.479 19.01 N ATOM 3611 CA ARG B1203 −40.731 −26.604 −28.854 18.59 C ATOM 3612 CB ARG B1203 −41.156 −25.584 −29.948 17.85 C ATOM 3613 CG ARG B1203 −42.573 −25.201 −29.778 22.3 C ATOM 3614 CD ARG B1203 −42.853 −23.874 −30.255 27.82 C ATOM 3615 NE ARG B1203 −42.669 −23.825 −31.688 36.07 N ATOM 3616 CZ ARG B1203 −43.656 −23.621 −32.572 35.92 C ATOM 3617 NH1 ARG B1203 −44.903 −23.457 −32.111 34.73 N ATOM 3618 NH2 ARG B1203 −43.375 −23.574 −33.901 31.08 N ATOM 3619 C ARG B1203 −39.217 −26.786 −28.933 17.32 C ATOM 3620 O ARG B1203 −38.669 −26.981 −30.009 16.84 O ATOM 3621 N ASP B1204 −38.537 −26.693 −27.819 16.22 N ATOM 3622 CA ASP B1204 −37.087 −26.9 −27.88 15.93 C ATOM 3623 CB ASP B1204 −36.399 −25.605 −28.307 14.57 C ATOM 3624 CG ASP B1204 −34.994 −25.832 −28.815 19.07 C ATOM 3625 OD1 ASP B1204 −34.264 −24.803 −28.903 18.92 O ATOM 3626 OD2 ASP B1204 −34.581 −27.029 −29.074 21.21 O ATOM 3627 C ASP B1204 −36.575 −27.412 −26.517 14.81 C ATOM 3628 O ASP B1204 −35.502 −27.041 −26.05 15.16 O ATOM 3629 N LEU B1205 −37.383 −28.239 −25.875 13.6 N ATOM 3630 CA LEU B1205 −37.041 −28.817 −24.611 13.38 C ATOM 3631 CB LEU B1205 −38.261 −29.547 −24.046 11.84 C ATOM 3632 CG LEU B1205 −38.072 −30.052 −22.634 10.06 C ATOM 3633 CD1 LEU B1205 −37.692 −28.865 −21.634 7.06 C ATOM 3634 CD2 LEU B1205 −39.28 −30.784 −22.242 7.43 C ATOM 3635 C LEU B1205 −35.89 −29.815 −24.833 14.11 C ATOM 3636 O LEU B1205 −36.033 −30.718 −25.665 15.58 O ATOM 3637 N ALA B1206 −34.783 −29.619 −24.1 11.95 N ATOM 3638 CA ALA B1206 −33.535 −30.33 −24.23 10.68 C ATOM 3639 CB ALA B1206 −32.831 −30.034 −25.596 12.55 C ATOM 3640 C ALA B1206 −32.67 −29.834 −23.122 8.83 C ATOM 3641 O ALA B1206 −32.888 −28.723 −22.579 8.67 O ATOM 3642 N ALA B1207 −31.68 −30.636 −22.748 7.74 N ATOM 3643 CA ALA B1207 −30.893 −30.32 −21.534 6.84 C ATOM 3644 CB ALA B1207 −29.986 −31.448 −21.186 7.04 C ATOM 3645 C ALA B1207 −30.145 −29.037 −21.756 6.97 C ATOM 3646 O ALA B1207 −29.853 −28.316 −20.814 7.07 O ATOM 3647 N ARG B1208 −29.857 −28.723 −23.021 8.48 N ATOM 3648 CA ARG B1208 −29.105 −27.484 −23.376 10.48 C ATOM 3649 CB ARG B1208 −28.612 −27.459 −24.831 10.31 C ATOM 3650 CG ARG B1208 −29.687 −27.862 −25.863 11.12 C ATOM 3651 CD ARG B1208 −29.252 −27.63 −27.365 8.82 C ATOM 3652 NE ARG B1208 −30.465 −27.73 −28.2 13.09 N ATOM 3653 CZ ARG B1208 −31.072 −28.876 −28.53 11.69 C ATOM 3654 NH1 ARG B1208 −30.58 −30.006 −28.144 16.97 N ATOM 3655 NH2 ARG B1208 −32.179 −28.902 −29.258 16.72 N ATOM 3656 C ARG B1208 −29.912 −26.26 −23.043 11.65 C ATOM 3657 O ARG B1208 −29.374 −25.15 −22.889 12.53 O ATOM 3658 N ASN B1209 −31.213 −26.477 −22.842 13.13 N ATOM 3659 CA ASN B1209 −32.14 −25.374 −22.622 12.9 C ATOM 3660 CB ASN B1209 −33.281 −25.547 −23.589 12.61 C ATOM 3661 CG ASN B1209 −32.907 −25.053 −24.946 14.64 C ATOM 3662 OD1 ASN B1209 −32.141 −24.081 −25.051 14.89 O ATOM 3663 ND2 ASN B1209 −33.363 −25.722 −25.976 14.02 N ATOM 3664 C ASN B1209 −32.641 −25.213 −21.198 13.91 C ATOM 3665 O ASN B1209 −33.525 −24.39 −20.955 16.03 O ATOM 3666 N CYS B1210 −32.125 −26.041 −20.284 13.09 N ATOM 3667 CA CYS B1210 −32.375 −25.967 −18.881 11.8 C ATOM 3668 CB CYS B1210 −32.63 −27.335 −18.338 12.69 C ATOM 3669 SG CYS B1210 −34.022 −28.189 −19.054 17.53 S ATOM 3670 C CYS B1210 −31.137 −25.492 −18.22 11.23 C ATOM 3671 O CYS B1210 −30.016 −26.019 −18.489 11.67 O ATOM 3672 N MET B1211 −31.34 −24.527 −17.333 10.14 N ATOM 3673 CA MET B1211 −30.242 −23.886 −16.565 10.47 C ATOM 3674 CB MET B1211 −30.323 −22.352 −16.588 9.5 C ATOM 3675 CG MET B1211 −30.138 −21.749 −18.03 11.4 C ATOM 3676 SD MET B1211 −28.622 −22.258 −18.911 15.66 S ATOM 3677 CE MET B1211 −29.284 −22.438 −20.557 15.6 C ATOM 3678 C MET B1211 −30.211 −24.387 −15.127 11.73 C ATOM 3679 O MET B1211 −31.275 −24.724 −14.552 12.17 O ATOM 3680 N LEU B1212 −29 −24.496 −14.577 12.21 N ATOM 3681 CA LEU B1212 −28.819 −24.898 −13.23 13.72 C ATOM 3682 CB LEU B1212 −27.911 −26.104 −13.209 15.2 C ATOM 3683 CG LEU B1212 −28.199 −27.458 −12.58 14.9 C ATOM 3684 CD1 LEU B1212 −26.877 −27.911 −12.068 19.56 C ATOM 3685 CD2 LEU B1212 −29.154 −27.446 −11.458 18.72 C ATOM 3686 C LEU B1212 −28.209 −23.774 −12.394 15.72 C ATOM 3687 O LEU B1212 −27.178 −23.229 −12.73 14.42 O ATOM 3688 N ASP B1213 −28.835 −23.439 −11.272 17.77 N ATOM 3689 CA ASP B1213 −28.276 −22.395 −10.489 19.65 C ATOM 3690 CB ASP B1213 −29.353 −21.455 −9.98 21.08 C ATOM 3691 CG ASP B1213 −30.28 −22.092 −8.886 26.99 C ATOM 3692 OD1 ASP B1213 −29.903 −23.095 −8.188 30.93 O ATOM 3693 OD2 ASP B1213 −31.406 −21.543 −8.717 30.83 O ATOM 3694 C ASP B1213 −27.46 −22.962 −9.377 20.76 C ATOM 3695 O ASP B1213 −27.306 −24.167 −9.271 20.15 O ATOM 3696 N GLU B1214 −26.976 −22.073 −8.511 23.75 N ATOM 3697 CA GLU B1214 −25.965 −22.404 −7.491 25.83 C ATOM 3698 CB GLU B1214 −25.358 −21.152 −6.856 25.58 C ATOM 3699 CG GLU B1214 −25.832 −20.942 −5.458 33.06 C ATOM 3700 CD GLU B1214 −26.949 −19.858 −5.364 42.46 C ATOM 3701 OE1 GLU B1214 −27.904 −19.886 −6.208 40.39 O ATOM 3702 OE2 GLU B1214 −26.834 −18.969 −4.437 46.68 O ATOM 3703 C GLU B1214 −26.478 −23.378 −6.427 25.29 C ATOM 3704 O GLU B1214 −25.668 −24.107 −5.833 26.69 O ATOM 3705 N LYS B1215 −27.791 −23.455 −6.219 24.02 N ATOM 3706 CA LYS B1215 −28.295 −24.503 −5.337 23.76 C ATOM 3707 CB LYS B1215 −29.237 −23.983 −4.278 24.17 C ATOM 3708 CG LYS B1215 −30.271 −23.059 −4.778 28.88 C ATOM 3709 CD LYS B1215 −29.893 −21.669 −4.214 37.25 C ATOM 3710 CE LYS B1215 −29.192 −21.827 −2.79 40.05 C ATOM 3711 NZ LYS B1215 −30.165 −22.103 −1.649 40.23 N ATOM 3712 C LYS B1215 −28.935 −25.684 −6.053 22.81 C ATOM 3713 O LYS B1215 −29.587 −26.555 −5.397 21.67 O ATOM 3714 N PHE B1216 −28.742 −25.725 −7.378 19.98 N ATOM 3715 CA PHE B1216 −29.093 −26.908 −8.121 19.25 C ATOM 3716 CB PHE B1216 −28.596 −28.213 −7.422 18.9 C ATOM 3717 CG PHE B1216 −27.111 −28.264 −7.317 17.96 C ATOM 3718 CD1 PHE B1216 −26.472 −27.984 −6.089 22.08 C ATOM 3719 CD2 PHE B1216 −26.341 −28.452 −8.451 15.15 C ATOM 3720 CE1 PHE B1216 −25.082 −27.968 −5.993 22.25 C ATOM 3721 CE2 PHE B1216 −24.969 −28.436 −8.389 16.63 C ATOM 3722 CZ PHE B1216 −24.317 −28.182 −7.178 20.9 C ATOM 3723 C PHE B1216 −30.579 −26.93 −8.405 18.18 C ATOM 3724 O PHE B1216 −31.197 −28.017 −8.558 17.35 O ATOM 3725 N THR B1217 −31.133 −25.72 −8.503 16.24 N ATOM 3726 CA THR B1217 −32.471 −25.614 −9.048 15.6 C ATOM 3727 CB THR B1217 −33.189 −24.352 −8.566 15.47 C ATOM 3728 OG1 THR B1217 −33.024 −24.2 −7.158 18.4 O ATOM 3729 CG2 THR B1217 −34.651 −24.371 −8.888 13.83 C ATOM 3730 C THR B1217 −32.262 −25.557 −10.554 14.84 C ATOM 3731 O THR B1217 −31.423 −24.774 −11.038 14.57 O ATOM 3732 N VAL B1218 −33.01 −26.395 −11.268 14.15 N ATOM 3733 CA VAL B1218 −33.018 −26.406 −12.706 12.77 C ATOM 3734 CB VAL B1218 −33.159 −27.874 −13.298 13.49 C ATOM 3735 CG1 VAL B1218 −33.104 −27.847 −14.83 9.57 C ATOM 3736 CG2 VAL B1218 −32.179 −28.925 −12.674 7.77 C ATOM 3737 C VAL B1218 −34.221 −25.557 −13.152 13.52 C ATOM 3738 O VAL B1218 −35.325 −25.715 −12.656 13.44 O ATOM 3739 N LYS B1219 −34.008 −24.668 −14.112 13.6 N ATOM 3740 CA LYS B1219 −35.076 −23.906 −14.656 13.99 C ATOM 3741 CB LYS B1219 −34.912 −22.43 −14.337 13.77 C ATOM 3742 CG LYS B1219 −34.736 −22.145 −12.842 15.83 C ATOM 3743 CD LYS B1219 −34.667 −20.645 −12.534 17.05 C ATOM 3744 CE LYS B1219 −34.331 −20.44 −11.093 19.12 C ATOM 3745 NZ LYS B1219 −35.386 −20.985 −10.223 12.71 N ATOM 3746 C LYS B1219 −35.093 −24.089 −16.135 13.43 C ATOM 3747 O LYS B1219 −34.081 −23.949 −16.788 14.83 O ATOM 3748 N VAL B1220 −36.266 −24.392 −16.652 13.41 N ATOM 3749 CA VAL B1220 −36.505 −24.466 −18.075 14.22 C ATOM 3750 CB VAL B1220 −37.875 −25.175 −18.41 13.64 C ATOM 3751 CG1 VAL B1220 −38.048 −25.272 −19.877 8.54 C ATOM 3752 CG2 VAL B1220 −37.865 −26.569 −17.79 14.53 C ATOM 3753 C VAL B1220 −36.449 −23.09 −18.686 14.19 C ATOM 3754 O VAL B1220 −37.167 −22.162 −18.266 14.96 O ATOM 3755 N ALA B1221 −35.561 −22.963 −19.636 13.87 N ATOM 3756 CA ALA B1221 −35.328 −21.717 −20.301 15.19 C ATOM 3757 CB ALA B1221 −33.785 −21.418 −20.29 15.26 C ATOM 3758 C ALA B1221 −35.897 −21.712 −21.722 16.2 C ATOM 3759 O ALA B1221 −35.991 −22.79 −22.392 17.52 O ATOM 3760 O ASP B1222 −36.185 −18.2 −23.979 22.75 O ATOM 3761 N ASP B1222 −36.322 −20.808 −22.202 20 ATOM 3762 CA ASP B1222 −36.839 −20.404 −23.504 20 ATOM 3763 C ASP B1222 −35.94 −19.354 −24.15 20 ATOM 3764 CB ASP B1222 −38.265 −19.865 −23.371 20 ATOM 3765 CG ASP B1222 −38.851 −19.436 −24.701 20 ATOM 3766 OD1 ASP B1222 −38.859 −20.258 −25.641 20 ATOM 3767 OD2 ASP B1222 −39.327 −18.297 −24.9 20 ATOM 3768 N PHE B1223 −34.78 −19.366 −24.725 23.53 N ATOM 3769 CA PHE B1223 −33.976 −18.324 −25.306 24.64 C ATOM 3770 CB PHE B1223 −32.475 −18.638 −25.161 24.08 C ATOM 3771 CG PHE B1223 −31.998 −18.609 −23.729 21.07 C ATOM 3772 CD1 PHE B1223 −31.895 −17.386 −23.043 18.95 C ATOM 3773 CD2 PHE B1223 −31.693 −19.817 −23.064 21.87 C ATOM 3774 CE1 PHE B1223 −31.484 −17.347 −21.715 19.02 C ATOM 3775 CE2 PHE B1223 −31.278 −19.813 −21.75 22.36 C ATOM 3776 CZ PHE B1223 −31.168 −18.553 −21.058 20.58 C ATOM 3777 C PHE B1223 −34.433 −18.023 −26.752 25.93 C ATOM 3778 O PHE B1223 −35.098 −17.003 −26.979 28.12 O ATOM 3779 N GLY B1224 −34.139 −18.899 −27.696 26.17 N ATOM 3780 CA GLY B1224 −34.669 −18.762 −29.081 26.43 C ATOM 3781 C GLY B1224 −34.263 −17.432 −29.737 25.34 C ATOM 3782 O GLY B1224 −33.489 −17.382 −30.665 26.25 O ATOM 3783 N LEU B1225 −34.786 −16.339 −29.259 24.71 N ATOM 3784 CA LEU B1225 −34.479 −15.087 −29.874 24.72 C ATOM 3785 CB LEU B1225 −35.596 −14.08 −29.58 26.46 C ATOM 3786 CG LEU B1225 −35.598 −12.769 −30.422 27.12 C ATOM 3787 CD1 LEU B1225 −35.356 −12.934 −31.951 23.65 C ATOM 3788 CD2 LEU B1225 −36.986 −12.146 −30.112 29.78 C ATOM 3789 C LEU B1225 −33.148 −14.542 −29.381 22.87 C ATOM 3790 O LEU B1225 −32.485 −13.767 −30.09 22.83 O ATOM 3791 N ALA B1226 −32.77 −14.953 −28.178 20.34 N ATOM 3792 CA ALA B1226 −31.498 −14.569 −27.602 19.02 C ATOM 3793 CB ALA B1226 −31.531 −14.727 −26.109 17.46 C ATOM 3794 C ALA B1226 −30.378 −15.378 −28.218 19.07 C ATOM 3795 O ALA B1226 −29.225 −15.02 −28.061 20.39 O ATOM 3796 N ARG B1227 −30.703 −16.45 −28.964 18.81 N ATOM 3797 CA ARG B1227 −29.694 −17.22 −29.655 18.06 C ATOM 3798 CB ARG B1227 −30.088 −18.681 −29.784 18.31 C ATOM 3799 CG ARG B1227 −29.835 −19.543 −28.561 17.06 C ATOM 3800 CD ARG B1227 −30.517 −20.942 −28.639 18.88 C ATOM 3801 NE ARG B1227 −30.674 −21.617 −27.318 20.95 N ATOM 3802 CZ ARG B1227 −29.662 −22.079 −26.576 19.76 C ATOM 3803 NH1 ARG B1227 −28.432 −21.986 −27.052 18.11 N ATOM 3804 NH2 ARG B1227 −29.864 −22.635 −25.366 17.86 N ATOM 3805 C ARG B1227 −29.386 −16.612 −31.009 18.92 C ATOM 3806 O ARG B1227 −30.151 −16.787 −31.98 20.81 O ATOM 3807 N ASP B1228 −28.265 −15.897 −31.089 18.42 N ATOM 3808 CA ASP B1228 −27.778 −15.365 −32.373 19.28 C ATOM 3809 CB ASP B1228 −26.42 −14.667 −32.241 19.39 C ATOM 3810 CG ASP B1228 −26.49 −13.339 −31.488 19.96 C ATOM 3811 OD1 ASP B1228 −27.59 −12.824 −31.102 21.82 O ATOM 3812 OD2 ASP B1228 −25.385 −12.84 −31.234 19.46 O ATOM 3813 C ASP B1228 −27.707 −16.324 −33.54 19.83 C ATOM 3814 O ASP B1228 −28.274 −16.027 −34.579 19.82 O ATOM 3815 N MET B1229 −26.956 −17.419 −33.38 22.04 N ATOM 3816 CA MET B1229 −27.017 −18.611 −34.222 24.36 C ATOM 3817 CB MET B1229 −25.71 −18.746 −34.988 23.85 C ATOM 3818 CG MET B1229 −25.502 −17.629 −35.865 25.1 C ATOM 3819 SD MET B1229 −23.917 −17.588 −36.672 29.2 S ATOM 3820 CE MET B1229 −22.717 −18.577 −35.636 32.72 C ATOM 3821 C MET B1229 −27.217 −19.932 −33.479 25.51 C ATOM 3822 O MET B1229 −27.127 −19.978 −32.257 24 O ATOM 3823 N TYR B1230 −27.46 −21.001 −34.261 29.08 N ATOM 3824 CA TYR B1230 −27.471 −22.413 −33.826 34.08 C ATOM 3825 CB TYR B1230 −28.893 −22.891 −33.966 34.58 C ATOM 3826 CG TYR B1230 −29.933 −21.946 −33.4 35.75 C ATOM 3827 CD1 TYR B1230 −30.167 −20.688 −33.993 40.7 C ATOM 3828 CE1 TYR B1230 −31.112 −19.783 −33.488 37.49 C ATOM 3829 CD2 TYR B1230 −30.716 −22.305 −32.318 35.53 C ATOM 3830 CE2 TYR B1230 −31.691 −21.421 −31.826 36.77 C ATOM 3831 CZ TYR B1230 −31.857 −20.169 −32.419 37.26 C ATOM 3832 OH TYR B1230 −32.784 −19.289 −31.938 39.37 O ATOM 3833 C TYR B1230 −26.584 −23.265 −34.755 35.95 C ATOM 3834 O TYR B1230 −26.276 −22.825 −35.864 36.53 O ATOM 3835 N ASP B1231 −26.162 −24.491 −34.382 39.69 N ATOM 3836 CA ASP B1231 −25.538 −25.425 −35.463 41.03 C ATOM 3837 CB ASP B1231 −23.995 −25.454 −35.35 42.61 C ATOM 3838 CG ASP B1231 −23.553 −26.179 −34.024 46.08 C ATOM 3839 OD1 ASP B1231 −22.866 −27.237 −34.085 44.26 O ATOM 3840 OD2 ASP B1231 −23.991 −25.72 −32.92 48.62 O ATOM 3841 C ASP B1231 −25.93 −26.803 −35.112 40.95 C ATOM 3842 O ASP B1231 −26.455 −26.898 −34.011 41.5 O ATOM 3843 N LYS B1232 −25.638 −27.845 −35.959 41.51 N ATOM 3844 CA LYS B1232 −25.472 −29.295 −35.504 40.13 C ATOM 3845 CB LYS B1232 −24.085 −29.456 −34.835 41.34 C ATOM 3846 CG LYS B1232 −23.694 −30.825 −34.164 42.89 C ATOM 3847 CD LYS B1232 −23.774 −30.788 −32.596 50.15 C ATOM 3848 CE LYS B1232 −22.592 −30.036 −31.827 55.04 C ATOM 3849 NZ LYS B1232 −21.62 −30.864 −30.923 57.08 N ATOM 3850 C LYS B1232 −26.567 −29.995 −34.603 39.71 C ATOM 3851 O LYS B1232 −26.902 −31.182 −34.778 41.39 O ATOM 3852 N GLU B1233 −27.076 −29.309 −33.594 36.6 N ATOM 3853 CA GLU B1233 −28.291 −29.742 −32.95 34.58 C ATOM 3854 CB GLU B1233 −28.459 −29.068 −31.552 33.63 C ATOM 3855 CG GLU B1233 −27.201 −28.787 −30.789 34.52 C ATOM 3856 CD GLU B1233 −26.607 −30.075 −30.268 39.4 C ATOM 3857 OE1 GLU B1233 −27.175 −31.113 −30.673 34.26 O ATOM 3858 OE2 GLU B1233 −25.58 −30.058 −29.494 41.29 O ATOM 3859 C GLU B1233 −29.512 −29.434 −33.859 32.39 C ATOM 3860 O GLU B1233 −30.54 −30.097 −33.805 31.63 O ATOM 3861 N TYR B1234 −29.388 −28.4 −34.664 31.28 N ATOM 3862 CA TYR B1234 −30.539 −27.798 −35.324 30.52 C ATOM 3863 CB TYR B1234 −30.68 −26.355 −34.903 28.19 C ATOM 3864 CG TYR B1234 −31.041 −26.123 −33.508 25.71 C ATOM 3865 CD1 TYR B1234 −30.067 −26.048 −32.545 23.54 C ATOM 3866 CE1 TYR B1234 −30.372 −25.814 −31.211 26.06 C ATOM 3867 CD2 TYR B1234 −32.361 −25.907 −33.142 25.16 C ATOM 3868 CE2 TYR B1234 −32.692 −25.663 −31.797 27.03 C ATOM 3869 CZ TYR B1234 −31.676 −25.639 −30.829 27.04 C ATOM 3870 OH TYR B1234 −31.945 −25.398 −29.498 27 O ATOM 3871 C TYR B1234 −30.413 −27.788 −36.846 32.17 C ATOM 3872 O TYR B1234 −29.369 −27.478 −37.391 31.62 O ATOM 3873 N TYR B1235 −31.509 −28.08 −37.519 33.9 N ATOM 3874 CA TYR B1235 −31.561 −28.031 −38.973 35.7 C ATOM 3875 CB TYR B1235 −32.229 −29.329 −39.529 38.55 C ATOM 3876 CG TYR B1235 −31.255 −30.498 −39.286 44.18 C ATOM 3877 CD1 TYR B1235 −30.527 −31.097 −40.361 48.85 C ATOM 3878 CE1 TYR B1235 −29.571 −32.17 −40.097 50.41 C ATOM 3879 CD2 TYR B1235 −30.956 −30.943 −37.925 48.72 C ATOM 3880 CE2 TYR B1235 −30.005 −31.974 −37.619 48.36 C ATOM 3881 CZ TYR B1235 −29.309 −32.604 −38.71 51.73 C ATOM 3882 OH TYR B1235 −28.405 −33.67 −38.431 50.9 O ATOM 3883 C TYR B1235 −32.282 −26.749 −39.291 33.92 C ATOM 3884 O TYR B1235 −33.203 −26.393 −38.584 33.68 O ATOM 3885 N SER B1236 −31.824 −26.034 −40.318 32.72 N ATOM 3886 CA SER B1236 −32.467 −24.785 −40.759 31.62 C ATOM 3887 CB SER B1236 −31.375 −23.692 −40.958 31.66 C ATOM 3888 OG SER B1236 −31.925 −22.409 −41.29 26.78 O ATOM 3889 C SER B1236 −33.328 −25.04 −42.009 30.87 C ATOM 3890 O SER B1236 −32.823 −25.681 −42.919 31.06 O ATOM 3891 N VAL B1237 −34.614 −24.638 −42.001 30.38 N ATOM 3892 CA VAL B1237 −35.513 −24.609 −43.174 31.34 C ATOM 3893 CB VAL B1237 −37.02 −24.115 −42.819 31.82 C ATOM 3894 CG1 VAL B1237 −38.189 −24.363 −43.965 29.46 C ATOM 3895 CG2 VAL B1237 −37.456 −24.647 −41.483 34.13 C ATOM 3896 C VAL B1237 −34.947 −23.539 −44.081 32.51 C ATOM 3897 O VAL B1237 −34.477 −22.53 −43.634 32.91 O ATOM 3898 N HIS B1238 −35.049 −23.735 −45.373 34.9 N ATOM 3899 CA HIS B1238 −34.462 −22.809 −46.339 37.53 C ATOM 3900 CB HIS B1238 −34.445 −23.514 −47.653 36.06 C ATOM 3901 CG HIS B1238 −33.489 −24.626 −47.685 32.65 C ATOM 3902 CD2 HIS B1238 −33.56 −25.853 −48.262 30.91 C ATOM 3903 ND1 HIS B1238 −32.268 −24.532 −47.074 28.37 N ATOM 3904 CE1 HIS B1238 −31.615 −25.658 −47.287 35.6 C ATOM 3905 NE2 HIS B1238 −32.378 −26.476 −48.01 31.54 N ATOM 3906 C HIS B1238 −35.279 −21.54 −46.54 39.46 C ATOM 3907 O HIS B1238 −34.9 −20.463 −46.144 41.81 O ATOM 3908 N ASN B1239 −36.386 −21.705 −47.232 41.97 N ATOM 3909 CA ASN B1239 −37.457 −20.761 −47.205 44.12 C ATOM 3910 CB ASN B1239 −38.723 −21.531 −47.615 45.61 C ATOM 3911 CG ASN B1239 −38.849 −21.718 −49.11 49.07 C ATOM 3912 OD1 ASN B1239 −39.966 −22.047 −49.593 51.28 O ATOM 3913 ND2 ASN B1239 −37.72 −21.548 −49.871 49.39 N ATOM 3914 C ASN B1239 −37.732 −20.193 −45.825 44.34 C ATOM 3915 O ASN B1239 −37.272 −19.103 −45.482 42.93 O ATOM 3916 N LYS B1240 −38.44 −21.031 −45.039 46.24 N ATOM 3917 CA LYS B1240 −39.575 −20.652 −44.125 46.09 C ATOM 3918 CB LYS B1240 −40.686 −21.755 −44.078 47.2 C ATOM 3919 CG LYS B1240 −41.403 −22.078 −42.682 48.07 C ATOM 3920 CD LYS B1240 −42.986 −22.34 −42.824 48.07 C ATOM 3921 CE LYS B1240 −43.353 −23.625 −43.614 47.33 C ATOM 3922 NZ LYS B1240 −43.305 −24.855 −42.778 46.55 N ATOM 3923 C LYS B1240 −39.042 −20.3 −42.796 44.7 C ATOM 3924 O LYS B1240 −38.808 −21.142 −41.918 45.03 O ATOM 3925 N THR B1241 −38.923 −19 −42.672 43.95 N ATOM 3926 CA THR B1241 −37.75 −18.379 −42.113 43.68 C ATOM 3927 CB THR B1241 −37.912 −17.912 −40.593 44.97 C ATOM 3928 OG1 THR B1241 −36.612 −17.659 −40.012 48.88 O ATOM 3929 CG2 THR B1241 −38.808 −18.875 −39.642 45.32 C ATOM 3930 C THR B1241 −36.598 −19.286 −42.401 41.6 C ATOM 3931 O THR B1241 −36.446 −19.833 −43.473 42.93 O ATOM 3932 N GLY B1242 −35.739 −19.421 −41.448 39.81 N ATOM 3933 CA GLY B1242 −34.996 −20.61 −41.362 36.11 C ATOM 3934 C GLY B1242 −35.436 −20.956 −39.967 33.19 C ATOM 3935 O GLY B1242 −34.711 −20.656 −39.027 32.74 O ATOM 3936 N ALA B1243 −36.661 −21.472 −39.836 29.81 N ATOM 3937 CA ALA B1243 −37.037 −22.105 −38.585 27.88 C ATOM 3938 CB ALA B1243 −38.491 −22.775 −38.648 27.63 C ATOM 3939 C ALA B1243 −35.917 −23.137 −38.209 25.69 C ATOM 3940 O ALA B1243 −35.434 −23.861 −39.04 23.82 O ATOM 3941 N LYS B1244 −35.471 −23.1 −36.955 24.7 N ATOM 3942 CA LYS B1244 −34.543 −24.063 −36.429 23.56 C ATOM 3943 CB LYS B1244 −33.705 −23.448 −35.326 23.12 C ATOM 3944 CG LYS B1244 −33.115 −22.087 −35.698 25.56 C ATOM 3945 CD LYS B1244 −31.993 −22.206 −36.679 26.2 C ATOM 3946 CE LYS B1244 −31.934 −20.959 −37.564 28.44 C ATOM 3947 NZ LYS B1244 −32.549 −19.815 −36.856 27.98 N ATOM 3948 C LYS B1244 −35.381 −25.227 −35.908 22.49 C ATOM 3949 O LYS B1244 −36.427 −25.057 −35.33 22.76 O ATOM 3950 N LEU B1245 −34.897 −26.421 −36.144 21.42 N ATOM 3951 CA LEU B1245 −35.613 −27.618 −35.829 19.61 C ATOM 3952 CB LEU B1245 −36.23 −28.184 −37.127 21.08 C ATOM 3953 CG LEU B1245 −37.226 −27.274 −37.878 23.54 C ATOM 3954 CD1 LEU B1245 −36.77 −26.914 −39.317 23.91 C ATOM 3955 CD2 LEU B1245 −38.488 −28.039 −37.994 30.03 C ATOM 3956 C LEU B1245 −34.584 −28.554 −35.206 17.53 C ATOM 3957 O LEU B1245 −33.66 −29.055 −35.916 14.78 O ATOM 3958 N PRO B1246 −34.692 −28.735 −33.861 16.71 N ATOM 3959 CD PRO B1246 −35.669 −28.048 −32.962 16.55 C ATOM 3960 CA PRO B1246 −33.865 −29.676 −33.104 15.54 C ATOM 3961 CB PRO B1246 −34.257 −29.351 −31.666 16.13 C ATOM 3962 CG PRO B1246 −35.652 −28.846 −31.726 12.22 C ATOM 3963 C PRO B1246 −34.36 −31.108 −33.453 15.49 C ATOM 3964 O PRO B1246 −34.977 −31.795 −32.611 16.52 O ATOM 3965 N VAL B1247 −34.123 −31.535 −34.689 13.12 N ATOM 3966 CA VAL B1247 −34.584 −32.798 −35.143 13.03 C ATOM 3967 CB VAL B1247 −34.022 −33.173 −36.545 13.66 C ATOM 3968 CG1 VAL B1247 −33.97 −32.026 −37.403 16.62 C ATOM 3969 CG2 VAL B1247 −32.671 −33.871 −36.495 16.62 C ATOM 3970 C VAL B1247 −34.507 −33.995 −34.183 11.34 C ATOM 3971 O VAL B1247 −35.466 −34.721 −34.083 11.5 O ATOM 3972 N LYS B1248 −33.381 −34.195 −33.51 11.79 N ATOM 3973 CA LYS B1248 −33.165 −35.38 −32.689 12.47 C ATOM 3974 CB LYS B1248 −31.702 −35.589 −32.463 12.8 C ATOM 3975 CG LYS B1248 −30.995 −36.234 −33.691 15.64 C ATOM 3976 CD LYS B1248 −29.37 −36.242 −33.586 18.07 C ATOM 3977 CE LYS B1248 −28.673 −36.979 −34.801 15.79 C ATOM 3978 NZ LYS B1248 −29.745 −37.139 −35.892 23.64 N ATOM 3979 C LYS B1248 −33.908 −35.348 −31.382 10.54 C ATOM 3980 O LYS B1248 −33.981 −36.36 −30.728 10.31 O ATOM 3981 N TRP B1249 −34.525 −34.213 −31.034 9.66 N ATOM 3982 CA TRP B1249 −35.405 −34.107 −29.845 8.39 C ATOM 3983 CB TRP B1249 −35.086 −32.836 −29.014 7.29 C ATOM 3984 CG TRP B1249 −33.914 −33.017 −28.158 5.7 C ATOM 3985 CD2 TRP B1249 −32.548 −33.029 −28.582 4.8 C ATOM 3986 CE2 TRP B1249 −31.755 −33.293 −27.442 3.54 C ATOM 3987 CE3 TRP B1249 −31.909 −32.804 −29.806 9.04 C ATOM 3988 CD1 TRP B1249 −33.896 −33.289 −26.791 4.28 C ATOM 3989 NE1 TRP B1249 −32.607 −33.458 −26.374 2.45 N ATOM 3990 CZ2 TRP B1249 −30.337 −33.352 −27.5 2 C ATOM 3991 CZ3 TRP B1249 −30.474 −32.872 −29.844 8.31 C ATOM 3992 CH2 TRP B1249 −29.74 −33.16 −28.702 4.96 C ATOM 3993 C TRP B1249 −36.828 −33.99 −30.325 9.48 C ATOM 3994 O TRP B1249 −37.726 −33.99 −29.522 11.52 O ATOM 3995 N MET B1250 −37.053 −33.901 −31.63 10.09 N ATOM 3996 CA MET B1250 −38.384 −33.689 −32.159 11.64 C ATOM 3997 CB MET B1250 −38.295 −33.04 −33.507 11.33 C ATOM 3998 CG MET B1250 −38.313 −31.485 −33.482 12.69 C ATOM 3999 SD MET B1250 −37.811 −30.796 −35.124 16.39 S ATOM 4000 CE MET B1250 −39.348 −30.884 −36.046 17.08 C ATOM 4001 C MET B1250 −39.178 −34.974 −32.272 13.02 C ATOM 4002 O MET B1250 −38.606 −36.105 −32.53 12.68 O ATOM 4003 N ALA B1251 −40.501 −34.838 −32.06 12.87 N ATOM 4004 CA ALA B1251 −41.405 −35.982 −32.177 13.1 C ATOM 4005 CB ALA B1251 −42.699 −35.724 −31.481 12.42 C ATOM 4006 C ALA B1251 −41.62 −36.363 −33.651 15.54 C ATOM 4007 O ALA B1251 −41.512 −35.498 −34.572 14.8 O ATOM 4008 N LEU B1252 −41.903 −37.662 −33.866 17.95 N ATOM 4009 CA LEU B1252 −42.248 −38.215 −35.18 19.26 C ATOM 4010 CB LEU B1252 −42.867 −39.609 −35.016 20.92 C ATOM 4011 CG LEU B1252 −43.079 −40.544 −36.227 21.26 C ATOM 4012 CD1 LEU B1252 −41.988 −40.407 −37.34 19.45 C ATOM 4013 CD2 LEU B1252 −43.292 −42.011 −35.699 19.03 C ATOM 4014 C LEU B1252 −43.215 −37.333 −35.962 19.23 C ATOM 4015 O LEU B1252 −42.91 −36.899 −37.062 19.86 O ATOM 4016 N GLU B1253 −44.374 −37.05 −35.405 18.89 N ATOM 4017 CA GLU B1253 −45.26 −36.124 −36.066 20.29 C ATOM 4018 CB GLU B1253 −46.574 −36.042 −35.299 19.85 C ATOM 4019 CG GLU B1253 −46.507 −35.19 −33.996 22.81 C ATOM 4020 CD GLU B1253 −46.092 −35.973 −32.754 24.46 C ATOM 4021 OE1 GLU B1253 −45.675 −37.15 −32.878 27.79 O ATOM 4022 OE2 GLU B1253 −46.214 −35.408 −31.643 26.76 O ATOM 4023 C GLU B1253 −44.664 −34.692 −36.414 21.64 C ATOM 4024 O GLU B1253 −44.968 −34.162 −37.492 22.96 O ATOM 4025 N SER B1254 −43.818 −34.079 −35.567 21.49 N ATOM 4026 CA SER B1254 −43.302 −32.735 −35.855 21.38 C ATOM 4027 CB SER B1254 −42.609 −32.116 −34.647 21.56 C ATOM 4028 OG SER B1254 −43.485 −32.087 −33.503 25.03 O ATOM 4029 C SER B1254 −42.313 −32.823 −36.976 21.95 C ATOM 4030 O SER B1254 −42.22 −31.926 −37.784 22.06 O ATOM 4031 N LEU B1255 −41.534 −33.896 −37.031 22.64 N ATOM 4032 CA LEU B1255 −40.623 −34.095 −38.146 22.06 C ATOM 4033 CB LEU B1255 −39.865 −35.409 −37.985 20.16 C ATOM 4034 CG LEU B1255 −38.889 −35.49 −36.825 17.35 C ATOM 4035 CD1 LEU B1255 −38.374 −36.987 −36.629 13.13 C ATOM 4036 CD2 LEU B1255 −37.76 −34.489 −37.004 14.62 C ATOM 4037 C LEU B1255 −41.387 −34.15 −39.467 23.82 C ATOM 4038 O LEU B1255 −40.89 −33.691 −40.511 25.05 O ATOM 4039 N GLN B1256 −42.575 −34.753 −39.424 24.85 N ATOM 4040 CA GLN B1256 −43.34 −35.01 −40.605 26.22 C ATOM 4041 CB GLN B1256 −44.294 −36.186 −40.422 25.39 C ATOM 4042 CG GLN B1256 −43.687 −37.577 −40.193 26.12 C ATOM 4043 CD GLN B1256 −44.774 −38.604 −39.754 27.1 C ATOM 4044 OE1 GLN B1256 −45.184 −39.42 −40.533 29.2 O ATOM 4045 NE2 GLN B1256 −45.273 −38.501 −38.525 26.57 N ATOM 4046 C GLN B1256 −44.166 −33.781 −40.914 27.29 C ATOM 4047 O GLN B1256 −44.508 −33.567 −42.066 29.76 O ATOM 4048 N THR B1257 −44.5 −32.968 −39.926 27.03 N ATOM 4049 CA THR B1257 −45.449 −31.874 −40.149 26.26 C ATOM 4050 CB THR B1257 −46.737 −32.13 −39.348 27.06 C ATOM 4051 OG1 THR B1257 −46.459 −32.004 −37.938 24.23 O ATOM 4052 CG2 THR B1257 −47.303 −33.527 −39.645 25.82 C ATOM 4053 C THR B1257 −44.927 −30.485 −39.743 26.76 C ATOM 4054 O THR B1257 −45.495 −29.455 −40.084 26.46 O ATOM 4055 N GLN B1258 −43.854 −30.465 −38.979 27.16 N ATOM 4056 CA GLN B1258 −43.232 −29.234 −38.532 28.56 C ATOM 4057 CB GLN B1258 −42.773 −28.422 −39.75 28.63 C ATOM 4058 CG GLN B1258 −41.445 −27.703 −39.541 32.3 C ATOM 4059 CD GLN B1258 −41.202 −26.525 −40.556 33.04 C ATOM 4060 OE1 GLN B1258 −40.718 −25.425 −40.163 35.92 O ATOM 4061 NE2 GLN B1258 −41.511 −26.766 −41.852 31.94 N ATOM 4062 C GLN B1258 −44.152 −28.424 −37.578 27.21 C ATOM 4063 O GLN B1258 −43.982 −27.187 −37.391 27.96 O ATOM 4064 N LYS B1259 −45.122 −29.117 −36.987 25.61 N ATOM 4065 CA LYS B1259 −45.992 −28.515 −35.993 24.97 C ATOM 4066 CB LYS B1259 −47.448 −28.482 −36.486 26.14 C ATOM 4067 CG LYS B1259 −47.723 −27.151 −37.225 32.4 C ATOM 4068 CD LYS B1259 −48.102 −27.291 −38.71 40.86 C ATOM 4069 CE LYS B1259 −49.665 −27.375 −38.896 50.91 C ATOM 4070 NZ LYS B1259 −50.394 −28.321 −37.902 53.68 N ATOM 4071 C LYS B1259 −45.826 −29.129 −34.59 22.27 C ATOM 4072 O LYS B1259 −45.634 −30.333 −34.484 21.35 O ATOM 4073 N PHE B1260 −45.856 −28.275 −33.542 19.76 N ATOM 4074 CA PHE B1260 −45.587 −28.652 −32.148 17.39 C ATOM 4075 CB PHE B1260 −44.45 −27.875 −31.589 14.45 C ATOM 4076 CG PHE B1260 −43.248 −27.866 −32.479 16.95 C ATOM 4077 CD1 PHE B1260 −43.232 −27.143 −33.676 12.95 C ATOM 4078 CD2 PHE B1260 −42.1 −28.615 −32.149 18.21 C ATOM 4079 CE1 PHE B1260 −42.09 −27.176 −34.51 14.99 C ATOM 4080 CE2 PHE B1260 −40.962 −28.61 −33.022 15.9 C ATOM 4081 CZ PHE B1260 −40.981 −27.874 −34.185 11.08 C ATOM 4082 C PHE B1260 −46.778 −28.545 −31.202 18.09 C ATOM 4083 O PHE B1260 −47.724 −27.776 −31.422 18.72 O ATOM 4084 N THR B1261 −46.726 −29.367 −30.148 17.79 N ATOM 4085 CA THR B1261 −47.745 −29.416 −29.111 17.31 C ATOM 4086 CB THR B1261 −48.793 −30.515 −29.388 16.69 C ATOM 4087 OG1 THR B1261 −48.125 −31.755 −29.671 17.09 O ATOM 4088 CG2 THR B1261 −49.667 −30.138 −30.574 17.08 C ATOM 4089 C THR B1261 −47.083 −29.751 −27.801 16.71 C ATOM 4090 O THR B1261 −45.87 −30.073 −27.768 16.18 O ATOM 4091 N THR B1262 −47.886 −29.729 −26.728 15.26 N ATOM 4092 CA THR B1262 −47.439 −30.274 −25.427 14.24 C ATOM 4093 CB THR B1262 −48.509 −29.994 −24.355 12.83 C ATOM 4094 OG1 THR B1262 −48.54 −28.588 −24.19 14.64 O ATOM 4095 CG2 THR B1262 −48.162 −30.554 −23.009 12.65 C ATOM 4096 C THR B1262 −47.08 −31.73 −25.49 13.76 C ATOM 4097 O THR B1262 −46.206 −32.128 −24.782 16.54 O ATOM 4098 N LYS B1263 −47.735 −32.535 −26.329 14.41 N ATOM 4099 CA LYS B1263 −47.326 −33.942 −26.538 14.1 C ATOM 4100 CB LYS B1263 −48.35 −34.761 −27.329 13.72 C ATOM 4101 CG LYS B1263 −49.67 −34.811 −26.68 13.94 C ATOM 4102 CD LYS B1263 −49.545 −35.067 −25.196 14.53 C ATOM 4103 CE LYS B1263 −50.85 −35.583 −24.602 13.05 C ATOM 4104 NZ LYS B1263 −50.49 −36.259 −23.363 17.05 N ATOM 4105 C LYS B1263 −45.98 −34.027 −27.257 14.57 C ATOM 4106 O LYS B1263 −45.2 −34.932 −26.975 15.41 O ATOM 4107 N SER B1264 −45.698 −33.099 −28.16 11.65 N ATOM 4108 CA SER B1264 −44.441 −33.146 −28.787 13.31 C ATOM 4109 CB SER B1264 −44.492 −32.375 −30.104 12.51 C ATOM 4110 OG SER B1264 −44.451 −31.004 −29.879 16.54 O ATOM 4111 C SER B1264 −43.313 −32.699 −27.811 13 C ATOM 4112 O SER B1264 −42.197 −33.169 −27.925 14.49 O ATOM 4113 N ASP B1265 −43.639 −31.859 −26.829 13.66 N ATOM 4114 CA ASP B1265 −42.758 −31.435 −25.724 13.49 C ATOM 4115 CB ASP B1265 −43.434 −30.31 −24.857 14.45 C ATOM 4116 CG ASP B1265 −43.277 −28.836 −25.42 15.31 C ATOM 4117 OD1 ASP B1265 −42.551 −28.551 −26.437 11.54 O ATOM 4118 OD2 ASP B1265 −43.948 −27.93 −24.789 14.05 O ATOM 4119 C ASP B1265 −42.544 −32.683 −24.821 13.36 C ATOM 4120 O ASP B1265 −41.438 −32.905 −24.309 12.68 O ATOM 4121 N VAL B1266 −43.595 −33.467 −24.587 10.21 N ATOM 4122 CA VAL B1266 −43.391 −34.728 −23.865 10.13 C ATOM 4123 CB VAL B1266 −44.755 −35.518 −23.608 10.77 C ATOM 4124 CG1 VAL B1266 −44.502 −36.889 −23.116 5.97 C ATOM 4125 CG2 VAL B1266 −45.649 −34.727 −22.654 7.57 C ATOM 4126 C VAL B1266 −42.382 −35.637 −24.548 8.48 C ATOM 4127 O VAL B1266 −41.442 −36.08 −23.913 9.29 O ATOM 4128 N TRP B1267 −42.506 −35.856 −25.849 8.05 N ATOM 4129 CA TRP B1267 −41.517 −36.661 −26.578 8.38 C ATOM 4130 CB TRP B1267 −41.77 −36.609 −28.027 9.04 C ATOM 4131 CG TRP B1267 −40.748 −37.362 −28.859 13.03 C ATOM 4132 CD2 TRP B1267 −41.036 −38.518 −29.698 11.67 C ATOM 4133 CE2 TRP B1267 −39.819 −38.935 −30.278 9.47 C ATOM 4134 CE3 TRP B1267 −42.215 −39.227 −29.994 10.04 C ATOM 4135 CD1 TRP B1267 −39.388 −37.129 −28.961 8.94 C ATOM 4136 NE1 TRP B1267 −38.826 −38.097 −29.82 12.78 N ATOM 4137 CZ2 TRP B1267 −39.755 −40.002 −31.17 9.52 C ATOM 4138 CZ3 TRP B1267 −42.168 −40.258 −30.893 10.1 C ATOM 4139 CH2 TRP B1267 −40.934 −40.653 −31.466 11.36 C ATOM 4140 C TRP B1267 −40.119 −36.117 −26.29 9.58 C ATOM 4141 O TRP B1267 −39.173 −36.924 −25.943 11.1 O ATOM 4142 N SER B1268 −39.984 −34.779 −26.408 7.45 N ATOM 4143 CA SER B1268 −38.736 −34.075 −26.174 5.51 C ATOM 4144 CB SER B1268 −38.926 −32.562 −26.31 7.41 C ATOM 4145 OG SER B1268 −38.927 −32.233 −27.655 11.13 O ATOM 4146 C SER B1268 −38.241 −34.274 −24.815 4.11 C ATOM 4147 O SER B1268 −37.066 −34.539 −24.634 4.39 O ATOM 4148 N PHE B1269 −39.125 −34.142 −23.834 3.73 N ATOM 4149 CA PHE B1269 −38.794 −34.445 −22.45 4.56 C ATOM 4150 CB PHE B1269 −40.038 −34.29 −21.58 5.96 C ATOM 4151 CG PHE B1269 −39.81 −34.636 −20.125 6.7 C ATOM 4152 CD1 PHE B1269 −39.078 −33.763 −19.287 9.71 C ATOM 4153 CD2 PHE B1269 −40.265 −35.832 −19.623 4.42 C ATOM 4154 CE1 PHE B1269 −38.847 −34.07 −17.953 8.28 C ATOM 4155 CE2 PHE B1269 −40.061 −36.155 −18.32 8.23 C ATOM 4156 CZ PHE B1269 −39.355 −35.241 −17.468 12.92 C ATOM 4157 C PHE B1269 −38.181 −35.834 −22.267 5.12 C ATOM 4158 O PHE B1269 −37.199 −36.012 −21.516 6.6 O ATOM 4159 N GLY B1270 −38.728 −36.828 −22.949 4.58 N ATOM 4160 CA GLY B1270 −38.154 −38.129 −22.823 5.87 C ATOM 4161 C GLY B1270 −36.772 −38.256 −23.358 7.68 C ATOM 4162 O GLY B1270 −35.909 −38.968 −22.753 8.82 O ATOM 4163 N VAL B1271 −36.514 −37.556 −24.478 8.32 N ATOM 4164 CA VAL B1271 −35.076 −37.437 −25.021 8.41 C ATOM 4165 CB VAL B1271 −35.045 −36.627 −26.371 7.21 C ATOM 4166 CG1 VAL B1271 −33.805 −36.88 −27.078 8.43 C ATOM 4167 CG2 VAL B1271 −36.143 −37.058 −27.294 5.25 C ATOM 4168 C VAL B1271 −34.114 −36.804 −24.012 8.67 C ATOM 4169 O VAL B1271 −32.971 −37.231 −23.82 9.62 O ATOM 4170 N LEU B1272 −34.621 −35.749 −23.379 10.91 N ATOM 4171 CA LEU B1272 −33.95 −35.009 −22.261 11.66 C ATOM 4172 CB LEU B1272 −34.818 −33.81 −21.792 11.01 C ATOM 4173 CG LEU B1272 −34.161 −32.875 −20.766 13.19 C ATOM 4174 CD1 LEU B1272 −34.927 −31.529 −20.726 7.24 C ATOM 4175 CD2 LEU B1272 −34.025 −33.436 −19.332 10.52 C ATOM 4176 C LEU B1272 −33.668 −35.96 −21.094 10.21 C ATOM 4177 O LEU B1272 −32.556 −35.972 −20.597 10.12 O ATOM 4178 N LEU B1273 −34.65 −36.774 −20.685 9.18 N ATOM 4179 CA LEU B1273 −34.331 −37.803 −19.659 11.07 C ATOM 4180 CB LEU B1273 −35.542 −38.655 −19.303 10.87 C ATOM 4181 CG LEU B1273 −36.725 −37.912 −18.694 16.19 C ATOM 4182 CD1 LEU B1273 −37.954 −38.84 −18.631 16.15 C ATOM 4183 CD2 LEU B1273 −36.396 −37.352 −17.34 14.22 C ATOM 4184 C LEU B1273 −33.183 −38.741 −20.076 9.8 C ATOM 4185 O LEU B1273 −32.389 −39.109 −19.277 9.52 O ATOM 4186 N TRP B1274 −33.15 −39.094 −21.358 11.24 N ATOM 4187 CA TRP B1274 −32.163 −39.995 −21.948 10.94 C ATOM 4188 CB TRP B1274 −32.565 −40.397 −23.414 9.58 C ATOM 4189 CG TRP B1274 −31.633 −41.432 −24.04 10.2 C ATOM 4190 CD2 TRP B1274 −30.43 −41.158 −24.748 8.46 C ATOM 4191 CE2 TRP B1274 −29.842 −42.409 −25.082 9.48 C ATOM 4192 CE3 TRP B1274 −29.77 −39.972 −25.119 8.54 C ATOM 4193 CD1 TRP B1274 −31.735 −42.841 −23.974 11.41 C ATOM 4194 NE1 TRP B1274 −30.673 −43.405 −24.622 9.81 N ATOM 4195 CZ2 TRP B1274 −28.617 −42.499 −25.784 6.65 C ATOM 4196 CZ3 TRP B1274 −28.6 −40.065 −25.824 9.41 C ATOM 4197 CH2 TRP B1274 −28.024 −41.323 −26.151 8.82 C ATOM 4198 C TRP B1274 −30.795 −39.344 −21.861 10.81 C ATOM 4199 O TRP B1274 −29.829 −39.961 −21.379 11.74 O ATOM 4200 N GLU B1275 −30.715 −38.082 −22.242 10.72 N ATOM 4201 CA GLU B1275 −29.426 −37.332 −22.148 10.68 C ATOM 4202 CB GLU B1275 −29.639 −35.857 −22.527 10.88 C ATOM 4203 CG GLU B1275 −30.153 −35.543 −23.903 11.46 C ATOM 4204 CD GLU B1275 −30.4 −34.021 −24.049 14.34 C ATOM 4205 OE1 GLU B1275 −31.524 −33.501 −23.805 15.39 O ATOM 4206 OE2 GLU B1275 −29.401 −33.309 −24.396 22.77 O ATOM 4207 C GLU B1275 −28.909 −37.315 −20.749 10.34 C ATOM 4208 O GLU B1275 −27.707 −37.337 −20.528 10.71 O ATOM 4209 N LEU B1276 −29.809 −37.115 −19.785 11.05 N ATOM 4210 CA LEU B1276 −29.43 −37.1 −18.346 10.79 C ATOM 4211 CB LEU B1276 −30.632 −36.812 −17.47 12.25 C ATOM 4212 CG LEU B1276 −31.013 −35.427 −16.907 13.19 C ATOM 4213 CD1 LEU B1276 −30.601 −34.396 −17.903 20.48 C ATOM 4214 CD2 LEU B1276 −32.537 −35.354 −16.588 10.2 C ATOM 4215 C LEU B1276 −28.834 −38.412 −17.94 10.65 C ATOM 4216 O LEU B1276 −27.765 −38.417 −17.393 11.03 O ATOM 4217 N MET B1277 −29.498 −39.527 −18.296 10.47 N ATOM 4218 CA MET B1277 −29.091 −40.868 −17.899 10.55 C ATOM 4219 CB MET B1277 −30.237 −41.888 −18.047 10.09 C ATOM 4220 CG MET B1277 −31.411 −41.644 −17.096 14.97 C ATOM 4221 SD MET B1277 −30.866 −41.259 −15.312 20.21 S ATOM 4222 CE MET B1277 −31.078 −42.892 −14.719 17.84 C ATOM 4223 C MET B1277 −27.823 −41.309 −18.596 10.99 C ATOM 4224 O MET B1277 −27.194 −42.218 −18.136 12.08 O ATOM 4225 N THR B1278 −27.456 −40.657 −19.701 12.51 N ATOM 4226 CA THR B1278 −26.236 −40.961 −20.482 11.87 C ATOM 4227 CB THR B1278 −26.515 −41.002 −21.99 12.63 C ATOM 4228 OG1 THR B1278 −27.031 −39.745 −22.452 8.58 O ATOM 4229 CG2 THR B1278 −27.547 −42.16 −22.375 10.3 C ATOM 4230 C THR B1278 −25.239 −39.865 −20.205 13.76 C ATOM 4231 O THR B1278 −24.179 −39.799 −20.812 14.83 O ATOM 4232 N ARG B1279 −25.582 −39.023 −19.222 14.86 N ATOM 4233 CA ARG B1279 −24.78 −37.831 −18.858 15.36 C ATOM 4234 CB ARG B1279 −23.525 −38.248 −18.1 15.01 C ATOM 4235 CG ARG B1279 −23.844 −38.717 −16.667 15.98 C ATOM 4236 CD ARG B1279 −22.587 −38.783 −15.851 19.69 C ATOM 4237 NE ARG B1279 −21.75 −37.562 −15.876 19.77 N ATOM 4238 CZ ARG B1279 −20.576 −37.432 −15.229 19.3 C ATOM 4239 NH1 ARG B1279 −20.15 −38.439 −14.507 19.24 N ATOM 4240 NH2 ARG B1279 −19.831 −36.31 −15.296 18.68 N ATOM 4241 C ARG B1279 −24.4 −37.045 −20.084 14.5 C ATOM 4242 O ARG B1279 −23.215 −36.816 −20.333 13.92 O ATOM 4243 N GLY B1280 −25.398 −36.714 −20.886 14.34 N ATOM 4244 CA GLY B1280 −25.185 −35.899 −22.099 16.19 C ATOM 4245 C GLY B1280 −24.691 −36.567 −23.394 17.54 C ATOM 4246 O GLY B1280 −24.179 −35.859 −24.239 18.98 O ATOM 4247 N ALA B1281 −24.788 −37.899 −23.583 17.6 N ATOM 4248 CA ALA B1281 −24.37 −38.477 −24.854 17.07 C ATOM 4249 CB ALA B1281 −24.456 −39.91 −24.849 17.2 C ATOM 4250 C ALA B1281 −25.354 −37.928 −25.858 18.67 C ATOM 4251 O ALA B1281 −26.479 −37.691 −25.487 18.23 O ATOM 4252 N PRO B1282 −24.918 −37.652 −27.114 18.85 N ATOM 4253 CD PRO B1282 −23.561 −37.714 −27.7 19.07 C ATOM 4254 CA PRO B1282 −25.936 −37.183 −28.063 19.03 C ATOM 4255 CB PRO B1282 −25.114 −36.547 −29.185 19.41 C ATOM 4256 CG PRO B1282 −23.823 −37.421 −29.231 20.06 C ATOM 4257 C PRO B1282 −26.794 −38.329 −28.631 18.75 C ATOM 4258 O PRO B1282 −26.266 −39.369 −28.982 18.98 O ATOM 4259 N PRO B1283 −28.118 −38.108 −28.775 19.17 N ATOM 4260 CD PRO B1283 −28.853 −36.859 −28.437 18.86 C ATOM 4261 CA PRO B1283 −29.024 −39.124 −29.297 19.02 C ATOM 4262 CB PRO B1283 −30.43 −38.501 −29.009 18.56 C ATOM 4263 CG PRO B1283 −30.258 −37.142 −28.879 17.23 C ATOM 4264 C PRO B1283 −28.841 −39.395 −30.798 19.32 C ATOM 4265 O PRO B1283 −28.662 −38.429 −31.591 21.46 O ATOM 4266 N TYR B1284 −28.971 −40.664 −31.192 19.19 N ATOM 4267 CA TYR B1284 −28.753 −41.129 −32.591 18.43 C ATOM 4268 CB TYR B1284 −29.945 −40.797 −33.455 18.2 C ATOM 4269 CG TYR B1284 −31.282 −40.712 −32.714 17.9 C ATOM 4270 CD1 TYR B1284 −32.126 −41.84 −32.634 12.98 C ATOM 4271 CE1 TYR B1284 −33.257 −41.797 −31.972 14.34 C ATOM 4272 CD2 TYR B1284 −31.705 −39.506 −32.127 14.75 C ATOM 4273 CE2 TYR B1284 −32.907 −39.437 −31.442 13.46 C ATOM 4274 CZ TYR B1284 −33.697 −40.579 −31.388 16.98 C ATOM 4275 OH TYR B1284 −34.93 −40.54 −30.755 16.26 O ATOM 4276 C TYR B1284 −27.438 −40.55 −33.221 19.56 C ATOM 4277 O TYR B1284 −27.451 −39.885 −34.266 17.04 O ATOM 4278 N PRO B1285 −26.3 −40.75 −32.519 20.97 N ATOM 4279 CD PRO B1285 −26.047 −41.534 −31.294 19.88 C ATOM 4280 CA PRO B1285 −25.1 −40.093 −32.988 22.62 C ATOM 4281 CB PRO B1285 −24.025 −40.589 −32 20.54 C ATOM 4282 CG PRO B1285 −24.632 −41.818 −31.389 22.01 C ATOM 4283 C PRO B1285 −24.786 −40.524 −34.415 24.49 C ATOM 4284 O PRO B1285 −24.241 −39.737 −35.18 25.5 O ATOM 4285 N ASP B1286 −25.164 −41.749 −34.766 27.37 N ATOM 4286 CA ASP B1286 −24.704 −42.331 −36.018 31.08 C ATOM 4287 CB ASP B1286 −24.187 −43.772 −35.778 32.37 C ATOM 4288 CG ASP B1286 −22.72 −43.794 −35.198 37.41 C ATOM 4289 OD1 ASP B1286 −22.403 −44.628 −34.255 38.84 O ATOM 4290 OD2 ASP B1286 −21.907 −42.938 −35.687 38.04 O ATOM 4291 C ASP B1286 −25.71 −42.214 −37.204 31.19 C ATOM 4292 O ASP B1286 −25.473 −42.825 −38.251 31.88 O ATOM 4293 N VAL B1287 −26.783 −41.421 −37.002 29.92 N ATOM 4294 CA VAL B1287 −27.83 −41.055 −37.968 28.47 C ATOM 4295 CB VAL B1287 −29.195 −41.458 −37.484 28.62 C ATOM 4296 CG1 VAL B1287 −29.805 −42.395 −38.473 30.75 C ATOM 4297 CG2 VAL B1287 −29.117 −42.081 −36.084 30.13 C ATOM 4298 C VAL B1287 −28.018 −39.58 −38.409 27.43 C ATOM 4299 O VAL B1287 −27.907 −38.621 −37.615 24.94 O ATOM 4300 N ASN B1288 −28.357 −39.439 −39.7 25.37 N ATOM 4301 CA ASN B1288 −28.695 −38.162 −40.252 23.52 C ATOM 4302 CB ASN B1288 −28.217 −38.016 −41.715 24.34 C ATOM 4303 CG ASN B1288 −29.032 −38.899 −42.718 22.8 C ATOM 4304 OD1 ASN B1288 −30.22 −39.086 −42.568 23.33 O ATOM 4305 ND2 ASN B1288 −28.376 −39.421 −43.706 18.01 N ATOM 4306 C ASN B1288 −30.196 −38.069 −40.154 22.61 C ATOM 4307 O ASN B1288 −30.911 −39.051 −39.908 21.14 O ATOM 4308 N THR B1289 −30.686 −36.882 −40.389 21.92 N ATOM 4309 CA THR B1289 −32.097 −36.631 −40.185 22.85 C ATOM 4310 CB THR B1289 −32.339 −35.133 −40.101 22.97 C ATOM 4311 OG1 THR B1289 −32.875 −34.697 −41.323 27.53 O ATOM 4312 CG2 THR B1289 −31.049 −34.441 −39.957 21.76 C ATOM 4313 C THR B1289 −33.046 −37.19 −41.219 22.8 C ATOM 4314 O THR B1289 −34.233 −37.072 −41.045 23.92 O ATOM 4315 N PHE B1290 −32.555 −37.753 −42.324 22.88 N ATOM 4316 CA PHE B1290 −33.446 −38.501 −43.188 22.14 C ATOM 4317 CB PHE B1290 −32.842 −38.696 −44.574 21.33 C ATOM 4318 CG PHE B1290 −33.712 −39.497 −45.465 19.38 C ATOM 4319 CD1 PHE B1290 −34.76 −38.915 −46.123 17.77 C ATOM 4320 CD2 PHE B1290 −33.516 −40.86 −45.595 22.41 C ATOM 4321 CE1 PHE B1290 −35.614 −39.679 −46.916 20.2 C ATOM 4322 CE2 PHE B1290 −34.389 −41.647 −46.369 22.41 C ATOM 4323 CZ PHE B1290 −35.419 −41.053 −47.042 20.49 C ATOM 4324 C PHE B1290 −33.762 −39.853 −42.511 22.8 C ATOM 4325 O PHE B1290 −34.938 −40.28 −42.341 23.53 O ATOM 4326 N ASP B1291 −32.691 −40.489 −42.084 23.39 N ATOM 4327 CA ASP B1291 −32.716 −41.81 −41.531 25.68 C ATOM 4328 CB ASP B1291 −31.286 −42.354 −41.462 26.6 C ATOM 4329 CG ASP B1291 −30.783 −42.791 −42.821 31.08 C ATOM 4330 OD1 ASP B1291 −30.091 −41.973 −43.493 39.79 O ATOM 4331 OD2 ASP B1291 −31.118 −43.917 −43.254 34.14 O ATOM 4332 C ASP B1291 −33.404 −41.887 −40.173 25.96 C ATOM 4333 O ASP B1291 −34.082 −42.896 −39.876 27.77 O ATOM 4334 N ILE B1292 −33.219 −40.865 −39.354 24.64 N ATOM 4335 CA ILE B1292 −33.978 −40.718 −38.086 24.06 C ATOM 4336 CB ILE B1292 −33.717 −39.333 −37.395 23.91 C ATOM 4337 CG2 ILE B1292 −34.52 −38.228 −38.039 22.83 C ATOM 4338 CG1 ILE B1292 −34.137 −39.381 −35.934 25.2 C ATOM 4339 CD1 ILE B1292 −33.285 −40.209 −35.142 29.16 C ATOM 4340 C ILE B1292 −35.493 −40.957 −38.258 22.98 C ATOM 4341 O ILE B1292 −36.167 −41.598 −37.392 22.39 O ATOM 4342 N THR B1293 −36.038 −40.498 −39.379 20.83 N ATOM 4343 CA THR B1293 −37.497 −40.546 −39.512 19.69 C ATOM 4344 CB THR B1293 −37.956 −39.539 −40.585 19.99 C ATOM 4345 OG1 THR B1293 −37.454 −38.237 −40.201 19.82 O ATOM 4346 CG2 THR B1293 −39.542 −39.516 −40.79 18.66 C ATOM 4347 C THR B1293 −37.916 −41.972 −39.768 18.48 C ATOM 4348 O THR B1293 −38.92 −42.457 −39.319 18.06 O ATOM 4349 N VAL B1294 −37.033 −42.675 −40.427 19.37 N ATOM 4350 CA VAL B1294 −37.265 −44.057 −40.852 18.14 C ATOM 4351 CB VAL B1294 −36.276 −44.44 −41.987 16.93 C ATOM 4352 CG1 VAL B1294 −36.204 −45.932 −42.144 16.99 C ATOM 4353 CG2 VAL B1294 −36.642 −43.726 −43.24 16.98 C ATOM 4354 C VAL B1294 −37.007 −44.934 −39.68 18.45 C ATOM 4355 O VAL B1294 −37.697 −45.952 −39.506 20.56 O ATOM 4356 N TYR B1295 −35.997 −44.564 −38.899 16.67 N ATOM 4357 CA TYR B1295 −35.638 −45.276 −37.722 16.51 C ATOM 4358 CB TYR B1295 −34.492 −44.495 −37.098 18.46 C ATOM 4359 CG TYR B1295 −33.946 −45.014 −35.785 22.08 C ATOM 4360 CD1 TYR B1295 −32.897 −45.936 −35.786 18.65 C ATOM 4361 CE1 TYR B1295 −32.39 −46.441 −34.598 21.13 C ATOM 4362 CD2 TYR B1295 −34.508 −44.595 −34.522 20.64 C ATOM 4363 CE2 TYR B1295 −33.997 −45.107 −33.318 22.26 C ATOM 4364 CZ TYR B1295 −32.924 −46.021 −33.376 22.13 C ATOM 4365 OH TYR B1295 −32.382 −46.571 −32.246 22.52 O ATOM 4366 C TYR B1295 −36.854 −45.256 −36.846 16 C ATOM 4367 O TYR B1295 −37.362 −46.275 −36.484 16.15 O ATOM 4368 N LEU B1296 −37.335 −44.069 −36.518 17.4 N ATOM 4369 CA LEU B1296 −38.569 −43.871 −35.695 18.14 C ATOM 4370 CB LEU B1296 −38.857 −42.369 −35.415 16.41 C ATOM 4371 CG LEU B1296 −37.827 −41.579 −34.591 17.12 C ATOM 4372 CD1 LEU B1296 −38.248 −40.118 −34.316 17.69 C ATOM 4373 CD2 LEU B1296 −37.568 −42.248 −33.297 19.55 C ATOM 4374 C LEU B1296 −39.796 −44.499 −36.276 19.05 C ATOM 4375 O LEU B1296 −40.678 −45.011 −35.565 19.99 O ATOM 4376 N LEU B1297 −39.903 −44.392 −37.584 21.12 N ATOM 4377 CA LEU B1297 −41.05 −44.95 −38.301 21.99 C ATOM 4378 CB LEU B1297 −41.041 −44.458 −39.76 22.16 C ATOM 4379 CG LEU B1297 −42.349 −43.788 −40.253 24.1 C ATOM 4380 CD1 LEU B1297 −42.933 −42.852 −39.23 27.09 C ATOM 4381 CD2 LEU B1297 −42.214 −43.055 −41.568 22.63 C ATOM 4382 C LEU B1297 −40.944 −46.474 −38.189 22.27 C ATOM 4383 O LEU B1297 −41.937 −47.138 −38.123 23.87 O ATOM 4384 N GLN B1298 −39.745 −47.049 −38.124 22.59 N ATOM 4385 CA GLN B1298 −39.64 −48.519 −37.939 22.65 C ATOM 4386 CB GLN B1298 −38.239 −49.031 −38.273 22.35 C ATOM 4387 CG GLN B1298 −37.925 −48.986 −39.772 22.45 C ATOM 4388 CD GLN B1298 −36.406 −48.945 −40.084 25.99 C ATOM 4389 OE1 GLN B1298 −35.576 −48.486 −39.278 28.63 O ATOM 4390 NE2 GLN B1298 −36.052 −49.376 −41.283 28.14 N ATOM 4391 C GLN B1298 −40.01 −48.972 −36.511 21.75 C ATOM 4392 O GLN B1298 −39.95 −50.191 −36.19 21.69 O ATOM 4393 N GLY B1299 −40.401 −48.004 −35.663 19.9 N ATOM 4394 CA GLY B1299 −40.685 −48.284 −34.269 16.6 C ATOM 4395 C GLY B1299 −39.444 −48.332 −33.427 15.5 C ATOM 4396 O GLY B1299 −39.528 −48.659 −32.23 18.01 O ATOM 4397 N ARG B1300 −38.279 −48.013 −33.986 13.06 N ATOM 4398 CA ARG B1300 −37.018 −48.036 −33.185 11.49 C ATOM 4399 CB ARG B1300 −35.761 −48.001 −34.1 10.35 C ATOM 4400 CG ARG B1300 −35.596 −49.253 −34.881 8.8 C ATOM 4401 CD ARG B1300 −34.804 −49.057 −36.208 11.14 C ATOM 4402 NE ARG B1300 −35.001 −50.267 −37.006 14.02 N ATOM 4403 CZ ARG B1300 −34.449 −51.482 −36.788 14.19 C ATOM 4404 NH1 ARG B1300 −33.565 −51.753 −35.769 12.76 N ATOM 4405 NH2 ARG B1300 −34.807 −52.443 −37.609 7.95 N ATOM 4406 C ARG B1300 −36.982 −46.825 −32.278 12.12 C ATOM 4407 O ARG B1300 −37.476 −45.745 −32.664 11.41 O ATOM 4408 N ARG B1301 −36.379 −47.001 −31.085 12.18 N ATOM 4409 CA ARG B1301 −36.242 −45.941 −30.083 10.47 C ATOM 4410 CB ARG B1301 −37.226 −46.167 −28.949 10.51 C ATOM 4411 CG ARG B1301 −38.659 −45.805 −29.248 10.7 C ATOM 4412 CD ARG B1301 −38.823 −44.561 −30.173 12.65 C ATOM 4413 NE ARG B1301 −40.219 −44.305 −30.478 10.61 N ATOM 4414 CZ ARG B1301 −40.823 −44.551 −31.628 13.77 C ATOM 4415 NH1 ARG B1301 −40.167 −45.018 −32.687 9.33 N ATOM 4416 NH2 ARG B1301 −42.121 −44.303 −31.709 16.57 N ATOM 4417 C ARG B1301 −34.833 −45.866 −29.54 10.44 C ATOM 4418 O ARG B1301 −33.998 −46.702 −29.83 9.22 O ATOM 4419 N LEU B1302 −34.55 −44.825 −28.783 9.97 N ATOM 4420 CA LEU B1302 −33.246 −44.705 −28.137 9.91 C ATOM 4421 CB LEU B1302 −33.199 −43.365 −27.393 8.2 C ATOM 4422 CG LEU B1302 −33.005 −42.134 −28.25 7.77 C ATOM 4423 CD1 LEU B1302 −33.264 −40.843 −27.548 2 C ATOM 4424 CD2 LEU B1302 −31.622 −42.163 −28.913 7.03 C ATOM 4425 C LEU B1302 −33.065 −45.833 −27.143 9.92 C ATOM 4426 O LEU B1302 −33.97 −46.117 −26.398 11.67 O ATOM 4427 N LEU B1303 −31.895 −46.44 −27.111 11.44 N ATOM 4428 CA LEU B1303 −31.592 −47.581 −26.212 14.3 C ATOM 4429 CB LEU B1303 −30.298 −48.268 −26.624 12.85 C ATOM 4430 CG LEU B1303 −30.486 −49.01 −27.953 17.01 C ATOM 4431 CD1 LEU B1303 −29.325 −49.927 −28.102 18.45 C ATOM 4432 CD2 LEU B1303 −31.815 −49.797 −28.015 16.49 C ATOM 4433 C LEU B1303 −31.546 −47.25 −24.715 14.72 C ATOM 4434 O LEU B1303 −31.279 −46.11 −24.356 14.39 O ATOM 4435 N GLN B1304 −31.854 −48.245 −23.865 15.16 N ATOM 4436 CA GLN B1304 −31.831 −47.99 −22.453 15.6 C ATOM 4437 CB GLN B1304 −32.393 −49.143 −21.651 14.32 C ATOM 4438 CG GLN B1304 −32.316 −48.821 −20.17 16.69 C ATOM 4439 CD GLN B1304 −33.193 −49.657 −19.327 17.17 C ATOM 4440 OE1 GLN B1304 −33.604 −49.242 −18.239 20.26 O ATOM 4441 NE2 GLN B1304 −33.452 −50.876 −19.778 19.03 N ATOM 4442 C GLN B1304 −30.407 −47.632 −22.036 16.11 C ATOM 4443 O GLN B1304 −29.497 −48.327 −22.357 18.26 O ATOM 4444 N PRO B1305 −30.193 −46.471 −21.426 16.5 N ATOM 4445 CD PRO B1305 −31.101 −45.362 −21.151 15.37 C ATOM 4446 CA PRO B1305 −28.853 −46.198 −20.991 17.68 C ATOM 4447 CB PRO B1305 −28.946 −44.768 −20.507 17.49 C ATOM 4448 CG PRO B1305 −30.161 −44.252 −21.136 17.86 C ATOM 4449 C PRO B1305 −28.443 −47.116 −19.839 20 C ATOM 4450 O PRO B1305 −29.298 −47.56 −19.067 19.29 O ATOM 4451 N GLU B1306 −27.158 −47.439 −19.757 22.81 N ATOM 4452 CA GLU B1306 −26.626 −48.241 −18.644 26.21 C ATOM 4453 CB GLU B1306 −25.118 −48.456 −18.828 25.64 C ATOM 4454 CG GLU B1306 −24.533 −49.314 −17.738 27.34 C ATOM 4455 CD GLU B1306 −23.03 −49.575 −17.862 30.37 C ATOM 4456 OE1 GLU B1306 −22.589 −50.618 −17.295 36.66 O ATOM 4457 OE2 GLU B1306 −22.289 −48.75 −18.461 32.22 O ATOM 4458 C GLU B1306 −26.871 −47.488 −17.331 27.16 C ATOM 4459 O GLU B1306 −26.692 −46.268 −17.269 29.39 O ATOM 4460 N TYR B1307 −27.253 −48.177 −16.268 27.98 N ATOM 4461 CA TYR B1307 −27.544 −47.459 −14.999 28.39 C ATOM 4462 CB TYR B1307 −26.449 −46.465 −14.617 30.07 C ATOM 4463 CG TYR B1307 −25.01 −46.917 −14.645 32.11 C ATOM 4464 CD1 TYR B1307 −24.052 −46.15 −15.339 33.72 C ATOM 4465 CE1 TYR B1307 −22.695 −46.523 −15.342 33.05 C ATOM 4466 CD2 TYR B1307 −24.578 −48.076 −13.95 33.11 C ATOM 4467 CE2 TYR B1307 −23.218 −48.466 −13.973 34.52 C ATOM 4468 CZ TYR B1307 −22.305 −47.662 −14.672 33.21 C ATOM 4469 OH TYR B1307 −20.998 −47.985 −14.726 35.57 O ATOM 4470 C TYR B1307 −28.861 −46.67 −14.974 27.38 C ATOM 4471 O TYR B1307 −29.237 −46.121 −13.927 27.77 O ATOM 4472 N CYS B1308 −29.532 −46.556 −16.106 25.63 N ATOM 4473 CA CYS B1308 −30.936 −46.164 −16.106 24.55 C ATOM 4474 CB CYS B1308 −31.397 −45.777 −17.483 22.73 C ATOM 4475 SG CYS B1308 −33.095 −45.158 −17.55 23.51 S ATOM 4476 C CYS B1308 −31.832 −47.271 −15.538 24.84 C ATOM 4477 O CYS B1308 −31.897 −48.393 −16.081 23.68 O ATOM 4478 N PRO B1309 −32.6 −46.935 −14.466 25.41 N ATOM 4479 CD PRO B1309 −32.656 −45.647 −13.763 24.46 C ATOM 4480 CA PRO B1309 −33.584 −47.895 −13.88 24.77 C ATOM 4481 CB PRO B1309 −34.204 −47.104 −12.715 23.63 C ATOM 4482 CG PRO B1309 −33.172 −46.086 −12.433 25.74 C ATOM 4483 C PRO B1309 −34.642 −48.229 −14.909 24.26 C ATOM 4484 O PRO B1309 −34.95 −47.377 −15.795 23.66 O ATOM 4485 N ASP B1310 −35.19 −49.439 −14.799 24.29 N ATOM 4486 CA ASP B1310 −36.185 −49.915 −15.796 24.2 C ATOM 4487 CB ASP B1310 −36.631 −51.401 −15.563 26.57 C ATOM 4488 CG ASP B1310 −35.495 −52.422 −15.751 29.97 C ATOM 4489 OD1 ASP B1310 −34.485 −52.019 −16.361 36.47 O ATOM 4490 OD2 ASP B1310 −35.597 −53.597 −15.263 30.68 O ATOM 4491 C ASP B1310 −37.418 −49.003 −15.83 21.98 C ATOM 4492 O ASP B1310 −37.941 −48.708 −16.926 21.91 O ATOM 4493 N PRO B1311 −37.923 −48.602 −14.646 19.96 N ATOM 4494 CD PRO B1311 −37.599 −49.016 −13.268 20.32 C ATOM 4495 CA PRO B1311 −39.113 −47.777 −14.668 19.05 C ATOM 4496 CB PRO B1311 −39.524 −47.708 −13.183 18.27 C ATOM 4497 CG PRO B1311 −38.379 −48.115 −12.44 18.5 C ATOM 4498 C PRO B1311 −38.918 −46.399 −15.249 17.86 C ATOM 4499 O PRO B1311 −39.899 −45.735 −15.688 17.53 O ATOM 4500 N LEU B1312 −37.67 −45.965 −15.271 16.14 N ATOM 4501 CA LEU B1312 −37.465 −44.677 −15.858 16.38 C ATOM 4502 CB LEU B1312 −36.183 −43.984 −15.37 16.29 C ATOM 4503 CG LEU B1312 −36.067 −42.524 −15.792 16.08 C ATOM 4504 CD1 LEU B1312 −37.295 −41.659 −15.348 11.99 C ATOM 4505 CD2 LEU B1312 −34.769 −41.986 −15.207 17.66 C ATOM 4506 C LEU B1312 −37.488 −44.812 −17.338 16.51 C ATOM 4507 O LEU B1312 −38.021 −43.942 −17.987 18.01 O ATOM 4508 N TYR B1313 −36.933 −45.913 −17.868 17.37 N ATOM 4509 CA TYR B1313 −36.921 −46.179 −19.269 16.68 C ATOM 4510 CB TYR B1313 −36.045 −47.372 −19.607 18.13 C ATOM 4511 CG TYR B1313 −35.809 −47.569 −21.126 19.09 C ATOM 4512 CD1 TYR B1313 −35.4 −46.494 −21.925 17.61 C ATOM 4513 CE1 TYR B1313 −35.201 −46.641 −23.29 14.2 C ATOM 4514 CD2 TYR B1313 −36.056 −48.82 −21.769 17.57 C ATOM 4515 CE2 TYR B1313 −35.828 −48.972 −23.114 13.44 C ATOM 4516 CZ TYR B1313 −35.396 −47.877 −23.866 15.63 C ATOM 4517 OH TYR B1313 −35.189 −47.951 −25.217 17.24 O ATOM 4518 C TYR B1313 −38.286 −46.441 −19.728 17.75 C ATOM 4519 O TYR B1313 −38.61 −46.123 −20.875 18.79 O ATOM 4520 N GLU B1314 −39.111 −47.023 −18.873 18.63 N ATOM 4521 CA GLU B1314 −40.523 −47.214 −19.258 21.23 C ATOM 4522 CB GLU B1314 −41.366 −48.074 −18.279 22.12 C ATOM 4523 CG GLU B1314 −42.245 −49.17 −19.065 33.76 C ATOM 4524 CD GLU B1314 −43.49 −48.606 −19.922 44.3 C ATOM 4525 OE1 GLU B1314 −43.455 −48.565 −21.212 43.29 O ATOM 4526 OE2 GLU B1314 −44.521 −48.207 −19.278 47.53 O ATOM 4527 C GLU B1314 −41.229 −45.89 −19.486 19.2 C ATOM 4528 O GLU B1314 −42.049 −45.786 −20.418 18.94 O ATOM 4529 N VAL B1315 −40.898 −44.905 −18.64 16.5 N ATOM 4530 CA VAL B1315 −41.316 −43.504 −18.813 15.13 C ATOM 4531 CB VAL B1315 −40.713 −42.501 −17.729 15.61 C ATOM 4532 CG1 VAL B1315 −41.278 −41.055 −17.932 14.24 C ATOM 4533 CG2 VAL B1315 −40.98 −43.034 −16.234 13.55 C ATOM 4534 C VAL B1315 −40.922 −43.015 −20.153 14.83 C ATOM 4535 O VAL B1315 −41.775 −42.65 −20.949 15.7 O ATOM 4536 N MET B1316 −39.633 −43.05 −20.434 15.52 N ATOM 4537 CA MET B1316 −39.114 −42.518 −21.691 17.71 C ATOM 4538 CB MET B1316 −37.623 −42.804 −21.81 18.78 C ATOM 4539 CG MET B1316 −36.714 −42.253 −20.696 17.64 C ATOM 4540 SD MET B1316 −35.014 −42.678 −21.236 22.89 S ATOM 4541 CE MET B1316 −34.237 −43.094 −19.653 17.64 C ATOM 4542 C MET B1316 −39.821 −43.142 −22.882 16.73 C ATOM 4543 O MET B1316 −40.287 −42.435 −23.76 17.39 O ATOM 4544 N LEU B1317 −39.934 −44.469 −22.886 16.32 N ATOM 4545 CA LEU B1317 −40.676 −45.179 −23.93 15.32 C ATOM 4546 CB LEU B1317 −40.662 −46.667 −23.706 15.3 C ATOM 4547 CG LEU B1317 −39.334 −47.379 −23.955 14.27 C ATOM 4548 CD1 LEU B1317 −39.561 −48.82 −23.47 8.02 C ATOM 4549 CD2 LEU B1317 −38.892 −47.248 −25.466 9.83 C ATOM 4550 C LEU B1317 −42.099 −44.727 −24.053 14.63 C ATOM 4551 O LEU B1317 −42.565 −44.533 −25.151 15.33 O ATOM 4552 N LYS B1318 −42.787 −44.512 −22.949 14.75 N ATOM 4553 CA LYS B1318 −44.142 −43.957 −23.059 16.87 C ATOM 4554 CB LYS B1318 −44.887 −43.938 −21.685 18.94 C ATOM 4555 CG LYS B1318 −45.16 −45.282 −21.027 19.41 C ATOM 4556 CD LYS B1318 −46.49 −45.359 −20.291 25.33 C ATOM 4557 CE LYS B1318 −46.597 −46.665 −19.415 28.28 C ATOM 4558 NZ LYS B1318 −45.911 −46.56 −18.01 30.63 N ATOM 4559 C LYS B1318 −44.077 −42.499 −23.668 16.78 C ATOM 4560 O LYS B1318 −45.021 −42.028 −24.327 18.11 O ATOM 4561 N CYS B1319 −42.999 −41.776 −23.414 14.19 N ATOM 4562 CA CYS B1319 −42.924 −40.434 −23.935 14.09 C ATOM 4563 CB CYS B1319 −41.718 −39.695 −23.331 14.7 C ATOM 4564 SG CYS B1319 −41.84 −39.372 −21.566 11.89 S ATOM 4565 C CYS B1319 −42.792 −40.447 −25.456 13.72 C ATOM 4566 O CYS B1319 −43.091 −39.457 −26.064 13.34 O ATOM 4567 N TRP B1320 −42.324 −41.566 −26.028 13.62 N ATOM 4568 CA TRP B1320 −41.978 −41.687 −27.437 14.07 C ATOM 4569 CB TRP B1320 −40.553 −42.252 −27.636 11.41 C ATOM 4570 CG TRP B1320 −39.484 −41.481 −26.985 11.53 C ATOM 4571 CD2 TRP B1320 −38.262 −42.01 −26.378 15.7 C ATOM 4572 CE2 TRP B1320 −37.53 −40.897 −25.884 13.52 C ATOM 4573 CE3 TRP B1320 −37.735 −43.317 −26.194 8.48 C ATOM 4574 CD1 TRP B1320 −39.384 −40.132 −26.883 10.51 C ATOM 4575 NE1 TRP B1320 −38.257 −39.769 −26.169 9.79 N ATOM 4576 CZ2 TRP B1320 −36.315 −41.053 −25.226 11.01 C ATOM 4577 CZ3 TRP B1320 −36.609 −43.469 −25.541 8.17 C ATOM 4578 CH2 TRP B1320 −35.888 −42.337 −25.043 12.57 C ATOM 4579 C TRP B1320 −42.987 −42.565 −28.133 15.9 C ATOM 4580 O TRP B1320 −42.714 −43.143 −29.198 16.2 O ATOM 4581 N HIS B1321 −44.173 −42.685 −27.532 17.08 N ATOM 4582 CA HIS B1321 −45.261 −43.363 −28.185 15.92 C ATOM 4583 CB HIS B1321 −46.5 −43.344 −27.347 14.2 C ATOM 4584 CG HIS B1321 −47.434 −44.45 −27.703 19.14 C ATOM 4585 CD2 HIS B1321 −47.608 −45.684 −27.166 22.36 C ATOM 4586 ND1 HIS B1321 −48.269 −44.394 −28.79 26.22 N ATOM 4587 CE1 HIS B1321 −48.952 −45.526 −28.89 24.74 C ATOM 4588 NE2 HIS B1321 −48.567 −46.322 −27.911 23.76 N ATOM 4589 C HIS B1321 −45.551 −42.714 −29.528 16.58 C ATOM 4590 O HIS B1321 −45.591 −41.478 −29.617 18.29 O ATOM 4591 N PRO B1322 −45.786 −43.53 −30.577 16.64 N ATOM 4592 CD PRO B1322 −45.701 −45.007 −30.548 16.05 C ATOM 4593 CA PRO B1322 −46.182 −43.061 −31.892 16.76 C ATOM 4594 CB PRO B1322 −46.609 −44.369 −32.58 17.01 C ATOM 4595 CG PRO B1322 −45.74 −45.372 −31.976 14.36 C ATOM 4596 C PRO B1322 −47.376 −42.105 −31.842 17.71 C ATOM 4597 O PRO B1322 −47.397 −41.119 −32.583 16.57 O ATOM 4598 N LYS B1323 −48.366 −42.426 −30.988 18.6 N ATOM 4599 CA LYS B1323 −49.609 −41.605 −30.857 20.46 C ATOM 4600 CB LYS B1323 −50.852 −42.449 −30.599 20.9 C ATOM 4601 CG LYS B1323 −50.822 −43.817 −31.131 26.18 C ATOM 4602 CD LYS B1323 −51.711 −43.993 −32.377 33.01 C ATOM 4603 CE LYS B1323 −52.13 −45.519 −32.59 36.06 C ATOM 4604 NZ LYS B1323 −52.282 −45.886 −34.085 37.09 N ATOM 4605 C LYS B1323 −49.494 −40.621 −29.71 19 C ATOM 4606 O LYS B1323 −49.409 −41.013 −28.554 17.22 O ATOM 4607 N ALA B1324 −49.491 −39.356 −30.06 19.16 N ATOM 4608 CA ALA B1324 −49.339 −38.265 −29.085 20.18 C ATOM 4609 CB ALA B1324 −49.562 −36.911 −29.773 19.6 C ATOM 4610 C ALA B1324 −50.25 −38.408 −27.868 20.98 C ATOM 4611 O ALA B1324 −49.836 −38.189 −26.728 21.38 O ATOM 4612 N GLU B1325 −51.495 −38.801 −28.113 22.65 N ATOM 4613 CA GLU B1325 −52.46 −38.931 −27.031 24.7 C ATOM 4614 CB GLU B1325 −53.939 −38.946 −27.489 25.28 C ATOM 4615 CG GLU B1325 −54.193 −38.902 −28.924 30.62 C ATOM 4616 CD GLU B1325 −53.75 −40.2 −29.585 36.79 C ATOM 4617 OE1 GLU B1325 −53.291 −40.133 −30.771 36.59 O ATOM 4618 OE2 GLU B1325 −53.846 −41.257 −28.888 38.64 O ATOM 4619 C GLU B1325 −52.186 −40.048 −26.063 23.25 C ATOM 4620 O GLU B1325 −52.792 −40.066 −24.997 24.62 O ATOM 4621 N MET B1326 −51.276 −40.945 −26.409 22.92 N ATOM 4622 CA MET B1326 −50.868 −42.053 −25.54 23.34 C ATOM 4623 CB MET B1326 −50.321 −43.185 −26.382 24.62 C ATOM 4624 CG MET B1326 −51.294 −43.556 −27.446 32.3 C ATOM 4625 SD MET B1326 −52.808 −44.354 −26.742 38.17 S ATOM 4626 CE MET B1326 −52.914 −45.848 −27.84 34.43 C ATOM 4627 C MET B1326 −49.748 −41.628 −24.606 21.64 C ATOM 4628 O MET B1326 −49.332 −42.397 −23.734 22.41 O ATOM 4629 N ARG B1327 −49.245 −40.425 −24.821 18.28 N ATOM 4630 CA ARG B1327 −48.081 −39.982 −24.146 16.16 C ATOM 4631 CB ARG B1327 −47.379 −38.925 −24.998 14.09 C ATOM 4632 CG ARG B1327 −46.835 −39.546 −26.213 13.42 C ATOM 4633 CD ARG B1327 −45.957 −38.589 −26.997 13.18 C ATOM 4634 NE ARG B1327 −45.905 −39.079 −28.352 11.83 N ATOM 4635 CZ ARG B1327 −45.771 −38.322 −29.438 13.53 C ATOM 4636 NH1 ARG B1327 −45.625 −37.033 −29.301 13.63 N ATOM 4637 NH2 ARG B1327 −45.765 −38.877 −30.668 12.12 N ATOM 4638 C ARG B1327 −48.55 −39.447 −22.818 15.22 C ATOM 4639 O ARG B1327 −49.596 −38.751 −22.766 15.83 O ATOM 4640 N PRO B1328 −47.788 −39.734 −21.739 14.57 N ATOM 4641 CD PRO B1328 −46.543 −40.522 −21.631 15.56 C ATOM 4642 CA PRO B1328 −48.155 −39.17 −20.447 14.81 C ATOM 4643 CB PRO B1328 −47.009 −39.646 −19.526 14.49 C ATOM 4644 CG PRO B1328 −45.89 −39.938 −20.437 14.09 C ATOM 4645 C PRO B1328 −48.168 −37.63 −20.504 14.44 C ATOM 4646 O PRO B1328 −47.362 −37.037 −21.186 14.21 O ATOM 4647 N SER B1329 −49.061 −37.013 −19.76 15.23 N ATOM 4648 CA SER B1329 −49.065 −35.577 −19.489 15.32 C ATOM 4649 CB SER B1329 −50.377 −35.136 −18.769 16.24 C ATOM 4650 OG SER B1329 −50.475 −35.595 −17.432 17.82 O ATOM 4651 C SER B1329 −47.953 −35.272 −18.598 14.45 C ATOM 4652 O SER B1329 −47.386 −36.189 −17.96 15.18 O ATOM 4653 N PHE B1330 −47.618 −33.985 −18.5 15.11 N ATOM 4654 CA PHE B1330 −46.528 −33.582 −17.536 13.94 C ATOM 4655 CB PHE B1330 −46.061 −32.16 −17.801 12.57 C ATOM 4656 CG PHE B1330 −45.132 −32.059 −18.976 7.65 C ATOM 4657 CD1 PHE B1330 −43.828 −32.576 −18.882 5.76 C ATOM 4658 CD2 PHE B1330 −45.551 −31.446 −20.148 3.23 C ATOM 4659 CE1 PHE B1330 −42.976 −32.543 −19.978 9.3 C ATOM 4660 CE2 PHE B1330 −44.681 −31.378 −21.294 5.74 C ATOM 4661 CZ PHE B1330 −43.408 −31.926 −21.219 6.8 C ATOM 4662 C PHE B1330 −46.793 −33.884 −16.06 14.54 C ATOM 4663 O PHE B1330 −45.891 −34.202 −15.333 14.93 O ATOM 4664 N SER B1331 −48.054 −33.866 −15.675 16.48 N ATOM 4665 CA SER B1331 −48.5 −34.249 −14.339 18.67 C ATOM 4666 CB SER B1331 −50.03 −34.095 −14.237 19.21 C ATOM 4667 OG SER B1331 −50.368 −32.723 −14.292 22.71 O ATOM 4668 C SER B1331 −48.175 −35.696 −14.026 19.57 C ATOM 4669 O SER B1331 −47.687 −35.99 −12.934 20.05 O ATOM 4670 N GLU B1332 −48.47 −36.604 −14.96 19.67 N ATOM 4671 CA GLU B1332 −48.151 −38.023 −14.72 20.35 C ATOM 4672 CB GLU B1332 −48.712 −38.922 −15.844 21.1 C ATOM 4673 CG GLU B1332 −49.989 −38.333 −16.37 25.88 C ATOM 4674 CD GLU B1332 −50.609 −39.105 −17.505 32.07 C ATOM 4675 OE1 GLU B1332 −50.996 −40.266 −17.25 37.09 O ATOM 4676 OE2 GLU B1332 −50.743 −38.557 −18.626 29.37 O ATOM 4677 C GLU B1332 −46.666 −38.179 −14.629 17.39 C ATOM 4678 O GLU B1332 −46.157 −38.872 −13.803 18.56 O ATOM 4679 N LEU B1333 −45.962 −37.512 −15.49 17.55 N ATOM 4680 CA LEU B1333 −44.492 −37.546 −15.487 17 C ATOM 4681 CB LEU B1333 −43.952 −36.584 −16.542 16.13 C ATOM 4682 CG LEU B1333 −43.485 −37.135 −17.893 16.66 C ATOM 4683 CD1 LEU B1333 −43.469 −38.652 −18.04 11.84 C ATOM 4684 CD2 LEU B1333 −44.25 −36.425 −18.993 15.31 C ATOM 4685 C LEU B1333 −43.949 −37.147 −14.136 17.56 C ATOM 4686 O LEU B1333 −43.079 −37.842 −13.573 17.14 O ATOM 4687 N VAL B1334 −44.455 −36.034 −13.593 17.51 N ATOM 4688 CA VAL B1334 −43.955 −35.678 −12.272 18.47 C ATOM 4689 CB VAL B1334 −44.143 −34.153 −11.829 18.11 C ATOM 4690 CG1 VAL B1334 −44.442 −33.243 −13.018 14.01 C ATOM 4691 CG2 VAL B1334 −45.126 −34.083 −10.693 15.6 C ATOM 4692 C VAL B1334 −44.396 −36.63 −11.139 19.77 C ATOM 4693 O VAL B1334 −43.644 −36.832 −10.142 19.19 O ATOM 4694 N SER B1335 −45.588 −37.22 −11.291 19.42 N ATOM 4695 CA SER B1335 −45.993 −38.174 −10.308 20.01 C ATOM 4696 CB SER B1335 −47.422 −38.604 −10.5 19.55 C ATOM 4697 OG SER B1335 −48.127 −37.893 −9.525 24.31 O ATOM 4698 C SER B1335 −45.084 −39.35 −10.397 20.57 C ATOM 4699 O SER B1335 −44.477 −39.799 −9.382 22.6 O ATOM 4700 N ARG B1336 −44.932 −39.81 −11.615 19.14 N ATOM 4701 CA ARG B1336 −44.274 −41.073 −11.816 20.87 C ATOM 4702 CB ARG B1336 −44.554 −41.564 −13.257 21.65 C ATOM 4703 CG ARG B1336 −43.906 −42.881 −13.563 25.26 C ATOM 4704 CD ARG B1336 −44.784 −44.042 −13.136 30.89 C ATOM 4705 NE ARG B1336 −43.944 −45.064 −12.524 34.5 N ATOM 4706 CZ ARG B1336 −44.048 −45.462 −11.251 37.83 C ATOM 4707 NH1 ARG B1336 −43.176 −46.392 −10.831 34.4 N ATOM 4708 NH2 ARG B1336 −45.001 −44.926 −10.416 33 N ATOM 4709 C ARG B1336 −42.772 −40.978 −11.488 19.91 C ATOM 4710 O ARG B1336 −42.178 −41.918 −10.906 20.62 O ATOM 4711 N ILE B1337 −42.183 −39.828 −11.823 17.75 N ATOM 4712 CA ILE B1337 −40.813 −39.639 −11.58 17.06 C ATOM 4713 CB ILE B1337 −40.183 −38.583 −12.531 17.62 C ATOM 4714 CG2 ILE B1337 −38.69 −38.364 −12.157 16.92 C ATOM 4715 CG1 ILE B1337 −40.247 −39.011 −14.001 16.78 C ATOM 4716 CD1 ILE B1337 −40.004 −37.848 −15.033 17.27 C ATOM 4717 C ILE B1337 −40.514 −39.39 −10.072 17.05 C ATOM 4718 O ILE B1337 −39.44 −39.766 −9.582 16.58 O ATOM 4719 N SER B1338 −41.446 −38.791 −9.323 17.74 N ATOM 4720 CA SER B1338 −41.214 −38.622 −7.839 19.11 C ATOM 4721 CB SER B1338 −42.322 −37.796 −7.116 18.77 C ATOM 4722 OG SER B1338 −42.68 −36.632 −7.87 21.59 O ATOM 4723 C SER B1338 −41.086 −39.958 −7.155 17.75 C ATOM 4724 O SER B1338 −40.175 −40.172 −6.406 18.2 O ATOM 4725 N ALA B1339 −42.03 −40.827 −7.479 18.2 N ATOM 4726 CA ALA B1339 −42.127 −42.207 −7.068 17.95 C ATOM 4727 CB ALA B1339 −43.227 −42.836 −7.861 16.27 C ATOM 4728 C ALA B1339 −40.84 −42.941 −7.32 19.39 C ATOM 4729 O ALA B1339 −40.314 −43.655 −6.409 21.18 O ATOM 4730 N ILE B1340 −40.301 −42.781 −8.552 20.07 N ATOM 4731 CA ILE B1340 −39.065 −43.48 −8.95 17.93 C ATOM 4732 CB ILE B1340 −38.853 −43.383 −10.432 17.93 C ATOM 4733 CG2 ILE B1340 −37.443 −43.926 −10.849 16.49 C ATOM 4734 CG1 ILE B1340 −39.964 −44.074 −11.175 17.37 C ATOM 4735 CD1 ILE B1340 −39.847 −44.016 −12.777 16.33 C ATOM 4736 C ILE B1340 −37.884 −42.87 −8.179 18.75 C ATOM 4737 O ILE B1340 −36.949 −43.573 −7.793 17.26 O ATOM 4738 N PHE B1341 −37.965 −41.545 −7.969 20.47 N ATOM 4739 CA PHE B1341 −36.935 −40.757 −7.283 20.98 C ATOM 4740 CB PHE B1341 −37.206 −39.264 −7.419 19.62 C ATOM 4741 CG PHE B1341 −36.215 −38.396 −6.69 17.4 C ATOM 4742 CD1 PHE B1341 −34.924 −38.216 −7.209 18.52 C ATOM 4743 CD2 PHE B1341 −36.562 −37.789 −5.463 15.18 C ATOM 4744 CE1 PHE B1341 −33.962 −37.381 −6.529 22.53 C ATOM 4745 CE2 PHE B1341 −35.657 −36.973 −4.732 19.9 C ATOM 4746 CZ PHE B1341 −34.31 −36.737 −5.272 21.72 C ATOM 4747 C PHE B1341 −36.898 −41.127 −5.827 23.05 C ATOM 4748 O PHE B1341 −35.809 −41.317 −5.277 23.42 O ATOM 4749 N SER B1342 −38.062 −41.212 −5.201 25.6 N ATOM 4750 CA SER B1342 −38.149 −41.713 −3.819 31.43 C ATOM 4751 CB SER B1342 −39.567 −41.807 −3.363 31.39 C ATOM 4752 OG SER B1342 −39.717 −40.757 −2.434 36.05 O ATOM 4753 C SER B1342 −37.516 −43.06 −3.501 34.23 C ATOM 4754 O SER B1342 −36.693 −43.154 −2.57 35.16 O ATOM 4755 N THR B1343 −37.901 −44.101 −4.257 36.83 N ATOM 4756 CA THR B1343 −37.229 −45.397 −4.165 38.38 C ATOM 4757 CB THR B1343 −37.554 −46.287 −5.308 38.54 C ATOM 4758 OG1 THR B1343 −36.597 −46.025 −6.353 38.96 O ATOM 4759 CG2 THR B1343 −38.995 −46.003 −5.763 37.89 C ATOM 4760 C THR B1343 −35.742 −45.266 −4.224 39.74 C ATOM 4761 O THR B1343 −35.032 −46.224 −3.938 41.03 O ATOM 4762 N PHE B1344 −35.233 −44.1 −4.58 41.26 N ATOM 4763 CA PHE B1344 −33.799 −44.038 −4.73 42.8 C ATOM 4764 CB PHE B1344 −33.345 −43.216 −5.903 41.57 C ATOM 4765 CG PHE B1344 −32.811 −44.036 −6.983 38.68 C ATOM 4766 CD1 PHE B1344 −33.674 −44.636 −7.897 39.26 C ATOM 4767 CD2 PHE B1344 −31.458 −44.289 −7.056 35.03 C ATOM 4768 CE1 PHE B1344 −33.166 −45.431 −8.921 37.52 C ATOM 4769 CE2 PHE B1344 −30.932 −45.052 −8.046 33.41 C ATOM 4770 CZ PHE B1344 −31.769 −45.642 −8.984 38.56 C ATOM 4771 C PHE B1344 −32.936 −43.789 −3.544 45.59 C ATOM 4772 O PHE B1344 −33.206 −42.962 −2.646 45.42 O ATOM 4773 N ILE B1345 −31.827 −44.505 −3.656 49.05 N ATOM 4774 CA ILE B1345 −30.833 −44.778 −2.628 51.82 C ATOM 4775 CB ILE B1345 −31.443 −44.651 −1.138 52.15 C ATOM 4776 CG2 ILE B1345 −32.243 −45.949 −0.677 53.65 C ATOM 4777 CG1 ILE B1345 −30.429 −44.02 −0.126 52.44 C ATOM 4778 CD1 ILE B1345 −29.161 −44.876 0.167 49.33 C ATOM 4779 C ILE B1345 −30.383 −46.197 −3.124 53.09 C ATOM 4780 O ILE B1345 −29.175 −46.436 −3.442 53.28 O ATOM 4781 N GLY B1346 −31.38 −47.09 −3.271 53.8 N ATOM 4782 CA GLY B1346 −31.227 −48.359 −3.998 54.24 C ATOM 4783 C GLY B1346 −32.269 −48.514 −5.109 54.24 C ATOM 4784 O GLY B1346 −32.572 −47.603 −5.915 53.17 O ATOM 4785 OXT GLY B1346 −32.842 −49.608 −5.198 54.15 O ATOM 4786 C18 M97 C1 −6.757 10.413 1.931 13.34 C ATOM 4787 C17 M97 C1 −6.821 11.541 2.986 11.83 C ATOM 4788 C16 M97 C1 −5.784 12.663 2.878 15.81 C ATOM 4789 C15 M97 C1 −5.684 13.145 1.409 17.14 C ATOM 4790 C23 M97 C1 −5.215 14.43 1.015 15.54 C ATOM 4791 C22 M97 C1 −5.141 14.811 −0.321 12.44 C ATOM 4792 C21 M97 C1 −5.545 13.904 −1.323 14.75 C ATOM 4793 C20 M97 C1 −6.025 12.648 −0.947 16.78 C ATOM 4794 C19 M97 C1 −6.1 12.29 0.385 17.2 C ATOM 4795 N3 M97 C1 −6.631 10.999 0.557 13.75 N ATOM 4796 C3 M97 C1 −6.844 10.562 −0.666 13.83 C ATOM 4797 C2 M97 C1 −6.514 11.51 −1.566 17.04 C ATOM 4798 C6 M97 C1 −6.692 11.372 −3.093 13.93 C ATOM 4799 C8 M97 C1 −5.475 11.814 −3.914 12.39 C ATOM 4800 O2 M97 C1 −4.314 11.482 −3.73 11.64 O ATOM 4801 N2 M97 C1 −5.811 12.562 −4.949 13.09 N ATOM 4802 C7 M97 C1 −7.135 12.751 −4.996 13.15 C ATOM 4803 O1 M97 C1 −7.643 13.406 −5.899 12.05 O ATOM 4804 C1 M97 C1 −7.819 12.181 −3.728 14.16 C ATOM 4805 C4 M97 C1 −9.155 11.566 −3.893 16.46 C ATOM 4806 C10 M97 C1 −10.106 11.501 −2.902 16.63 C ATOM 4807 C11 M97 C1 −10.181 11.877 −1.578 21.54 C ATOM 4808 C12 M97 C1 −11.335 11.655 −0.794 16.81 C ATOM 4809 C13 M97 C1 −12.39 11.019 −1.396 15.57 C ATOM 4810 C14 M97 C1 −12.336 10.641 −2.722 16.22 C ATOM 4811 C9 M97 C1 −11.197 10.875 −3.485 17.96 C ATOM 4812 N1 M97 C1 −10.896 10.615 −4.784 18.43 N ATOM 4813 C5 M97 C1 −9.655 11.061 −5.036 19.08 C ATOM 4814 C18 M97 D1 −27.796 −19.375 −23.523 24.48 C ATOM 4815 C17 M97 D1 −27.404 −18.301 −24.565 25.28 C ATOM 4816 C16 M97 D1 −28.222 −17.006 −24.512 22.55 C ATOM 4817 C15 M97 D1 −28.24 −16.516 −23.076 22.61 C ATOM 4818 C23 M97 D1 −28.488 −15.163 −22.754 23.09 C ATOM 4819 C22 M97 D1 −28.498 −14.791 −21.391 24.77 C ATOM 4820 C21 M97 D1 −28.295 −15.729 −20.363 22.55 C ATOM 4821 C20 M97 D1 −28.099 −17.062 −20.721 19.7 C ATOM 4822 C19 M97 D1 −28.082 −17.41 −22.029 19.61 C ATOM 4823 N3 M97 D1 −27.855 −18.769 −22.162 22.53 N ATOM 4824 C3 M97 D1 −27.736 −19.275 −20.961 22.1 C ATOM 4825 C2 M97 D1 −27.884 −18.269 −20.099 21.74 C ATOM 4826 C6 M97 D1 −27.783 −18.535 −18.611 22.97 C ATOM 4827 C8 M97 D1 −28.6 −17.631 −17.729 21.97 C ATOM 4828 O2 M97 D1 −29.818 −17.491 −17.8 24.31 O ATOM 4829 N2 M97 D1 −27.842 −17.074 −16.78 24.76 N ATOM 4830 C7 M97 D1 −26.556 −17.369 −16.9 22.86 C ATOM 4831 O1 M97 D1 −25.701 −16.934 −16.141 24.63 O ATOM 4832 C1 M97 D1 −26.415 −18.195 −18.118 26.09 C ATOM 4833 C4 M97 D1 −25.204 −18.618 −18.914 28.08 C ATOM 4834 C10 M97 D1 −24.147 −19.415 −18.721 27.23 C ATOM 4835 C11 M97 D1 −23.744 −20.094 −17.651 29.15 C ATOM 4836 C12 M97 D1 −22.572 −20.813 −17.843 30.82 C ATOM 4837 C13 M97 D1 −21.838 −20.791 −19.03 29.97 C ATOM 4838 C14 M97 D1 −22.247 −20.076 −20.127 28.69 C ATOM 4839 C9 M97 D1 −23.408 −19.39 −19.928 30.21 C ATOM 4840 N1 M97 D1 −24.007 −18.618 −20.831 32.6 N ATOM 4841 C5 M97 D1 −25.078 −18.18 −20.181 33.7 C ATOM 4842 O HOH F1 −29.32 −45.647 −32.002 16.53 O ATOM 4843 O HOH F5 6.241 −1.313 7.848 9.44 O ATOM 4844 O HOH F6 9.31 −0.294 −12.45 10.96 O ATOM 4845 O HOH F8 −0.518 −17.255 −13.443 12.19 O ATOM 4846 O HOH F11 −41.781 −18.635 −8.479 18.73 O ATOM 4847 O HOH F13 −7.464 −2.012 15.403 16.58 O ATOM 4848 O HOH F15 14.609 −0.995 6.201 11.01 O ATOM 4849 O HOH F16 8.312 34.844 14.609 21.07 O ATOM 4850 O HOH F17 3.508 8.749 −10.788 15.51 O ATOM 4851 O HOH F18 14.725 −4.454 5.272 30.25 O ATOM 4852 O HOH F19 −13.905 −9.795 −22.444 15.68 O ATOM 4853 O HOH F21 −42.866 −29.624 −28.883 28.13 O ATOM 4854 O HOH F22 −26.774 −0.392 −19.528 11.42 O ATOM 4855 O HOH F23 −11.848 −12.69 −13.164 37.75 O ATOM 4856 O HOH F24 4.702 −18.668 −5.903 19.11 O ATOM 4857 O HOH F25 −33.344 −32.268 −6.818 31.15 O ATOM 4858 O HOH F26 −25.708 −43.353 −8.875 20.32 O ATOM 4859 O HOH F29 −45.908 −39.581 −34.22 19.74 O ATOM 4860 O HOH F30 −30.706 −12.15 −30.792 11.84 O ATOM 4861 O HOH F31 −33.571 −22.557 −28.722 29.36 O ATOM 4862 O HOH F33 −50.609 −28.235 −27.266 30.52 O ATOM 4863 O HOH F34 −27.54 −39.356 −4.277 23.05 O ATOM 4864 O HOH F38 −16.68 −38.138 −14.134 19.08 O ATOM 4865 O HOH F41 −8.258 −22.143 −2.471 21.09 O ATOM 4866 O HOH F42 −6.61 −0.884 3.132 4.31 O ATOM 4867 O HOH F43 −37.744 −19.121 −10.97 9.19 O ATOM 4868 O HOH F44 −13.126 9.645 −6.048 28.15 O ATOM 4869 O HOH F47 −20.145 −18.005 −8.987 50.58 O ATOM 4870 O HOH F48 10.711 2.092 12.972 21.72 O ATOM 4871 O HOH F49 −36.132 −38.07 −31.151 6.14 O ATOM 4872 O HOH F51 −35.488 −29.638 −28.278 11.04 O ATOM 4873 O HOH F52 14.842 −11.981 10.718 30.87 O ATOM 4874 O HOH F55 −35.382 −49.541 −30.387 26.91 O ATOM 4875 O HOH F56 −11.404 −13.613 12.021 10.79 O ATOM 4876 O HOH F59 0.123 −4.338 −14.067 16.42 O ATOM 4877 O HOH F61 2.695 29 −0.436 14.27 O ATOM 4878 O HOH F63 −17.953 −3.003 −15.671 12.17 O ATOM 4879 O HOH F65 −36.272 −14.628 −12.624 12.14 O ATOM 4880 O HOH F66 −37.039 −52.238 −39.018 10.87 O ATOM 4881 O HOH F68 −1.256 −13.25 7.793 7.61 O ATOM 4882 O HOH F69 13.93 −6.17 1.302 7.23 O ATOM 4883 O HOH F74 −21.281 −26.8 −15.829 36.75 O ATOM 4884 O HOH F75 −8.945 −12.697 −14.696 15.11 O ATOM 4885 O HOH F78 −41.02 −15.364 −18.372 32.16 O ATOM 4886 O HOH F79 2.29 10.714 −1.259 16.47 O ATOM 4887 O HOH F80 −48.619 −49.393 −27.169 27.17 O ATOM 4888 O HOH F81 −49.904 −38.791 −33.25 27.2 O ATOM 4889 O HOH F82 −13.586 −12.029 −4.742 30.12 O ATOM 4890 O HOH F84 15.912 −6.318 −3.476 24.03 O ATOM 4891 O HOH F86 −8.824 20.746 3.879 17.29 O ATOM 4892 O HOH F87 −0.697 −8.031 11.805 9.36 O ATOM 4893 O HOH F89 −48.633 −6.161 −17.326 10.19 O ATOM 4894 O HOH F90 −42.9 −45.555 −34.406 17.72 O ATOM 4895 O HOH F92 11.987 −1.35 20.511 35.19 O ATOM 4896 O HOH F93 −28.968 −46.992 −11.157 38.03 O ATOM 4897 O HOH F94 19.165 5.56 −3.202 13.7 O ATOM 4898 O HOH F95 −10.566 −5.79 −17.051 15.61 O ATOM 4899 O HOH F98 −36.062 −17.343 −13.063 5.49 O ATOM 4900 O HOH F99 −32.503 −51.224 −24.017 10.16 O ATOM 4901 O HOH F103 9.945 0.105 2.08 15.57 O ATOM 4902 O HOH F106 4.418 −17.639 13.148 16.93 O ATOM 4903 O HOH F107 −45.986 −2.509 −16.086 15.03 O ATOM 4904 O HOH F109 −2.683 −19.25 −13.776 28.45 O ATOM 4905 O HOH F110 −4.254 −4.332 −13.533 18.93 O ATOM 4906 O HOH F111 −11.1 6.177 −16.231 25.82 O ATOM 4907 O HOH F113 −27.258 −24.151 −30.7 14.97 O ATOM 4908 O HOH F118 −11.233 12.9 −14.378 51.8 O ATOM 4909 O HOH F119 −40.043 −29.384 −26.812 7.78 O ATOM 4910 O HOH F122 −27.638 −41.749 −41.794 20.81 O ATOM 4911 O HOH F123 −37.295 −51.413 −19.137 29.17 O ATOM 4912 O HOH F127 12.353 29.785 0.805 34.63 O ATOM 4913 O HOH F132 −46.845 −25.3 −34.335 18.55 O ATOM 4914 O HOH F133 −10.658 24.394 −8.533 13.92 O ATOM 4915 O HOH F135 −27.625 −23.545 −23.649 23.5 O ATOM 4916 O HOH F139 −7.482 −18.693 −10.139 26.8 O ATOM 4917 O HOH F140 −37.308 3.619 −35.119 10.72 O ATOM 4918 O HOH F141 −9.487 −12.65 7.885 27.37 O ATOM 4919 O HOH F147 −14.473 −15.515 −13.357 28.23 O ATOM 4920 O HOH F151 −49.253 −31.734 −19.766 12.77 O ATOM 4921 O HOH F152 −33.874 −21.649 −26.009 35.39 O ATOM 4922 O HOH F160 −27.074 −43.992 −33.171 26.02 O ATOM 4923 O HOH F162 −1.216 −8.886 9.489 6.68 O ATOM 4924 O HOH F163 −8.684 −9.212 −17.193 20.8 O ATOM 4925 O HOH F164 −24.704 −27.369 −24.384 23.89 O ATOM 4926 O HOH F165 10.661 −0.274 −9.633 19.75 O ATOM 4927 O HOH F167 −39.405 −17 −10.792 13.52 O ATOM 4928 O HOH F171 −19.563 −0.808 −17.608 25.97 O ATOM 4929 O HOH F175 −1.316 6.842 6.302 30.22 O ATOM 4930 O HOH F181 −23.672 −36.748 −6.006 33.39 O ATOM 4931 O HOH F187 −19.483 18.366 1.47 18.85 O ATOM 4932 O HOH F191 −20.833 −30.336 −23.71 17.88 O ATOM 4933 O HOH F192 −23.256 −24.86 −6.405 25.34 O ATOM 4934 O HOH F195 −27.943 −43.121 −7.194 24.93 O ATOM 4935 O HOH F196 −9.437 −4.406 3.163 32.85 O ATOM 4936 O HOH F199 −14.351 −15.223 −16.592 35.52 O ATOM 4937 O HOH F201 −28.051 −20.14 −37.061 2.96 O ATOM 4938 O HOH F204 13.399 −2.13 13.08 38.46 O ATOM 4939 O HOH F206 −0.623 6.957 −15.231 43.14 O ATOM 4940 O HOH F209 3.949 29.41 −7.507 9.37 O ATOM 4941 O HOH F214 −4.368 13.84 −12.583 17.62 O ATOM 4942 O HOH F216 −38.765 −22.875 −29.099 25.73 O ATOM 4943 O HOH F220 4.401 7.618 −0.759 21.38 O ATOM 4944 O HOH F224 −46.22 −27.713 −23.131 21.06 O ATOM 4945 O HOH F232 −17.824 −0.269 1.213 29.39 O ATOM 4946 O HOH F234 −41.265 −32.211 −31.685 23.51 O ATOM 4947 O HOH F236 14.698 −0.179 1.827 20.96 O ATOM 4948 O HOH F238 −16.579 11.275 −2.474 28.52 O ATOM 4949 O HOH F239 −36.288 −36.794 −42.538 29.54 O ATOM 4950 O HOH F243 −28.661 −43.161 −29.758 16.75 O ATOM 4951 O HOH F244 −36.382 −42.158 −29.189 16.52 O ATOM 4952 O HOH F245 −8.091 −23.484 0.658 15.9 O ATOM 4953 O HOH F256 −47.173 −21.426 −26.921 17.64 O ATOM 4954 O HOH F264 10.977 −5.747 10.557 16.36 O ATOM 4955 O HOH F267 −36.06 1.427 −13.036 40.7 O ATOM 4956 O HOH F268 11.515 6.152 5.718 11.46 O ATOM 4957 O HOH F269 −6.05 34.979 5.439 23.66 O ATOM 4958 O HOH F271 −8.98 −0.279 5.32 15.75 O ATOM 4959 O HOH F276 2.974 11.07 9.919 22.17 O ATOM 4960 O HOH F278 −14.111 −9.961 6.282 44.67 O ATOM 4961 O HOH F279 −29.218 −45.75 −28.633 11.2 O ATOM 4962 O HOH F282 −42.477 −21.253 −27.923 18.5 O ATOM 4963 O HOH F283 −34.014 −4.394 2.354 12.22 O ATOM 4964 O HOH F284 4.7 22.988 −7.778 23.08 O ATOM 4965 O HOH F289 −8.366 −21.818 2.824 18.62 O ATOM 4966 O HOH F290 1.692 9.464 29.595 34.19 O ATOM 4967 O HOH F291 −23.192 −11.572 −29.113 40.34 O ATOM 4968 O HOH F293 −48.105 −36.996 −38.885 30.74 O ATOM 4969 O HOH F298 −24.065 −44.956 −29.789 44.17 O ATOM 4970 O HOH F299 −17.055 −9.208 8.875 44.85 O ATOM 4971 O HOH F310 −10.136 18.804 6.712 30.24 O ATOM 4972 O HOH F311 −11.822 24.153 −6.297 18.14 O ATOM 4973 O HOH F316 9.546 31.815 −11.844 9.61 O ATOM 4974 O HOH F317 11.95 30.507 −11.564 11.26 O ATOM 4975 O HOH F321 −6.987 10.303 −12.194 12.61 O ATOM 4976 O HOH F323 −8.229 12.163 −14.579 17.55 O ATOM 4977 O HOH F324 3.683 −0.89 5.686 18.78 O ATOM 4978 O HOH F325 −11.488 −14.186 −3.45 20.66 O ATOM 4979 O HOH F327 −11.968 −13.195 7.446 33.2 O ATOM 4980 O HOH F328 −16.3 −13.463 9.956 22.62 O ATOM 4981 O HOH F329 −9.272 −14.428 11.275 15.93 O ATOM 4982 O HOH F330 −1.857 −22.856 −1.675 31.54 O ATOM 4983 O HOH F331 11.811 −10.851 12.466 27.69 O ATOM 4984 O HOH F332 15.961 −8.575 7.8 18.32 O ATOM 4985 O HOH F333 18.235 −17.932 8.891 22.9 O ATOM 4986 O HOH F340 −24.46 −9.744 −25.665 12.78 O ATOM 4987 O HOH F342 −27.314 −21.134 −29.776 13.86 O ATOM 4988 O HOH F348 −40.626 −30.693 −29.559 28.67 O ATOM 4989 O HOH F351 −9.41 −15.753 7.013 14 O ATOM 4990 O HOH F352 −32.049 −50.283 −33.663 35.95 O ATOM 4991 O HOH F356 −18.866 −15.309 −30.177 24.26 O ATOM 4992 O HOH F358 −33.287 −55.033 −37.052 9.53 O ATOM 4993 O HOH F359 4.652 −3.504 10.226 33.1 O ATOM 4994 O HOH F360 −31.099 −32.445 −33.508 5.43 O ATOM 4995 O HOH F361 5.952 9.627 −8.466 18.68 O ATOM 4996 O HOH F362 12.851 −5.168 −0.578 11.64 O ATOM 4997 O HOH F363 −31.321 −33.548 −8.199 25.88 O ATOM 4998 O HOH F365 −14.509 −15.416 −24.15 28.59 O ATOM 4999 O HOH F368 −12.027 4.182 −4.641 5.68 O ATOM 5000 O HOH F372 2.882 −3.106 −13.774 28.16 O ATOM 5001 O HOH F373 −38.023 −25.397 −32.152 17.02 O ATOM 5002 O HOH F374 11.155 −20.718 −4.4 29.01 O ATOM 5003 O HOH F376 −10.556 7.527 −1.55 18.42 O ATOM 5004 O HOH F377 −48.85 −18.397 −12.457 12.98 O ATOM 5005 O HOH F380 −36.569 −37.246 −33.524 11.2 O ATOM 5006 O HOH F381 −24.863 −41.265 −28.065 25.79 O ATOM 5007 O HOH F383 −45.552 −0.183 −14.246 21.66 O ATOM 5008 O HOH F384 4.701 −21.598 −7.352 26.64 O ATOM 5009 O HOH F386 −0.6 −0.52 6.816 31.53 O ATOM 5010 O HOH F387 −10.111 −2.953 5.26 17.96 O ATOM 5011 O HOH F388 −25.049 −17.468 −7.969 32.9 O ATOM 5012 O HOH F389 −26.332 −11.606 −6.498 36.6 O ATOM 5013 O HOH F391 14.913 −6.481 8.487 36.2 O ATOM 5014 O HOH F394 16.259 −15.826 −6.447 37.58 O ATOM 5015 O HOH F395 −9.203 4.244 6.795 17.76 O ATOM 5016 O HOH F396 −40.086 0.372 −8.964 21.08 O ATOM 5017 O HOH F398 16.994 −6.858 0.059 42.45 O ATOM 5018 O HOH F402 2.118 −1.406 8.674 16.11 O ATOM 5019 O HOH F405 0.837 9.273 11.254 24.81 O ATOM 5020 O HOH F407 3.045 12.282 −8.946 33.67 O ATOM 5021 O HOH F410 −51.076 −26.098 −29.893 35.22 O ATOM 5022 O HOH F413 5.628 −20.263 13.119 19.98 O ATOM 5023 O HOH F414 −3.942 17.588 8.986 20.79 O ATOM 5024 O HOH F415 −4.646 12.122 15.494 35.45 O ATOM 5025 O HOH F420 −21.567 −21.045 −15.42 45.94 O ATOM 5026 O HOH F421 −33.27 −1.351 −28.007 16.96 O ATOM 5027 O HOH F422 −33.732 −14.336 −37.208 18.79 O ATOM 5028 O HOH F423 −24.498 −22.642 −29.114 26.48 O ATOM 5029 O HOH F427 −42.526 −46.274 −14.79 18.27 O ATOM 5030 O HOH F430 −14.75 −31.131 −19.055 48.87 O ATOM 5031 O HOH F431 −34.878 6.53 −28.368 19.91 O ATOM 5032 O HOH F432 10.549 29.362 −2.166 24.44 O ATOM 5033 O HOH F433 8.3 29.965 −3.709 42.01 O ATOM 5034 O HOH F434 4.93 35.082 7.767 27.24 O ATOM 5035 O HOH F435 7.01 38.01 9.004 21.31 O ATOM 5036 O HOH F436 18.755 27.791 9.77 46.05 O ATOM 5037 O HOH F438 0.35 28.842 15.624 13.72 O ATOM 5038 O HOH F439 6.557 22.735 17.683 31.05 O ATOM 5039 O HOH F440 3.297 0.092 −13.573 29.27 O ATOM 5040 O HOH F441 −7.94 23.432 −18.434 28.66 O ATOM 5041 O HOH F442 1.802 29.841 −11.164 42.98 O ATOM 5042 O HOH F443 −50.163 −32.075 −16.975 13.52 O ATOM 5043 O HOH F444 −50.324 −33.207 −22.394 34.24 O ATOM 5044 O HOH F445 −30.405 −27.894 −41.835 20.26 O ATOM 5045 O HOH F446 −42.528 −50.128 −39.155 34.7 O ATOM 5046 O HOH F447 −6.122 −20.519 10.241 31.88 O ATOM 5047 O HOH F448 −9.471 −17.911 15.198 29.11 O ATOM 5048 O HOH F449 −10.256 8.058 1.039 22.58 O ATOM 5049 O HOH F450 −10.084 8.041 6.965 35.26 O ATOM 5050 O HOH F451 −8.258 10.019 15.224 14.39 O ATOM 5051 O HOH F452 −3.132 9.777 17.396 43.71 O ATOM 5052 O HOH F453 −7.844 6.196 15.354 25.77 O ATOM 5053 O HOH F454 −33.488 −47.929 −40.055 17.2 O ATOM 5054 O HOH F455 −32.976 −45.657 −40.842 24.75 O ATOM 5055 O HOH F456 −15.149 9.534 2.929 44.29 O ATOM 5056 O HOH F457 −16.433 16.612 −6.304 32 O ATOM 5057 O HOH F458 −38.154 −3.576 −2.259 34.13 O ATOM 5058 O HOH F459 −33.967 0.453 −7.339 31.91 O

TABLE 1B (SEQ ID NO: 2) ATOM 1 CB LEU 1046 −19.713 −2.925 −36.938 37.65 C ATOM 2 CG LEU 1046 −19.834 −3.388 −35.494 38.45 C ATOM 3 CD1 LEU 1046 −20.915 −2.586 −34.807 37.79 C ATOM 4 CD2 LEU 1046 −20.107 −4.883 −35.426 38.03 C ATOM 5 C LEU 1046 −22.28 −3.028 −37.251 37.24 C ATOM 6 O LEU 1046 −22.669 −1.886 −37.029 36.06 O ATOM 7 N LEU 1046 −20.8 −2.523 −39.117 37.83 N ATOM 8 CA LEU 1046 −20.858 −3.287 −37.783 38.05 C ATOM 9 N LEU 1047 −22.803 −4.188 −36.833 37.34 N ATOM 10 CA LEU 1047 −24.322 −4.334 −36.88 37.41 C ATOM 11 CB LEU 1047 −24.559 −5.846 −36.963 38.63 C ATOM 12 CG LEU 1047 −24.045 −6.619 −38.197 39.63 C ATOM 13 CD1 LEU 1047 −23.493 −7.978 −37.765 40.91 C ATOM 14 CD2 LEU 1047 −25.172 −6.793 −39.21 40.19 C ATOM 15 C LEU 1047 −25.1 −3.582 −35.917 36.45 C ATOM 16 O LEU 1047 −25.898 −2.729 −36.286 36.58 O ATOM 17 N GLN 1048 −24.943 −4.046 −34.699 36.14 N ATOM 18 CA GLN 1048 −25.308 −3.208 −33.552 37.2 C ATOM 19 CB GLN 1048 −24.1 −3.359 −32.547 38.59 C ATOM 20 CG GLN 1048 −22.726 −3.016 −33.094 41.49 C ATOM 21 CD GLN 1048 −21.59 −3.712 −32.361 43.83 C ATOM 22 OE1 GLN 1048 −21.408 −3.52 −31.158 44.72 O ATOM 23 NE2 GLN 1048 −20.825 −4.534 −33.079 42.9 N ATOM 24 C GLN 1048 −25.331 −1.753 −33.995 35.99 C ATOM 25 O GLN 1048 −26.367 −1.101 −33.978 35.9 O ATOM 26 N ASN 1049 −24.192 −1.292 −34.49 34.21 N ATOM 27 CA ASN 1049 −24.188 0.042 −34.802 33.13 C ATOM 28 CB ASN 1049 −22.763 0.474 −35.102 34.55 C ATOM 29 CG ASN 1049 −22.03 0.787 −33.852 36.88 C ATOM 30 OD1 ASN 1049 −22.593 1.274 −32.899 38.35 O ATOM 31 ND2 ASN 1049 −20.756 0.562 −33.862 36.72 N ATOM 32 C ASN 1049 −25.042 0.484 −35.87 31.5 C ATOM 33 O ASN 1049 −24.714 1.503 −36.268 33.07 O ATOM 34 N THR 1050 −26.135 −0.177 −36.286 29.28 N ATOM 35 CA THR 1050 −27.071 0.242 −37.372 27.57 C ATOM 36 CB THR 1050 −26.772 −0.569 −38.656 27.93 C ATOM 37 OG1 THR 1050 −26.853 −1.982 −38.404 28.31 O ATOM 38 CG2 THR 1050 −25.354 −0.265 −39.069 28.62 C ATOM 39 C THR 1050 −28.501 −0.015 −36.874 26.39 C ATOM 40 O THR 1050 −29.511 0.174 −37.56 26.33 O ATOM 41 N VAL 1051 −28.568 −0.357 −35.614 23.92 N ATOM 42 CA VAL 1051 −29.836 −0.634 −35.034 22.71 C ATOM 43 CB VAL 1051 −29.705 −1.748 −34.014 22.99 C ATOM 44 CG1 VAL 1051 −31.041 −2.037 −33.406 21.99 C ATOM 45 CG2 VAL 1051 −29.082 −2.987 −34.659 23.78 C ATOM 46 C VAL 1051 −30.375 0.589 −34.295 22.22 C ATOM 47 O VAL 1051 −29.95 0.831 −33.199 20.21 O ATOM 48 N HIS 1052 −31.251 1.366 −34.82 22.87 N ATOM 49 CA HIS 1052 −31.674 2.419 −33.928 24 C ATOM 50 CB HIS 1052 −31.576 3.704 −34.653 24.15 C ATOM 51 CG HIS 1052 −32.273 4.827 −33.985 23.62 C ATOM 52 CD2 HIS 1052 −33.461 5.416 −34.247 24.61 C ATOM 53 ND1 HIS 1052 −31.722 5.51 −32.926 25.74 N ATOM 54 CE1 HIS 1052 −32.534 6.488 −32.571 25.69 C ATOM 55 NE2 HIS 1052 −33.596 6.453 −33.358 27.01 N ATOM 56 C HIS 1052 −33.129 2.083 −33.65 24.08 C ATOM 57 O HIS 1052 −33.725 1.402 −34.453 25.06 O ATOM 58 N ILE 1053 −33.727 2.592 −32.609 25.32 N ATOM 59 CA ILE 1053 −35.131 2.237 −32.376 26.95 C ATOM 60 CB ILE 1053 −35.181 1.212 −31.221 27.35 C ATOM 61 CG2 ILE 1053 −36.585 1.044 −30.766 26.5 C ATOM 62 CG1 ILE 1053 −34.506 −0.12 −31.596 27.84 C ATOM 63 CD ILE 1053 −32.991 −0.116 −31.455 30.41 C ATOM 64 C ILE 1053 −35.828 3.54 −31.879 27.08 C ATOM 65 O ILE 1053 −35.243 4.138 −31.014 27.08 O ATOM 66 N ASP 1054 −36.982 3.996 −32.351 27.49 N ATOM 67 CA ASP 1054 −37.546 5.236 −31.77 27.84 C ATOM 68 CB ASP 1054 −38.199 6.114 −32.815 28.33 C ATOM 69 CG ASP 1054 −38.818 7.383 −32.249 28.99 C ATOM 70 OD1 ASP 1054 −38.773 7.627 −31.021 28.77 O ATOM 71 OD2 ASP 1054 −39.366 8.145 −33.064 30.36 O ATOM 72 C ASP 1054 −38.537 4.749 −30.768 27.75 C ATOM 73 O ASP 1054 −39.568 4.12 −31.051 28.21 O ATOM 74 N LEU 1055 −38.158 4.976 −29.561 28.32 N ATOM 75 CA LEU 1055 −38.975 4.494 −28.544 29.2 C ATOM 76 CB LEU 1055 −38.127 4.545 −27.289 28.05 C ATOM 77 CG LEU 1055 −36.86 3.674 −27.342 27.28 C ATOM 78 CD1 LEU 1055 −36.032 3.941 −26.098 27.69 C ATOM 79 CD2 LEU 1055 −37.238 2.199 −27.412 26.67 C ATOM 80 C LEU 1055 −40.331 5.239 −28.441 30.11 C ATOM 81 O LEU 1055 −41.3 4.617 −28.07 30.04 O ATOM 82 N SER 1056 −40.451 6.507 −28.822 30.85 N ATOM 83 CA SER 1056 −41.728 7.269 −28.615 33.07 C ATOM 84 CB SER 1056 −41.442 8.729 −28.747 32.67 C ATOM 85 OG SER 1056 −41.007 8.96 −30.076 31.6 O ATOM 86 C SER 1056 −42.712 6.925 −29.718 34.59 C ATOM 87 O SER 1056 −43.94 7.153 −29.689 35.04 O ATOM 88 N ALA 1057 −42.081 6.42 −30.703 36.25 N ATOM 89 CA ALA 1057 −42.822 6.002 −31.859 38.14 C ATOM 90 CB ALA 1057 −41.819 5.716 −32.996 36.82 C ATOM 91 C ALA 1057 −43.573 4.697 −31.555 39.49 C ATOM 92 O ALA 1057 −44.274 4.161 −32.415 40.68 O ATOM 93 N ILE 1058 −43.475 4.255 −30.311 40.19 N ATOM 94 CA ILE 1058 −43.995 2.962 −29.948 41.59 C ATOM 95 CB ILE 1058 −42.872 2.192 −29.127 42.24 C ATOM 96 CG2 ILE 1058 −42.904 2.642 −27.671 45.17 C ATOM 97 CG1 ILE 1058 −43.068 0.676 −29.213 43.34 C ATOM 98 CD ILE 1058 −42.673 0.062 −30.552 43.01 C ATOM 99 C ILE 1058 −45.257 2.918 −29.14 41.13 C ATOM 100 O ILE 1058 −45.292 3.407 −28.015 41.55 O ATOM 101 N ASP 1059 −46.315 2.389 −29.753 41.15 N ATOM 102 CA ASP 1059 −47.605 2.129 −29.055 41.81 C ATOM 103 CB ASP 1059 −48.138 0.801 −29.462 42.5 C ATOM 104 CG ASP 1059 −49.4 0.451 −28.71 42.86 C ATOM 105 OD1 ASP 1059 −49.464 0.728 −27.494 43.52 O ATOM 106 OD2 ASP 1059 −50.325 −0.113 −29.323 44.01 O ATOM 107 C ASP 1059 −47.288 2.221 −27.554 41.59 C ATOM 108 O ASP 1059 −46.381 1.613 −27.024 42.14 O ATOM 109 N PRO 1060 −48.13 2.869 −26.869 41.04 N ATOM 110 CD PRO 1060 −48.701 3.943 −27.675 41.33 C ATOM 111 CA PRO 1060 −48.061 3.174 −25.457 41.53 C ATOM 112 CB PRO 1060 −48.349 4.654 −25.458 40.32 C ATOM 113 CG PRO 1060 −49.253 4.76 −26.709 40.85 C ATOM 114 C PRO 1060 −48.658 2.397 −24.392 41.35 C ATOM 115 O PRO 1060 −48.591 2.565 −23.203 42.29 O ATOM 116 N GLU 1061 −49.145 1.297 −24.822 41.69 N ATOM 117 CA GLU 1061 −49.723 0.813 −23.678 41.96 C ATOM 118 CB GLU 1061 −51.163 0.879 −23.965 43.79 C ATOM 119 CG GLU 1061 −51.39 0.487 −25.385 47.3 C ATOM 120 CD GLU 1061 −52.836 0.513 −25.748 49.83 C ATOM 121 OE1 GLU 1061 −53.643 0.923 −24.889 50.97 O ATOM 122 OE2 GLU 1061 −53.172 0.124 −26.887 51.87 O ATOM 123 C GLU 1061 −49.023 −0.456 −23.755 40.72 C ATOM 124 O GLU 1061 −48.908 −1.181 −22.797 40 O ATOM 125 N LEU 1062 −48.49 −0.721 −24.936 39.26 N ATOM 126 CA LEU 1062 −47.736 −1.936 −25.047 37.05 C ATOM 127 CB LEU 1062 −47.144 −2.067 −26.447 36.62 C ATOM 128 CG LEU 1062 −46.166 −3.232 −26.606 36.37 C ATOM 129 CD1 LEU 1062 −46.871 −4.543 −26.286 37.04 C ATOM 130 CD2 LEU 1062 −45.613 −3.252 −28.022 35.34 C ATOM 131 C LEU 1062 −46.61 −1.713 −24.034 36.08 C ATOM 132 O LEU 1062 −46.172 −2.59 −23.284 35 O ATOM 133 N VAL 1063 −46.211 −0.472 −23.986 35.17 N ATOM 134 CA VAL 1063 −45.136 −0.06 −23.15 35.46 C ATOM 135 CB VAL 1063 −44.642 1.236 −23.725 35.44 C ATOM 136 CG1 VAL 1063 −43.706 1.89 −22.788 35.6 C ATOM 137 CG2 VAL 1063 −43.997 0.967 −25.086 35.93 C ATOM 138 C VAL 1063 −45.523 0.057 −21.678 35.67 C ATOM 139 O VAL 1063 −44.712 −0.239 −20.794 35.29 O ATOM 140 N GLN 1064 −46.754 0.5 −21.423 35.76 N ATOM 141 CA GLN 1064 −47.262 0.647 −20.053 36.63 C ATOM 142 CB GLN 1064 −48.699 1.158 −20.085 38.64 C ATOM 143 CG GLN 1064 −49.181 1.631 −18.737 44.03 C ATOM 144 CD GLN 1064 −50.665 1.931 −18.728 47.48 C ATOM 145 OE1 GLN 1064 −51.319 1.924 −19.775 49.46 O ATOM 146 NE2 GLN 1064 −51.208 2.201 −17.544 48.03 N ATOM 147 C GLN 1064 −47.177 −0.761 −19.454 35.07 C ATOM 148 O GLN 1064 −46.523 −0.982 −18.435 34.95 O ATOM 149 N ALA 1065 −47.864 −1.693 −20.097 32.4 N ATOM 150 CA ALA 1065 −47.798 −3.114 −19.773 30.99 C ATOM 151 CB ALA 1065 −48.238 −3.895 −21.008 29.54 C ATOM 152 C ALA 1065 −46.37 −3.59 −19.366 29.66 C ATOM 153 O ALA 1065 −46.137 −4 −18.23 31.42 O ATOM 154 N VAL 1066 −45.417 −3.545 −20.298 26.55 N ATOM 155 CA VAL 1066 −44.063 −4.031 −20.015 24.46 C ATOM 156 CB VAL 1066 −43.31 −4.334 −21.353 23.5 C ATOM 157 CG1 VAL 1066 −44.296 −4.837 −22.408 23.77 C ATOM 158 CG2 VAL 1066 −42.598 −3.102 −21.852 22.22 C ATOM 159 C VAL 1066 −43.16 −3.163 −19.111 23.52 C ATOM 160 O VAL 1066 −42.126 −3.645 −18.638 24.4 O ATOM 161 N GLN 1067 −43.544 −1.911 −18.848 22.41 N ATOM 162 CA GLN 1067 −42.703 −1.021 −18.038 21.71 C ATOM 163 CB GLN 1067 −43.417 0.277 −17.642 23.75 C ATOM 164 CG GLN 1067 −42.446 1.315 −17.06 27.36 C ATOM 165 CD GLN 1067 −41.496 1.888 −18.115 28.42 C ATOM 166 OE1 GLN 1067 −40.309 2.121 −17.854 30.71 O ATOM 167 NE2 GLN 1067 −42.022 2.126 −19.308 28.25 N ATOM 168 C GLN 1067 −42.169 −1.645 −16.773 20.39 C ATOM 169 O GLN 1067 −41.027 −1.394 −16.392 17.45 O ATOM 170 N HIS 1068 −42.972 −2.464 −16.108 18.61 N ATOM 171 CA HIS 1068 −42.458 −3.041 −14.886 17.47 C ATOM 172 CB HIS 1068 −43.563 −3.74 −14.101 16.08 C ATOM 173 CG HIS 1068 −44.015 −5.023 −14.704 16.78 C ATOM 174 CD2 HIS 1068 −43.866 −6.3 −14.282 16.5 C ATOM 175 ND1 HIS 1068 −44.741 −5.082 −15.874 16.21 N ATOM 176 CE1 HIS 1068 −45.024 −6.344 −16.145 15.79 C ATOM 177 NE2 HIS 1068 −44.504 −7.102 −15.194 17.99 N ATOM 178 C HIS 1068 −41.251 −3.967 −15.081 17.41 C ATOM 179 O HIS 1068 −40.582 −4.28 −14.101 15.49 O ATOM 180 N VAL 1069 −40.949 −4.402 −16.31 15.97 N ATOM 181 CA VAL 1069 −39.75 −5.237 −16.509 15.14 C ATOM 182 CB VAL 1069 −39.978 −6.463 −17.444 14.83 C ATOM 183 CG1 VAL 1069 −40.968 −7.409 −16.839 16.23 C ATOM 184 CG2 VAL 1069 −40.429 −6.01 −18.813 17.27 C ATOM 185 C VAL 1069 −38.579 −4.455 −17.106 16.95 C ATOM 186 O VAL 1069 −37.484 −5.005 −17.258 13.59 O ATOM 187 N VAL 1070 −38.802 −3.19 −17.461 17.23 N ATOM 188 CA VAL 1070 −37.741 −2.37 −18.048 19.93 C ATOM 189 CB VAL 1070 −38.294 −1.133 −18.74 20.65 C ATOM 190 CG1 VAL 1070 −37.135 −0.251 −19.247 22.41 C ATOM 191 CG2 VAL 1070 −39.181 −1.565 −19.885 22.99 C ATOM 192 C VAL 1070 −36.783 −1.934 −16.969 20.17 C ATOM 193 O VAL 1070 −37.19 −1.383 −15.954 19.99 O ATOM 194 N ILE 1071 −35.497 −2.152 −17.202 21.73 N ATOM 195 CA ILE 1071 −34.52 −1.843 −16.175 24.48 C ATOM 196 CB ILE 1071 −33.326 −2.83 −16.285 24.86 C ATOM 197 CG2 ILE 1071 −32.302 −2.542 −15.218 25.75 C ATOM 198 CG1 ILE 1071 −33.828 −4.283 −16.134 27.22 C ATOM 199 CD ILE 1071 −34.561 −4.632 −14.81 30.1 C ATOM 200 C ILE 1071 −34.02 −0.401 −15.981 26.09 C ATOM 201 O ILE 1071 −33.915 0.054 −14.842 29.19 O ATOM 202 N GLY 1072 −33.74 0.345 −17.04 25.89 N ATOM 203 CA GLY 1072 −33.245 1.696 −16.813 24.16 C ATOM 204 C GLY 1072 −31.743 1.564 −16.874 24.08 C ATOM 205 O GLY 1072 −31.158 0.805 −16.098 23.13 O ATOM 206 N PRO 1073 −31.075 2.312 −17.755 24.22 N ATOM 207 CD PRO 1073 −31.504 3.335 −18.725 23.18 C ATOM 208 CA PRO 1073 −29.626 2.111 −17.78 24.27 C ATOM 209 CB PRO 1073 −29.194 2.872 −19.033 24.61 C ATOM 210 CG PRO 1073 −30.194 3.967 −19.142 24.35 C ATOM 211 C PRO 1073 −28.769 2.398 −16.555 24.59 C ATOM 212 O PRO 1073 −27.782 1.708 −16.346 24.13 O ATOM 213 N SER 1074 −29.118 3.376 −15.734 24.35 N ATOM 214 CA SER 1074 −28.298 3.626 −14.555 24.76 C ATOM 215 CB SER 1074 −28.922 4.721 −13.681 27.55 C ATOM 216 OG SER 1074 −30.159 4.284 −13.126 32.15 O ATOM 217 C SER 1074 −28.218 2.348 −13.723 22.97 C ATOM 218 O SER 1074 −27.185 2.03 −13.139 24.56 O ATOM 219 N SER 1075 −29.324 1.613 −13.705 21.28 N ATOM 220 CA SER 1075 −29.494 0.399 −12.907 19.44 C ATOM 221 CB SER 1075 −30.977 0.062 −12.849 18.46 C ATOM 222 OG SER 1075 −31.684 1.089 −12.195 14.27 O ATOM 223 C SER 1075 −28.732 −0.873 −13.249 20.54 C ATOM 224 O SER 1075 −28.633 −1.795 −12.429 21.36 O ATOM 225 N LEU 1076 −28.183 −0.923 −14.446 20.1 N ATOM 226 CA LEU 1076 −27.483 −2.104 −14.875 19.87 C ATOM 227 CB LEU 1076 −28.224 −2.699 −16.063 19.21 C ATOM 228 CG LEU 1076 −27.534 −3.89 −16.707 19.12 C ATOM 229 CD1 LEU 1076 −27.461 −5.021 −15.696 17.77 C ATOM 230 CD2 LEU 1076 −28.302 −4.319 −17.948 19.82 C ATOM 231 C LEU 1076 −26.041 −1.87 −15.285 20.54 C ATOM 232 O LEU 1076 −25.769 −0.986 −16.091 22.3 O ATOM 233 N ILE 1077 −25.105 −2.632 −14.731 19.46 N ATOM 234 CA ILE 1077 −23.738 −2.495 −15.208 18.87 C ATOM 235 CB ILE 1077 −22.653 −2.504 −14.094 19.56 C ATOM 236 CG2 ILE 1077 −21.285 −2.271 −14.737 19.59 C ATOM 237 CG1 ILE 1077 −22.892 −1.405 −13.059 21.62 C ATOM 238 CD ILE 1077 −24.062 −1.664 −12.118 28.65 C ATOM 239 C ILE 1077 −23.51 −3.766 −16.037 17.95 C ATOM 240 O ILE 1077 −23.793 −4.863 −15.563 15.66 O ATOM 241 N VAL 1078 −23.053 −3.637 −17.28 17.31 N ATOM 242 CA VAL 1078 −22.745 −4.842 −18.052 17.78 C ATOM 243 CB VAL 1078 −23.077 −4.777 −19.553 18.44 C ATOM 244 CG1 VAL 1078 −22.56 −6.065 −20.228 18.64 C ATOM 245 CG2 VAL 1078 −24.569 −4.616 −19.782 17.46 C ATOM 246 C VAL 1078 −21.243 −4.876 −17.998 19.43 C ATOM 247 O VAL 1078 −20.587 −3.934 −18.433 19.77 O ATOM 248 N HIS 1079 −20.68 −5.943 −17.467 20.51 N ATOM 249 CA HIS 1079 −19.24 −6.009 −17.402 21.34 C ATOM 250 CB HIS 1079 −18.849 −6.917 −16.23 19.83 C ATOM 251 CG HIS 1079 −19.417 −6.458 −14.919 19.74 C ATOM 252 CD2 HIS 1079 −20.228 −7.077 −14.027 19.88 C ATOM 253 ND1 HIS 1079 −19.212 −5.185 −14.427 20.23 N ATOM 254 CE1 HIS 1079 −19.876 −5.038 −13.293 18.18 C ATOM 255 NE2 HIS 1079 −20.5 −6.172 −13.028 19.41 N ATOM 256 C HIS 1079 −18.73 −6.499 −18.768 22.35 C ATOM 257 O HIS 1079 −18.699 −7.702 −19.04 21.87 O ATOM 258 N PHE 1080 −18.366 −5.555 −19.639 23.27 N ATOM 259 CA PHE 1080 −17.898 −5.913 −20.977 25.46 C ATOM 260 CB PHE 1080 −17.882 −4.686 −21.918 27.46 C ATOM 261 CG PHE 1080 −19.259 −4.25 −22.39 29.48 C ATOM 262 CD1 PHE 1080 −20.027 −5.062 −23.223 30.23 C ATOM 263 CD2 PHE 1080 −19.798 −3.04 −21.968 30 C ATOM 264 CE1 PHE 1080 −21.318 −4.669 −23.622 31.49 C ATOM 265 CE2 PHE 1080 −21.078 −2.644 −22.36 30.98 C ATOM 266 CZ PHE 1080 −21.838 −3.459 −23.187 30.57 C ATOM 267 C PHE 1080 −16.536 −6.6 −20.987 26.31 C ATOM 268 O PHE 1080 −16.179 −7.225 −21.975 26.79 O ATOM 269 N ASN 1081 −15.765 −6.508 −19.907 27.81 N ATOM 270 CA ASN 1081 −14.479 −7.194 −19.918 29.51 C ATOM 271 CB ASN 1081 −13.346 −6.286 −19.398 32.42 C ATOM 272 CG ASN 1081 −12.313 −5.938 −20.504 36.54 C ATOM 273 OD1 ASN 1081 −12.536 −5.047 −21.34 36.01 O ATOM 274 ND2 ASN 1081 −11.193 −6.663 −20.514 36.11 N ATOM 275 C ASN 1081 −14.538 −8.517 −19.146 28.92 C ATOM 276 O ASN 1081 −13.544 −8.976 −18.587 29.73 O ATOM 277 N GLU 1082 −15.714 −9.14 −19.149 27.42 N ATOM 278 CA GLU 1082 −15.91 −10.408 −18.464 27.47 C ATOM 279 CB GLU 1082 −16.04 −10.16 −16.981 28.91 C ATOM 280 CG GLU 1082 −14.864 −10.669 −16.224 31.39 C ATOM 281 CD GLU 1082 −15.313 −11.523 −15.08 33.01 C ATOM 282 OE1 GLU 1082 −15.894 −10.968 −14.122 30.29 O ATOM 283 OE2 GLU 1082 −15.11 −12.751 −15.15 33.33 O ATOM 284 C GLU 1082 −17.11 −11.203 −18.964 26.21 C ATOM 285 O GLU 1082 −18.227 −11.076 −18.471 27.02 O ATOM 286 N VAL 1083 −16.846 −12.06 −19.93 24.63 N ATOM 287 CA VAL 1083 −17.86 −12.87 −20.574 23.96 C ATOM 288 CB VAL 1083 −17.298 −13.188 −22 23.43 C ATOM 289 CG1 VAL 1083 −18.161 −14.146 −22.766 23.66 C ATOM 290 CG2 VAL 1083 −17.164 −11.872 −22.762 24.22 C ATOM 291 C VAL 1083 −18.239 −14.119 −19.748 22.62 C ATOM 292 O VAL 1083 −17.357 −14.809 −19.245 22.61 O ATOM 293 N ILE 1084 −19.539 −14.371 −19.543 21.85 N ATOM 294 CA ILE 1084 −19.95 −15.584 −18.81 22.19 C ATOM 295 CB ILE 1084 −21.503 −15.625 −18.472 23.79 C ATOM 296 CG2 ILE 1084 −21.863 −16.953 −17.767 24.46 C ATOM 297 CG1 ILE 1084 −21.889 −14.48 −17.523 24.21 C ATOM 298 CD ILE 1084 −23.311 −14.031 −17.657 27.1 C ATOM 299 C ILE 1084 −19.588 −16.697 −19.82 21.17 C ATOM 300 O ILE 1084 −18.999 −17.715 −19.466 22 O ATOM 301 N GLY 1085 −19.905 −16.471 −21.091 20.77 N ATOM 302 CA GLY 1085 −19.577 −17.449 −22.115 21.09 C ATOM 303 C GLY 1085 −20.052 −17.055 −23.5 22.33 C ATOM 304 O GLY 1085 −20.901 −16.179 −23.636 21.38 O ATOM 305 N ARG 1086 −19.501 −17.678 −24.536 24.79 N ATOM 306 CA ARG 1086 −19.944 −17.371 −25.886 27.33 C ATOM 307 CB ARG 1086 −19.034 −16.315 −26.53 30.23 C ATOM 308 CG ARG 1086 −17.68 −16.806 −26.973 34.24 C ATOM 309 CD ARG 1086 −16.572 −15.889 −26.484 36.27 C ATOM 310 NE ARG 1086 −16.649 −14.513 −26.972 38.68 N ATOM 311 CZ ARG 1086 −15.93 −13.53 −26.443 40.82 C ATOM 312 NH1 ARG 1086 −15.116 −13.806 −25.431 42.74 N ATOM 313 NH2 ARG 1086 −16.009 −12.29 −26.908 40.02 N ATOM 314 C ARG 1086 −20.039 −18.618 −26.755 26.1 C ATOM 315 O ARG 1086 −19.714 −19.722 −26.323 26.61 O ATOM 316 N GLY 1087 −20.526 −18.421 −27.97 25.65 N ATOM 317 CA GLY 1087 −20.693 −19.502 −28.918 24.38 C ATOM 318 C GLY 1087 −21.688 −19 −29.939 24.55 C ATOM 319 O GLY 1087 −21.875 −17.796 −30.112 23.97 O ATOM 320 N HIS 1088 −22.325 −19.946 −30.604 25.2 N ATOM 321 CA HIS 1088 −23.333 −19.7 −31.616 25.57 C ATOM 322 CB HIS 1088 −23.894 −21.035 −32.012 28.7 C ATOM 323 CG HIS 1088 −22.846 −21.938 −32.566 32.77 C ATOM 324 CD2 HIS 1088 −22.251 −21.968 −33.785 32.79 C ATOM 325 ND1 HIS 1088 −22.396 −23.074 −31.911 34.14 N ATOM 326 CE1 HIS 1088 −21.605 −23.783 −32.719 35.12 C ATOM 327 NE2 HIS 1088 −21.517 −23.138 −33.868 34.26 N ATOM 328 C HIS 1088 −24.476 −18.786 −31.172 25.12 C ATOM 329 O HIS 1088 −25.102 −18.116 −31.997 24.17 O ATOM 330 N PHE 1089 −24.776 −18.797 −29.875 23.19 N ATOM 331 CA PHE 1089 −25.859 −17.976 −29.332 22.94 C ATOM 332 CB PHE 1089 −26.286 −18.457 −27.929 22.43 C ATOM 333 CG PHE 1089 −25.143 −18.641 −26.966 22.92 C ATOM 334 CD1 PHE 1089 −24.626 −19.908 −26.724 22.34 C ATOM 335 CD2 PHE 1089 −24.553 −17.545 −26.334 24.58 C ATOM 336 CE1 PHE 1089 −23.54 −20.084 −25.877 23.16 C ATOM 337 CE2 PHE 1089 −23.462 −17.715 −25.482 22.08 C ATOM 338 CZ PHE 1089 −22.955 −18.985 −25.257 21.68 C ATOM 339 C PHE 1089 −25.351 −16.561 −29.248 22.27 C ATOM 340 O PHE 1089 −26.116 −15.601 −29.243 20.96 O ATOM 341 N GLY 1090 −24.035 −16.452 −29.167 23.56 N ATOM 342 CA GLY 1090 −23.423 −15.151 −29.11 23.31 C ATOM 343 C GLY 1090 −22.48 −14.936 −27.958 23.5 C ATOM 344 O GLY 1090 −21.532 −15.694 −27.727 24.61 O ATOM 345 N CYS 1091 −22.778 −13.877 −27.225 21.88 N ATOM 346 CA CYS 1091 −21.968 −13.472 −26.116 21.85 C ATOM 347 CB CYS 1091 −21.026 −12.375 −26.578 22.79 C ATOM 348 SG CYS 1091 −19.78 −12.017 −25.368 29.92 S ATOM 349 C CYS 1091 −22.807 −12.981 −24.951 21.01 C ATOM 350 O CYS 1091 −23.561 −12.013 −25.071 20.39 O ATOM 351 N VAL 1092 −22.66 −13.683 −23.83 20.12 N ATOM 352 CA VAL 1092 −23.357 −13.391 −22.586 17.5 C ATOM 353 CB VAL 1092 −23.984 −14.676 −22.018 16.22 C ATOM 354 CG1 VAL 1092 −24.836 −14.367 −20.794 14.54 C ATOM 355 CG2 VAL 1092 −24.828 −15.333 −23.087 15.2 C ATOM 356 C VAL 1092 −22.325 −12.833 −21.61 16.82 C ATOM 357 O VAL 1092 −21.296 −13.464 −21.335 16.7 O ATOM 358 N TYR 1093 −22.593 −11.633 −21.109 15.42 N ATOM 359 CA TYR 1093 −21.682 −10.994 −20.185 17.23 C ATOM 360 CB TYR 1093 −21.427 −9.531 −20.566 17.62 C ATOM 361 CG TYR 1093 −20.851 −9.299 −21.945 20.58 C ATOM 362 CD1 TYR 1093 −21.686 −9.105 −23.037 21.94 C ATOM 363 CE1 TYR 1093 −21.165 −8.829 −24.305 24.31 C ATOM 364 CD2 TYR 1093 −19.466 −9.224 −22.147 21.64 C ATOM 365 CE2 TYR 1093 −18.932 −8.951 −23.409 23.55 C ATOM 366 CZ TYR 1093 −19.79 −8.751 −24.484 25.26 C ATOM 367 OH TYR 1093 −19.291 −8.455 −25.738 26.62 O ATOM 368 C TYR 1093 −22.211 −11.008 −18.773 18.22 C ATOM 369 O TYR 1093 −23.396 −11.209 −18.521 19.61 O ATOM 370 N HIS 1094 −21.289 −10.793 −17.853 18.6 N ATOM 371 CA HIS 1094 −21.604 −10.698 −16.452 18.83 C ATOM 372 CB HIS 1094 −20.316 −10.789 −15.638 19.99 C ATOM 373 CG HIS 1094 −19.836 −12.185 −15.394 21.1 C ATOM 374 CD2 HIS 1094 −18.704 −12.818 −15.783 22.5 C ATOM 375 ND1 HIS 1094 −20.491 −13.057 −14.551 21.79 N ATOM 376 CE1 HIS 1094 −19.777 −14.161 −14.421 21.06 C ATOM 377 NE2 HIS 1094 −18.687 −14.04 −15.157 21.09 N ATOM 378 C HIS 1094 −22.177 −9.281 −16.328 18.78 C ATOM 379 O HIS 1094 −21.78 −8.382 −17.073 18.3 O ATOM 380 N GLY 1095 −23.116 −9.099 −15.41 19.1 N ATOM 381 CA GLY 1095 −23.7 −7.791 −15.188 19.67 C ATOM 382 C GLY 1095 −24.024 −7.631 −13.713 21.24 C ATOM 383 O GLY 1095 −24.131 −8.621 −12.986 19.08 O ATOM 384 N THR 1096 −24.141 −6.388 −13.259 23.02 N ATOM 385 CA THR 1096 −24.501 −6.095 −11.874 22.84 C ATOM 386 CB THR 1096 −23.404 −5.275 −11.14 23.36 C ATOM 387 OG1 THR 1096 −22.428 −6.166 −10.589 26.41 O ATOM 388 CG2 THR 1096 −24.01 −4.451 −10.016 24.26 C ATOM 389 C THR 1096 −25.793 −5.281 −11.94 21.4 C ATOM 390 O THR 1096 −25.842 −4.216 −12.559 20.93 O ATOM 391 N LEU 1097 −26.841 −5.798 −11.314 21.53 N ATOM 392 CA LEU 1097 −28.141 −5.141 −11.326 21.82 C ATOM 393 CB LEU 1097 −29.209 −6.159 −11.758 20.06 C ATOM 394 CG LEU 1097 −30.646 −5.76 −12.111 19.25 C ATOM 395 CD1 LEU 1097 −30.665 −4.708 −13.216 18.42 C ATOM 396 CD2 LEU 1097 −31.385 −7.007 −12.565 16.83 C ATOM 397 C LEU 1097 −28.519 −4.53 −9.981 21.19 C ATOM 398 O LEU 1097 −28.367 −5.164 −8.938 19.7 O ATOM 399 N LEU 1098 −28.996 −3.286 −10.021 23.17 N ATOM 400 CA LEU 1098 −29.46 −2.583 −8.822 24.41 C ATOM 401 CB LEU 1098 −29.613 −1.09 −9.083 26.16 C ATOM 402 CG LEU 1098 −28.496 −0.161 −8.629 29.18 C ATOM 403 CD1 LEU 1098 −29.114 1.203 −8.341 28.63 C ATOM 404 CD2 LEU 1098 −27.822 −0.709 −7.365 29.03 C ATOM 405 C LEU 1098 −30.837 −3.144 −8.541 24.65 C ATOM 406 O LEU 1098 −31.779 −2.833 −9.276 23.31 O ATOM 407 N ASP 1099 −30.973 −3.96 −7.497 24.68 N ATOM 408 CA ASP 1099 −32.283 −4.545 −7.224 26.36 C ATOM 409 CB ASP 1099 −32.18 −5.778 −6.306 27.06 C ATOM 410 CG ASP 1099 −32.004 −5.446 −4.831 29.17 C ATOM 411 OD1 ASP 1099 −31.643 −6.4 −4.128 31.65 O ATOM 412 OD2 ASP 1099 −32.229 −4.305 −4.365 28.08 O ATOM 413 C ASP 1099 −33.244 −3.518 −6.686 27.55 C ATOM 414 O ASP 1099 −32.875 −2.344 −6.562 26.26 O ATOM 415 N ASN 1100 −34.477 −3.923 −6.374 29.32 N ATOM 416 CA ASN 1100 −35.391 −2.909 −5.913 30.82 C ATOM 417 CB ASN 1100 −36.817 −3.375 −5.712 28.63 C ATOM 418 CG ASN 1100 −37.784 −2.203 −5.776 27.15 C ATOM 419 OD1 ASN 1100 −37.902 −1.518 −6.802 25.47 O ATOM 420 ND2 ASN 1100 −38.459 −1.946 −4.667 25.33 N ATOM 421 C ASN 1100 −34.817 −2.17 −4.731 34.06 C ATOM 422 O ASN 1100 −34.99 −0.959 −4.698 33.4 O ATOM 423 N ASP 1101 −34.244 −2.749 −3.684 36.87 N ATOM 424 CA ASP 1101 −33.561 −1.645 −3.071 40.16 C ATOM 425 CB ASP 1101 −33.957 −1.09 −1.753 42.43 C ATOM 426 CG ASP 1101 −33.365 0.343 −1.643 44.17 C ATOM 427 OD1 ASP 1101 −33.676 1.142 −2.566 43.29 O ATOM 428 OD2 ASP 1101 −32.573 0.673 −0.723 44.41 O ATOM 429 C ASP 1101 −32.097 −1.555 −3.027 40.36 C ATOM 430 O ASP 1101 −31.468 −1.272 −4.032 40.01 O ATOM 431 N GLY 1102 −31.538 −1.723 −1.849 40.9 N ATOM 432 CA GLY 1102 −30.121 −1.537 −1.771 40.87 C ATOM 433 C GLY 1102 −29.265 −2.35 −2.702 39.17 C ATOM 434 O GLY 1102 −28.437 −1.801 −3.436 38.81 O ATOM 435 N LYS 1103 −29.541 −3.645 −2.757 37.87 N ATOM 436 CA LYS 1103 −28.614 −4.503 −3.44 35.83 C ATOM 437 CB LYS 1103 −28.57 −5.866 −2.672 37.7 C ATOM 438 CG LYS 1103 −29.817 −6.811 −2.577 41.49 C ATOM 439 CD LYS 1103 −30.76 −6.723 −1.312 43.33 C ATOM 440 CE LYS 1103 −32.272 −6.806 −1.734 43.17 C ATOM 441 NZ LYS 1103 −33.348 −7.174 −0.746 44.65 N ATOM 442 C LYS 1103 −28.306 −4.733 −4.911 32.44 C ATOM 443 O LYS 1103 −29.144 −4.908 −5.808 32.36 O ATOM 444 N LYS 1104 −26.985 −4.671 −5.06 29.44 N ATOM 445 CA LYS 1104 −26.201 −4.881 −6.257 29.31 C ATOM 446 CB LYS 1104 −24.733 −4.422 −5.988 31.35 C ATOM 447 CG LYS 1104 −24.465 −2.898 −5.603 33.76 C ATOM 448 CD LYS 1104 −23.118 −2.693 −4.801 37.44 C ATOM 449 CE LYS 1104 −22.131 −1.588 −5.33 39.69 C ATOM 450 NZ LYS 1104 −22.349 −0.137 −4.967 39.76 N ATOM 451 C LYS 1104 −26.285 −6.422 −6.37 28.22 C ATOM 452 O LYS 1104 −25.698 −7.139 −5.554 26.29 O ATOM 453 N ILE 1105 −27.052 −6.91 −7.349 26.65 N ATOM 454 CA ILE 1105 −27.265 −8.348 −7.598 26.94 C ATOM 455 CB ILE 1105 −28.789 −8.661 −7.72 27.99 C ATOM 456 CG2 ILE 1105 −29.026 −9.839 −8.673 30.38 C ATOM 457 CG1 ILE 1105 −29.391 −8.883 −6.322 30.76 C ATOM 458 CD ILE 1105 −28.852 −10.101 −5.536 35.19 C ATOM 459 C ILE 1105 −26.558 −8.837 −8.877 25.68 C ATOM 460 O ILE 1105 −26.505 −8.118 −9.874 24.13 O ATOM 461 N HIS 1106 −26.034 −10.06 −8.854 23.56 N ATOM 462 CA HIS 1106 −25.334 −10.602 −10.023 22.94 C ATOM 463 CB HIS 1106 −24.409 −11.758 −9.615 24.08 C ATOM 464 CG HIS 1106 −23.469 −12.194 −10.699 27.15 C ATOM 465 CD2 HIS 1106 −23.422 −11.885 −12.018 28.42 C ATOM 466 ND1 HIS 1106 −22.378 −13.001 −10.458 27.68 N ATOM 467 CE1 HIS 1106 −21.695 −13.161 −11.578 29.8 C ATOM 468 NE2 HIS 1106 −22.307 −12.493 −12.54 29.95 N ATOM 469 C HIS 1106 −26.296 −11.099 −11.09 20.67 C ATOM 470 O HIS 1106 −27.245 −11.815 −10.798 21.19 O ATOM 471 N CYS 1107 −26.062 −10.724 −12.335 17.6 N ATOM 472 CA CYS 1107 −26.938 −11.208 −13.385 17.33 C ATOM 473 CB CYS 1107 −28.014 −10.171 −13.699 18.03 C ATOM 474 SG CYS 1107 −27.321 −8.564 −14.194 19.36 S ATOM 475 C CYS 1107 −26.13 −11.512 −14.638 17.39 C ATOM 476 O CYS 1107 −24.931 −11.213 −14.715 17.99 O ATOM 477 N ALA 1108 −26.793 −12.125 −15.608 14.48 N ATOM 478 CA ALA 1108 −26.172 −12.458 −16.878 15.95 C ATOM 479 CB ALA 1108 −26.418 −13.93 −17.204 15.75 C ATOM 480 C ALA 1108 −26.89 −11.56 −17.883 15.24 C ATOM 481 O ALA 1108 −28.107 −11.399 −17.798 12.68 O ATOM 482 N VAL 1109 −26.177 −10.958 −18.827 15.61 N ATOM 483 CA VAL 1109 −26.885 −10.087 −19.76 16.53 C ATOM 484 CB VAL 1109 −26.732 −8.557 −19.371 18.81 C ATOM 485 CG1 VAL 1109 −26.215 −8.404 −17.944 20.45 C ATOM 486 CG2 VAL 1109 −25.815 −7.839 −20.346 19.51 C ATOM 487 C VAL 1109 −26.504 −10.231 −21.227 17.08 C ATOM 488 O VAL 1109 −25.378 −10.611 −21.561 17.04 O ATOM 489 N LYS 1110 −27.461 −9.952 −22.107 17.38 N ATOM 490 CA LYS 1110 −27.158 −9.965 −23.534 17.22 C ATOM 491 CB LYS 1110 −26.814 −11.372 −24.044 19.64 C ATOM 492 CG LYS 1110 −27.959 −12.334 −24.212 18.31 C ATOM 493 CD LYS 1110 −28.051 −12.821 −25.655 19.3 C ATOM 494 CE LYS 1110 −26.738 −13.341 −26.235 20.56 C ATOM 495 NZ LYS 1110 −26.86 −13.284 −27.731 20.37 N ATOM 496 C LYS 1110 −28.156 −9.305 −24.468 15.54 C ATOM 497 O LYS 1110 −29.348 −9.176 −24.183 14.09 O ATOM 498 N SER 1111 −27.58 −8.874 −25.586 15.93 N ATOM 499 CA SER 1111 −28.193 −8.161 −26.691 16.27 C ATOM 500 CB SER 1111 −27.094 −7.361 −27.375 15.21 C ATOM 501 OG SER 1111 −27.529 −6.71 −28.544 18.36 O ATOM 502 C SER 1111 −28.889 −9.092 −27.599 15.76 C ATOM 503 O SER 1111 −28.454 −10.211 −27.947 12.53 O ATOM 504 N LEU 1112 −30.098 −8.685 −27.952 17.34 N ATOM 505 CA LEU 1112 −30.711 −9.683 −28.742 20.62 C ATOM 506 CB LEU 1112 −32.234 −9.458 −28.562 20.06 C ATOM 507 CG LEU 1112 −32.642 −9.744 −27.101 21.55 C ATOM 508 CD1 LEU 1112 −33.953 −9.403 −26.868 19.7 C ATOM 509 CD2 LEU 1112 −32.411 −11.154 −26.774 19.53 C ATOM 510 C LEU 1112 −30.167 −9.375 −30.102 21.91 C ATOM 511 O LEU 1112 −30.723 −8.688 −30.799 23.49 O ATOM 512 N ASN 1113 −29.063 −10.052 −30.556 22.86 N ATOM 513 CA ASN 1113 −28.909 −9.404 −31.85 23.45 C ATOM 514 CB ASN 1113 −27.43 −9.495 −32.245 23.43 C ATOM 515 CG ASN 1113 −26.585 −9.117 −31.09 25.58 C ATOM 516 OD1 ASN 1113 −26.541 −8.023 −30.63 25.22 O ATOM 517 ND2 ASN 1113 −25.914 −10.072 −30.585 22.74 N ATOM 518 C ASN 1113 −29.885 −9.566 −33 22.92 C ATOM 519 O ASN 1113 −29.831 −8.839 −33.944 23.28 O ATOM 520 N ARG 1114 −30.958 −10.381 −32.816 21.82 N ATOM 521 CA ARG 1114 −31.849 −10.5 −33.937 22.01 C ATOM 522 CB ARG 1114 −32.4 −11.948 −33.913 22.1 C ATOM 523 CG ARG 1114 −31.25 −12.857 −34.102 25.83 C ATOM 524 CD ARG 1114 −31.459 −14.259 −33.982 28.53 C ATOM 525 NE ARG 1114 −32.736 −14.557 −34.514 30.33 N ATOM 526 CZ ARG 1114 −33.501 −15.502 −34.01 32.37 C ATOM 527 NH1 ARG 1114 −33.154 −16.204 −32.927 30.58 N ATOM 528 NH2 ARG 1114 −34.661 −15.652 −34.574 33.1 N ATOM 529 C ARG 1114 −32.938 −9.462 −33.984 21.79 C ATOM 530 O ARG 1114 −33.683 −9.45 −34.91 22.34 O ATOM 531 N ILE 1115 −33.051 −8.545 −33.03 22.68 N ATOM 532 CA ILE 1115 −34.107 −7.541 −33.104 21.2 C ATOM 533 CB ILE 1115 −34.741 −7.354 −31.703 24.03 C ATOM 534 CG2 ILE 1115 −35.642 −6.144 −31.668 23.21 C ATOM 535 CG1 ILE 1115 −35.589 −8.58 −31.351 24.72 C ATOM 536 CD ILE 1115 −35.868 −8.729 −29.851 26.57 C ATOM 537 C ILE 1115 −33.318 −6.335 −33.548 21.28 C ATOM 538 O ILE 1115 −32.489 −5.821 −32.809 20.76 O ATOM 539 N THR 1116 −33.595 −5.909 −34.77 22.08 N ATOM 540 CA THR 1116 −32.856 −4.857 −35.452 23.07 C ATOM 541 CB THR 1116 −32.421 −5.438 −36.786 23.06 C ATOM 542 OG1 THR 1116 −33.597 −5.795 −37.535 23.74 O ATOM 543 CG2 THR 1116 −31.615 −6.729 −36.558 24.03 C ATOM 544 C THR 1116 −33.622 −3.572 −35.704 23.05 C ATOM 545 O THR 1116 −33.056 −2.585 −36.174 23.27 O ATOM 546 N ASP 1117 −34.92 −3.61 −35.44 22.99 N ATOM 547 CA ASP 1117 −35.759 −2.447 −35.643 24.43 C ATOM 548 CB ASP 1117 −36.122 −2.292 −37.121 26.12 C ATOM 549 CG ASP 1117 −37.083 −3.345 −37.6 28.5 C ATOM 550 OD1 ASP 1117 −37.787 −3.933 −36.756 30.79 O ATOM 551 OD2 ASP 1117 −37.151 −3.569 −38.826 30.95 O ATOM 552 C ASP 1117 −37.002 −2.491 −34.764 23.72 C ATOM 553 O ASP 1117 −37.291 −3.5 −34.122 23.98 O ATOM 554 N ILE 1118 −37.743 −1.388 −34.77 24.56 N ATOM 555 CA ILE 1118 −38.888 −1.211 −33.891 25.74 C ATOM 556 CB ILE 1118 −39.278 0.274 −33.878 25.32 C ATOM 557 CG2 ILE 1118 −39.571 0.743 −35.276 26.13 C ATOM 558 CG1 ILE 1118 −40.435 0.497 −32.915 24.98 C ATOM 559 CD ILE 1118 −40.733 1.964 −32.613 28.73 C ATOM 560 C ILE 1118 −40.092 −2.113 −34.069 25.74 C ATOM 561 O ILE 1118 −40.779 −2.448 −33.099 25.12 O ATOM 562 N GLY 1119 −40.346 −2.504 −35.307 25.89 N ATOM 563 CA GLY 1119 −41.422 −3.437 −35.543 25.68 C ATOM 564 C GLY 1119 −41.012 −4.734 −34.844 25.67 C ATOM 565 O GLY 1119 −41.864 −5.425 −34.288 25.14 O ATOM 566 N GLU 1120 −39.715 −5.066 −34.85 23.75 N ATOM 567 CA GLU 1120 −39.226 −6.295 −34.212 23.95 C ATOM 568 CB GLU 1120 −37.817 −6.627 −34.706 24.69 C ATOM 569 CG GLU 1120 −37.823 −7.463 −35.977 25.41 C ATOM 570 CD GLU 1120 −36.543 −7.319 −36.777 27.56 C ATOM 571 OE1 GLU 1120 −35.575 −6.731 −36.247 26.97 O ATOM 572 OE2 GLU 1120 −36.499 −7.797 −37.934 28.81 O ATOM 573 C GLU 1120 −39.262 −6.176 −32.692 23.53 C ATOM 574 O GLU 1120 −39.737 −7.076 −31.996 20.73 O ATOM 575 N VAL 1121 −38.759 −5.057 −32.192 22.95 N ATOM 576 CA VAL 1121 −38.797 −4.775 −30.769 24.45 C ATOM 577 CB VAL 1121 −38.396 −3.315 −30.51 24.85 C ATOM 578 CG1 VAL 1121 −38.695 −2.929 −29.063 21.7 C ATOM 579 CG2 VAL 1121 −36.933 −3.111 −30.857 23.7 C ATOM 580 C VAL 1121 −40.259 −4.934 −30.333 26.12 C ATOM 581 O VAL 1121 −40.567 −5.618 −29.349 26.27 O ATOM 582 N SER 1122 −41.16 −4.303 −31.084 26.23 N ATOM 583 CA SER 1122 −42.583 −4.322 −30.75 27.11 C ATOM 584 CB SER 1122 −43.374 −3.492 −31.766 28.38 C ATOM 585 OG SER 1122 −44.763 −3.526 −31.482 32.31 O ATOM 586 C SER 1122 −43.171 −5.722 −30.644 26.65 C ATOM 587 O SER 1122 −43.865 −6.045 −29.677 25.95 O ATOM 588 N GLN 1123 −42.893 −6.553 −31.641 26.43 N ATOM 589 CA GLN 1123 −43.39 −7.919 −31.636 26.5 C ATOM 590 CB GLN 1123 −43.046 −8.607 −32.955 29.41 C ATOM 591 CG GLN 1123 −43.203 −10.123 −32.919 33.88 C ATOM 592 CD GLN 1123 −43.393 −10.721 −34.301 36.39 C ATOM 593 OE1 GLN 1123 −42.587 −10.498 −35.203 36.5 O ATOM 594 NE2 GLN 1123 −44.467 −11.489 −34.472 38.02 N ATOM 595 C GLN 1123 −42.801 −8.714 −30.47 25.95 C ATOM 596 O GLN 1123 −43.454 −9.597 −29.918 24.87 O ATOM 597 N PHE 1124 −41.557 −8.402 −30.114 24.65 N ATOM 598 CA PHE 1124 −40.871 −9.079 −29.023 23.66 C ATOM 599 CB PHE 1124 −39.414 −8.629 −28.955 23.72 C ATOM 600 CG PHE 1124 −38.77 −8.86 −27.618 23.58 C ATOM 601 CD1 PHE 1124 −38.694 −10.14 −27.076 25.18 C ATOM 602 CD2 PHE 1124 −38.24 −7.798 −26.902 24 C ATOM 603 CE1 PHE 1124 −38.097 −10.354 −25.834 25.88 C ATOM 604 CE2 PHE 1124 −37.642 −8 −25.662 25.31 C ATOM 605 CZ PHE 1124 −37.568 −9.276 −25.128 25.33 C ATOM 606 C PHE 1124 −41.544 −8.749 −27.715 24.78 C ATOM 607 O PHE 1124 −41.873 −9.621 −26.92 26.5 O ATOM 608 N LEU 1125 −41.723 −7.466 −27.479 23.2 N ATOM 609 CA LEU 1125 −42.356 −7.073 −26.261 22.77 C ATOM 610 CB LEU 1125 −42.567 −5.598 −26.229 21.09 C ATOM 611 CG LEU 1125 −41.236 −4.899 −26.129 17.73 C ATOM 612 CD1 LEU 1125 −41.631 −3.496 −26.146 19.09 C ATOM 613 CD2 LEU 1125 −40.427 −5.218 −24.871 16.2 C ATOM 614 C LEU 1125 −43.682 −7.72 −26.132 25.71 C ATOM 615 O LEU 1125 −44.116 −8.03 −25.032 23.93 O ATOM 616 N THR 1126 −44.368 −7.944 −27.228 26.97 N ATOM 617 CA THR 1126 −45.639 −8.549 −26.998 30.56 C ATOM 618 CB THR 1126 −46.474 −8.47 −28.349 30.39 C ATOM 619 OG1 THR 1126 −47.089 −7.172 −28.448 31.21 O ATOM 620 CG2 THR 1126 −47.536 −9.509 −28.425 32.25 C ATOM 621 C THR 1126 −45.308 −9.955 −26.367 32.6 C ATOM 622 O THR 1126 −46.214 −10.759 −26.142 30.99 O ATOM 623 N GLU 1127 −44.006 −10.139 −25.994 35.71 N ATOM 624 CA GLU 1127 −43.324 −11.363 −25.421 37.11 C ATOM 625 CB GLU 1127 −42.663 −12.118 −26.553 36.36 C ATOM 626 CG GLU 1127 −43.597 −12.481 −27.631 39.29 C ATOM 627 CD GLU 1127 −44.476 −13.585 −27.184 41.29 C ATOM 628 OE1 GLU 1127 −44.087 −14.213 −26.181 41.62 O ATOM 629 OE2 GLU 1127 −45.523 −13.843 −27.816 43.61 O ATOM 630 C GLU 1127 −42.227 −11.228 −24.313 36.65 C ATOM 631 O GLU 1127 −41.449 −12.168 −24.042 36.3 O ATOM 632 N GLY 1128 −42.13 −10.02 −23.774 37.88 N ATOM 633 CA GLY 1128 −41.248 −9.679 −22.675 36.79 C ATOM 634 C GLY 1128 −42.463 −9.503 −21.803 36.28 C ATOM 635 O GLY 1128 −42.531 −8.689 −20.88 34.64 O ATOM 636 N ILE 1129 −43.485 −10.238 −22.251 36.52 N ATOM 637 CA ILE 1129 −44.786 −10.362 −21.617 37.06 C ATOM 638 CB ILE 1129 −45.997 −10.386 −22.653 35.43 C ATOM 639 CG2 ILE 1129 −47.188 −11.204 −22.111 33.75 C ATOM 640 CG1 ILE 1129 −46.554 −8.978 −22.897 35.19 C ATOM 641 CD ILE 1129 −46.993 −8.179 −21.639 36.58 C ATOM 642 C ILE 1129 −44.562 −11.78 −21.112 38.14 C ATOM 643 O ILE 1129 −43.906 −12.012 −20.096 40.02 O ATOM 644 N ILE 1130 −45.05 −12.697 −21.936 39.77 N ATOM 645 CA ILE 1130 −45.059 −14.15 −21.818 39.09 C ATOM 646 CB ILE 1130 −45.827 −14.638 −23.165 37.23 C ATOM 647 CG2 ILE 1130 −46.725 −15.832 −22.942 35.01 C ATOM 648 CG1 ILE 1130 −46.834 −13.555 −23.613 36.25 C ATOM 649 CD ILE 1130 −47.219 −13.572 −25.099 35.76 C ATOM 650 C ILE 1130 −43.655 −14.881 −21.549 41.51 C ATOM 651 O ILE 1130 −43.156 −15.56 −22.452 39.43 O ATOM 652 N MET 1131 −43.035 −14.698 −20.346 42.91 N ATOM 653 CA MET 1131 −41.742 −15.349 −19.835 44.95 C ATOM 654 CB MET 1131 −40.472 −15.204 −20.764 46.01 C ATOM 655 CG MET 1131 −39.274 −16.281 −20.43 45.5 C ATOM 656 SD MET 1131 −37.426 −16.086 −20.877 48.89 S ATOM 657 CE MET 1131 −36.526 −17.834 −20.399 44.9 C ATOM 658 C MET 1131 −41.305 −14.898 −18.397 45.24 C ATOM 659 O MET 1131 −40.606 −15.644 −17.7 46.07 O ATOM 660 N LYS 1132 −41.711 −13.684 −17.992 45.8 N ATOM 661 CA LYS 1132 −41.448 −13.047 −16.667 44.47 C ATOM 662 CB LYS 1132 −41.153 −11.536 −16.863 44.62 C ATOM 663 CG LYS 1132 −41.633 −10.562 −15.744 45.98 C ATOM 664 CD LYS 1132 −40.704 −10.607 −14.528 47.24 C ATOM 665 CE LYS 1132 −41.097 −9.681 −13.372 48.16 C ATOM 666 NZ LYS 1132 −39.906 −9.52 −12.48 50.03 N ATOM 667 C LYS 1132 −42.766 −13.202 −15.908 43.38 C ATOM 668 O LYS 1132 −42.822 −13.535 −14.706 44.16 O ATOM 669 N ASP 1133 −43.81 −12.924 −16.69 40.97 N ATOM 670 CA ASP 1133 −45.216 −12.985 −16.338 37.24 C ATOM 671 CB ASP 1133 −45.968 −11.948 −17.229 39.7 C ATOM 672 CG ASP 1133 −45.378 −10.475 −17.104 44.34 C ATOM 673 OD1 ASP 1133 −45.471 −9.672 −18.073 46.2 O ATOM 674 OD2 ASP 1133 −44.832 −10.103 −16.036 45.51 O ATOM 675 C ASP 1133 −45.599 −14.51 −16.559 32.78 C ATOM 676 O ASP 1133 −46.634 −14.894 −17.119 29.59 O ATOM 677 N PHE 1134 −44.642 −15.327 −16.103 27.86 N ATOM 678 CA PHE 1134 −44.601 −16.796 −16.002 22.57 C ATOM 679 CB PHE 1134 −43.753 −17.483 −17.107 22.44 C ATOM 680 CG PHE 1134 −44.565 −18.066 −18.259 19.89 C ATOM 681 CD1 PHE 1134 −43.967 −18.296 −19.503 16.65 C ATOM 682 CD2 PHE 1134 −45.934 −18.311 −18.126 18.05 C ATOM 683 CE1 PHE 1134 −44.725 −18.745 −20.598 15.13 C ATOM 684 CE2 PHE 1134 −46.697 −18.762 −19.214 16.83 C ATOM 685 CZ PHE 1134 −46.092 −18.973 −20.449 16.75 C ATOM 686 C PHE 1134 −43.795 −16.804 −14.689 19.23 C ATOM 687 O PHE 1134 −42.732 −16.175 −14.607 15.87 O ATOM 688 N SER 1135 −44.293 −17.468 −13.656 15.8 N ATOM 689 CA SER 1135 −43.575 −17.473 −12.397 13.93 C ATOM 690 CB SER 1135 −44.165 −16.454 −11.426 12.94 C ATOM 691 OG SER 1135 −43.254 −16.177 −10.383 15.88 O ATOM 692 C SER 1135 −43.654 −18.829 −11.775 12.54 C ATOM 693 O SER 1135 −44.695 −19.221 −11.262 11.79 O ATOM 694 N HIS 1136 −42.548 −19.547 −11.831 11.97 N ATOM 695 CA HIS 1136 −42.491 −20.859 −11.253 12.4 C ATOM 696 CB HIS 1136 −43.068 −21.88 −12.226 10.91 C ATOM 697 CG HIS 1136 −43.199 −23.24 −11.633 12.1 C ATOM 698 CD2 HIS 1136 −44.246 −23.858 −11.036 10.8 C ATOM 699 ND1 HIS 1136 −42.127 −24.097 −11.518 10.52 N ATOM 700 CE1 HIS 1136 −42.506 −25.185 −10.872 11.14 C ATOM 701 NE2 HIS 1136 −43.786 −25.065 −10.569 11.88 N ATOM 702 C HIS 1136 −41.034 −21.143 −10.917 13.17 C ATOM 703 O HIS 1136 −40.127 −20.784 −11.67 12.81 O ATOM 704 N PRO 1137 −40.79 −21.774 −9.763 14.54 N ATOM 705 CD PRO 1137 −41.762 −22.325 −8.797 13.56 C ATOM 706 CA PRO 1137 −39.414 −22.076 −9.36 15.38 C ATOM 707 CB PRO 1137 −39.597 −22.831 −8.035 13.45 C ATOM 708 CG PRO 1137 −40.974 −23.438 −8.155 17.2 C ATOM 709 C PRO 1137 −38.568 −22.842 −10.386 15.05 C ATOM 710 O PRO 1137 −37.334 −22.756 −10.366 14.8 O ATOM 711 N ASN 1138 −39.23 −23.571 −11.286 14.53 N ATOM 712 CA ASN 1138 −38.546 −24.338 −12.328 13.54 C ATOM 713 CB ASN 1138 −38.979 −25.801 −12.281 11.91 C ATOM 714 CG ASN 1138 −38.491 −26.491 −11.042 15.12 C ATOM 715 OD1 ASN 1138 −39.279 −26.876 −10.183 14.55 O ATOM 716 ND2 ASN 1138 −37.176 −26.639 −10.928 15.25 N ATOM 717 C ASN 1138 −38.752 −23.804 −13.736 12.76 C ATOM 718 O ASN 1138 −38.733 −24.573 −14.699 13.13 O ATOM 719 N VAL 1139 −38.967 −22.493 −13.836 14.58 N ATOM 720 CA VAL 1139 −39.148 −21.797 −15.115 14.5 C ATOM 721 CB VAL 1139 −40.634 −21.332 −15.343 16.08 C ATOM 722 CG1 VAL 1139 −40.715 −20.404 −16.561 14.73 C ATOM 723 CG2 VAL 1139 −41.543 −22.544 −15.556 14.08 C ATOM 724 C VAL 1139 −38.246 −20.56 −15.074 15.17 C ATOM 725 O VAL 1139 −38.351 −19.736 −14.157 13.04 O ATOM 726 N LEU 1140 −37.358 −20.427 −16.059 14.62 N ATOM 727 CA LEU 1140 −36.445 −19.281 −16.098 13.44 C ATOM 728 CB LEU 1140 −35.213 −19.59 −16.962 12.31 C ATOM 729 CG LEU 1140 −34.085 −18.546 −16.992 10.46 C ATOM 730 CD1 LEU 1140 −33.328 −18.594 −15.684 13.12 C ATOM 731 CD2 LEU 1140 −33.128 −18.82 −18.148 9.58 C ATOM 732 C LEU 1140 −37.118 −18.024 −16.634 14.11 C ATOM 733 O LEU 1140 −37.551 −17.962 −17.786 14.02 O ATOM 734 N SER 1141 −37.201 −17.012 −15.791 15.03 N ATOM 735 CA SER 1141 −37.794 −15.759 −16.214 17.47 C ATOM 736 CB SER 1141 −38.961 −15.397 −15.302 17.42 C ATOM 737 OG SER 1141 −39.908 −16.448 −15.288 16.21 O ATOM 738 C SER 1141 −36.75 −14.654 −16.178 18.33 C ATOM 739 O SER 1141 −35.783 −14.702 −15.405 19.08 O ATOM 740 N LEU 1142 −36.949 −13.664 −17.031 18.51 N ATOM 741 CA LEU 1142 −36.046 −12.537 −17.079 20.96 C ATOM 742 CB LEU 1142 −36.333 −11.641 −18.288 24.4 C ATOM 743 CG LEU 1142 −37.635 −11.494 −19.093 26.67 C ATOM 744 CD1 LEU 1142 −37.157 −11.596 −20.531 28.07 C ATOM 745 CD2 LEU 1142 −38.723 −12.554 −18.83 30.08 C ATOM 746 C LEU 1142 −36.199 −11.719 −15.831 20.09 C ATOM 747 O LEU 1142 −37.276 −11.671 −15.243 18.69 O ATOM 748 N LEU 1143 −35.102 −11.099 −15.418 19.75 N ATOM 749 CA LEU 1143 −35.129 −10.217 −14.275 18.51 C ATOM 750 CB LEU 1143 −33.714 −10.014 −13.7 20.09 C ATOM 751 CG LEU 1143 −33.069 −11.105 −12.816 20.67 C ATOM 752 CD1 LEU 1143 −31.795 −10.548 −12.2 19.71 C ATOM 753 CD2 LEU 1143 −34.021 −11.539 −11.693 20.92 C ATOM 754 C LEU 1143 −35.662 −8.929 −14.905 18.23 C ATOM 755 O LEU 1143 −36.354 −8.141 −14.258 18.44 O ATOM 756 N GLY 1144 −35.359 −8.731 −16.191 16.4 N ATOM 757 CA GLY 1144 −35.837 −7.543 −16.874 14.04 C ATOM 758 C GLY 1144 −35.224 −7.371 −18.245 15.5 C ATOM 759 O GLY 1144 −34.485 −8.226 −18.713 15.81 O ATOM 760 N ILE 1145 −35.539 −6.274 −18.911 16.87 N ATOM 761 CA ILE 1145 −34.972 −6.031 −20.225 18.26 C ATOM 762 CB ILE 1145 −35.981 −6.403 −21.409 19.17 C ATOM 763 CG2 ILE 1145 −36.919 −7.552 −21.014 19.39 C ATOM 764 CG1 ILE 1145 −36.829 −5.188 −21.848 21.36 C ATOM 765 CD ILE 1145 −37.787 −4.592 −20.8 25.83 C ATOM 766 C ILE 1145 −34.699 −4.549 −20.34 18.79 C ATOM 767 O ILE 1145 −35.295 −3.764 −19.609 19.26 O ATOM 768 N CYS 1146 −33.713 −4.129 −21.11 21.57 N ATOM 769 CA CYS 1146 −33.808 −2.713 −21.347 24.57 C ATOM 770 CB CYS 1146 −32.932 −1.749 −20.568 27.61 C ATOM 771 SG CYS 1146 −33.831 −0.088 −20.586 32.88 S ATOM 772 C CYS 1146 −33.743 −2.422 −22.789 23.95 C ATOM 773 O CYS 1146 −33.051 −3.059 −23.594 24.57 O ATOM 774 N LEU 1147 −34.617 −1.474 −23.069 23.64 N ATOM 775 CA LEU 1147 −34.914 −0.935 −24.363 23.73 C ATOM 776 CB LEU 1147 −36.373 −0.494 −24.408 23.23 C ATOM 777 CG LEU 1147 −37.678 −1.312 −24.387 24.45 C ATOM 778 CD1 LEU 1147 −37.461 −2.649 −25.062 23.58 C ATOM 779 CD2 LEU 1147 −38.205 −1.491 −22.981 24.44 C ATOM 780 C LEU 1147 −34.067 0.269 −24.673 23.59 C ATOM 781 O LEU 1147 −34.394 1.389 −24.275 23.87 O ATOM 782 N ARG 1148 −33.001 0.038 −25.412 23.12 N ATOM 783 CA ARG 1148 −32.106 1.095 −25.808 22.97 C ATOM 784 CB ARG 1148 −30.734 0.495 −25.988 23.4 C ATOM 785 CG ARG 1148 −30.35 −0.366 −24.817 24.2 C ATOM 786 CD ARG 1148 −28.914 −0.697 −24.921 21.72 C ATOM 787 NE ARG 1148 −28.681 −1.755 −25.884 20.32 N ATOM 788 CZ ARG 1148 −27.484 −2.001 −26.385 20.41 C ATOM 789 NH1 ARG 1148 −26.471 −1.248 −25.996 19.37 N ATOM 790 NH2 ARG 1148 −27.284 −2.999 −27.237 19.66 N ATOM 791 C ARG 1148 −32.534 1.748 −27.12 22.97 C ATOM 792 O ARG 1148 −33.294 1.182 −27.908 21.03 O ATOM 793 N SER 1149 −32.069 2.956 −27.361 23.25 N ATOM 794 CA SER 1149 −32.407 3.517 −28.637 23.55 C ATOM 795 CB SER 1149 −32.661 4.995 −28.55 24.41 C ATOM 796 OG SER 1149 −31.484 5.636 −28.145 25.43 O ATOM 797 C SER 1149 −31.292 3.142 −29.624 23.14 C ATOM 798 O SER 1149 −31.555 3.159 −30.796 23.95 O ATOM 799 N GLU 1150 −30.052 2.888 −29.203 23.72 N ATOM 800 CA GLU 1150 −29.119 2.289 −30.16 25.39 C ATOM 801 CB GLU 1150 −27.729 2.816 −30.061 27.71 C ATOM 802 CG GLU 1150 −27.793 4.064 −29.446 32.33 C ATOM 803 CD GLU 1150 −27.698 5.005 −30.524 35.64 C ATOM 804 OE1 GLU 1150 −26.732 5.794 −30.561 34.51 O ATOM 805 OE2 GLU 1150 −28.587 4.89 −31.384 37 O ATOM 806 C GLU 1150 −28.961 0.921 −29.518 23.45 C ATOM 807 O GLU 1150 −28.64 0.859 −28.325 21.36 O ATOM 808 N GLY 1151 −28.982 −0.078 −30.413 22.51 N ATOM 809 CA GLY 1151 −28.828 −1.495 −30.147 21.13 C ATOM 810 C GLY 1151 −30.042 −2.16 −29.833 20.26 C ATOM 811 O GLY 1151 −30.916 −1.448 −29.502 20.28 O ATOM 812 N SER 1152 −30.155 −3.445 −30.24 20.15 N ATOM 813 CA SER 1152 −31.201 −4.317 −29.94 19.17 C ATOM 814 CB SER 1152 −30.704 −5.674 −30.274 20.12 C ATOM 815 OG SER 1152 −29.814 −5.608 −31.375 20.17 O ATOM 816 C SER 1152 −31.474 −4.253 −28.464 18.39 C ATOM 817 O SER 1152 −30.637 −3.799 −27.66 15.67 O ATOM 818 N PRO 1153 −32.619 −4.743 −28.024 18.17 N ATOM 819 CD PRO 1153 −33.834 −4.874 −28.851 15.64 C ATOM 820 CA PRO 1153 −32.914 −4.755 −26.603 16.33 C ATOM 821 CB PRO 1153 −34.306 −5.346 −26.545 18.14 C ATOM 822 CG PRO 1153 −34.939 −4.917 −27.824 17.45 C ATOM 823 C PRO 1153 −31.918 −5.665 −25.921 17.54 C ATOM 824 O PRO 1153 −31.433 −6.614 −26.549 17.31 O ATOM 825 N LEU 1154 −31.624 −5.412 −24.651 16.29 N ATOM 826 CA LEU 1154 −30.743 −6.284 −23.875 16.17 C ATOM 827 CB LEU 1154 −29.845 −5.47 −22.952 16.61 C ATOM 828 CG LEU 1154 −28.429 −5.058 −23.319 16.57 C ATOM 829 CD1 LEU 1154 −28.235 −4.914 −24.811 15.54 C ATOM 830 CD2 LEU 1154 −28.161 −3.773 −22.572 15.34 C ATOM 831 C LEU 1154 −31.663 −7.095 −22.962 15.58 C ATOM 832 O LEU 1154 −32.679 −6.569 −22.521 15.77 O ATOM 833 N VAL 1155 −31.348 −8.362 −22.703 14.14 N ATOM 834 CA VAL 1155 −32.147 −9.128 −21.742 14.36 C ATOM 835 CB VAL 1155 −32.666 −10.516 −22.236 16.13 C ATOM 836 CG1 VAL 1155 −34.096 −10.383 −22.707 17.55 C ATOM 837 CG2 VAL 1155 −31.778 −11.09 −23.31 14.8 C ATOM 838 C VAL 1155 −31.24 −9.405 −20.56 13.32 C ATOM 839 O VAL 1155 −30.046 −9.654 −20.728 12.82 O ATOM 840 N VAL 1156 −31.817 −9.344 −19.366 13.23 N ATOM 841 CA VAL 1156 −31.095 −9.583 −18.123 13.25 C ATOM 842 CB VAL 1156 −31.197 −8.352 −17.18 11.59 C ATOM 843 CG1 VAL 1156 −30.163 −8.455 −16.064 9.84 C ATOM 844 CG2 VAL 1156 −31.001 −7.072 −17.976 10.35 C ATOM 845 C VAL 1156 −31.713 −10.806 −17.432 13.41 C ATOM 846 O VAL 1156 −32.897 −10.813 −17.102 12.45 O ATOM 847 N LEU 1157 −30.904 −11.839 −17.228 14.42 N ATOM 848 CA LEU 1157 −31.358 −13.065 −16.587 14.54 C ATOM 849 CB LEU 1157 −31.107 −14.235 −17.529 17.37 C ATOM 850 CG LEU 1157 −32.159 −14.084 −18.616 17.45 C ATOM 851 CD1 LEU 1157 −31.523 −13.964 −19.97 15.68 C ATOM 852 CD2 LEU 1157 −33.12 −15.235 −18.51 14.04 C ATOM 853 C LEU 1157 −30.666 −13.312 −15.263 15.03 C ATOM 854 O LEU 1157 −29.591 −12.768 −15.021 14.87 O ATOM 855 N PRO 1158 −31.29 −14.11 −14.369 15.01 N ATOM 856 CD PRO 1158 −32.657 −14.659 −14.452 14.36 C ATOM 857 CA PRO 1158 −30.676 −14.411 −13.067 14.63 C ATOM 858 CB PRO 1158 −31.664 −15.38 −12.424 12.4 C ATOM 859 CG PRO 1158 −32.975 −14.977 −13.006 16.67 C ATOM 860 C PRO 1158 −29.354 −15.117 −13.36 14.38 C ATOM 861 O PRO 1158 −29.27 −15.852 −14.346 14.05 O ATOM 862 N TYR 1159 −28.328 −14.908 −12.544 14.53 N ATOM 863 CA TYR 1159 −27.079 −15.618 −12.797 16.89 C ATOM 864 CB TYR 1159 −25.916 −15.097 −11.927 17.44 C ATOM 865 CG TYR 1159 −24.597 −15.847 −12.146 20.62 C ATOM 866 CD1 TYR 1159 −24.05 −15.994 −13.426 19.72 C ATOM 867 CE1 TYR 1159 −22.843 −16.704 −13.627 21.21 C ATOM 868 CD2 TYR 1159 −23.906 −16.42 −11.072 20.45 C ATOM 869 CE2 TYR 1159 −22.705 −17.124 −11.266 19.01 C ATOM 870 CZ TYR 1159 −22.18 −17.266 −12.539 20.38 C ATOM 871 OH TYR 1159 −21.009 −17.988 −12.714 18.95 O ATOM 872 C TYR 1159 −27.345 −17.084 −12.475 16.92 C ATOM 873 O TYR 1159 −27.794 −17.419 −11.377 17.08 O ATOM 874 N MET 1160 −27.097 −17.939 −13.463 17.77 N ATOM 875 CA MET 1160 −27.272 −19.382 −13.334 19.63 C ATOM 876 CB MET 1160 −28.094 −19.903 −14.538 20.87 C ATOM 877 CG MET 1160 −29.59 −19.473 −14.517 23.25 C ATOM 878 SD MET 1160 −30.392 −20 −12.946 26.21 S ATOM 879 CE MET 1160 −31.976 −19.029 −12.819 25.57 C ATOM 880 C MET 1160 −25.838 −19.959 −13.289 19.44 C ATOM 881 O MET 1160 −25.262 −20.285 −14.323 19.44 O ATOM 882 N LYS 1161 −25.283 −20.054 −12.07 20.74 N ATOM 883 CA LYS 1161 −23.897 −20.517 −11.782 21.83 C ATOM 884 CB LYS 1161 −23.718 −20.814 −10.255 23.08 C ATOM 885 CG LYS 1161 −22.277 −21.256 −9.7 26.14 C ATOM 886 CD LYS 1161 −22.276 −21.43 −8.113 29.21 C ATOM 887 CE LYS 1161 −21.135 −22.295 −7.464 30.75 C ATOM 888 NZ LYS 1161 −21.405 −22.621 −5.992 32.69 N ATOM 889 C LYS 1161 −23.378 −21.704 −12.581 21.45 C ATOM 890 O LYS 1161 −22.233 −21.692 −13.029 22.38 O ATOM 891 N HIS 1162 −24.209 −22.721 −12.768 21.1 N ATOM 892 CA HIS 1162 −23.77 −23.916 −13.475 21.05 C ATOM 893 CB HIS 1162 −24.271 −25.147 −12.729 21.67 C ATOM 894 CG HIS 1162 −23.95 −25.13 −11.267 23.58 C ATOM 895 CD2 HIS 1162 −24.75 −24.981 −10.184 25.8 C ATOM 896 ND1 HIS 1162 −22.664 −25.242 −10.782 22.88 N ATOM 897 CE1 HIS 1162 −22.686 −25.164 −9.461 24.94 C ATOM 898 NE2 HIS 1162 −23.94 −25.005 −9.074 27.06 N ATOM 899 C HIS 1162 −24.145 −24.003 −14.948 20.46 C ATOM 900 O HIS 1162 −23.893 −25.021 −15.601 20.52 O ATOM 901 N GLY 1163 −24.748 −22.944 −15.473 16.19 N ATOM 902 CA GLY 1163 −25.101 −22.941 −16.879 15.75 C ATOM 903 C GLY 1163 −26.153 −23.945 −17.287 14.03 C ATOM 904 O GLY 1163 −27.039 −24.295 −16.505 14.31 O ATOM 905 N ASP 1164 −26.054 −24.402 −18.529 13.99 N ATOM 906 CA ASP 1164 −27.003 −25.356 −19.055 15.09 C ATOM 907 CB ASP 1164 −26.891 −25.453 −20.586 17.44 C ATOM 908 CG ASP 1164 −25.468 −25.264 −21.092 20.23 C ATOM 909 OD1 ASP 1164 −24.817 −24.255 −20.729 26.07 O ATOM 910 OD2 ASP 1164 −25.007 −26.121 −21.872 21.73 O ATOM 911 C ASP 1164 −26.853 −26.719 −18.399 15.19 C ATOM 912 O ASP 1164 −25.765 −27.128 −17.969 11.3 O ATOM 913 N LEU 1165 −27.979 −27.399 −18.29 15.65 N ATOM 914 CA LEU 1165 −28.022 −28.704 −17.674 17.38 C ATOM 915 CB LEU 1165 −29.472 −29.172 −17.594 19.29 C ATOM 916 CG LEU 1165 −29.893 −30.157 −16.507 23.06 C ATOM 917 CD1 LEU 1165 −29.794 −29.502 −15.132 24.16 C ATOM 918 CD2 LEU 1165 −31.336 −30.597 −16.783 22.91 C ATOM 919 C LEU 1165 −27.191 −29.661 −18.523 18.34 C ATOM 920 O LEU 1165 −26.598 −30.599 −17.999 16.81 O ATOM 921 N ARG 1166 −27.115 −29.426 −19.828 16.61 N ATOM 922 CA ARG 1166 −26.328 −30.347 −20.631 20.77 C ATOM 923 CB ARG 1166 −26.59 −30.209 −22.129 21.19 C ATOM 924 CG ARG 1166 −25.748 −31.255 −22.956 29.35 C ATOM 925 CD ARG 1166 −24.754 −30.446 −23.364 33.96 C ATOM 926 NE ARG 1166 −23.929 −30.501 −24.55 41.69 N ATOM 927 CZ ARG 1166 −23.013 −31.595 −24.116 43.95 C ATOM 928 NH1 ARG 1166 −22.272 −31.74 −25.146 44.72 N ATOM 929 NH2 ARG 1166 −23.215 −32.382 −23.404 44.74 N ATOM 930 C ARG 1166 −24.826 −30.272 −20.398 19.99 C ATOM 931 O ARG 1166 −24.174 −31.312 −20.34 19.94 O ATOM 932 N ASN 1167 −24.262 −29.069 −20.302 20.09 N ATOM 933 CA ASN 1167 −22.826 −28.947 −20.049 19.35 C ATOM 934 CB ASN 1167 −22.35 −27.498 −20.026 21.75 C ATOM 935 CG ASN 1167 −22.323 −26.86 −21.38 26.57 C ATOM 936 OD1 ASN 1167 −22.67 −25.69 −21.512 29.34 O ATOM 937 ND2 ASN 1167 −21.89 −27.601 −22.393 26.01 N ATOM 938 C ASN 1167 −22.595 −29.437 −18.655 19.05 C ATOM 939 O ASN 1167 −21.566 −30.028 −18.345 20.21 O ATOM 940 N PHE 1168 −23.551 −29.154 −17.788 17 N ATOM 941 CA PHE 1168 −23.364 −29.544 −16.419 16.81 C ATOM 942 CB PHE 1168 −24.575 −29.188 −15.577 16.11 C ATOM 943 CG PHE 1168 −24.368 −29.47 −14.139 17.57 C ATOM 944 CD1 PHE 1168 −23.567 −28.633 −13.361 17.68 C ATOM 945 CD2 PHE 1168 −24.888 −30.625 −13.572 17.09 C ATOM 946 CE1 PHE 1168 −23.286 −28.954 −12.042 16.42 C ATOM 947 CE2 PHE 1168 −24.613 −30.953 −12.258 16.65 C ATOM 948 CZ PHE 1168 −23.809 −30.118 −11.49 16.79 C ATOM 949 C PHE 1168 −23.054 −31.024 −16.257 17.57 C ATOM 950 O PHE 1168 −22.004 −31.379 −15.725 17.47 O ATOM 951 N ILE 1169 −23.967 −31.872 −16.733 18.48 N ATOM 952 CA ILE 1169 −23.849 −33.323 −16.618 19.22 C ATOM 953 CB ILE 1169 −25.221 −33.994 −16.911 18.85 C ATOM 954 CG2 ILE 1169 −26.323 −33.291 −16.107 20.15 C ATOM 955 CG1 ILE 1169 −25.562 −33.883 −18.398 19.02 C ATOM 956 CD ILE 1169 −26.743 −34.735 −18.851 21.26 C ATOM 957 C ILE 1169 −22.742 −33.938 −17.49 20.6 C ATOM 958 O ILE 1169 −22.254 −35.022 −17.203 21.94 O ATOM 959 N ARG 1170 −22.346 −33.234 −18.547 24.45 N ATOM 960 CA ARG 1170 −21.269 −33.682 −19.438 27.69 C ATOM 961 CB ARG 1170 −21.419 −32.978 −20.852 28.31 C ATOM 962 CG ARG 1170 −22.013 −33.766 −22.12 33.76 C ATOM 963 CD ARG 1170 −21.062 −33.577 −23.383 38.78 C ATOM 964 NE ARG 1170 −21.589 −33.737 −24.767 44.17 N ATOM 965 CZ ARG 1170 −21.776 −34.883 −25.421 45.25 C ATOM 966 NH1 ARG 1170 −21.509 −36.042 −24.837 45.69 N ATOM 967 NH2 ARG 1170 −22.158 −34.868 −26.699 46.99 N ATOM 968 C ARG 1170 −19.801 −33.42 −18.85 28.11 C ATOM 969 O ARG 1170 −18.863 −33.886 −19.461 28.96 O ATOM 970 N ASN 1171 −19.616 −32.761 −17.676 31.77 N ATOM 971 CA ASN 1171 −18.278 −32.351 −17.071 35.84 C ATOM 972 CB ASN 1171 −18.34 −30.837 −16.751 35.9 C ATOM 973 CG ASN 1171 −17.124 −30.291 −15.963 36.69 C ATOM 974 OD1 ASN 1171 −15.967 −30.5 −16.337 38.54 O ATOM 975 ND2 ASN 1171 −17.402 −29.552 −14.892 38.57 N ATOM 976 C ASN 1171 −17.734 −33.05 −15.837 38.26 C ATOM 977 O ASN 1171 −18.335 −33.996 −15.33 37.47 O ATOM 978 N GLU 1172 −16.634 −32.526 −15.299 42.42 N ATOM 979 CA GLU 1172 −16.084 −33.21 −14.185 44.62 C ATOM 980 CB GLU 1172 −14.662 −33.533 −14.33 47.34 C ATOM 981 CG GLU 1172 −14.476 −34.899 −14.945 51.52 C ATOM 982 CD GLU 1172 −13 −35.209 −15.021 54.32 C ATOM 983 OE1 GLU 1172 −12.209 −34.331 −14.607 56.07 O ATOM 984 OE2 GLU 1172 −12.619 −36.306 −15.481 55.09 O ATOM 985 C GLU 1172 −16.394 −32.813 −12.868 45.4 C ATOM 986 O GLU 1172 −15.676 −32.606 −11.9 45.64 O ATOM 987 N THR 1173 −17.5 −33.46 −12.882 45.94 N ATOM 988 CA THR 1173 −18.303 −33.412 −11.801 45.89 C ATOM 989 CB THR 1173 −18.9 −31.986 −11.806 48.24 C ATOM 990 OG1 THR 1173 −19.351 −31.627 −13.121 51.69 O ATOM 991 CG2 THR 1173 −17.814 −30.958 −11.388 49.83 C ATOM 992 C THR 1173 −19.225 −34.615 −12.011 44.29 C ATOM 993 O THR 1173 −19.564 −34.981 −13.109 44.1 O ATOM 994 N HIS 1174 −19.669 −35.201 −10.93 42.7 N ATOM 995 CA HIS 1174 −20.433 −36.472 −10.943 41.89 C ATOM 996 CB HIS 1174 −19.872 −37.118 −9.842 39.55 C ATOM 997 CG HIS 1174 −18.497 −37.364 −10.145 37.93 C ATOM 998 CD2 HIS 1174 −18.032 −38.092 −11.169 36.9 C ATOM 999 ND1 HIS 1174 −17.45 −36.607 −9.675 37.27 N ATOM 1000 CE1 HIS 1174 −16.388 −36.875 −10.408 37.46 C ATOM 1001 NE2 HIS 1174 −16.72 −37.767 −11.321 38.87 N ATOM 1002 C HIS 1174 −21.626 −36.098 −10.522 43.19 C ATOM 1003 O HIS 1174 −22.216 −36.764 −9.624 40.83 O ATOM 1004 N ASN 1175 −22.132 −35.21 −11.301 45 N ATOM 1005 CA ASN 1175 −22.901 −34.607 −10.372 46.48 C ATOM 1006 CB ASN 1175 −22.07 −33.389 −10.053 48.49 C ATOM 1007 CG ASN 1175 −21.478 −33.586 −8.735 50.32 C ATOM 1008 OD1 ASN 1175 −22.172 −33.645 −7.717 50.43 O ATOM 1009 ND2 ASN 1175 −20.165 −33.807 −8.744 52.85 N ATOM 1010 C ASN 1175 −24.337 −34.512 −10.263 45.16 C ATOM 1011 O ASN 1175 −24.947 −33.607 −9.572 45.76 O ATOM 1012 N PRO 1176 −24.862 −35.721 −10.584 42.63 N ATOM 1013 CD PRO 1176 −25.399 −35.28 −11.89 42.59 C ATOM 1014 CA PRO 1176 −24.501 −37.027 −11.106 39.43 C ATOM 1015 CB PRO 1176 −23.589 −36.804 −12.308 40.33 C ATOM 1016 CG PRO 1176 −24.229 −35.822 −12.818 41.13 C ATOM 1017 C PRO 1176 −24.454 −38.352 −10.571 35.88 C ATOM 1018 O PRO 1176 −24.315 −39.218 −11.379 36.9 O ATOM 1019 N THR 1177 −24.742 −38.551 −9.294 31.21 N ATOM 1020 CA THR 1177 −25.219 −39.893 −8.976 27.86 C ATOM 1021 CB THR 1177 −25.691 −39.919 −7.539 28.3 C ATOM 1022 OG1 THR 1177 −26.718 −38.926 −7.34 28.69 O ATOM 1023 CG2 THR 1177 −24.519 −39.58 −6.658 29.42 C ATOM 1024 C THR 1177 −26.551 −39.987 −9.875 25.62 C ATOM 1025 O THR 1177 −27.064 −38.967 −10.392 24.15 O ATOM 1026 N VAL 1178 −27.117 −41.19 −10.018 23.06 N ATOM 1027 CA VAL 1178 −28.349 −41.394 −10.787 20 C ATOM 1028 CB VAL 1178 −28.65 −42.913 −10.982 21.95 C ATOM 1029 CG1 VAL 1178 −30.109 −43.124 −11.338 22.35 C ATOM 1030 CG2 VAL 1178 −27.774 −43.49 −12.098 21.65 C ATOM 1031 C VAL 1178 −29.551 −40.708 −10.115 19.06 C ATOM 1032 O VAL 1178 −30.457 −40.256 −10.801 14.69 O ATOM 1033 N LYS 1179 −29.555 −40.61 −8.784 17.59 N ATOM 1034 CA LYS 1179 −30.674 −39.95 −8.098 17.37 C ATOM 1035 CB LYS 1179 −30.595 −40.091 −6.573 15.86 C ATOM 1036 CG LYS 1179 −31.893 −39.607 −5.945 17.43 C ATOM 1037 CD LYS 1179 −31.973 −39.615 −4.431 18.96 C ATOM 1038 CE LYS 1179 −33.444 −39.433 −4.033 19.52 C ATOM 1039 NZ LYS 1179 −33.713 −39.473 −2.586 23.06 N ATOM 1040 C LYS 1179 −30.722 −38.466 −8.432 16.18 C ATOM 1041 O LYS 1179 −31.795 −37.904 −8.696 16 O ATOM 1042 N ASP 1180 −29.545 −37.85 −8.368 16.29 N ATOM 1043 CA ASP 1180 −29.319 −36.44 −8.672 16.7 C ATOM 1044 CB ASP 1180 −27.8 −36.166 −8.754 21.3 C ATOM 1045 CG ASP 1180 −27.093 −36.177 −7.382 24.33 C ATOM 1046 OD1 ASP 1180 −25.843 −36.324 −7.358 24.63 O ATOM 1047 OD2 ASP 1180 −27.766 −36.02 −6.34 25.45 O ATOM 1048 C ASP 1180 −29.941 −36.166 −10.046 16.85 C ATOM 1049 O ASP 1180 −30.788 −35.284 −10.204 17.45 O ATOM 1050 N LEU 1181 −29.495 −36.942 −11.031 14.01 N ATOM 1051 CA LEU 1181 −29.948 −36.844 −12.417 15.35 C ATOM 1052 CB LEU 1181 −29.241 −37.908 −13.252 12.86 C ATOM 1053 CG LEU 1181 −28.102 −37.644 −14.236 16.66 C ATOM 1054 CD1 LEU 1181 −27.429 −36.281 −14.107 14.78 C ATOM 1055 CD2 LEU 1181 −27.138 −38.797 −14.016 16.96 C ATOM 1056 C LEU 1181 −31.465 −36.989 −12.604 15.84 C ATOM 1057 O LEU 1181 −32.057 −36.288 −13.425 13.36 O ATOM 1058 N ILE 1182 −32.083 −37.924 −11.884 16.57 N ATOM 1059 CA ILE 1182 −33.535 −38.106 −11.971 18.12 C ATOM 1060 CB ILE 1182 −34.009 −39.375 −11.205 19.44 C ATOM 1061 CG2 ILE 1182 −35.549 −39.429 −11.179 18.44 C ATOM 1062 CG1 ILE 1182 −33.477 −40.659 −11.866 22.47 C ATOM 1063 CD ILE 1182 −32.11 −40.629 −12.516 26.66 C ATOM 1064 C ILE 1182 −34.088 −36.87 −11.276 17.03 C ATOM 1065 O ILE 1182 −35.165 −36.364 −11.611 15.91 O ATOM 1066 N GLY 1183 −33.315 −36.388 −10.307 15.99 N ATOM 1067 CA GLY 1183 −33.702 −35.204 −9.562 17.43 C ATOM 1068 C GLY 1183 −33.873 −34.015 −10.488 17.32 C ATOM 1069 O GLY 1183 −34.833 −33.258 −10.36 16.44 O ATOM 1070 N PHE 1184 −32.95 −33.843 −11.427 17.05 N ATOM 1071 CA PHE 1184 −33.052 −32.724 −12.357 17.09 C ATOM 1072 CB PHE 1184 −31.749 −32.522 −13.141 18.5 C ATOM 1073 CG PHE 1184 −30.522 −32.379 −12.283 19.66 C ATOM 1074 CD1 PHE 1184 −30.502 −31.544 −11.167 20.39 C ATOM 1075 CD2 PHE 1184 −29.367 −33.075 −12.616 22.04 C ATOM 1076 CE1 PHE 1184 −29.335 −31.414 −10.398 22.54 C ATOM 1077 CE2 PHE 1184 −28.208 −32.956 −11.865 23.06 C ATOM 1078 CZ PHE 1184 −28.186 −32.127 −10.754 23.72 C ATOM 1079 C PHE 1184 −34.199 −32.938 −13.338 15.91 C ATOM 1080 O PHE 1184 −34.91 −31.994 −13.682 15.75 O ATOM 1081 N GLY 1185 −34.377 −34.172 −13.794 14.93 N ATOM 1082 CA GLY 1185 −35.457 −34.458 −14.723 15.28 C ATOM 1083 C GLY 1185 −36.789 −34.122 −14.088 15.23 C ATOM 1084 O GLY 1185 −37.713 −33.646 −14.75 12.8 O ATOM 1085 N LEU 1186 −36.864 −34.366 −12.783 14.32 N ATOM 1086 CA LEU 1186 −38.056 −34.098 −12.006 14.34 C ATOM 1087 CB LEU 1186 −37.88 −34.62 −10.572 13.65 C ATOM 1088 CG LEU 1186 −39.029 −34.398 −9.581 16.71 C ATOM 1089 CD1 LEU 1186 −40.35 −34.885 −10.173 12.78 C ATOM 1090 CD2 LEU 1186 −38.722 −35.145 −8.28 14.5 C ATOM 1091 C LEU 1186 −38.351 −32.601 −11.996 14.32 C ATOM 1092 O LEU 1186 −39.479 −32.196 −12.256 14.05 O ATOM 1093 N GLN 1187 −37.351 −31.77 −11.71 13.6 N ATOM 1094 CA GLN 1187 −37.605 −30.34 −11.698 13.35 C ATOM 1095 CB GLN 1187 −36.387 −29.575 −11.206 14.52 C ATOM 1096 CG GLN 1187 −35.823 −30.07 −9.902 16.14 C ATOM 1097 CD GLN 1187 −34.745 −29.136 −9.4 18.91 C ATOM 1098 OE1 GLN 1187 −35.02 −27.993 −9.054 23.4 O ATOM 1099 NE2 GLN 1187 −33.51 −29.609 −9.375 19 N ATOM 1100 C GLN 1187 −38.004 −29.829 −13.081 11.58 C ATOM 1101 O GLN 1187 −38.696 −28.821 −13.194 13.07 O ATOM 1102 N VAL 1188 −37.576 −30.506 −14.138 11.09 N ATOM 1103 CA VAL 1188 −37.949 −30.071 −15.492 11.72 C ATOM 1104 CB VAL 1188 −37.075 −30.744 −16.577 9.94 C ATOM 1105 CG1 VAL 1188 −37.652 −30.471 −17.966 11.58 C ATOM 1106 CG2 VAL 1188 −35.659 −30.193 −16.495 9.54 C ATOM 1107 C VAL 1188 −39.418 −30.373 −15.781 11.54 C ATOM 1108 O VAL 1188 −40.106 −29.587 −16.419 12.41 O ATOM 1109 N ALA 1189 −39.894 −31.519 −15.304 14.27 N ATOM 1110 CA ALA 1189 −41.281 −31.913 −15.513 13.61 C ATOM 1111 CB ALA 1189 −41.481 −33.359 −15.09 13.82 C ATOM 1112 C ALA 1189 −42.195 −31.007 −14.706 13.97 C ATOM 1113 O ALA 1189 −43.352 −30.79 −15.072 16.38 O ATOM 1114 N LYS 1190 −41.674 −30.504 −13.593 12.74 N ATOM 1115 CA LYS 1190 −42.434 −29.617 −12.722 15.29 C ATOM 1116 CB LYS 1190 −41.708 −29.434 −11.399 14.89 C ATOM 1117 CG LYS 1190 −42.14 −30.477 −10.409 18.23 C ATOM 1118 CD LYS 1190 −41.278 −30.504 −9.175 18.47 C ATOM 1119 CE LYS 1190 −41.793 −31.579 −8.246 18.95 C ATOM 1120 NZ LYS 1190 −41.279 −31.37 −6.871 20.27 N ATOM 1121 C LYS 1190 −42.637 −28.279 −13.398 14.43 C ATOM 1122 O LYS 1190 −43.721 −27.703 −13.373 15.22 O ATOM 1123 N GLY 1191 −41.573 −27.782 −14.001 13.21 N ATOM 1124 CA GLY 1191 −41.666 −26.523 −14.706 12.63 C ATOM 1125 C GLY 1191 −42.579 −26.713 −15.895 12.4 C ATOM 1126 O GLY 1191 −43.406 −25.849 −16.174 12.86 O ATOM 1127 N MET 1192 −42.442 −27.85 −16.582 12.14 N ATOM 1128 CA MET 1192 −43.271 −28.144 −17.741 11.6 C ATOM 1129 CB MET 1192 −42.701 −29.326 −18.541 10.64 C ATOM 1130 CG MET 1192 −41.421 −29.006 −19.336 13.7 C ATOM 1131 SD MET 1192 −41.513 −27.621 −20.534 17.92 S ATOM 1132 CE MET 1192 −42.921 −28.121 −21.647 20.8 C ATOM 1133 C MET 1192 −44.736 −28.383 −17.363 12.32 C ATOM 1134 O MET 1192 −45.624 −28.038 −18.147 13.61 O ATOM 1135 N LYS 1193 −44.993 −28.955 −16.181 11.86 N ATOM 1136 CA LYS 1193 −46.373 −29.158 −15.712 12.84 C ATOM 1137 CB LYS 1193 −46.395 −29.822 −14.301 13.93 C ATOM 1138 CG LYS 1193 −47.766 −29.826 −13.567 17.85 C ATOM 1139 CD LYS 1193 −47.72 −30.237 −12.045 23.67 C ATOM 1140 CE LYS 1193 −46.391 −29.929 −11.3 26.38 C ATOM 1141 NZ LYS 1193 −45.901 −28.542 −10.955 30.9 N ATOM 1142 C LYS 1193 −46.955 −27.734 −15.649 12.03 C ATOM 1143 O LYS 1193 −48.068 −27.479 −16.108 12.04 O ATOM 1144 N TYR 1194 −46.18 −26.795 −15.112 12.64 N ATOM 1145 CA TYR 1194 −46.647 −25.407 −14.997 12.34 C ATOM 1146 CB TYR 1194 −45.668 −24.591 −14.147 11.64 C ATOM 1147 CG TYR 1194 −45.962 −23.1 −14.065 11.89 C ATOM 1148 CD1 TYR 1194 −46.907 −22.58 −13.167 12.34 C ATOM 1149 CE1 TYR 1194 −47.178 −21.199 −13.125 13.81 C ATOM 1150 CD2 TYR 1194 −45.304 −22.208 −14.911 12.87 C ATOM 1151 CE2 TYR 1194 −45.572 −20.84 −14.879 12.27 C ATOM 1152 CZ TYR 1194 −46.502 −20.34 −13.994 12.63 C ATOM 1153 OH TYR 1194 −46.763 −18.991 −14.015 13.8 O ATOM 1154 C TYR 1194 −46.863 −24.747 −16.369 14.72 C ATOM 1155 O TYR 1194 −47.966 −24.29 −16.668 13.67 O ATOM 1156 N LEU 1195 −45.829 −24.707 −17.205 14.63 N ATOM 1157 CA LEU 1195 −45.961 −24.114 −18.53 14.48 C ATOM 1158 CB LEU 1195 −44.659 −24.313 −19.327 11.22 C ATOM 1159 CG LEU 1195 −43.558 −23.232 −19.419 12.32 C ATOM 1160 CD1 LEU 1195 −43.924 −22.016 −18.591 11.57 C ATOM 1161 CD2 LEU 1195 −42.204 −23.817 −19 9.97 C ATOM 1162 C LEU 1195 −47.153 −24.75 −19.26 14.78 C ATOM 1163 O LEU 1195 −48.011 −24.048 −19.799 15.68 O ATOM 1164 N ALA 1196 −47.226 −26.077 −19.255 15.59 N ATOM 1165 CA ALA 1196 −48.323 −26.76 −19.931 17.53 C ATOM 1166 CB ALA 1196 −48.122 −28.286 −19.882 17.48 C ATOM 1167 C ALA 1196 −49.71 −26.397 −19.395 17.02 C ATOM 1168 O ALA 1196 −50.7 −26.616 −20.083 18.22 O ATOM 1169 N SER 1197 −49.799 −25.859 −18.181 18.14 N ATOM 1170 CA SER 1197 −51.109 −25.484 −17.646 18.76 C ATOM 1171 CB SER 1197 −51.115 −25.544 −16.114 19.04 C ATOM 1172 OG SER 1197 −50.19 −24.624 −15.551 20.46 O ATOM 1173 C SER 1197 −51.49 −24.081 −18.123 18.11 C ATOM 1174 O SER 1197 −52.665 −23.732 −18.177 20.7 O ATOM 1175 N LYS 1198 −50.487 −23.29 −18.48 18.69 N ATOM 1176 CA LYS 1198 −50.698 −21.937 −18.988 19.35 C ATOM 1177 CB LYS 1198 −49.478 −21.06 −18.689 20.72 C ATOM 1178 CG LYS 1198 −49.059 −21.106 −17.24 19.87 C ATOM 1179 CD LYS 1198 −50.309 −21.238 −16.407 21.44 C ATOM 1180 CE LYS 1198 −50.069 −21.004 −14.947 22.31 C ATOM 1181 NZ LYS 1198 −51.33 −20.451 −14.393 23.65 N ATOM 1182 C LYS 1198 −50.86 −22.094 −20.488 19.76 C ATOM 1183 O LYS 1198 −50.899 −21.117 −21.234 20.25 O ATOM 1184 N LYS 1199 −50.943 −23.356 −20.901 19.44 N ATOM 1185 CA LYS 1199 −51.079 −23.747 −22.302 21.24 C ATOM 1186 CB LYS 1199 −52.326 −23.134 −22.952 23.73 C ATOM 1187 CG LYS 1199 −53.683 −23.601 −22.468 27.68 C ATOM 1188 CD LYS 1199 −54.769 −22.601 −22.926 32.24 C ATOM 1189 CE LYS 1199 −55.458 −22.948 −24.274 35.47 C ATOM 1190 NZ LYS 1199 −54.653 −22.791 −25.529 34.96 N ATOM 1191 C LYS 1199 −49.88 −23.276 −23.119 21.02 C ATOM 1192 O LYS 1199 −50.037 −22.907 −24.277 20.05 O ATOM 1193 N PHE 1200 −48.687 −23.274 −22.546 18.53 N ATOM 1194 CA PHE 1200 −47.542 −22.814 −23.312 18.34 C ATOM 1195 CB PHE 1200 −46.658 −21.964 −22.404 19.51 C ATOM 1196 CG PHE 1200 −45.328 −21.61 −22.982 18.89 C ATOM 1197 CD1 PHE 1200 −44.242 −22.452 −22.793 19.96 C ATOM 1198 CD2 PHE 1200 −45.133 −20.398 −23.634 20.92 C ATOM 1199 CE1 PHE 1200 −42.977 −22.092 −23.23 21.7 C ATOM 1200 CE2 PHE 1200 −43.865 −20.025 −24.08 20.16 C ATOM 1201 CZ PHE 1200 −42.786 −20.872 −23.876 20.78 C ATOM 1202 C PHE 1200 −46.778 −23.969 −23.946 17.03 C ATOM 1203 O PHE 1200 −46.409 −24.92 −23.282 16.04 O ATOM 1204 N VAL 1201 −46.575 −23.887 −25.253 17.46 N ATOM 1205 CA VAL 1201 −45.868 −24.933 −25.977 18.28 C ATOM 1206 CB VAL 1201 −46.586 −25.227 −27.312 17.97 C ATOM 1207 CG1 VAL 1201 −45.917 −26.389 −28.045 16.62 C ATOM 1208 CG2 VAL 1201 −48.053 −25.553 −27.018 19.79 C ATOM 1209 C VAL 1201 −44.427 −24.474 −26.19 17.03 C ATOM 1210 O VAL 1201 −44.146 −23.552 −26.951 16.94 O ATOM 1211 N HIS 1202 −43.516 −25.127 −25.484 18.22 N ATOM 1212 CA HIS 1202 −42.117 −24.766 −25.55 19.44 C ATOM 1213 CB HIS 1202 −41.352 −25.573 −24.503 20.61 C ATOM 1214 CG HIS 1202 −39.987 −25.039 −24.218 23.13 C ATOM 1215 CD2 HIS 1202 −39.507 −24.329 −23.17 22.29 C ATOM 1216 ND1 HIS 1202 −38.938 −25.18 −25.101 25.25 N ATOM 1217 CE1 HIS 1202 −37.87 −24.579 −24.608 23.7 C ATOM 1218 NE2 HIS 1202 −38.189 −24.055 −23.438 24.81 N ATOM 1219 C HIS 1202 −41.5 −24.923 −26.946 19.79 C ATOM 1220 O HIS 1202 −41.037 −23.946 −27.514 19.21 O ATOM 1221 N ARG 1203 −41.491 −26.145 −27.484 21.16 N ATOM 1222 CA ARG 1203 −40.951 −26.456 −28.821 20.86 C ATOM 1223 CB ARG 1203 −41.293 −25.36 −29.847 22.37 C ATOM 1224 CG ARG 1203 −42.756 −24.976 −29.983 27.08 C ATOM 1225 CD ARG 1203 −42.888 −23.623 −30.689 30.84 C ATOM 1226 NE ARG 1203 −42.868 −23.673 −32.153 36.66 N ATOM 1227 CZ ARG 1203 −43.94 −23.521 −32.934 38.15 C ATOM 1228 NH1 ARG 1203 −45.139 −23.308 −32.399 37.56 N ATOM 1229 NH2 ARG 1203 −43.811 −23.569 −34.258 38.08 N ATOM 1230 C ARG 1203 −39.442 −26.705 −28.93 20.03 C ATOM 1231 O ARG 1203 −38.962 −27.062 −30.001 20.19 O ATOM 1232 N ASP 1204 −38.68 −26.498 −27.866 18.22 N ATOM 1233 CA ASP 1204 −37.242 −26.727 −27.961 17.39 C ATOM 1234 CB ASP 1204 −36.519 −25.454 −28.397 18.69 C ATOM 1235 CG ASP 1204 −35.059 −25.705 −28.756 20.08 C ATOM 1236 OD1 ASP 1204 −34.278 −24.736 −28.736 20.95 O ATOM 1237 OD2 ASP 1204 −34.697 −26.864 −29.063 20.4 O ATOM 1238 C ASP 1204 −36.713 −27.183 −26.617 16.06 C ATOM 1239 O ASP 1204 −35.627 −26.811 −26.194 14.59 O ATOM 1240 N LEU 1205 −37.524 −27.984 −25.947 15.88 N ATOM 1241 CA LEU 1205 −37.178 −28.529 −24.656 15.06 C ATOM 1242 CB LEU 1205 −38.41 −29.214 −24.078 15.7 C ATOM 1243 CG LEU 1205 −38.336 −29.828 −22.689 16.1 C ATOM 1244 CD1 LEU 1205 −38.054 −28.738 −21.67 17.91 C ATOM 1245 CD2 LEU 1205 −39.655 −30.512 −22.377 18.02 C ATOM 1246 C LEU 1205 −36.067 −29.543 −24.93 15.1 C ATOM 1247 O LEU 1205 −36.226 −30.41 −25.777 13.35 O ATOM 1248 N ALA 1206 −34.944 −29.396 −24.234 13.57 N ATOM 1249 CA ALA 1206 −33.775 −30.261 −24.359 12.02 C ATOM 1250 CB ALA 1206 −33.038 −29.999 −25.683 12.69 C ATOM 1251 C ALA 1206 −32.917 −29.824 −23.184 11.59 C ATOM 1252 O ALA 1206 −33.116 −28.719 −22.665 11.21 O ATOM 1253 N ALA 1207 −31.968 −30.648 −22.754 11.55 N ATOM 1254 CA ALA 1207 −31.153 −30.25 −21.606 13.24 C ATOM 1255 CB ALA 1207 −30.255 −31.394 −21.164 12.55 C ATOM 1256 C ALA 1207 −30.324 −28.984 −21.838 13.57 C ATOM 1257 O ALA 1207 −29.973 −28.29 −20.884 12.7 O ATOM 1258 N ARG 1208 −30.008 −28.66 −23.087 14.61 N ATOM 1259 CA ARG 1208 −29.226 −27.451 −23.316 15.15 C ATOM 1260 CB ARG 1208 −28.74 −27.384 −24.759 15.13 C ATOM 1261 CG ARG 1208 −29.829 −27.618 −25.745 15.45 C ATOM 1262 CD ARG 1208 −29.409 −27.3 −27.17 14.22 C ATOM 1263 NE ARG 1208 −30.574 −27.433 −28.039 16.17 N ATOM 1264 CZ ARG 1208 −31.128 −28.598 −28.368 17.5 C ATOM 1265 NH1 ARG 1208 −30.616 −29.734 −27.913 15.22 N ATOM 1266 NH2 ARG 1208 −32.211 −28.63 −29.132 17.23 N ATOM 1267 C ARG 1208 −30.094 −26.238 −23.004 15.44 C ATOM 1268 O ARG 1208 −29.59 −25.126 −22.823 14.4 O ATOM 1269 N ASN 1209 −31.402 −26.452 −22.915 15.58 N ATOM 1270 CA ASN 1209 −32.323 −25.351 −22.64 15.77 C ATOM 1271 CB ASN 1209 −33.479 −25.394 −23.644 18.91 C ATOM 1272 CG ASN 1209 −33.06 −24.919 −25.021 18.29 C ATOM 1273 OD1 ASN 1209 −32.54 −23.817 −25.167 22.07 O ATOM 1274 ND2 ASN 1209 −33.282 −25.741 −26.03 20.52 N ATOM 1275 C ASN 1209 −32.869 −25.211 −21.218 15.85 C ATOM 1276 O ASN 1209 −33.85 −24.493 −20.997 14.98 O ATOM 1277 N CYS 1210 −32.235 −25.897 −20.265 14.98 N ATOM 1278 CA CYS 1210 −32.605 −25.834 −18.848 13.93 C ATOM 1279 CB CYS 1210 −32.902 −27.23 −18.301 14.01 C ATOM 1280 SG CYS 1210 −34.181 −28.128 −19.141 18.21 S ATOM 1281 C CYS 1210 −31.381 −25.299 −18.117 13.47 C ATOM 1282 O CYS 1210 −30.281 −25.796 −18.337 14.75 O ATOM 1283 N MET 1211 −31.542 −24.306 −17.251 11.84 N ATOM 1284 CA MET 1211 −30.389 −23.777 −16.526 12.37 C ATOM 1285 CB MET 1211 −30.373 −22.25 −16.618 12.33 C ATOM 1286 CG MET 1211 −30.417 −21.723 −18.04 15.48 C ATOM 1287 SD MET 1211 −28.921 −22.155 −18.986 16.79 S ATOM 1288 CE MET 1211 −29.629 −22.57 −20.593 17.49 C ATOM 1289 C MET 1211 −30.355 −24.221 −15.051 13.11 C ATOM 1290 O MET 1211 −31.405 −24.444 −14.433 12.82 O ATOM 1291 N LEU 1212 −29.138 −24.339 −14.515 14.5 N ATOM 1292 CA LEU 1212 −28.858 −24.757 −13.126 18.15 C ATOM 1293 CB LEU 1212 −27.783 −25.854 −13.117 18.33 C ATOM 1294 CG LEU 1212 −28.063 −27.342 −12.907 23.14 C ATOM 1295 CD1 LEU 1212 −26.759 −28.114 −12.725 22.22 C ATOM 1296 CD2 LEU 1212 −28.895 −27.512 −11.67 22.5 C ATOM 1297 C LEU 1212 −28.318 −23.607 −12.264 18.5 C ATOM 1298 O LEU 1212 −27.306 −23.003 −12.624 17.66 O ATOM 1299 N ASP 1213 −28.945 −23.3 −11.131 19.27 N ATOM 1300 CA ASP 1213 −28.396 −22.225 −10.308 21.32 C ATOM 1301 CB ASP 1213 −29.477 −21.318 −9.693 21.56 C ATOM 1302 CG ASP 1213 −30.303 −22.006 −8.609 23.87 C ATOM 1303 OD1 ASP 1213 −29.909 −23.083 −8.098 22.69 O ATOM 1304 OD2 ASP 1213 −31.359 −21.435 −8.26 23.31 O ATOM 1305 C ASP 1213 −27.537 −22.792 −9.199 22.81 C ATOM 1306 O ASP 1213 −27.369 −24.013 −9.088 21.8 O ATOM 1307 N GLU 1214 −27.015 −21.875 −8.387 23.36 N ATOM 1308 CA GLU 1214 −26.15 −22.172 −7.263 25.25 C ATOM 1309 CB GLU 1214 −25.713 −20.823 −6.591 27.38 C ATOM 1310 CG GLU 1214 −26.765 −19.881 −5.826 31.52 C ATOM 1311 CD GLU 1214 −27.635 −18.892 −6.678 36.11 C ATOM 1312 OE1 GLU 1214 −28.537 −19.36 −7.408 37.3 O ATOM 1313 OE2 GLU 1214 −27.447 −17.642 −6.592 38.7 O ATOM 1314 C GLU 1214 −26.736 −23.199 −6.26 25.42 C ATOM 1315 O GLU 1214 −25.992 −23.936 −5.608 25.26 O ATOM 1316 N LYS 1215 −28.062 −23.282 −6.172 25.13 N ATOM 1317 CA LYS 1215 −28.709 −24.231 −5.258 25.77 C ATOM 1318 CB LYS 1215 −29.843 −23.524 −4.475 28.21 C ATOM 1319 CG LYS 1215 −29.356 −22.414 −3.48 33.22 C ATOM 1320 CD LYS 1215 −30.496 −21.715 −2.665 36.61 C ATOM 1321 CE LYS 1215 −29.956 −20.614 −1.691 39.24 C ATOM 1322 NZ LYS 1215 −30.983 −19.842 −0.882 40.6 N ATOM 1323 C LYS 1215 −29.23 −25.491 −5.998 25.36 C ATOM 1324 O LYS 1215 −30.031 −26.261 −5.464 24.65 O ATOM 1325 N PHE 1216 −28.739 −25.682 −7.225 23.22 N ATOM 1326 CA PHE 1216 −29.075 −26.811 −8.091 21.85 C ATOM 1327 CB PHE 1216 −28.465 −28.108 −7.517 23.16 C ATOM 1328 CG PHE 1216 −26.958 −28.012 −7.263 24.21 C ATOM 1329 CD1 PHE 1216 −26.463 −27.77 −5.975 26.27 C ATOM 1330 CD2 PHE 1216 −26.043 −28.113 −8.314 23.83 C ATOM 1331 CE1 PHE 1216 −25.081 −27.629 −5.741 24.88 C ATOM 1332 CE2 PHE 1216 −24.659 −27.972 −8.088 25.08 C ATOM 1333 CZ PHE 1216 −24.183 −27.73 −6.803 25.51 C ATOM 1334 C PHE 1216 −30.569 −26.93 −8.396 20.58 C ATOM 1335 O PHE 1216 −31.144 −28.015 −8.54 17.6 O ATOM 1336 N THR 1217 −31.179 −25.759 −8.521 19.63 N ATOM 1337 CA THR 1217 −32.576 −25.635 −8.871 17.9 C ATOM 1338 CB THR 1217 −33.199 −24.4 −8.134 18.25 C ATOM 1339 OG1 THR 1217 −33.309 −24.708 −6.736 22.27 O ATOM 1340 CG2 THR 1217 −34.587 −24.057 −8.663 18.17 C ATOM 1341 C THR 1217 −32.473 −25.47 −10.396 16.93 C ATOM 1342 O THR 1217 −31.649 −24.686 −10.886 16.95 O ATOM 1343 N VAL 1218 −33.243 −26.282 −11.127 14.5 N ATOM 1344 CA VAL 1218 −33.271 −26.27 −12.593 12.8 C ATOM 1345 CB VAL 1218 −33.428 −27.71 −13.207 13.21 C ATOM 1346 CG1 VAL 1218 −33.421 −27.636 −14.734 9.72 C ATOM 1347 CG2 VAL 1218 −32.297 −28.638 −12.73 11.3 C ATOM 1348 C VAL 1218 −34.455 −25.437 −13.066 12.06 C ATOM 1349 O VAL 1218 −35.546 −25.515 −12.503 10.84 O ATOM 1350 N LYS 1219 −34.229 −24.646 −14.107 12.68 N ATOM 1351 CA LYS 1219 −35.268 −23.8 −14.659 13.73 C ATOM 1352 CB LYS 1219 −35.033 −22.337 −14.228 13.19 C ATOM 1353 CG LYS 1219 −34.861 −22.121 −12.692 17.83 C ATOM 1354 CD LYS 1219 −35.229 −20.688 −12.283 21.91 C ATOM 1355 CE LYS 1219 −35.232 −20.482 −10.768 22.55 C ATOM 1356 NZ LYS 1219 −33.871 −20.066 −10.367 26.09 N ATOM 1357 C LYS 1219 −35.258 −23.95 −16.187 13.7 C ATOM 1358 O LYS 1219 −34.202 −23.854 −16.83 14.06 O ATOM 1359 N VAL 1220 −36.437 −24.224 −16.746 12.71 N ATOM 1360 CA VAL 1220 −36.641 −24.392 −18.188 13.54 C ATOM 1361 CB VAL 1220 −38.027 −25.056 −18.466 10.73 C ATOM 1362 CG1 VAL 1220 −38.189 −25.371 −19.946 12.56 C ATOM 1363 CG2 VAL 1220 −38.177 −26.319 −17.619 13.35 C ATOM 1364 C VAL 1220 −36.617 −22.987 −18.794 13.96 C ATOM 1365 O VAL 1220 −37.273 −22.079 −18.28 13.77 O ATOM 1366 N ALA 1221 −35.866 −22.814 −19.874 15.44 N ATOM 1367 CA ALA 1221 −35.742 −21.521 −20.529 17.32 C ATOM 1368 CB ALA 1221 −34.291 −21.059 −20.472 19.47 C ATOM 1369 C ALA 1221 −36.193 −21.558 −21.967 18.52 C ATOM 1370 O ALA 1221 −36.144 −22.607 −22.622 17.22 O ATOM 1371 N ASP 1222 −36.655 −20.409 −22.44 19.34 N ATOM 1372 CA ASP 1222 −37.05 −20.259 −23.823 20.45 C ATOM 1373 C ASP 1222 −36.096 −19.138 −24.197 21.22 C ATOM 1374 O ASP 1222 −36.346 −17.986 −23.881 20.31 O ATOM 1375 CB ASP 1222 −38.513 −19.79 −23.946 0 C ATOM 1376 CG ASP 1222 −38.938 −19.5 −25.394 0 C ATOM 1377 OD1 ASP 1222 −38.028 −19.47 −26.254 0 O ATOM 1378 OD2 ASP 1222 −40.162 −19.394 −25.634 0 O1− ATOM 1379 N PHE 1223 −34.946 −19.467 −24.764 22.78 N ATOM 1380 CA PHE 1223 −34.068 −18.376 −25.174 24.51 C ATOM 1381 CB PHE 1223 −32.649 −18.78 −25.064 23.52 C ATOM 1382 CG PHE 1223 −32.181 −18.589 −23.73 22.43 C ATOM 1383 CD1 PHE 1223 −32.106 −17.305 −23.205 22.25 C ATOM 1384 CD2 PHE 1223 −31.915 −19.675 −22.943 22.04 C ATOM 1385 CE1 PHE 1223 −31.767 −17.121 −21.898 23.44 C ATOM 1386 CE2 PHE 1223 −31.579 −19.511 −21.655 23.35 C ATOM 1387 CZ PHE 1223 −31.497 −18.23 −21.115 21.72 C ATOM 1388 C PHE 1223 −34.508 −18.133 −26.543 26.06 C ATOM 1389 O PHE 1223 −35.441 −17.365 −26.738 27.77 O ATOM 1390 N GLY 1224 −33.816 −18.621 −27.533 25.8 N ATOM 1391 CA GLY 1224 −34.608 −18.551 −28.715 26.02 C ATOM 1392 C GLY 1224 −34.467 −17.321 −29.46 24.52 C ATOM 1393 O GLY 1224 −33.784 −17.447 −30.43 26.4 O ATOM 1394 N LEU 1225 −35.099 −16.199 −29.133 23.41 N ATOM 1395 CA LEU 1225 −34.742 −15.069 −29.965 22.22 C ATOM 1396 CB LEU 1225 −35.724 −13.898 −29.921 24.33 C ATOM 1397 CG LEU 1225 −35.597 −13.386 −31.376 24.95 C ATOM 1398 CD1 LEU 1225 −36.22 −14.383 −32.359 27.59 C ATOM 1399 CD2 LEU 1225 −36.271 −12.083 −31.549 27.1 C ATOM 1400 C LEU 1225 −33.399 −14.576 −29.482 21.21 C ATOM 1401 O LEU 1225 −32.701 −13.862 −30.192 23.15 O ATOM 1402 N ALA 1226 −33.014 −14.967 −28.279 18.87 N ATOM 1403 CA ALA 1226 −31.743 −14.53 −27.759 18.09 C ATOM 1404 CB ALA 1226 −31.729 −14.712 −26.281 17.96 C ATOM 1405 C ALA 1226 −30.563 −15.254 −28.404 19.16 C ATOM 1406 O ALA 1226 −29.424 −14.798 −28.296 19.43 O ATOM 1407 N ARG 1227 −30.825 −16.383 −29.063 19.46 N ATOM 1408 CA ARG 1227 −29.762 −17.127 −29.734 19.73 C ATOM 1409 CB ARG 1227 −30.173 −18.589 −29.955 21.4 C ATOM 1410 CG ARG 1227 −29.913 −19.468 −28.749 21.1 C ATOM 1411 CD ARG 1227 −30.775 −20.709 −28.773 24.1 C ATOM 1412 NE ARG 1227 −30.764 −21.366 −27.479 24.33 N ATOM 1413 CZ ARG 1227 −29.659 −21.795 −26.901 25.32 C ATOM 1414 NH1 ARG 1227 −28.485 −21.653 −27.513 23.64 N ATOM 1415 NH2 ARG 1227 −29.722 −22.259 −25.669 22.87 N ATOM 1416 C ARG 1227 −29.502 −16.471 −31.081 19.24 C ATOM 1417 O ARG 1227 −30.343 −16.548 −31.967 19.55 O ATOM 1418 N ASP 1228 −28.353 −15.814 −31.225 18.7 N ATOM 1419 CA ASP 1228 −27.993 −15.164 −32.476 20.06 C ATOM 1420 CB ASP 1228 −26.596 −14.543 −32.363 22.84 C ATOM 1421 CG ASP 1228 −26.564 −13.326 −31.44 25.1 C ATOM 1422 OD1 ASP 1228 −27.649 −12.775 −31.148 28.18 O ATOM 1423 OD2 ASP 1228 −25.463 −12.912 −31.015 24.23 O ATOM 1424 C ASP 1228 −28.032 −16.191 −33.614 21.09 C ATOM 1425 O ASP 1228 −28.69 −15.971 −34.635 20.36 O ATOM 1426 N MET 1229 −27.319 −17.303 −33.401 22.55 N ATOM 1427 CA MET 1229 −27.226 −18.451 −34.317 25.14 C ATOM 1428 CB MET 1229 −25.849 −18.58 −34.936 26.88 C ATOM 1429 CG MET 1229 −25.515 −17.46 −35.798 31.32 C ATOM 1430 SD MET 1229 −24.024 −17.65 −36.705 35.03 S ATOM 1431 CE MET 1229 −23.377 −16.183 −36.259 34.46 C ATOM 1432 C MET 1229 −27.431 −19.769 −33.598 26.07 C ATOM 1433 O MET 1229 −27.166 −19.877 −32.409 24.93 O ATOM 1434 N TYR 1230 −27.867 −20.747 −34.392 28.36 N ATOM 1435 CA TYR 1230 −28.082 −22.125 −33.992 31.64 C ATOM 1436 CB TYR 1230 −29.453 −22.541 −34.464 32.55 C ATOM 1437 CG TYR 1230 −30.516 −21.962 −33.652 35.13 C ATOM 1438 CD1 TYR 1230 −30.798 −20.603 −33.714 36.14 C ATOM 1439 CE1 TYR 1230 −31.725 −20.077 −32.932 36.69 C ATOM 1440 CD2 TYR 1230 −31.171 −22.761 −32.768 36.34 C ATOM 1441 CE2 TYR 1230 −32.087 −22.251 −31.994 37.04 C ATOM 1442 CZ TYR 1230 −32.365 −20.915 −32.096 38.54 C ATOM 1443 OH TYR 1230 −33.288 −20.428 −31.255 40.67 O ATOM 1444 C TYR 1230 −27.115 −23.13 −34.593 33.96 C ATOM 1445 O TYR 1230 −26.726 −22.999 −35.739 31.96 O ATOM 1446 N ASP 1231 −26.708 −24.121 −33.842 37.48 N ATOM 1447 CA ASP 1231 −25.919 −25.139 −34.375 40.93 C ATOM 1448 CB ASP 1231 −24.61 −25.288 −33.497 44.37 C ATOM 1449 CG ASP 1231 −23.925 −24.048 −33.276 48.97 C ATOM 1450 OD1 ASP 1231 −24.038 −23.129 −34.127 52.21 O ATOM 1451 OD2 ASP 1231 −23.288 −23.979 −32.223 52.03 O ATOM 1452 C ASP 1231 −26.456 −26.616 −34.314 40.83 C ATOM 1453 O ASP 1231 −27.297 −26.882 −33.463 42.4 O ATOM 1454 N LYS 1232 −26.267 −27.085 −35.575 42.17 N ATOM 1455 CA LYS 1232 −25.533 −28.505 −35.598 41.36 C ATOM 1456 CB LYS 1232 −24.062 −27.847 −35.332 43.03 C ATOM 1457 CG LYS 1232 −23.742 −27.489 −33.868 42.47 C ATOM 1458 CD LYS 1232 −22.298 −27.062 −33.676 44.85 C ATOM 1459 CE LYS 1232 −22.066 −26.5 −32.281 45.67 C ATOM 1460 NZ LYS 1232 −22.63 −27.363 −31.219 45.92 N ATOM 1461 C LYS 1232 −25.864 −29.353 −34.331 42.16 C ATOM 1462 O LYS 1232 −24.92 −29.911 −33.817 42.14 O ATOM 1463 N GLU 1233 −27.06 −29.753 −34.739 41.02 N ATOM 1464 CA GLU 1233 −28.195 −29.943 −33.706 38.27 C ATOM 1465 CB GLU 1233 −27.97 −29.831 −32.326 38.85 C ATOM 1466 CG GLU 1233 −28.074 −28.876 −31.65 39.43 C ATOM 1467 CD GLU 1233 −27.167 −29.213 −30.633 40.62 C ATOM 1468 OE1 GLU 1233 −27.027 −30.394 −30.339 41.43 O ATOM 1469 OE2 GLU 1233 −26.558 −28.342 −30.077 40.48 O ATOM 1470 C GLU 1233 −29.459 −29.134 −34.191 36.4 C ATOM 1471 O GLU 1233 −30.524 −29.669 −33.898 34.53 O ATOM 1472 N TYR 1234 −29.475 −28.188 −35.121 36.25 N ATOM 1473 CA TYR 1234 −30.734 −27.685 −35.527 36.56 C ATOM 1474 CB TYR 1234 −30.911 −26.216 −35.002 33.99 C ATOM 1475 CG TYR 1234 −31.224 −25.972 −33.511 31.79 C ATOM 1476 CD1 TYR 1234 −30.212 −25.93 −32.539 31.24 C ATOM 1477 CE1 TYR 1234 −30.517 −25.712 −31.174 30.51 C ATOM 1478 CD2 TYR 1234 −32.541 −25.784 −33.081 30.83 C ATOM 1479 CE2 TYR 1234 −32.85 −25.571 −31.73 31.34 C ATOM 1480 CZ TYR 1234 −31.84 −25.539 −30.786 30.26 C ATOM 1481 OH TYR 1234 −32.168 −25.366 −29.461 30.54 O ATOM 1482 C TYR 1234 −30.732 −27.612 −37.001 38.61 C ATOM 1483 O TYR 1234 −29.768 −27.222 −37.647 38.99 O ATOM 1484 N TYR 1235 −31.838 −28.06 −37.605 40.77 N ATOM 1485 CA TYR 1235 −31.738 −27.772 −38.957 42.64 C ATOM 1486 CB TYR 1235 −31.678 −29.069 −39.669 46.84 C ATOM 1487 CG TYR 1235 −32.849 −29.778 −39.865 50.38 C ATOM 1488 CD1 TYR 1235 −34.004 −29.171 −39.769 53.12 C ATOM 1489 CE1 TYR 1235 −35.198 −29.749 −40.213 55.79 C ATOM 1490 CD2 TYR 1235 −32.817 −31.021 −40.357 53.24 C ATOM 1491 CE2 TYR 1235 −34.04 −31.664 −40.801 55.03 C ATOM 1492 CZ TYR 1235 −35.279 −30.998 −40.743 55.74 C ATOM 1493 OH TYR 1235 −36.599 −31.478 −41.034 56.64 O ATOM 1494 C TYR 1235 −32.684 −26.594 −39.33 42.38 C ATOM 1495 O TYR 1235 −33.349 −26.096 −38.446 40.51 O ATOM 1496 N SER 1236 −32.562 −26.056 −40.555 43.09 N ATOM 1497 CA SER 1236 −33.212 −24.801 −41.007 45.87 C ATOM 1498 CB SER 1236 −32.195 −23.721 −41.381 45.81 C ATOM 1499 OG SER 1236 −32.456 −22.403 −40.912 46.19 O ATOM 1500 C SER 1236 −33.855 −25.128 −42.242 46.98 C ATOM 1501 O SER 1236 −33.2 −25.525 −43.229 46.05 O ATOM 1502 N VAL 1237 −35.127 −24.83 −42.112 49.49 N ATOM 1503 CA VAL 1237 −36.152 −25.135 −42.976 53.03 C ATOM 1504 CB VAL 1237 −36.004 −26.282 −43.795 54.51 C ATOM 1505 CG1 VAL 1237 −37.535 −26.564 −44.634 55.14 C ATOM 1506 CG2 VAL 1237 −34.579 −26.099 −44.653 55.8 C ATOM 1507 C VAL 1237 −37.635 −25.216 −42.705 53.76 C ATOM 1508 O VAL 1237 −38.019 −25.752 −41.647 56 O ATOM 1509 N HIS 1238 −37.758 −23.997 −43.136 52.4 N ATOM 1510 CA HIS 1238 −37.717 −23.906 −44.535 51.91 C ATOM 1511 CB HIS 1238 −38.465 −22.886 −45.254 54.35 C ATOM 1512 CG HIS 1238 −39.616 −23.437 −45.974 57.6 C ATOM 1513 CD2 HIS 1238 −40.346 −22.958 −47.004 58.86 C ATOM 1514 ND1 HIS 1238 −40.192 −24.626 −45.598 58.65 N ATOM 1515 CE1 HIS 1238 −41.237 −24.859 −46.368 60.01 C ATOM 1516 NE2 HIS 1238 −41.353 −23.862 −47.23 59.82 N ATOM 1517 C HIS 1238 −36.249 −23.225 −44.582 48.89 C ATOM 1518 O HIS 1238 −35.761 −22.506 −43.669 48.04 O ATOM 1519 N ASN 1239 −35.594 −23.733 −45.588 45.16 N ATOM 1520 CA ASN 1239 −34.522 −23.154 −46.263 42.36 C ATOM 1521 CB ASN 1239 −34.461 −23.909 −47.567 39.19 C ATOM 1522 CG ASN 1239 −33.336 −24.794 −47.582 36.67 C ATOM 1523 OD1 ASN 1239 −32.361 −24.421 −47.049 32.64 O ATOM 1524 ND2 ASN 1239 −33.421 −25.953 −48.131 35.18 N ATOM 1525 C ASN 1239 −35.228 −21.819 −46.602 41.96 C ATOM 1526 O ASN 1239 −34.606 −20.882 −47.041 40.93 O ATOM 1527 N LYS 1240 −36.529 −21.728 −46.411 42.34 N ATOM 1528 CA LYS 1240 −37.182 −20.524 −46.813 43.5 C ATOM 1529 CB LYS 1240 −38.236 −20.938 −47.786 45.68 C ATOM 1530 CG LYS 1240 −38.978 −19.876 −48.424 49.63 C ATOM 1531 CD LYS 1240 −39.862 −20.598 −49.314 52.15 C ATOM 1532 CE LYS 1240 −40.698 −19.81 −50.23 53.54 C ATOM 1533 NZ LYS 1240 −41.324 −20.804 −51.138 53.01 N ATOM 1534 C LYS 1240 −37.69 −19.72 −45.646 42.44 C ATOM 1535 O LYS 1240 −37.456 −18.534 −45.622 43.49 O ATOM 1536 N THR 1241 −38.354 −20.336 −44.673 40.41 N ATOM 1537 CA THR 1241 −38.785 −19.59 −43.49 38.28 C ATOM 1538 CB THR 1241 −39.811 −20.311 −42.655 37.86 C ATOM 1539 OG1 THR 1241 −39.215 −21.421 −41.969 35.48 O ATOM 1540 CG2 THR 1241 −40.791 −20.851 −43.504 37.56 C ATOM 1541 C THR 1241 −37.666 −19.407 −42.501 37.63 C ATOM 1542 O THR 1241 −37.766 −18.558 −41.64 38.27 O ATOM 1543 N GLY 1242 −36.621 −20.22 −42.576 36.14 N ATOM 1544 CA GLY 1242 −35.569 −20.096 −41.584 33.51 C ATOM 1545 C GLY 1242 −35.945 −20.657 −40.222 32.78 C ATOM 1546 O GLY 1242 −35.296 −20.446 −39.216 32.4 O ATOM 1547 N ALA 1243 −36.965 −21.453 −40.154 30.86 N ATOM 1548 CA ALA 1243 −37.285 −21.872 −38.837 30.24 C ATOM 1549 CB ALA 1243 −38.591 −22.411 −38.953 31.17 C ATOM 1550 C ALA 1243 −36.196 −22.869 −38.28 29.29 C ATOM 1551 O ALA 1243 −35.507 −23.504 −39.074 28.68 O ATOM 1552 N LYS 1244 −35.951 −22.972 −36.968 27.71 N ATOM 1553 CA LYS 1244 −34.908 −23.918 −36.53 27.48 C ATOM 1554 CB LYS 1244 −33.923 −23.33 −35.522 28.19 C ATOM 1555 CG LYS 1244 −33.554 −21.899 −35.836 29.18 C ATOM 1556 CD LYS 1244 −32.685 −21.772 −37.068 30.21 C ATOM 1557 CE LYS 1244 −32.757 −20.362 −37.658 34.05 C ATOM 1558 NZ LYS 1244 −33.43 −19.381 −36.754 35.34 N ATOM 1559 C LYS 1244 −35.595 −25.092 −35.941 27.46 C ATOM 1560 O LYS 1244 −36.579 −24.986 −35.212 27.05 O ATOM 1561 N LEU 1245 −35.016 −26.227 −36.213 26.57 N ATOM 1562 CA LEU 1245 −35.698 −27.39 −35.828 25.63 C ATOM 1563 CB LEU 1245 −36.319 −27.817 −37.122 26.81 C ATOM 1564 CG LEU 1245 −37.185 −26.893 −37.928 27.54 C ATOM 1565 CD1 LEU 1245 −36.824 −27.236 −39.225 29.71 C ATOM 1566 CD2 LEU 1245 −38.559 −27.221 −37.86 29.25 C ATOM 1567 C LEU 1245 −34.862 −28.475 −35.12 23.78 C ATOM 1568 O LEU 1245 −33.954 −29.072 −35.711 24.46 O ATOM 1569 N PRO 1246 −35.134 −28.688 −33.814 21.49 N ATOM 1570 CD PRO 1246 −36.076 −27.899 −32.992 22.41 C ATOM 1571 CA PRO 1246 −34.45 −29.686 −32.982 20.52 C ATOM 1572 CB PRO 1246 −34.893 −29.326 −31.563 20.74 C ATOM 1573 CG PRO 1246 −36.27 −28.784 −31.769 22.45 C ATOM 1574 C PRO 1246 −34.929 −31.054 −33.419 18.08 C ATOM 1575 O PRO 1246 −35.579 −31.778 −32.663 17.77 O ATOM 1576 N VAL 1247 −34.609 −31.386 −34.664 17.04 N ATOM 1577 CA VAL 1247 −35.005 −32.65 −35.261 16.91 C ATOM 1578 CB VAL 1247 −34.141 −33.039 −36.451 18.82 C ATOM 1579 CG1 VAL 1247 −34.435 −32.219 −37.548 17.47 C ATOM 1580 CG2 VAL 1247 −32.717 −32.843 −36.16 22.1 C ATOM 1581 C VAL 1247 −34.917 −33.816 −34.315 16.17 C ATOM 1582 O VAL 1247 −35.866 −34.571 −34.161 15.61 O ATOM 1583 N LYS 1248 −33.768 −33.966 −33.677 15.85 N ATOM 1584 CA LYS 1248 −33.576 −35.092 −32.784 14.63 C ATOM 1585 CB LYS 1248 −32.092 −35.337 −32.625 17.18 C ATOM 1586 CG LYS 1248 −31.533 −35.883 −33.913 19.71 C ATOM 1587 CD LYS 1248 −30.083 −36.145 −33.764 22.1 C ATOM 1588 CE LYS 1248 −29.479 −36.741 −34.994 23.2 C ATOM 1589 NZ LYS 1248 −28.029 −36.572 −34.748 29.5 N ATOM 1590 C LYS 1248 −34.291 −35.113 −31.44 15.45 C ATOM 1591 O LYS 1248 −34.255 −36.141 −30.745 13.52 O ATOM 1592 N TRP 1249 −34.935 −33.999 −31.079 12.34 N ATOM 1593 CA TRP 1249 −35.734 −33.909 −29.855 12.07 C ATOM 1594 CB TRP 1249 −35.377 −32.678 −29.002 11.94 C ATOM 1595 CG TRP 1249 −34.121 −32.803 −28.185 11.75 C ATOM 1596 CD2 TRP 1249 −32.786 −32.749 −28.683 9.74 C ATOM 1597 CE2 TRP 1249 −31.921 −32.988 −27.594 11.73 C ATOM 1598 CE3 TRP 1249 −32.235 −32.534 −29.955 11.43 C ATOM 1599 CD1 TRP 1249 −34.021 −33.056 −26.836 10.88 C ATOM 1600 NE1 TRP 1249 −32.699 −33.171 −26.48 10.21 N ATOM 1601 CZ2 TRP 1249 −30.528 −33.017 −27.737 12.35 C ATOM 1602 CZ3 TRP 1249 −30.85 −32.564 −30.102 9.5 C ATOM 1603 CH2 TRP 1249 −30.013 −32.804 −28.995 11.36 C ATOM 1604 C TRP 1249 −37.187 −33.763 −30.288 13.69 C ATOM 1605 O TRP 1249 −38.075 −33.743 −29.447 14.98 O ATOM 1606 N MET 1250 −37.435 −33.665 −31.595 13.34 N ATOM 1607 CA MET 1250 −38.799 −33.485 −32.102 13.11 C ATOM 1608 CB MET 1250 −38.806 −32.79 −33.475 11.56 C ATOM 1609 CG MET 1250 −38.605 −31.283 −33.468 15.9 C ATOM 1610 SD MET 1250 −38.179 −30.668 −35.141 17.57 S ATOM 1611 CE MET 1250 −39.682 −31.196 −36.142 17.78 C ATOM 1612 C MET 1250 −39.579 −34.772 −32.239 12.68 C ATOM 1613 O MET 1250 −39.028 −35.823 −32.568 13.57 O ATOM 1614 N ALA 1251 −40.884 −34.68 −32.026 12.09 N ATOM 1615 CA ALA 1251 −41.718 −35.859 −32.137 13.59 C ATOM 1616 CB ALA 1251 −42.981 −35.663 −31.356 13.36 C ATOM 1617 C ALA 1251 −42.044 −36.246 −33.58 16.39 C ATOM 1618 O ALA 1251 −42.113 −35.397 −34.48 14.98 O ATOM 1619 N LEU 1252 −42.254 −37.548 −33.773 17.37 N ATOM 1620 CA LEU 1252 −42.573 −38.11 −35.074 17.41 C ATOM 1621 CB LEU 1252 −43.224 −39.505 −34.909 17.7 C ATOM 1622 CG LEU 1252 −43.415 −40.392 −36.149 15.74 C ATOM 1623 CD1 LEU 1252 −42.258 −40.179 −37.122 14.12 C ATOM 1624 CD2 LEU 1252 −43.491 −41.858 −35.733 16.89 C ATOM 1625 C LEU 1252 −43.49 −37.2 −35.88 17.33 C ATOM 1626 O LEU 1252 −43.167 −36.85 −37.008 16.45 O ATOM 1627 N GLU 1253 −44.609 −36.78 −35.293 18.42 N ATOM 1628 CA GLU 1253 −45.558 −35.955 −36.034 20.38 C ATOM 1629 CB GLU 1253 −46.936 −35.976 −35.347 22.08 C ATOM 1630 CG GLU 1253 −47.116 −35.11 −34.102 23.88 C ATOM 1631 CD GLU 1253 −46.628 −35.757 −32.814 27.39 C ATOM 1632 OE1 GLU 1253 −46.309 −36.965 −32.809 28.41 O ATOM 1633 OE2 GLU 1253 −46.575 −35.044 −31.791 29.51 O ATOM 1634 C GLU 1253 −45.127 −34.518 −36.358 21.17 C ATOM 1635 O GLU 1253 −45.629 −33.92 −37.32 20.27 O ATOM 1636 N SER 1254 −44.198 −33.972 −35.574 19.04 N ATOM 1637 CA SER 1254 −43.695 −32.62 −35.817 20.94 C ATOM 1638 CB SER 1254 −42.98 −32.078 −34.573 17.59 C ATOM 1639 OG SER 1254 −43.826 −32.137 −33.439 17.95 O ATOM 1640 C SER 1254 −42.705 −32.72 −36.971 20.79 C ATOM 1641 O SER 1254 −42.545 −31.793 −37.757 21.89 O ATOM 1642 N LEU 1255 −42.033 −33.858 −37.066 21.85 N ATOM 1643 CA LEU 1255 −41.078 −34.054 −38.149 23.75 C ATOM 1644 CB LEU 1255 −40.31 −35.356 −37.971 22.37 C ATOM 1645 CG LEU 1255 −39.313 −35.423 −36.82 21.95 C ATOM 1646 CD1 LEU 1255 −38.573 −36.757 −36.904 22.01 C ATOM 1647 CD2 LEU 1255 −38.337 −34.255 −36.903 20.85 C ATOM 1648 C LEU 1255 −41.833 −34.1 −39.466 25.17 C ATOM 1649 O LEU 1255 −41.315 −33.701 −40.51 25.31 O ATOM 1650 N GLN 1256 −43.06 −34.601 −39.397 26.07 N ATOM 1651 CA GLN 1256 −43.92 −34.717 −40.555 27.58 C ATOM 1652 CB GLN 1256 −44.909 −35.877 −40.345 27.79 C ATOM 1653 CG GLN 1256 −44.289 −37.284 −40.403 30.43 C ATOM 1654 CD GLN 1256 −45.281 −38.364 −39.99 33.67 C ATOM 1655 OE1 GLN 1256 −45.421 −39.39 −40.654 35.61 O ATOM 1656 NE2 GLN 1256 −45.972 −38.132 −38.88 34.01 N ATOM 1657 C GLN 1256 −44.657 −33.395 −40.834 27.62 C ATOM 1658 O GLN 1256 −44.562 −32.87 −41.937 29.77 O ATOM 1659 N THR 1257 −45.358 −32.837 −39.845 27.72 N ATOM 1660 CA THR 1257 −46.1 −31.578 −40.036 27.3 C ATOM 1661 CB THR 1257 −47.357 −31.499 −39.114 26.41 C ATOM 1662 OG1 THR 1257 −46.963 −31.701 −37.75 26.82 O ATOM 1663 CG2 THR 1257 −48.414 −32.514 −39.521 25.55 C ATOM 1664 C THR 1257 −45.381 −30.216 −39.847 27.61 C ATOM 1665 O THR 1257 −45.77 −29.234 −40.466 27.07 O ATOM 1666 N GLN 1258 −44.355 −30.167 −39 28.64 N ATOM 1667 CA GLN 1258 −43.603 −28.941 −38.626 29.71 C ATOM 1668 CB GLN 1258 −43.165 −28.034 −39.826 30.88 C ATOM 1669 CG GLN 1258 −41.693 −27.435 −39.662 34.29 C ATOM 1670 CD GLN 1258 −41.388 −26.084 −40.38 35.42 C ATOM 1671 OE1 GLN 1258 −41.11 −25.07 −39.724 37.02 O ATOM 1672 NE2 GLN 1258 −41.413 −26.085 −41.712 35.8 N ATOM 1673 C GLN 1258 −44.51 −28.144 −37.677 28.89 C ATOM 1674 O GLN 1258 −44.27 −26.967 −37.414 29.27 O ATOM 1675 N LYS 1259 −45.553 −28.805 −37.168 28.49 N ATOM 1676 CA LYS 1259 −46.496 −28.196 −36.221 28.29 C ATOM 1677 CB LYS 1259 −47.963 −28.4 −36.727 28.96 C ATOM 1678 CG LYS 1259 −48.203 −28.05 −38.258 31 C ATOM 1679 CD LYS 1259 −49.257 −26.931 −38.585 32.59 C ATOM 1680 CE LYS 1259 −50.617 −27.453 −39.126 33.31 C ATOM 1681 NZ LYS 1259 −51.559 −27.921 −38.065 36.13 N ATOM 1682 C LYS 1259 −46.215 −28.858 −34.828 26.44 C ATOM 1683 O LYS 1259 −46.07 −30.079 −34.741 26.47 O ATOM 1684 N PHE 1260 −46.088 −28.045 −33.767 25.21 N ATOM 1685 CA PHE 1260 −45.781 −28.507 −32.388 24.1 C ATOM 1686 CB PHE 1260 −44.607 −27.704 −31.792 23.41 C ATOM 1687 CG PHE 1260 −43.308 −27.831 −32.547 25.91 C ATOM 1688 CD1 PHE 1260 −43.116 −27.165 −33.758 27.41 C ATOM 1689 CD2 PHE 1260 −42.265 −28.605 −32.036 27.23 C ATOM 1690 CE1 PHE 1260 −41.902 −27.269 −34.449 26.54 C ATOM 1691 CE2 PHE 1260 −41.049 −28.714 −32.721 27.29 C ATOM 1692 CZ PHE 1260 −40.871 −28.045 −33.927 26.57 C ATOM 1693 C PHE 1260 −46.937 −28.426 −31.368 22.89 C ATOM 1694 O PHE 1260 −47.811 −27.568 −31.478 22.69 O ATOM 1695 N THR 1261 −46.919 −29.294 −30.354 21.28 N ATOM 1696 CA THR 1261 −47.968 −29.297 −29.325 21.08 C ATOM 1697 CB THR 1261 −49.112 −30.269 −29.709 21.01 C ATOM 1698 OG1 THR 1261 −48.76 −31.601 −29.316 21.47 O ATOM 1699 CG2 THR 1261 −49.338 −30.256 −31.227 21.65 C ATOM 1700 C THR 1261 −47.389 −29.708 −27.957 20.48 C ATOM 1701 O THR 1261 −46.199 −30.017 −27.857 17.26 O ATOM 1702 N THR 1262 −48.204 −29.707 −26.902 20.44 N ATOM 1703 CA THR 1262 −47.678 −30.099 −25.592 19.37 C ATOM 1704 CB THR 1262 −48.688 −29.783 −24.445 18.52 C ATOM 1705 OG1 THR 1262 −48.865 −28.364 −24.364 22.58 O ATOM 1706 CG2 THR 1262 −48.153 −30.24 −23.091 17.69 C ATOM 1707 C THR 1262 −47.24 −31.571 −25.597 17.47 C ATOM 1708 O THR 1262 −46.342 −31.946 −24.851 18.79 O ATOM 1709 N LYS 1263 −47.834 −32.392 −26.47 19.24 N ATOM 1710 CA LYS 1263 −47.446 −33.809 −26.592 18.23 C ATOM 1711 CB LYS 1263 −48.518 −34.637 −27.304 16.94 C ATOM 1712 CG LYS 1263 −49.874 −34.561 −26.667 19.51 C ATOM 1713 CD LYS 1263 −49.769 −34.879 −25.188 23.06 C ATOM 1714 CE LYS 1263 −51.108 −35.281 −24.587 22.44 C ATOM 1715 NZ LYS 1263 −50.893 −35.855 −23.223 24.48 N ATOM 1716 C LYS 1263 −46.14 −33.96 −27.367 17.16 C ATOM 1717 O LYS 1263 −45.417 −34.929 −27.17 18.48 O ATOM 1718 N SER 1264 −45.838 −33.039 −28.271 16.85 N ATOM 1719 CA SER 1264 −44.569 −33.169 −28.971 17.48 C ATOM 1720 CB SER 1264 −44.558 −32.344 −30.259 17.7 C ATOM 1721 OG SER 1264 −44.882 −30.994 −30.001 18.83 O ATOM 1722 C SER 1264 −43.496 −32.696 −27.968 17.45 C ATOM 1723 O SER 1264 −42.329 −33.071 −28.077 17.64 O ATOM 1724 N ASP 1265 −43.928 −31.889 −26.988 14.49 N ATOM 1725 CA ASP 1265 −43.089 −31.368 −25.888 14.77 C ATOM 1726 CB ASP 1265 −43.831 −30.278 −25.093 16.44 C ATOM 1727 CG ASP 1265 −43.451 −28.85 −25.492 17.46 C ATOM 1728 OD1 ASP 1265 −42.537 −28.634 −26.318 17.88 O ATOM 1729 OD2 ASP 1265 −44.092 −27.925 −24.949 18.78 O ATOM 1730 C ASP 1265 −42.801 −32.522 −24.911 12.9 C ATOM 1731 O ASP 1265 −41.713 −32.626 −24.349 13.55 O ATOM 1732 N VAL 1266 −43.818 −33.35 −24.681 11.93 N ATOM 1733 CA VAL 1266 −43.692 −34.515 −23.816 13.82 C ATOM 1734 CB VAL 1266 −45.068 −35.254 −23.686 14.9 C ATOM 1735 CG1 VAL 1266 −44.876 −36.7 −23.246 10.56 C ATOM 1736 CG2 VAL 1266 −45.966 −34.507 −22.686 12.47 C ATOM 1737 C VAL 1266 −42.65 −35.397 −24.52 14.39 C ATOM 1738 O VAL 1266 −41.717 −35.906 −23.892 14.25 O ATOM 1739 N TRP 1267 −42.788 −35.55 −25.835 14.88 N ATOM 1740 CA TRP 1267 −41.816 −36.352 −26.578 15.69 C ATOM 1741 CB TRP 1267 −42.062 −36.328 −28.087 16.09 C ATOM 1742 CG TRP 1267 −41.057 −37.186 −28.883 17.05 C ATOM 1743 CD2 TRP 1267 −41.368 −38.331 −29.682 17.26 C ATOM 1744 CE2 TRP 1267 −40.157 −38.801 −30.243 17.57 C ATOM 1745 CE3 TRP 1267 −42.556 −39.004 −29.981 17.76 C ATOM 1746 CD1 TRP 1267 −39.694 −37.01 −28.986 17.69 C ATOM 1747 NE1 TRP 1267 −39.151 −37.98 −29.804 18.08 N ATOM 1748 CZ2 TRP 1267 −40.107 −39.916 −31.087 19.89 C ATOM 1749 CZ3 TRP 1267 −42.505 −40.112 −30.822 18.54 C ATOM 1750 CH2 TRP 1267 −41.289 −40.556 −31.362 19.43 C ATOM 1751 C TRP 1267 −40.411 −35.813 −26.332 16.62 C ATOM 1752 O TRP 1267 −39.511 −36.586 −26.023 17.18 O ATOM 1753 N SER 1268 −40.217 −34.501 −26.488 14.99 N ATOM 1754 CA SER 1268 −38.891 −33.91 −26.286 14.28 C ATOM 1755 CB SER 1268 −38.876 −32.398 −26.566 14.67 C ATOM 1756 OG SER 1268 −39.424 −32.051 −27.825 19.01 O ATOM 1757 C SER 1268 −38.408 −34.098 −24.858 12.79 C ATOM 1758 O SER 1268 −37.216 −34.252 −24.62 12.21 O ATOM 1759 N PHE 1269 −39.327 −34.039 −23.9 10.34 N ATOM 1760 CA PHE 1269 −38.932 −34.194 −22.512 12.36 C ATOM 1761 CB PHE 1269 −40.12 −33.897 −21.59 12.12 C ATOM 1762 CG PHE 1269 −39.85 −34.2 −20.149 15.09 C ATOM 1763 CD1 PHE 1269 −39.046 −33.365 −19.372 14.94 C ATOM 1764 CD2 PHE 1269 −40.355 −35.363 −19.582 14.21 C ATOM 1765 CE1 PHE 1269 −38.751 −33.695 −18.053 15.06 C ATOM 1766 CE2 PHE 1269 −40.063 −35.699 −18.267 15.58 C ATOM 1767 CZ PHE 1269 −39.26 −34.863 −17.503 14.09 C ATOM 1768 C PHE 1269 −38.371 −35.603 −22.286 11.45 C ATOM 1769 O PHE 1269 −37.429 −35.791 −21.522 14.03 O ATOM 1770 N GLY 1270 −38.945 −36.591 −22.965 12.93 N ATOM 1771 CA GLY 1270 −38.442 −37.947 −22.849 13.38 C ATOM 1772 C GLY 1270 −37.016 −38.029 −23.388 12.82 C ATOM 1773 O GLY 1270 −36.209 −38.804 −22.873 13.02 O ATOM 1774 N VAL 1271 −36.702 −37.248 −24.428 12.51 N ATOM 1775 CA VAL 1271 −35.34 −37.23 −24.987 12.39 C ATOM 1776 CB VAL 1271 −35.256 −36.469 −26.371 12.83 C ATOM 1777 CG1 VAL 1271 −33.818 −36.39 −26.846 14.09 C ATOM 1778 CG2 VAL 1271 −36.044 −37.203 −27.429 12.97 C ATOM 1779 C VAL 1271 −34.414 −36.555 −23.96 11.86 C ATOM 1780 O VAL 1271 −33.262 −36.961 −23.81 13.66 O ATOM 1781 N LEU 1272 −34.927 −35.537 −23.254 12.4 N ATOM 1782 CA LEU 1272 −34.163 −34.832 −22.21 11.28 C ATOM 1783 CB LEU 1272 −34.961 −33.628 −21.648 12.83 C ATOM 1784 CG LEU 1272 −34.465 −32.674 −20.527 12.7 C ATOM 1785 CD1 LEU 1272 −35.271 −31.379 −20.589 11.58 C ATOM 1786 CD2 LEU 1272 −34.622 −33.302 −19.134 16.29 C ATOM 1787 C LEU 1272 −33.857 −35.824 −21.083 10.67 C ATOM 1788 O LEU 1272 −32.73 −35.884 −20.59 9.63 O ATOM 1789 N LEU 1273 −34.853 −36.612 −20.682 10.3 N ATOM 1790 CA LEU 1273 −34.622 −37.59 −19.62 12.31 C ATOM 1791 CB LEU 1273 −35.879 −38.415 −19.343 13.07 C ATOM 1792 CG LEU 1273 −37.038 −37.707 −18.634 15.53 C ATOM 1793 CD1 LEU 1273 −38.259 −38.639 −18.597 13.92 C ATOM 1794 CD2 LEU 1273 −36.605 −37.302 −17.236 12.41 C ATOM 1795 C LEU 1273 −33.494 −38.518 −20.061 11.72 C ATOM 1796 O LEU 1273 −32.638 −38.887 −19.265 10.87 O ATOM 1797 N TRP 1274 −33.508 −38.888 −21.34 10.2 N ATOM 1798 CA TRP 1274 −32.487 −39.765 −21.891 11.44 C ATOM 1799 CB TRP 1274 −32.866 −40.2 −23.321 10.95 C ATOM 1800 CG TRP 1274 −31.903 −41.19 −23.98 10.98 C ATOM 1801 CD2 TRP 1274 −30.712 −40.861 −24.698 9.72 C ATOM 1802 CE2 TRP 1274 −30.124 −42.072 −25.12 11.07 C ATOM 1803 CE3 TRP 1274 −30.083 −39.652 −25.024 13.5 C ATOM 1804 CD1 TRP 1274 −31.989 −42.562 −23.993 10.52 C ATOM 1805 NE1 TRP 1274 −30.921 −43.096 −24.679 9.57 N ATOM 1806 CZ2 TRP 1274 −28.93 −42.109 −25.858 13.29 C ATOM 1807 CZ3 TRP 1274 −28.897 −39.688 −25.756 13.28 C ATOM 1808 CH2 TRP 1274 −28.335 −40.91 −26.166 12.43 C ATOM 1809 C TRP 1274 −31.104 −39.087 −21.867 11.05 C ATOM 1810 O TRP 1274 −30.12 −39.746 −21.551 10.69 O ATOM 1811 N GLU 1275 −31.015 −37.79 −22.184 11.93 N ATOM 1812 CA GLU 1275 −29.706 −37.111 −22.147 12.13 C ATOM 1813 CB GLU 1275 −29.778 −35.657 −22.624 14.74 C ATOM 1814 CG GLU 1275 −30.309 −35.362 −24.01 18.02 C ATOM 1815 CD GLU 1275 −30.436 −33.856 −24.191 20.57 C ATOM 1816 OE1 GLU 1275 −31.573 −33.324 −24.15 19.95 O ATOM 1817 OE2 GLU 1275 −29.385 −33.197 −24.333 21.55 O ATOM 1818 C GLU 1275 −29.203 −37.059 −20.694 12.79 C ATOM 1819 O GLU 1275 −27.999 −37.121 −20.435 9.21 O ATOM 1820 N LEU 1276 −30.139 −36.898 −19.759 11.64 N ATOM 1821 CA LEU 1276 −29.83 −36.83 −18.333 13.52 C ATOM 1822 CB LEU 1276 −31.128 −36.608 −17.524 13.33 C ATOM 1823 CG LEU 1276 −31.604 −35.226 −17.028 12.41 C ATOM 1824 CD1 LEU 1276 −31.498 −34.247 −18.143 17.11 C ATOM 1825 CD2 LEU 1276 −33.046 −35.271 −16.511 11.26 C ATOM 1826 C LEU 1276 −29.15 −38.125 −17.882 15.4 C ATOM 1827 O LEU 1276 −28.046 −38.11 −17.327 16.84 O ATOM 1828 N MET 1277 −29.804 −39.249 −18.154 14.23 N ATOM 1829 CA MET 1277 −29.288 −40.553 −17.76 16.99 C ATOM 1830 CB MET 1277 −30.375 −41.605 −17.97 17.95 C ATOM 1831 CG MET 1277 −31.64 −41.311 −17.168 21.05 C ATOM 1832 SD MET 1277 −31.277 −41.118 −15.408 28.97 S ATOM 1833 CE MET 1277 −30.177 −42.52 −15.198 24.12 C ATOM 1834 C MET 1277 −27.986 −40.976 −18.442 16.88 C ATOM 1835 O MET 1277 −27.249 −41.794 −17.902 17.63 O ATOM 1836 N THR 1278 −27.703 −40.425 −19.62 16.09 N ATOM 1837 CA THR 1278 −26.466 −40.753 −20.339 16.44 C ATOM 1838 CB THR 1278 −26.677 −40.824 −21.869 15.75 C ATOM 1839 OG1 THR 1278 −27.275 −39.605 −22.322 14.11 O ATOM 1840 CG2 THR 1278 −27.55 −42.021 −22.261 16.13 C ATOM 1841 C THR 1278 −25.412 −39.675 −20.096 16.13 C ATOM 1842 O THR 1278 −24.332 −39.707 −20.682 16.66 O ATOM 1843 N ARG 1279 −25.745 −38.744 −19.212 16.79 N ATOM 1844 CA ARG 1279 −24.908 −37.593 −18.881 17.42 C ATOM 1845 CB ARG 1279 −23.641 −37.996 −18.127 17.17 C ATOM 1846 CG ARG 1279 −23.982 −38.325 −16.685 19.24 C ATOM 1847 CD ARG 1279 −22.78 −38.507 −15.793 20.29 C ATOM 1848 NE ARG 1279 −22.028 −37.264 −15.776 22.44 N ATOM 1849 CZ ARG 1279 −20.833 −37.071 −15.228 24.32 C ATOM 1850 NH1 ARG 1279 −20.181 −38.022 −14.565 25.1 N ATOM 1851 NH2 ARG 1279 −20.267 −35.895 −15.386 23.97 N ATOM 1852 C ARG 1279 −24.534 −36.77 −20.082 17.7 C ATOM 1853 O ARG 1279 −23.371 −36.456 −20.262 21.43 O ATOM 1854 N GLY 1280 −25.503 −36.432 −20.924 15.97 N ATOM 1855 CA GLY 1280 −25.186 −35.597 −22.068 16.82 C ATOM 1856 C GLY 1280 −24.787 −36.224 −23.392 17.54 C ATOM 1857 O GLY 1280 −24.189 −35.542 −24.221 16.85 O ATOM 1858 N ALA 1281 −25.111 −37.498 −23.6 17.75 N ATOM 1859 CA ALA 1281 −24.802 −38.185 −24.853 17.82 C ATOM 1860 CB ALA 1281 −25.111 −39.671 −24.708 16.36 C ATOM 1861 C ALA 1281 −25.662 −37.587 −25.972 18.54 C ATOM 1862 O ALA 1281 −26.8 −37.201 −25.727 18.61 O ATOM 1863 N PRO 1282 −25.133 −37.482 −27.207 18.63 N ATOM 1864 CD PRO 1282 −23.748 −37.732 −27.652 19.37 C ATOM 1865 CA PRO 1282 −25.969 −36.916 −28.279 19.93 C ATOM 1866 CB PRO 1282 −24.942 −36.503 −29.346 20.38 C ATOM 1867 CG PRO 1282 −23.812 −37.491 −29.157 19.28 C ATOM 1868 C PRO 1282 −26.983 −37.973 −28.768 20.28 C ATOM 1869 O PRO 1282 −26.594 −39.101 −29.08 20.76 O ATOM 1870 N PRO 1283 −28.29 −37.634 −28.852 20.54 N ATOM 1871 CD PRO 1283 −28.977 −36.338 −28.822 20.35 C ATOM 1872 CA PRO 1283 −29.214 −38.685 −29.314 21.42 C ATOM 1873 CB PRO 1283 −30.604 −38.102 −29.052 20.81 C ATOM 1874 CG PRO 1283 −30.371 −36.751 −28.434 21.83 C ATOM 1875 C PRO 1283 −29.054 −39.061 −30.783 21.78 C ATOM 1876 O PRO 1283 −28.764 −38.205 −31.615 22.56 O ATOM 1877 N TYR 1284 −29.274 −40.337 −31.092 20.5 N ATOM 1878 CA TYR 1284 −29.159 −40.848 −32.46 21.94 C ATOM 1879 CB TYR 1284 −30.292 −40.303 −33.317 22.25 C ATOM 1880 CG TYR 1284 −31.641 −40.352 −32.651 21.17 C ATOM 1881 CD1 TYR 1284 −32.432 −41.504 −32.706 20.04 C ATOM 1882 CE1 TYR 1284 −33.676 −41.545 −32.084 18.05 C ATOM 1883 CD2 TYR 1284 −32.122 −39.247 −31.955 19.85 C ATOM 1884 CE2 TYR 1284 −33.348 −39.277 −31.331 19.2 C ATOM 1885 CZ TYR 1284 −34.125 −40.42 −31.396 18.12 C ATOM 1886 OH TYR 1284 −35.343 −40.403 −30.772 15.51 O ATOM 1887 C TYR 1284 −27.85 −40.349 −33.034 22.78 C ATOM 1888 O TYR 1284 −27.828 −39.743 −34.1 20.74 O ATOM 1889 N PRO 1285 −26.729 −40.632 −32.372 24.32 N ATOM 1890 CD PRO 1285 −26.367 −41.515 −31.248 25.4 C ATOM 1891 CA PRO 1285 −25.535 −40.079 −33.002 26.46 C ATOM 1892 CB PRO 1285 −24.43 −40.483 −32.031 25.47 C ATOM 1893 CG PRO 1285 −24.901 −41.795 −31.53 25.65 C ATOM 1894 C PRO 1285 −25.149 −40.395 −34.446 28.83 C ATOM 1895 O PRO 1285 −24.72 −39.505 −35.186 28.91 O ATOM 1896 N ASP 1286 −25.312 −41.639 −34.859 30.51 N ATOM 1897 CA ASP 1286 −24.845 −42.035 −36.171 34.63 C ATOM 1898 CB ASP 1286 −24.278 −43.468 −35.991 37.19 C ATOM 1899 CG ASP 1286 −22.867 −43.46 −35.32 40.75 C ATOM 1900 OD1 ASP 1286 −22.625 −44.11 −34.265 42.38 O ATOM 1901 OD2 ASP 1286 −21.982 −42.776 −35.881 42.78 O ATOM 1902 C ASP 1286 −25.778 −41.846 −37.407 35.2 C ATOM 1903 O ASP 1286 −25.432 −42.243 −38.535 35.64 O ATOM 1904 N VAL 1287 −26.884 −41.115 −37.173 33.72 N ATOM 1905 CA VAL 1287 −27.987 −40.815 −38.126 33.27 C ATOM 1906 CB VAL 1287 −29.318 −41.221 −37.487 32.97 C ATOM 1907 CG1 VAL 1287 −29.1 −42.389 −36.558 32.75 C ATOM 1908 CG2 VAL 1287 −29.893 −40.035 −36.693 34.84 C ATOM 1909 C VAL 1287 −28.233 −39.357 −38.616 32.3 C ATOM 1910 O VAL 1287 −28.04 −38.4 −37.861 31.13 O ATOM 1911 N ASN 1288 −28.724 −39.201 −39.852 30 N ATOM 1912 CA ASN 1288 −29.047 −37.87 −40.387 27.35 C ATOM 1913 CB ASN 1288 −28.569 −37.722 −41.843 25.1 C ATOM 1914 CG ASN 1288 −29.298 −38.651 −42.807 23.58 C ATOM 1915 OD1 ASN 1288 −30.486 −38.905 −42.657 20.67 O ATOM 1916 ND2 ASN 1288 −28.586 −39.14 −43.814 21.64 N ATOM 1917 C ASN 1288 −30.575 −37.662 −40.279 26.78 C ATOM 1918 O ASN 1288 −31.322 −38.629 −40.141 25.63 O ATOM 1919 N THR 1289 −31.033 −36.412 −40.355 27.2 N ATOM 1920 CA THR 1289 −32.457 −36.08 −40.193 28.7 C ATOM 1921 CB THR 1289 −32.638 −34.569 −40.092 29.7 C ATOM 1922 OG1 THR 1289 −32.974 −34.004 −41.359 32.14 O ATOM 1923 CG2 THR 1289 −31.363 −33.978 −39.679 30.98 C ATOM 1924 C THR 1289 −33.422 −36.64 −41.205 28.93 C ATOM 1925 O THR 1289 −34.637 −36.448 −41.092 29.84 O ATOM 1926 N PHE 1290 −32.885 −37.331 −42.202 28.3 N ATOM 1927 CA PHE 1290 −33.758 −37.948 −43.159 28.01 C ATOM 1928 CB PHE 1290 −33.15 −38.156 −44.519 28.4 C ATOM 1929 CG PHE 1290 −34.013 −39.008 −45.375 30.93 C ATOM 1930 CD1 PHE 1290 −35.181 −38.489 −45.906 30.67 C ATOM 1931 CD2 PHE 1290 −33.737 −40.355 −45.547 29.81 C ATOM 1932 CE1 PHE 1290 −36.058 −39.292 −46.589 32.06 C ATOM 1933 CE2 PHE 1290 −34.615 −41.167 −46.231 32.26 C ATOM 1934 CZ PHE 1290 −35.777 −40.635 −46.752 31.34 C ATOM 1935 C PHE 1290 −34.152 −39.321 −42.675 27.78 C ATOM 1936 O PHE 1290 −35.296 −39.718 −42.827 27.15 O ATOM 1937 N ASP 1291 −33.237 −40.09 −42.117 26.53 N ATOM 1938 CA ASP 1291 −33.727 −41.38 −41.705 28.3 C ATOM 1939 CB ASP 1291 −32.878 −42.484 −42.312 31.72 C ATOM 1940 CG ASP 1291 −31.43 −42.208 −42.173 34.91 C ATOM 1941 OD1 ASP 1291 −31.077 −41.644 −41.112 36.01 O ATOM 1942 OD2 ASP 1291 −30.662 −42.549 −43.101 32.69 O ATOM 1943 C ASP 1291 −33.923 −41.575 −40.212 26.5 C ATOM 1944 O ASP 1291 −34.187 −42.688 −39.761 25.11 O ATOM 1945 N ILE 1292 −33.793 −40.505 −39.436 24.99 N ATOM 1946 CA ILE 1292 −34.075 −40.621 −38.016 24.84 C ATOM 1947 CB ILE 1292 −33.607 −39.358 −37.223 25.08 C ATOM 1948 CG2 ILE 1292 −34.193 −38.124 −37.85 24.46 C ATOM 1949 CG1 ILE 1292 −34.071 −39.404 −35.759 23.22 C ATOM 1950 CD ILE 1292 −34.253 −40.785 −35.155 25.97 C ATOM 1951 C ILE 1292 −35.61 −40.707 −38.075 24.13 C ATOM 1952 O ILE 1292 −36.254 −41.303 −37.217 23.5 O ATOM 1953 N THR 1293 −36.179 −40.143 −39.14 23.68 N ATOM 1954 CA THR 1293 −37.624 −40.139 −39.33 24.12 C ATOM 1955 CB THR 1293 −38.036 −39.061 −40.377 26.66 C ATOM 1956 OG1 THR 1293 −37.503 −37.787 −39.975 28.33 O ATOM 1957 CG2 THR 1293 −39.558 −38.934 −40.463 27.13 C ATOM 1958 C THR 1293 −38.115 −41.527 −39.741 24.12 C ATOM 1959 O THR 1293 −39.176 −41.98 −39.316 23.92 O ATOM 1960 N VAL 1294 −37.323 −42.201 −40.559 22.73 N ATOM 1961 CA VAL 1294 −37.638 −43.542 −40.998 22.69 C ATOM 1962 CB VAL 1294 −36.657 −43.948 −42.108 23.12 C ATOM 1963 CG1 VAL 1294 −36.576 −45.413 −42.18 23.01 C ATOM 1964 CG2 VAL 1294 −37.084 −43.339 −43.438 23.05 C ATOM 1965 C VAL 1294 −37.51 −44.466 −39.76 22.25 C ATOM 1966 O VAL 1294 −38.398 −45.284 −39.49 22.56 O ATOM 1967 N TYR 1295 −36.405 −44.297 −39.017 20.41 N ATOM 1968 CA TYR 1295 −36.074 −45.036 −37.775 19.13 C ATOM 1969 CB TYR 1295 −34.786 −44.436 −37.133 20.43 C ATOM 1970 CG TYR 1295 −34.263 −45.004 −35.773 22.2 C ATOM 1971 CD1 TYR 1295 −33.174 −45.889 −35.729 22.09 C ATOM 1972 CE1 TYR 1295 −32.652 −46.373 −34.502 22.58 C ATOM 1973 CD2 TYR 1295 −34.823 −44.609 −34.54 21.45 C ATOM 1974 CE2 TYR 1295 −34.299 −45.093 −33.299 22.41 C ATOM 1975 CZ TYR 1295 −33.216 −45.979 −33.302 22.9 C ATOM 1976 OH TYR 1295 −32.719 −46.521 −32.132 23.86 O ATOM 1977 C TYR 1295 −37.238 −44.967 −36.781 17.02 C ATOM 1978 O TYR 1295 −37.635 −45.987 −36.217 17.06 O ATOM 1979 N LEU 1296 −37.768 −43.764 −36.557 15.78 N ATOM 1980 CA LEU 1296 −38.892 −43.564 −35.636 15.62 C ATOM 1981 CB LEU 1296 −39.19 −42.069 −35.44 13.27 C ATOM 1982 CG LEU 1296 −38.167 −41.253 −34.648 14.85 C ATOM 1983 CD1 LEU 1296 −38.665 −39.812 −34.44 13.49 C ATOM 1984 CD2 LEU 1296 −37.931 −41.928 −33.301 12.69 C ATOM 1985 C LEU 1296 −40.107 −44.233 −36.242 17.24 C ATOM 1986 O LEU 1296 −40.917 −44.859 −35.547 17.7 O ATOM 1987 N LEU 1297 −40.224 −44.085 −37.555 18.13 N ATOM 1988 CA LEU 1297 −41.313 −44.68 −38.292 20.85 C ATOM 1989 CB LEU 1297 −41.21 −44.288 −39.778 22.8 C ATOM 1990 CG LEU 1297 −42.437 −43.505 −40.283 24.14 C ATOM 1991 CD1 LEU 1297 −43.187 −42.928 −39.098 26.68 C ATOM 1992 CD2 LEU 1297 −42.036 −42.403 −41.242 24.5 C ATOM 1993 C LEU 1297 −41.316 −46.203 −38.086 21.11 C ATOM 1994 O LEU 1297 −42.353 −46.759 −37.735 21.79 O ATOM 1995 N GLN 1298 −40.167 −46.864 −38.265 21.59 N ATOM 1996 CA GLN 1298 −40.059 −48.32 −38.058 21.53 C ATOM 1997 CB GLN 1298 −38.663 −48.825 −38.468 22.02 C ATOM 1998 CG GLN 1298 −38.339 −48.635 −39.955 22.67 C ATOM 1999 CD GLN 1298 −36.856 −48.747 −40.277 25.11 C ATOM 2000 OE1 GLN 1298 −36.02 −48.914 −39.385 25.42 O ATOM 2001 NE2 GLN 1298 −36.522 −48.646 −41.566 27.23 N ATOM 2002 C GLN 1298 −40.305 −48.629 −36.58 21.21 C ATOM 2003 O GLN 1298 −40.241 −49.785 −36.143 23.95 O ATOM 2004 N GLY 1299 −40.571 −47.578 −35.81 19.63 N ATOM 2005 CA GLY 1299 −40.842 −47.739 −34.395 16.55 C ATOM 2006 C GLY 1299 −39.635 −47.944 −33.491 16.17 C ATOM 2007 O GLY 1299 −39.782 −48.481 −32.394 15.64 O ATOM 2008 N ARG 1300 −38.453 −47.536 −33.944 15.6 N ATOM 2009 CA ARG 1300 −37.23 −47.663 −33.15 14.57 C ATOM 2010 CB ARG 1300 −35.987 −47.624 −34.061 13.21 C ATOM 2011 CG ARG 1300 −35.606 −48.953 −34.696 12.55 C ATOM 2012 CD ARG 1300 −34.87 −48.794 −36.041 12.57 C ATOM 2013 NE ARG 1300 −35.26 −49.892 −36.918 14.36 N ATOM 2014 CZ ARG 1300 −34.748 −51.118 −36.859 15.98 C ATOM 2015 NH1 ARG 1300 −33.792 −51.41 −35.981 17.16 N ATOM 2016 NH2 ARG 1300 −35.251 −52.073 −37.624 12.34 N ATOM 2017 C ARG 1300 −37.171 −46.474 −32.196 14.89 C ATOM 2018 O ARG 1300 −37.633 −45.389 −32.536 14.23 O ATOM 2019 N ARG 1301 −36.615 −46.663 −31.006 14.09 N ATOM 2020 CA ARG 1301 −36.504 −45.548 −30.085 14.82 C ATOM 2021 CB ARG 1301 −37.522 −45.684 −28.96 15.03 C ATOM 2022 CG ARG 1301 −38.961 −45.614 −29.449 16.03 C ATOM 2023 CD ARG 1301 −39.267 −44.225 −30.023 16.85 C ATOM 2024 NE ARG 1301 −40.663 −44.068 −30.429 17.41 N ATOM 2025 CZ ARG 1301 −41.145 −44.345 −31.635 17.22 C ATOM 2026 NH1 ARG 1301 −40.354 −44.8 −32.598 15.84 N ATOM 2027 NH2 ARG 1301 −42.435 −44.167 −31.876 21.38 N ATOM 2028 C ARG 1301 −35.097 −45.495 −29.524 15.64 C ATOM 2029 O ARG 1301 −34.282 −46.375 −29.805 15.79 O ATOM 2030 N LEU 1302 −34.804 −44.455 −28.757 12.85 N ATOM 2031 CA LEU 1302 −33.493 −44.32 −28.141 15.61 C ATOM 2032 CB LEU 1302 −33.38 −42.956 −27.437 15.94 C ATOM 2033 CG LEU 1302 −33.299 −41.659 −28.26 12.87 C ATOM 2034 CD1 LEU 1302 −33.581 −40.444 −27.379 14 C ATOM 2035 CD2 LEU 1302 −31.927 −41.543 −28.882 15.39 C ATOM 2036 C LEU 1302 −33.409 −45.472 −27.131 16.47 C ATOM 2037 O LEU 1302 −34.375 −45.735 −26.408 16.43 O ATOM 2038 N LEU 1303 −32.276 −46.168 −27.086 16.41 N ATOM 2039 CA LEU 1303 −32.143 −47.309 −26.187 18.6 C ATOM 2040 CB LEU 1303 −31.037 −48.239 −26.727 19.3 C ATOM 2041 CG LEU 1303 −31.469 −48.766 −28.121 22.94 C ATOM 2042 CD1 LEU 1303 −30.288 −49.341 −28.91 22.68 C ATOM 2043 CD2 LEU 1303 −32.563 −49.818 −27.95 19.49 C ATOM 2044 C LEU 1303 −31.953 −46.931 −24.703 18.49 C ATOM 2045 O LEU 1303 −31.622 −45.788 −24.38 17.75 O ATOM 2046 N GLN 1304 −32.218 −47.876 −23.804 16.43 N ATOM 2047 CA GLN 1304 −32.094 −47.608 −22.376 17.47 C ATOM 2048 CB GLN 1304 −32.686 −48.76 −21.556 16.36 C ATOM 2049 CG GLN 1304 −32.738 −48.413 −20.069 20 C ATOM 2050 CD GLN 1304 −33.444 −49.453 −19.219 19.17 C ATOM 2051 OE1 GLN 1304 −33.769 −49.195 −18.06 23.21 O ATOM 2052 NE2 GLN 1304 −33.674 −50.632 −19.78 20.05 N ATOM 2053 C GLN 1304 −30.64 −47.385 −21.956 17.45 C ATOM 2054 O GLN 1304 −29.788 −48.223 −22.207 18.13 O ATOM 2055 N PRO 1305 −30.335 −46.245 −21.318 17.11 N ATOM 2056 CD PRO 1305 −31.109 −44.993 −21.246 17.67 C ATOM 2057 CA PRO 1305 −28.943 −46.017 −20.906 18.76 C ATOM 2058 CB PRO 1305 −28.948 −44.557 −20.464 17.33 C ATOM 2059 CG PRO 1305 −30.016 −43.951 −21.316 20.16 C ATOM 2060 C PRO 1305 −28.493 −46.925 −19.762 19.88 C ATOM 2061 O PRO 1305 −29.317 −47.39 −18.987 17.37 O ATOM 2062 N GLU 1306 −27.188 −47.169 −19.668 23.66 N ATOM 2063 CA GLU 1306 −26.634 −47.978 −18.586 28.01 C ATOM 2064 CB GLU 1306 −25.106 −48.108 −18.749 29.98 C ATOM 2065 CG GLU 1306 −24.401 −48.854 −17.605 34.82 C ATOM 2066 CD GLU 1306 −22.979 −49.299 −17.948 36.96 C ATOM 2067 OE1 GLU 1306 −22.688 −50.51 −17.812 38.32 O ATOM 2068 OE2 GLU 1306 −22.154 −48.447 −18.346 37.25 O ATOM 2069 C GLU 1306 −26.971 −47.185 −17.315 29.78 C ATOM 2070 O GLU 1306 −26.886 −45.961 −17.323 32.55 O ATOM 2071 N TYR 1307 −27.381 −47.857 −16.243 30.97 N ATOM 2072 CA TYR 1307 −27.716 −47.179 −14.971 30.01 C ATOM 2073 CB TYR 1307 −26.643 −46.14 −14.567 31.8 C ATOM 2074 CG TYR 1307 −25.18 −46.581 −14.564 33.12 C ATOM 2075 CD1 TYR 1307 −24.21 −45.814 −15.214 33.66 C ATOM 2076 CE1 TYR 1307 −22.866 −46.218 −15.262 34.33 C ATOM 2077 CD2 TYR 1307 −24.771 −47.765 −13.946 33.66 C ATOM 2078 CE2 TYR 1307 −23.429 −48.179 −13.986 34.02 C ATOM 2079 CZ TYR 1307 −22.484 −47.406 −14.654 35.13 C ATOM 2080 OH TYR 1307 −21.185 −47.867 −14.776 34.55 O ATOM 2081 C TYR 1307 −29.076 −46.452 −14.918 28.96 C ATOM 2082 O TYR 1307 −29.432 −45.895 −13.881 27.44 O ATOM 2083 N CYS 1308 −29.82 −46.405 −16.019 27.77 N ATOM 2084 CA CYS 1308 −31.126 −45.744 −15.988 25.91 C ATOM 2085 CB CYS 1308 −31.56 −45.362 −17.409 25.12 C ATOM 2086 SG CYS 1308 −33.321 −44.917 −17.596 24 S ATOM 2087 C CYS 1308 −32.055 −46.804 −15.414 25.06 C ATOM 2088 O CYS 1308 −31.968 −47.96 −15.812 23.71 O ATOM 2089 N PRO 1309 −32.952 −46.442 −14.477 24.93 N ATOM 2090 CD PRO 1309 −33.195 −45.18 −13.761 25.38 C ATOM 2091 CA PRO 1309 −33.817 −47.503 −13.954 23.94 C ATOM 2092 CB PRO 1309 −34.344 −46.928 −12.635 25.11 C ATOM 2093 CG PRO 1309 −33.496 −45.682 −12.386 26.23 C ATOM 2094 C PRO 1309 −34.961 −47.871 −14.891 23.92 C ATOM 2095 O PRO 1309 −35.53 −47.017 −15.567 24.15 O ATOM 2096 N ASP 1310 −35.291 −49.155 −14.902 22.35 N ATOM 2097 CA ASP 1310 −36.365 −49.695 −15.72 22.11 C ATOM 2098 CB ASP 1310 −36.698 −51.109 −15.24 25.28 C ATOM 2099 CG ASP 1310 −35.592 −52.102 −15.553 27.4 C ATOM 2100 OD1 ASP 1310 −34.505 −51.668 −15.992 28.7 O ATOM 2101 OD2 ASP 1310 −35.806 −53.317 −15.357 28.25 O ATOM 2102 C ASP 1310 −37.632 −48.84 −15.739 20.06 C ATOM 2103 O ASP 1310 −38.174 −48.544 −16.8 18.79 O ATOM 2104 N PRO 1311 −38.142 −48.451 −14.562 19.74 N ATOM 2105 CD PRO 1311 −37.807 −48.805 −13.174 18.73 C ATOM 2106 CA PRO 1311 −39.351 −47.629 −14.602 18.41 C ATOM 2107 CB PRO 1311 −39.741 −47.517 −13.128 17.9 C ATOM 2108 CG PRO 1311 −38.441 −47.673 −12.42 18.48 C ATOM 2109 C PRO 1311 −39.143 −46.265 −15.261 16.43 C ATOM 2110 O PRO 1311 −40.071 −45.71 −15.842 14.98 O ATOM 2111 N LEU 1312 −37.935 −45.716 −15.191 14.58 N ATOM 2112 CA LEU 1312 −37.73 −44.428 −15.824 13.14 C ATOM 2113 CB LEU 1312 −36.413 −43.778 −15.407 13.51 C ATOM 2114 CG LEU 1312 −36.337 −42.287 −15.754 11.5 C ATOM 2115 CD1 LEU 1312 −37.488 −41.494 −15.114 13.78 C ATOM 2116 CD2 LEU 1312 −35.01 −41.77 −15.254 13.81 C ATOM 2117 C LEU 1312 −37.74 −44.62 −17.316 13.15 C ATOM 2118 O LEU 1312 −38.261 −43.785 −18.051 11.21 O ATOM 2119 N TYR 1313 −37.162 −45.722 −17.777 14.68 N ATOM 2120 CA TYR 1313 −37.159 −45.972 −19.208 14.13 C ATOM 2121 CB TYR 1313 −36.325 −47.198 −19.573 15.38 C ATOM 2122 CG TYR 1313 −36.105 −47.341 −21.075 15.55 C ATOM 2123 CD1 TYR 1313 −35.638 −46.265 −21.841 17.29 C ATOM 2124 CE1 TYR 1313 −35.407 −46.393 −23.216 16.45 C ATOM 2125 CD2 TYR 1313 −36.338 −48.552 −21.721 14.65 C ATOM 2126 CE2 TYR 1313 −36.111 −48.694 −23.088 17.53 C ATOM 2127 CZ TYR 1313 −35.644 −47.608 −23.832 16.76 C ATOM 2128 OH TYR 1313 −35.418 −47.749 −25.18 17.88 O ATOM 2129 C TYR 1313 −38.591 −46.156 −19.687 14.31 C ATOM 2130 O TYR 1313 −38.936 −45.653 −20.751 14.78 O ATOM 2131 N GLU 1314 −39.421 −46.863 −18.913 15.45 N ATOM 2132 CA GLU 1314 −40.832 −47.065 −19.287 19.13 C ATOM 2133 CB GLU 1314 −41.636 −47.741 −18.155 21.74 C ATOM 2134 CG GLU 1314 −42.374 −49.072 −18.498 30.22 C ATOM 2135 CD GLU 1314 −43.763 −48.91 −19.15 35.3 C ATOM 2136 OE1 GLU 1314 −43.865 −48.965 −20.4 38.8 O ATOM 2137 OE2 GLU 1314 −44.76 −48.739 −18.411 38.41 O ATOM 2138 C GLU 1314 −41.414 −45.674 −19.54 17.22 C ATOM 2139 O GLU 1314 −42.127 −45.461 −20.52 17.96 O ATOM 2140 N VAL 1315 −41.111 −44.742 −18.635 15.21 N ATOM 2141 CA VAL 1315 −41.578 −43.359 −18.745 13.46 C ATOM 2142 CB VAL 1315 −40.957 −42.44 −17.656 14.51 C ATOM 2143 CG1 VAL 1315 −41.324 −40.976 −17.926 13.39 C ATOM 2144 CG2 VAL 1315 −41.438 −42.857 −16.274 12.16 C ATOM 2145 C VAL 1315 −41.138 −42.819 −20.092 14.52 C ATOM 2146 O VAL 1315 −41.951 −42.333 −20.887 10.37 O ATOM 2147 N MET 1316 −39.834 −42.921 −20.333 14.75 N ATOM 2148 CA MET 1316 −39.252 −42.436 −21.57 17.75 C ATOM 2149 CB MET 1316 −37.763 −42.803 −21.663 20.34 C ATOM 2150 CG MET 1316 −36.819 −42.276 −20.559 19.79 C ATOM 2151 SD MET 1316 −35.114 −42.567 −21.17 21.6 S ATOM 2152 CE MET 1316 −34.136 −42.746 −19.658 23.16 C ATOM 2153 C MET 1316 −39.987 −43.02 −22.77 18.51 C ATOM 2154 O MET 1316 −40.42 −42.274 −23.651 19.69 O ATOM 2155 N LEU 1317 −40.142 −44.345 −22.815 17.78 N ATOM 2156 CA LEU 1317 −40.829 −44.956 −23.945 17.94 C ATOM 2157 CB LEU 1317 −40.888 −46.473 −23.795 17.54 C ATOM 2158 CG LEU 1317 −39.502 −47.099 −23.888 18.27 C ATOM 2159 CD1 LEU 1317 −39.58 −48.542 −23.434 19.06 C ATOM 2160 CD2 LEU 1317 −38.961 −46.976 −25.315 18.11 C ATOM 2161 C LEU 1317 −42.226 −44.399 −24.094 19.36 C ATOM 2162 O LEU 1317 −42.676 −44.125 −25.206 19.4 O ATOM 2163 N LYS 1318 −42.917 −44.22 −22.976 18.7 N ATOM 2164 CA LYS 1318 −44.268 −43.685 −23.029 20.42 C ATOM 2165 CB LYS 1318 −44.879 −43.663 −21.625 21.8 C ATOM 2166 CG LYS 1318 −45.9 −44.794 −21.389 26.1 C ATOM 2167 CD LYS 1318 −46.046 −45.138 −19.905 26.99 C ATOM 2168 CE LYS 1318 −47.177 −46.138 −19.636 30.43 C ATOM 2169 NZ LYS 1318 −48.042 −45.717 −18.483 32.95 N ATOM 2170 C LYS 1318 −44.284 −42.288 −23.657 20.66 C ATOM 2171 O LYS 1318 −45.195 −41.942 −24.417 21.24 O ATOM 2172 N CYS 1319 −43.268 −41.49 −23.353 18.11 N ATOM 2173 CA CYS 1319 −43.188 −40.152 −23.918 16.47 C ATOM 2174 CB CYS 1319 −41.964 −39.408 −23.386 15.37 C ATOM 2175 SG CYS 1319 −42.114 −38.898 −21.672 12.54 S ATOM 2176 C CYS 1319 −43.074 −40.248 −25.422 18 C ATOM 2177 O CYS 1319 −43.512 −39.35 −26.139 15.45 O ATOM 2178 N TRP 1320 −42.489 −41.338 −25.911 18.62 N ATOM 2179 CA TRP 1320 −42.323 −41.463 −27.348 19.38 C ATOM 2180 CB TRP 1320 −40.935 −41.999 −27.689 17.86 C ATOM 2181 CG TRP 1320 −39.797 −41.256 −27.06 16.31 C ATOM 2182 CD2 TRP 1320 −38.626 −41.84 −26.488 16.1 C ATOM 2183 CE2 TRP 1320 −37.816 −40.782 −26.019 15.34 C ATOM 2184 CE3 TRP 1320 −38.182 −43.162 −26.327 14.66 C ATOM 2185 CD1 TRP 1320 −39.659 −39.902 −26.926 13.95 C ATOM 2186 NE1 TRP 1320 −38.471 −39.609 −26.299 14.46 N ATOM 2187 CZ2 TRP 1320 −36.587 −41.004 −25.396 16.01 C ATOM 2188 CZ3 TRP 1320 −36.967 −43.385 −25.714 13.39 C ATOM 2189 CH2 TRP 1320 −36.179 −42.311 −25.252 14.92 C ATOM 2190 C TRP 1320 −43.361 −42.293 −28.093 21.79 C ATOM 2191 O TRP 1320 −43.098 −42.741 −29.207 21.52 O ATOM 2192 N HIS 1321 −44.534 −42.501 −27.508 21.94 N ATOM 2193 CA HIS 1321 −45.57 −43.266 −28.198 22.23 C ATOM 2194 CB HIS 1321 −46.832 −43.3 −27.343 23.03 C ATOM 2195 CG HIS 1321 −47.853 −44.286 −27.811 24.08 C ATOM 2196 CD2 HIS 1321 −48.285 −45.442 −27.259 24.79 C ATOM 2197 ND1 HIS 1321 −48.555 −44.135 −28.986 25.03 N ATOM 2198 CE1 HIS 1321 −49.378 −45.157 −29.137 24.27 C ATOM 2199 NE2 HIS 1321 −49.233 −45.964 −28.103 26.25 N ATOM 2200 C HIS 1321 −45.87 −42.58 −29.538 22 C ATOM 2201 O HIS 1321 −45.966 −41.351 −29.602 19.88 O ATOM 2202 N PRO 1322 −46.016 −43.358 −30.63 21.9 N ATOM 2203 CD PRO 1322 −45.801 −44.808 −30.784 22.07 C ATOM 2204 CA PRO 1322 −46.3 −42.721 −31.926 22.49 C ATOM 2205 CB PRO 1322 −46.304 −43.905 −32.904 20.78 C ATOM 2206 CG PRO 1322 −46.567 −45.108 −32.037 20.57 C ATOM 2207 C PRO 1322 −47.579 −41.918 −31.963 23.4 C ATOM 2208 O PRO 1322 −47.778 −41.017 −32.789 22.39 O ATOM 2209 N LYS 1323 −48.405 −42.188 −30.98 24.92 N ATOM 2210 CA LYS 1323 −49.697 −41.569 −30.918 25.96 C ATOM 2211 CB LYS 1323 −50.574 −42.739 −30.573 28.31 C ATOM 2212 CG LYS 1323 −51.827 −42.832 −31.242 30.59 C ATOM 2213 CD LYS 1323 −51.727 −43.515 −32.566 32.35 C ATOM 2214 CE LYS 1323 −52.933 −44.485 −32.88 34.1 C ATOM 2215 NZ LYS 1323 −52.65 −45.312 −34.124 34.56 N ATOM 2216 C LYS 1323 −49.758 −40.444 −29.909 26.46 C ATOM 2217 O LYS 1323 −50.007 −40.667 −28.758 25.08 O ATOM 2218 N ALA 1324 −49.634 −39.187 −30.295 26.66 N ATOM 2219 CA ALA 1324 −49.62 −38.088 −29.304 27.92 C ATOM 2220 CB ALA 1324 −49.95 −36.785 −29.987 25.6 C ATOM 2221 C ALA 1324 −50.446 −38.245 −28.055 28.17 C ATOM 2222 O ALA 1324 −50.036 −37.905 −26.931 27.6 O ATOM 2223 N GLU 1325 −51.686 −38.71 −28.301 29.23 N ATOM 2224 CA GLU 1325 −52.504 −38.853 −27.162 29.6 C ATOM 2225 CB GLU 1325 −53.952 −38.627 −27.542 31.15 C ATOM 2226 CG GLU 1325 −54.643 −39.516 −28.214 34.14 C ATOM 2227 CD GLU 1325 −54.089 −39.858 −29.564 37.11 C ATOM 2228 OE1 GLU 1325 −53.647 −39.081 −30.455 37.72 O ATOM 2229 OE2 GLU 1325 −54.189 −41.064 −29.758 38.5 O ATOM 2230 C GLU 1325 −52.362 −40.01 −26.213 28.69 C ATOM 2231 O GLU 1325 −52.972 −39.871 −25.213 28.59 O ATOM 2232 N MET 1326 −51.468 −40.993 −26.388 28.82 N ATOM 2233 CA MET 1326 −51.245 −42.047 −25.396 29.26 C ATOM 2234 CB MET 1326 −50.955 −43.396 −26.095 32.22 C ATOM 2235 CG MET 1326 −52.066 −44.064 −26.984 38.68 C ATOM 2236 SD MET 1326 −53.888 −43.928 −26.71 45.38 S ATOM 2237 CE MET 1326 −54.572 −45.537 −27.685 43.56 C ATOM 2238 C MET 1326 −50.005 −41.619 −24.608 28 C ATOM 2239 O MET 1326 −49.463 −42.377 −23.802 28.97 O ATOM 2240 N ARG 1327 −49.56 −40.394 −24.86 25.84 N ATOM 2241 CA ARG 1327 −48.4 −39.855 −24.179 23.95 C ATOM 2242 CB ARG 1327 −47.76 −38.751 −25.018 22.84 C ATOM 2243 CG ARG 1327 −47.176 −39.309 −26.287 22.89 C ATOM 2244 CD ARG 1327 −46.312 −38.32 −27.012 21.37 C ATOM 2245 NE ARG 1327 −46.201 −38.754 −28.39 19.79 N ATOM 2246 CZ ARG 1327 −46.045 −37.934 −29.417 19 C ATOM 2247 NH1 ARG 1327 −45.971 −36.629 −29.214 17.36 N ATOM 2248 NH2 ARG 1327 −45.993 −38.425 −30.647 17.81 N ATOM 2249 C ARG 1327 −48.784 −39.293 −22.835 22.04 C ATOM 2250 O ARG 1327 −49.876 −38.761 −22.666 21.25 O ATOM 2251 N PRO 1328 −47.899 −39.441 −21.854 21.95 N ATOM 2252 CD PRO 1328 −46.644 −40.199 −21.724 22.8 C ATOM 2253 CA PRO 1328 −48.266 −38.874 −20.605 21.34 C ATOM 2254 CB PRO 1328 −47.249 −39.534 −19.606 21.48 C ATOM 2255 CG PRO 1328 −46.083 −39.682 −20.415 23.57 C ATOM 2256 C PRO 1328 −48.31 −37.37 −20.508 20.97 C ATOM 2257 O PRO 1328 −47.608 −36.705 −21.26 21.32 O ATOM 2258 N SER 1329 −49.152 −36.854 −19.61 20.09 N ATOM 2259 CA SER 1329 −49.285 −35.419 −19.361 19.4 C ATOM 2260 CB SER 1329 −50.552 −35.135 −18.548 19.48 C ATOM 2261 OG SER 1329 −50.436 −35.663 −17.232 21.56 O ATOM 2262 C SER 1329 −48.066 −35.09 −18.518 19.12 C ATOM 2263 O SER 1329 −47.354 −35.999 −18.093 18.4 O ATOM 2264 N PHE 1330 −47.8 −33.816 −18.259 19.43 N ATOM 2265 CA PHE 1330 −46.627 −33.511 −17.447 19.52 C ATOM 2266 CB PHE 1330 −46.166 −32.066 −17.716 17.45 C ATOM 2267 CG PHE 1330 −45.31 −31.927 −18.971 16.35 C ATOM 2268 CD1 PHE 1330 −44.005 −32.427 −18.999 16.41 C ATOM 2269 CD2 PHE 1330 −45.809 −31.319 −20.124 16.49 C ATOM 2270 CE1 PHE 1330 −43.212 −32.32 −20.152 15.43 C ATOM 2271 CE2 PHE 1330 −45.025 −31.21 −21.28 15.83 C ATOM 2272 CZ PHE 1330 −43.724 −31.711 −21.292 16.39 C ATOM 2273 C PHE 1330 −46.951 −33.816 −15.978 18.21 C ATOM 2274 O PHE 1330 −46.066 −34.112 −15.172 17.21 O ATOM 2275 N SER 1331 −48.247 −33.808 −15.67 21.81 N ATOM 2276 CA SER 1331 −48.763 −34.137 −14.341 22.73 C ATOM 2277 CB SER 1331 −50.291 −34.012 −14.318 25.32 C ATOM 2278 OG SER 1331 −50.7 −32.663 −14.454 25.24 O ATOM 2279 C SER 1331 −48.379 −35.581 −14.001 21.79 C ATOM 2280 O SER 1331 −47.698 −35.816 −12.999 21 O ATOM 2281 N GLU 1332 −48.824 −36.533 −14.831 23.52 N ATOM 2282 CA GLU 1332 −48.512 −37.95 −14.628 24.89 C ATOM 2283 CB GLU 1332 −49.171 −38.856 −15.729 29.5 C ATOM 2284 CG GLU 1332 −48.682 −38.665 −17.21 37.98 C ATOM 2285 CD GLU 1332 −49.432 −39.536 −18.28 43.96 C ATOM 2286 OE1 GLU 1332 −50.339 −40.303 −17.982 45.97 O ATOM 2287 OE2 GLU 1332 −49.132 −39.46 −19.444 47.85 O ATOM 2288 C GLU 1332 −46.981 −38.047 −14.635 22.38 C ATOM 2289 O GLU 1332 −46.393 −38.787 −13.855 23.87 O ATOM 2290 N LEU 1333 −46.327 −37.261 −15.481 20.18 N ATOM 2291 CA LEU 1333 −44.875 −37.295 −15.507 18.89 C ATOM 2292 CB LEU 1333 −44.318 −36.39 −16.622 20.31 C ATOM 2293 CG LEU 1333 −43.658 −37.081 −17.836 19.84 C ATOM 2294 CD1 LEU 1333 −44.137 −38.513 −17.983 21.18 C ATOM 2295 CD2 LEU 1333 −43.963 −36.29 −19.091 19.76 C ATOM 2296 C LEU 1333 −44.292 −36.926 −14.138 18.06 C ATOM 2297 O LEU 1333 −43.457 −37.67 −13.629 17.4 O ATOM 2298 N VAL 1334 −44.712 −35.829 −13.5 16.42 N ATOM 2299 CA VAL 1334 −44.101 −35.581 −12.195 14.44 C ATOM 2300 CB VAL 1334 −44.155 −34.045 −11.723 14.47 C ATOM 2301 CG1 VAL 1334 −44.851 −33.176 −12.744 12.5 C ATOM 2302 CG2 VAL 1334 −44.749 −33.899 −10.336 13.35 C ATOM 2303 C VAL 1334 −44.503 −36.562 −11.069 15.52 C ATOM 2304 O VAL 1334 −43.676 −36.818 −10.2 15.12 O ATOM 2305 N SER 1335 −45.698 −37.161 −11.059 15.65 N ATOM 2306 CA SER 1335 −45.927 −38.104 −9.947 17.61 C ATOM 2307 CB SER 1335 −47.396 −38.541 −9.762 19.13 C ATOM 2308 OG SER 1335 −48.28 −37.995 −10.714 21.27 O ATOM 2309 C SER 1335 −45.104 −39.319 −10.16 16.26 C ATOM 2310 O SER 1335 −44.45 −39.844 −9.265 15.18 O ATOM 2311 N ARG 1336 −45.057 −39.739 −11.396 16.43 N ATOM 2312 CA ARG 1336 −44.326 −40.942 −11.638 19.04 C ATOM 2313 CB ARG 1336 −44.461 −41.125 −13.056 23.11 C ATOM 2314 CG ARG 1336 −44.507 −42.397 −13.484 26.63 C ATOM 2315 CD ARG 1336 −45.813 −42.346 −14.321 29.99 C ATOM 2316 NE ARG 1336 −45.664 −41.73 −15.664 32.06 N ATOM 2317 CZ ARG 1336 −45.635 −42.334 −16.856 31.45 C ATOM 2318 NH1 ARG 1336 −45.722 −43.613 −17.103 33.52 N ATOM 2319 NH2 ARG 1336 −45.423 −41.616 −17.91 31.66 N ATOM 2320 C ARG 1336 −42.905 −40.758 −11.309 20.68 C ATOM 2321 O ARG 1336 −42.324 −41.569 −10.577 20.06 O ATOM 2322 N ILE 1337 −42.301 −39.726 −11.874 19.97 N ATOM 2323 CA ILE 1337 −40.913 −39.442 −11.613 19.1 C ATOM 2324 CB ILE 1337 −40.414 −38.268 −12.509 19.3 C ATOM 2325 CG2 ILE 1337 −38.941 −37.989 −12.218 16.69 C ATOM 2326 CG1 ILE 1337 −40.561 −38.655 −13.993 18.86 C ATOM 2327 CD ILE 1337 −40.445 −37.496 −14.979 19.36 C ATOM 2328 C ILE 1337 −40.602 −39.176 −10.112 18.87 C ATOM 2329 O ILE 1337 −39.518 −39.543 −9.663 18.78 O ATOM 2330 N SER 1338 −41.51 −38.572 −9.332 19.34 N ATOM 2331 CA SER 1338 −41.229 −38.346 −7.892 20.11 C ATOM 2332 CB SER 1338 −42.325 −37.541 −7.183 20.76 C ATOM 2333 OG SER 1338 −42.75 −36.416 −7.912 24.23 O ATOM 2334 C SER 1338 −41.226 −39.708 −7.224 18.9 C ATOM 2335 O SER 1338 −40.459 −39.975 −6.294 18.76 O ATOM 2336 N ALA 1339 −42.151 −40.536 −7.701 18.39 N ATOM 2337 CA ALA 1339 −42.345 −41.896 −7.23 18.01 C ATOM 2338 CB ALA 1339 −43.48 −42.548 −8.012 17.08 C ATOM 2339 C ALA 1339 −41.057 −42.677 −7.427 19.89 C ATOM 2340 O ALA 1339 −40.581 −43.341 −6.509 22.03 O ATOM 2341 N ILE 1340 −40.492 −42.583 −8.63 20.82 N ATOM 2342 CA ILE 1340 −39.253 −43.275 −8.976 21.34 C ATOM 2343 CB ILE 1340 −39.016 −43.206 −10.523 22.55 C ATOM 2344 CG2 ILE 1340 −37.663 −43.825 −10.888 23.59 C ATOM 2345 CG1 ILE 1340 −40.11 −43.985 −11.294 25.81 C ATOM 2346 CD ILE 1340 −41.497 −44.205 −10.626 29.71 C ATOM 2347 C ILE 1340 −38.07 −42.658 −8.21 21.59 C ATOM 2348 O ILE 1340 −37.153 −43.365 −7.79 18.89 O ATOM 2349 N PHE 1341 −38.127 −41.339 −8.007 22.51 N ATOM 2350 CA PHE 1341 −37.084 −40.571 −7.312 23.12 C ATOM 2351 CB PHE 1341 −37.366 −39.076 −7.448 21.04 C ATOM 2352 CG PHE 1341 −36.369 −38.216 −6.741 18.35 C ATOM 2353 CD1 PHE 1341 −35.128 −37.965 −7.31 17.9 C ATOM 2354 CD2 PHE 1341 −36.658 −37.671 −5.494 18.97 C ATOM 2355 CE1 PHE 1341 −34.186 −37.181 −6.652 18.18 C ATOM 2356 CE2 PHE 1341 −35.723 −36.886 −4.825 18.68 C ATOM 2357 CZ PHE 1341 −34.479 −36.64 −5.411 17.63 C ATOM 2358 C PHE 1341 −36.941 −40.905 −5.837 25.96 C ATOM 2359 O PHE 1341 −35.867 −41.019 −5.279 24.76 O ATOM 2360 N SER 1342 −38.107 −41.03 −5.204 28.8 N ATOM 2361 CA SER 1342 −38.188 −41.346 −3.8 33.62 C ATOM 2362 CB SER 1342 −39.589 −41.431 −3.385 34.36 C ATOM 2363 OG SER 1342 −39.895 −40.25 −2.726 37.13 O ATOM 2364 C SER 1342 −37.681 −42.675 −3.572 36.29 C ATOM 2365 O SER 1342 −36.913 −42.931 −2.739 36.94 O ATOM 2366 N THR 1343 −38.255 −43.619 −4.223 38.79 N ATOM 2367 CA THR 1343 −38.007 −45.046 −4.101 42.78 C ATOM 2368 CB THR 1343 −38.082 −45.62 −5.347 43.14 C ATOM 2369 OG1 THR 1343 −37.499 −44.974 −6.327 45.03 O ATOM 2370 CG2 THR 1343 −39.089 −46.338 −5.894 42.28 C ATOM 2371 C THR 1343 −36.447 −45.187 −4.538 44.77 C ATOM 2372 O THR 1343 −36.291 −46.076 −5.408 45.85 O ATOM 2373 N PHE 1344 −35.516 −44.538 −3.915 46.03 N ATOM 2374 CA PHE 1344 −34.193 −44.422 −4.598 47.65 C ATOM 2375 CB PHE 1344 −34.478 −43.644 −5.88 48.08 C ATOM 2376 CG PHE 1344 −33.55 −44.017 −6.982 46.41 C ATOM 2377 CD1 PHE 1344 −34.002 −44.165 −8.282 45.61 C ATOM 2378 CD2 PHE 1344 −32.205 −44.245 −6.71 45.61 C ATOM 2379 CE1 PHE 1344 −33.134 −44.529 −9.297 45.07 C ATOM 2380 CE2 PHE 1344 −31.332 −44.609 −7.721 44.04 C ATOM 2381 CZ PHE 1344 −31.798 −44.75 −9.016 44.55 C ATOM 2382 C PHE 1344 −33.357 −43.599 −3.602 49.92 C ATOM 2383 O PHE 1344 −33.488 −42.376 −3.477 51.55 O ATOM 2384 N ILE 1345 −32.396 −44.351 −3.076 51.14 N ATOM 2385 CA ILE 1345 −31.802 −43.901 −1.816 51.51 C ATOM 2386 CB ILE 1345 −30.772 −44.991 −1.309 51.18 C ATOM 2387 CG2 ILE 1345 −29.756 −44.342 −0.398 49.1 C ATOM 2388 CG1 ILE 1345 −31.473 −46.176 −0.598 51.89 C ATOM 2389 CD ILE 1345 −32.276 −45.84 0.682 51.67 C ATOM 2390 C ILE 1345 −31.323 −42.476 −1.708 52.76 C ATOM 2391 O ILE 1345 −30.098 −42.321 −2.071 51.79 O ATOM 2392 N GLY 1346 −32.172 −41.554 −1.404 52.64 N ATOM 2393 CA GLY 1346 −31.848 −40.112 −1.194 53.2 C ATOM 2394 C GLY 1346 −30.478 −40.01 −0.552 53.8 C ATOM 2395 OT1 GLY 1346 −30.041 −41.005 0.076 53.54 O ATOM 2396 OXT GLY 1346 −29.834 −38.946 −0.669 53.44 O TER 2397 GLY 346 HETATM 2398 C18 M97 1 −28.421 −19.33 −23.501 20.4 C HETATM 2399 C17 M97 1 −28.05 −18.355 −24.625 22.33 C HETATM 2400 C16 M97 1 −28.763 −17.001 −24.516 20.81 C HETATM 2401 C15 M97 1 −28.583 −16.465 −23.104 21.33 C HETATM 2402 C23 M97 1 −28.693 −15.112 −22.776 21.71 C HETATM 2403 C22 M97 1 −28.525 −14.706 −21.456 23.83 C HETATM 2404 C21 M97 1 −28.245 −15.591 −20.427 21.68 C HETATM 2405 C20 M97 1 −28.13 −16.961 −20.742 19.42 C HETATM 2406 C19 M97 1 −28.303 −17.326 −22.047 20.56 C HETATM 2407 N3 M97 1 −28.175 −18.712 −22.175 21.67 N HETATM 2408 C3 M97 1 −27.916 −19.167 −20.955 17.66 C HETATM 2409 C2 M97 1 −27.883 −18.147 −20.082 18.09 C HETATM 2410 C6 M97 1 −27.568 −18.343 −18.599 16.61 C HETATM 2411 C8 M97 1 −28.539 −17.7 −17.605 18.67 C HETATM 2412 O2 M97 1 −29.767 −17.736 −17.726 19.12 O HETATM 2413 N2 M97 1 −27.899 −17.101 −16.607 17.51 N HETATM 2414 C7 M97 1 −26.579 −17.132 −16.804 17.32 C HETATM 2415 O1 M97 1 −25.745 −16.754 −15.985 18.84 O HETATM 2416 C1 M97 1 −26.241 −17.726 −18.172 16.61 C HETATM 2417 C4 M97 1 −25.08 −18.719 −18.217 18.4 C HETATM 2418 C10 M97 1 −24.374 −18.961 −19.389 16.93 C HETATM 2419 C11 M97 1 −24.497 −18.49 −20.685 19.11 C HETATM 2420 C12 M97 1 −23.573 −18.885 −21.641 19.55 C HETATM 2421 C13 M97 1 −22.536 −19.749 −21.281 19.99 C HETATM 2422 C14 M97 1 −22.425 −20.218 −19.981 18.84 C HETATM 2423 C9 M97 1 −23.349 −19.826 −19.016 18.71 C HETATM 2424 N1 M97 1 −23.479 −20.067 −17.715 17.96 N HETATM 2425 C5 M97 1 −24.523 −19.402 −17.22 18.43 C HETATM 2426 O HOH 1 −29.733 −45.042 −32.394 23.71 O HETATM 2427 O HOH 11 −41.978 −18.659 −8.604 33.69 O HETATM 2428 O HOH 19 −14.344 −9.842 −22.4 23.99 O HETATM 2429 O HOH 21 −43.049 −29.657 −28.643 33.17 O HETATM 2430 O HOH 22 −27.163 −0.128 −19.346 37.35 O HETATM 2431 O HOH 23 −11.942 −12.723 −13.277 40.63 O HETATM 2432 O HOH 25 −33.037 −32.588 −8.01 24.8 O HETATM 2433 O HOH 26 −25.627 −43.198 −8.776 24.3 O HETATM 2434 O HOH 29 −46.913 −39.523 −36.653 28 O HETATM 2435 O HOH 30 −30.849 −12.281 −30.69 21.24 O HETATM 2436 O HOH 31 −34.444 −22.254 −29.224 14.19 O HETATM 2437 O HOH 33 −50.753 −27.924 −27.093 26.45 O HETATM 2438 O HOH 34 −27.308 −38.76 −4.252 35.8 O HETATM 2439 O HOH 38 −16.629 −37.696 −14.044 24.11 O HETATM 2440 O HOH 43 −37.896 −19.153 −11.112 20.78 O HETATM 2441 O HOH 45 −40.294 3.592 −21.002 46.87 O HETATM 2442 O HOH 47 −19.865 −18.501 −9.486 42.76 O HETATM 2443 O HOH 49 −36.45 −37.969 −30.939 15.37 O HETATM 2444 O HOH 50 −29.817 −27.464 −2.853 38.04 O HETATM 2445 O HOH 51 −35.913 −29.539 −28.732 15.99 O HETATM 2446 O HOH 55 −35.063 −49.437 −29.855 33.2 O HETATM 2447 O HOH 63 −17.108 −3.162 −15.949 31.66 O HETATM 2448 O HOH 65 −36.185 −14.548 −12.6 24.69 O HETATM 2449 O HOH 66 −37.492 −51.897 −39.152 22.65 O HETATM 2450 O HOH 74 −21.385 −26.942 −16.186 40.62 O HETATM 2451 O HOH 77 −32.568 −48.216 −6.703 47.5 O HETATM 2452 O HOH 78 −40.231 −18.222 −13.28 21.62 O HETATM 2453 O HOH 80 −49.359 −48.928 −27.562 28.98 O HETATM 2454 O HOH 81 −50.28 −38.693 −33.409 34.22 O HETATM 2455 O HOH 89 −48.667 −5.949 −17.295 35.77 O HETATM 2456 O HOH 90 −43.326 −45.18 −33.961 31.65 O HETATM 2457 O HOH 93 −29.409 −47.043 −11.708 31.44 O HETATM 2458 O HOH 95 −10.204 −6.223 −17.26 18.06 O HETATM 2459 O HOH 96 −31.221 −3.393 −19.944 22.32 O HETATM 2460 O HOH 98 −36.257 −17.223 −13.142 20.12 O HETATM 2461 O HOH 99 −33.234 −50.471 −24.546 20.45 O HETATM 2462 O HOH 107 −46.234 −2.234 −15.955 20.16 O HETATM 2463 O HOH 113 −27.073 −24.228 −30.542 26.4 O HETATM 2464 O HOH 119 −40.31 −29.4 −26.968 12.91 O HETATM 2465 O HOH 122 −27.616 −41.457 −42.019 25.56 O HETATM 2466 O HOH 123 −37.721 −50.822 −18.769 37.76 O HETATM 2467 O HOH 128 −36.977 −26.973 −6.723 47.18 O HETATM 2468 O HOH 132 −46.704 −25.042 −34.234 25.99 O HETATM 2469 O HOH 135 −27.544 −24.241 −23.965 30.92 O HETATM 2470 O HOH 140 −37.425 3.24 −35.007 18.34 O HETATM 2471 O HOH 143 −20.008 −12.815 −30.386 40.51 O HETATM 2472 O HOH 147 −14.407 −15.827 −13.914 30.48 O HETATM 2473 O HOH 151 −49.199 −31.854 −19.993 33.45 O HETATM 2474 O HOH 152 −33.758 −21.539 −26.003 45.57 O HETATM 2475 O HOH 156 −21.439 −40.205 −36.699 50.64 O HETATM 2476 O HOH 160 −27.226 −43.392 −33.693 25.08 O HETATM 2477 O HOH 164 −25.061 −26.966 −24.102 22.64 O HETATM 2478 O HOH 167 −39.626 −16.67 −10.802 34.02 O HETATM 2479 O HOH 171 −19.142 −1.168 −17.551 32.21 O HETATM 2480 O HOH 172 −30.803 −0.387 −20.702 32.83 O HETATM 2481 O HOH 176 −54.115 −25.794 −25.837 53.46 O HETATM 2482 O HOH 181 −23.869 −36.686 −5.557 40.21 O HETATM 2483 O HOH 184 −29.269 −30.565 −24.802 22.28 O HETATM 2484 O HOH 189 −50.2 −45.277 −19.345 38.58 O HETATM 2485 O HOH 191 −21.65 −29.789 −23.813 31.45 O HETATM 2486 O HOH 192 −23.062 −24.401 −6.237 35.26 O HETATM 2487 O HOH 194 −25.27 1.306 −15.454 29.8 O HETATM 2488 O HOH 195 −28.159 −42.387 −7.202 22.48 O HETATM 2489 O HOH 199 −13.955 −14.842 −16.709 32.78 O HETATM 2490 O HOH 200 −36.82 −41.718 0.531 50.12 O HETATM 2491 O HOH 201 −28.644 −20.12 −36.964 18.87 O HETATM 2492 O HOH 203 −50.477 −32.049 −17.177 24.64 O HETATM 2493 O HOH 216 −39.142 −22.788 −29.507 33.97 O HETATM 2494 O HOH 219 −47.47 −15.035 −20.201 35.71 O HETATM 2495 O HOH 224 −46.506 −27.482 −23.402 21.71 O HETATM 2496 O HOH 234 −41.895 −31.848 −31.831 20.74 O HETATM 2497 O HOH 235 −26.441 −19.233 −9.527 33.45 O HETATM 2498 O HOH 239 −37.357 −36.383 −42.714 31.76 O HETATM 2499 O HOH 240 −31.471 −4.986 0.652 22.91 O HETATM 2500 O HOH 243 −28.65 −42.512 −29.641 22.84 O HETATM 2501 O HOH 244 −36.603 −42.277 −29.106 19.94 O HETATM 2502 O HOH 248 −29.027 −13.664 −10.124 31.23 O HETATM 2503 O HOH 249 −40.094 −50.827 −15.065 43.7 O HETATM 2504 O HOH 251 −23.436 −42.81 −11.982 46.35 O HETATM 2505 O HOH 252 −31.443 −12.916 −9.468 43.08 O HETATM 2506 O HOH 253 −45.124 −10.841 −28.548 57.83 O HETATM 2507 O HOH 256 −47.989 −21.853 −27.175 28.06 O HETATM 2508 O HOH 257 −44.346 −21.809 −29.799 45.06 O HETATM 2509 O HOH 258 −48.882 −41.587 −10.969 52.61 O HETATM 2510 O HOH 259 −29.049 −34.816 −39.703 52.2 O HETATM 2511 O HOH 267 −36.421 1.247 −12.805 36 O HETATM 2512 O HOH 279 −29.355 −45.223 −28.378 33.41 O HETATM 2513 O HOH 282 −42.248 −20.932 −28.066 29.16 O HETATM 2514 O HOH 283 −33.773 −4.7 2.104 49.74 O HETATM 2515 O HOH 285 −21.851 −38.325 −6.435 31.66 O HETATM 2516 O HOH 287 −26.26 −43.568 −28.371 25.76 O HETATM 2517 O HOH 291 −22.18 −11.552 −29.799 43.2 O HETATM 2518 O HOH 293 −48.423 −37.306 −38.97 42.54 O HETATM 2519 O HOH 298 −24.451 −45.031 −29.768 43.48 O HETATM 2520 O HOH 340 −24.526 −9.586 −25.61 15.08 O HETATM 2521 O HOH 342 −27.622 −21.226 −29.674 29.04 O HETATM 2522 O HOH 348 −40.859 −30.744 −29.704 25.01 O HETATM 2523 O HOH 352 −32.508 −49.493 −33.945 34.9 O HETATM 2524 O HOH 356 −18.731 −15.159 −30.315 33.75 O HETATM 2525 O HOH 358 −34.046 −54.592 −37.088 20.7 O HETATM 2526 O HOH 360 −31.208 −32.444 −33.609 20.04 O HETATM 2527 O HOH 363 −30.618 −33.523 −8.002 25.2 O HETATM 2528 O HOH 365 −14.406 −16.156 −24.124 39.38 O HETATM 2529 O HOH 373 −38.591 −25.485 −32.288 30.06 O HETATM 2530 O HOH 377 −48.553 −17.92 −12.222 37.86 O HETATM 2531 O HOH 380 −36.774 −36.981 −33.348 22.77 O HETATM 2532 O HOH 381 −24.808 −41.352 −28.041 28 O HETATM 2533 O HOH 388 −24.856 −17.892 −7.816 27.87 O HETATM 2534 O HOH 389 −26.781 −11.754 −6.859 37.48 O HETATM 2535 O HOH 390 −26.698 −26.085 −28.658 43.43 O HETATM 2536 O HOH 396 −39.993 −0.244 −8.176 44.09 O HETATM 2537 O HOH 399 −22.572 −23.838 −19.334 35.76 O HETATM 2538 O HOH 408 −39.893 −27.132 −7.517 28.65 O HETATM 2539 O HOH 410 −51.294 −26.589 −30.152 36.54 O HETATM 2540 O HOH 416 −27.033 −4.323 −31.352 40.18 O HETATM 2541 O HOH 418 −32.288 −20.615 −47.531 46.09 O HETATM 2542 O HOH 420 −21.59 −20.992 −15.896 47.82 O HETATM 2543 O HOH 421 −33.255 −1.487 −28.193 15.19 O HETATM 2544 O HOH 422 −33.862 −14.639 −36.562 39.85 O HETATM 2545 O HOH 423 −24.055 −22.398 −28.638 38.93 O HETATM 2546 O HOH 424 −23.254 −24.538 −37.285 41.97 O HETATM 2547 O HOH 425 −27.795 −30.29 −26.912 29.38 O HETATM 2548 O HOH 426 −24.824 −29.707 −29.385 39.8 O HETATM 2549 O HOH 427 −42.553 −46.3 −15.041 21.97 O

The electronic representation of the c-Met structure was then displayed on a computer screen for visual inspection and analysis. All important motifs involved in c-Met ligand recognition and binding were identified, including those described above.

A three dimensional graphical representation of the c-Met binding pocket was then generated as part of an electronic representation of the ligand bound binding site. In an embodiment, the electronic representation of the binding pocket contains the coordinates of c-Met residues up to 6 Å from every atom of the ligand. This model contains twenty three amino acid residues (Table 4).

The structure coordinates of amino acid residues that constitute the binding pocket define the chemical environment of the ligand binding site, and thereby are useful in designing compounds that may interact with those residues.

The binding site amino acid residues are key residues for ligand binding. Alternatively, the binding site amino acid residues may be residues that are spatially related in the definition of the three-dimensional shape of the binding pocket. The amino acid residues may be contiguous or non-contiguous in the primary sequence.

The c-Met inhibition model is formed by three-dimensional coordinates of amino acid residues selected from the X-ray crystallographic structure of the complex of c-Met bound to the selective c-Met inhibitor as explained above. This model is mostly hydrophobic in nature. The only exception is c-Met hinge binding motif, which corresponds to the backbone amide of M1160 and the backbone carbonyl of P115.

Computer programs are also employed to estimate the attraction, repulsion, and steric hindrance of the ligand to the kinase inhibition model. Generally the tighter the fit between the inhibitor and c-Met at the molecular level and atomic level (e.g., the lower the steric hindrance, and/or the greater the attractive force), the more potent the potential drug will be because these properties are consistent with a tighter-binding constant.

To increase the likelihood of finding a suitable ligand, a set of seed molecules has been compiled. This set contains fragments that are modified to result in a molecule that tightly binds the model.

Alternatively, a potential ligand is obtained by screening a random chemical library. A ligand selected in this manner is then systematically modified by computer-modeling programs until one or more promising potential ligands are identified. Such analysis has been shown to be effective in the development of HIV protease inhibitors (Lam et al., Science 263:380-384 (1994); Wlodawer et al., Ann. Rev. Biochem. 62:543-585 (1993); Appelt, Perspectives in Drug Discovery and Design 1:23-48 (1993); Erickson, Perspectives in Drug Discovery and Design 1: 109-128 (1993). Such computer modeling allows the selection of a finite number of rational chemical modifications, as opposed to the countless number of essentially random chemical modifications that could be made, any of which any one might lead to a useful drug. Each chemical modification requires additional chemical steps, which while being reasonable for the synthesis of a finite number of compounds, quickly becomes overwhelming if all possible modifications needed to be synthesized. Thus, through the use of the structure coordinates disclosed herein and computer modeling, a large number of these compounds are rapidly screened on the computer monitor screen, and a few likely candidates are determined or identified without the laborious synthesis of untold numbers of compounds.

Once a potential ligand (agonist or antagonist) is identified, it is either selected from commercial libraries of compounds or synthesized de novo. As mentioned above, the de novo synthesis of one or even a relatively small group of specific compounds is reasonable in the art of drug design.

For all of the drug design strategies described herein further refinements to the structure of the drug are generally necessary and are made by the successive iterations of any and/or all of the steps provided by the aforementioned strategies.

Another aspect of the invention involves using the structure coordinates generated from the c-Met/inhibitor complex to generate a three-dimensional shape. This is achieved through the use of commercially available software that is capable of generating three-dimensional graphical representations of molecules or portions thereof from a set of structure coordinates.

The variations in coordinates discussed above may be generated because of mathematical manipulations of the c-Met/inhibitor complex structure coordinates. For example, the structure coordinates set forth in Table 1A or Table 1B could be manipulated by crystallographic permutations of the structure coordinates, fractionalization of the structure coordinates, integer additions or subtractions to sets of the structure coordinates, or combinations thereof.

Alternatively, modifications in the crystal structure due to mutations, additions, substitutions, and/or deletions of amino acids, or other changes in any of the components that make up the crystal also account for variations in structure coordinates. If such variations are within an acceptable standard error, as compared to the original coordinates, the resulting three-dimensional shape is considered to be the same. Thus, for example, a ligand that bound to the binding pocket of the c-Met kinase domain is also expected to bind to another binding pocket whose structure coordinates, when compared to those described, have a root mean square difference of equal to or less than about 1.5 Å, more preferably less than about 1.0 Å, and even more preferably, less than about 0.5 Å, from the backbone atoms.

Various computational analyses can be performed to analyze c-Met or other kinases or the kinase domains thereof. Such analyses may be carried out through the use of known software applications, such as ProMod, SWISS-MODEL (Swiss Institute of Bioinformatics), and the Molecular Similarity application of QUANTA (Accelrys, Inc., San Diego, Calif.). Programs, such as QUANTA permit comparisons between different structures, different conformations of the same structure, and different parts of the same structure. Comparison of structures using such computer software may involve the following steps: 1) loading the structures to be compared; 2) defining the atom equivalencies in the structures; 3) performing a fitting operation; and 4) analyzing the results. Each structure is identified by a name. One structure is identified as the target (i.e., the fixed structure) and all remaining structures are working structures (i.e., moving structures). Since atom equivalency with QUANTA is defined by user input, for the purpose of this invention, applicants define equivalent atoms as protein backbone atoms (N, Cα, C, and O) for all conserved residues between the two structures being compared. Only rigid fitting operations are also considered. When a rigid fitting method is used, the working structure is translated and rotated to obtain an optimum fit with the target structure. The fitting operation uses an algorithm that computes the optimum translation and rotation to be applied to the moving structure, such that the root mean square difference of the fit over the specified pairs of equivalent atoms is an absolute minimum. This number, given in angstroms (Å), is reported by software applications, such as QUANTA.

For the purpose of this invention, any c-Met molecule or molecular complex or kinase domain thereof that has a root mean square deviation of conserved residue backbone atoms (N, Cα, C, O) of less than about 1.5 Å, more preferably less than about 1.0 Å, and even more preferably less than about 0.5 Å, when superimposed on the relevant backbone atoms described by structure coordinates listed in Table 1A or Table 1B are considered equivalent.

The term “root mean square deviation” means the square root of the arithmetic mean of the squares of the deviations from the mean. It is a way to express the deviation or variation from a trend or object. For purposes of this invention, the “root mean square deviation” defines the variation in the backbone of a protein from the backbone of the c-Met or other kinases of the invention or the kinase domain portion thereof, as defined by the structure coordinates described herein.

3. Use of the c-Met Inhibition Model to Derive an Inhibition Model for Another Kinase

The c-Met inhibition model can be modified to construct a model for the inhibition of another kinase. This method is known as homology modeling. The model for the new kinase can be generated by replacing electronic representations of particular residues of the c-Met inhibition model with electronic representations of corresponding residues of the new kinase.

The new kinase is a kinase with a difference of at least one amino acid residue from the wild-type human c-Met. The another kinase can be a mutant c-Met protein, a paralog of c-Met protein, a family member or a related sequence (homologous) of c-Met, a kinase with at least 10% amino acid sequence identity or homology to c-Met, or a kinase with at least 30% nucleotide or amino acid sequence similarity to wild type c-Met.

There are several applications for this methodology.

3.1. Methodology to Derive an Inhibition Model for Another Kinase from the c-Met Inhibition Model

Typically, construction of such an inhibition model involves: performing sequence alignment between the amino acid sequence of other kinase against the amino acid sequence of c-Met, identifying conserved amino acid residues between c-Met and the kinase of interest, generating atomic coordinates of all conserved amino acids in the other kinase from the electronic representation of c-Met residues; generating conformations for the structurally variable residues in the other kinase; replacing the non-conserved residues of c-Met with residues from the other kinase structure; building side chain conformations; and refining and/or evaluating the structure.

This method is known as homology modeling. The method is accomplished using commercially available software. Non-limiting examples of such programs are MOE (CCG, Montreal, Canada), ICM (Molsoft, La Jolla, Calif.), and Insight II/Discover (Accelrys, Inc., San Diego, Calif.).

The success of homology models depends on the sequence alignment. Four motifs were selected to guide such an alignment: P-loop, salt-bridge, DFG-motif and the A-loop.

The geometry of the residues forming the kinase hinge is very important and differs from one kinase to the other. The hinge also assumes different conformations depending on the bound ligand. To optimize the shape and geometry of the model's binding pocket, fragments from known inhibitors were used. Those fragments were modified by attaching atomic groups suitable to complement the pocket.

Once the inhibition model is built, a three dimensional graphical representation of the binding pockets of c-Met paralogs, significant c-Met homologs, and/or other kinases is generated. The new kinase inhibition model is defined as an electronic representation of residues corresponding to the c-Met inhibition model.

The resulting pair-wise comparison of binding pocket residues provides a basis for evaluating similarities and differences in polarity and hydrophobicity, and therefore differences in the chemical environment, of the binding pockets of various kinases by using the inhibition model. This inhibitor model is important for drug design, e.g. designing inhibitors of c-Met paralogs, significant c-Met homologs, and/or other kinases. The kinase, for which an inhibitor is designed using the inhibitor model, can be any known kinase.

3.2. Similarity Assessment Method for Comparing Inhibition Models Derived for a Series of New Kinase Proteins.

To assess the similarity of inhibition models, a weighting system is applied. In one embodiment of the invention, residues are assigned the following weights:

-   -   2 critical for ligand binding residues     -   1 residue side chain lining the inhibition model     -   0.5 backbone atoms part of the inhibition model additions,         deletions and changes in backbone flexibility, lack of residue     -   −1 alignment dramatic changes in size and/or polarity inside the         inhibition model, lack of     -   −2 alignment of critical residues

The following illustrative examples demonstrate that the highest similarity assessment value of 25 is obtained when the system is applied to the c-Met protein. All other proteins are expected to score below the maximum of 25.

TABLE 2 (SEQ ID NOs: 11, 3, 4, 5, 6, 7, 8 and 9, respectively) C-MET AXL FLT-3 cKIT (SEQ ID (SEQ ID (SEQ ID (SEQ ID PROTEIN NO: 11) weight NO: 3) weight NO: 4) weight NO: 5) weight I_1084 2 L_542 1 L_616 1 L_595 1 G_1085 2 G_543 2 G_617 2 G_596 2 F_1089 2 F_547 2 F_621 2 F_600 2 V_1092 2 V_550 2 V_624 2 V_603 2 A_1108 1 A_565 1 A_642 1 A_621 1 V_1109b 0.5 V_566 0.5 V_643 0.5 V_1109 0.5 K_1110b 0.5 K_567 0.5 K_644 0.5 K_623 0.5 L_1140 1 M_598 0.5 V_675 0.5 V_654 0.5 V_1155 1 V_618 1 L_689 0.5 I_669 0.5 L_1157 1 L_620 1 F_691 0.5 T_670 −2 P_1158 1 P_621 1 E_692 −1 E_671 −1 Y_1159b 0.5 F_622 0.5 Y_693 0.5 Y_672 0.5 M_1160 1 M_623 1 C_694 0.5 C_673 0.5 K_1161b 0.5 K_624 0.5 C_695 0.5 C_674 0.5 H_1162b 0.5 H_625 0.5 Y_696 0.5 Y_675 0.5 G_1163 0.5 G_626 0.5 G_697 0.5 G_676 0.5 D_1164 1 D_627 1 D_698 1 D_677 1 M_1211 1 M_679 1 L_818 0.5 L_799 0.5 A_1221 1 A_689 1 C_828 0.5 C_809 0.5 D_1222 1 D_690 1 D_629 1 D_810 1 F_1223 1 F_691 1 F_630 1 F_811 1 A_1226 1 S_694 −1 A_833 1 A_814 1 R_1227 2 K_695 1 R_834 2 R_815 2 Similarity 25 20.5 19 17 assessment value IRK cFMS cABL PIM1 (SEQ ID (SEQ ID (SEQ ID (SEQ ID PROTEIN NO: 6) weight NO: 7) weight NO: 8) weight NO: 9) weight L_1002 1 L_588 1 L_266 1 L_44 1 G_1003 1 G_589 2 G_267 2 G_45 2 F_1007 2 F_593 2 Y_271 1 F_49 2 V_1010 2 V-596 2 V_274 2 V_52 2 A_1028 1 A_614 1 A_287 1 A_65 1 V_1029 0.5 V_615 0.5 V_288 0.5 I_66 0.5 K_1030 0.5 K_616 0.5 K_289 0.5 K_67 0.5 V_1060 0.5 V_647 0.5 V_317 0.5 V_103 1 V_1075 1 V_661 1 I_331 0.5 L_118 1 M_1076 0.5 T_663 −2 T_333 −2 L_120 1 E_1077 −1 E_664 −1 E_334 −1 E_121 −1 L_1078 0.5 Y_665 0.5 F_335 0.5 R_122 0.5 M_1079 1 C_666 0.5 M_336 1 P_123 −1 E_124 −1 A_1080 0.5 C_667 0.5 T_337 0.5 P_125 −1 H_1081 0.5 Y_668 0.5 Y_338 0.5 V_126 0.5 G_1082 0.5 G_669 0.5 G_339 0.5 Q_127 −1 D_1083 1 D_670 1 N_340 −2 D_128 1 M_1139 1 L_785 0.5 L_388 0.5 L_174 0.5 G_1149 −1 G_795 −1 A_398 1 I_185 1 D_1150 1 D_796 1 D_399 1 D_186 1 F_1151 1 F_797 1 F_400 1 F_187 1 T_1154 −1 A_800 1 S_403 −1 A_191 1 R_1155 2 R_801 2 R_404 2 L_192 −2 Similarity 16 15.5 11.5 11.5 assessment value

Residues which constitute a unique hydrophobic interaction critical for binding c-Met to the selective c-Met inhibitor are allocated a maximum weight of 2. Those residues include I1084, G1085, F1089, V1092 and R1227.

Conserved residue substitutions, are assigned half of this maximum value (1) to take into account size changes. Residues such as alanine, valine, leucine and isoleucine are exchanged by conserved substitutions. Similarly, the following residue pairs constitute conservative substitutions: serine and threonine, asparagine and glutamic acid, phenylalanine and tyrosine, and asparagine and glutamine.

When residues contribute only their backbone atoms to the creation of the inhibition model a weight of 0.5 is assigned.

Two penalty levels have been assigned (one severe (−2), one moderate (−1)) to residues which are considered to contribute negatively to the similarity assessment relative to c-Met.

Determination of the similarity assessment provides a critical analysis of the target inhibition model for a kinase relative to the one described in this application for the selective c-Met inhibitor and c-Met.

The results of the similarity assessments indicate the expected selectivity of novel ligands identified with the inhibition model. In one embodiment of the invention, similarity assessment values above 90% of that of the selective c-Met inhibitor and c-Met (25) indicate the lowest level of compound selectivity; similarity assessment values between 90% and 50% are expected at the next level; and similarity assessment values below 50% indicate the highest level of selectivity.

These similarity assessments of various inhibition models are also critical in order to identify regions within the inhibition models that can be employed to ensure adequate complementarity between the inhibition model and ligand to overcome these differences, and therefore, lead to increased likelihood of success in the electronic screening or design process.

For instance, in the design process, the presence of a polar residue in place of a hydrophobic one may significantly alter the inhibitor's chemical environment. Modifications of the inhibitor to include a polar complementary atomic group within the inhibitory model will provide maximum electrostatic interactions with the inhibition model.

4. Use of the Inhibition Model for Ligand Screening (Enrichment), Fitting and Selection

The kinase inhibition model is used for ligand screening (enrichment), fitting, and selection.

The electronic representation of compounds and/or fragments is generated as described above. In one embodiment of the invention, electronic representations of compounds and/or fragments are assembled into electronic databases. In another embodiment of the invention, these databases include chemical entities' coordinates in any SMILES, mol, sdf, or mol2 formats.

Selected chemical entities or fragments may be positioned in a variety of orientations inside the inhibition model. Chemical entities come from different sources including, but not limited to, proprietary compound repositories, commercial data bases, or virtual data bases. Non-limiting exemplary sources of fragments include reagent data bases, de-novo design, etc.

The selected chemical entities or fragments are used to perform a fitting of the electronic representation of compounds and/or fragments and the inhibition model. The fitting is done manually or is computer assisted (docking). In one embodiment, docking programs used in the present invention are ICM (Molsoft, La Jolla, Calif.), FelxiDock (Tripos, St. Louis, Mo.), GRAM (Medical Univ. Of South Carolina), DOCK3.5 and 4.0 (Univ. Calif. San Francisco), Glide (Schrödinger, Portland, Oreg.), Gold (Cambridge Crystallographic Data Centre, UK), FLEX-X (Bi-oSolveIT GmbH, Germany); or AUTODOCK (Scripps Research Institute).

The results of the fitting operation are then analyzed to quantify the association between the chemical entity and the binding pocket. The quality of fitting of these entities to the inhibition model is evaluated either by using a scoring function, shape complementarity, or estimating the interaction energy.

Methods for evaluating the association of a chemical entity with the target include energy minimization and molecular dynamics with standard molecular mechanics force fields, such as CHARMM and AMBER.

Additional data is obtained using Free Energy Perturbations (FEP), to account for other energetic effects such as desolvation penalties. Information about the chemical interactions with the target are then used to elucidate chemical modifications that can enhance selectivity of binding of the compound

Potential binding compounds are identified based on favorable geometric fit and energetically favorable complementary interactions. Energetically favorable electrostatic interactions include attractive charge-charge, dipole-dipole and charge-dipole interactions between the target enzyme, and the small molecule.

The association with the binding pocket is further assessed by means of visual inspection followed by energy minimization and molecular dynamics. Examples of such programs include: MOE (CCG, Montreal, Canada), QUANTA/CHARMM (Accelrys, Inc., San Diego, Calif.); Gaussian (M. J. Frisch, Gaussian, Inc., Carnegie, Pa.); AMBER (P. A. Kollman, University of California at San Francisco); Jaguar (Schrödinger, Portland, Oreg.); SPARTAN (Wavefunction, Inc., Irvine, Calif.); Impact (Schrödinger, Portland, Oreg.); Insight II/Discover (Accelrys, Inc., San Diego, Calif.); MacroModel (Schrödinger, Portland, Oreg.); Maestro (Schrödinger, Portland, Oreg.); and DelPhi (Accelrys, Inc., San Diego, Calif.).

Once suitable fragments have been identified, they are connected into a single compound or complex on the three-dimensional image displayed on a computer screen in relation to all or a portion of the inhibition model.

5. Use of the Inhibition Model for Ligand Design

The design of compounds using the inhibition model includes calculation of non-covalent molecular interactions important in the compound's binding association including hydrogen bonding, van der Waals interactions, hydrophobic interactions and electrostatic interactions.

The compound's binding affinity to the inhibition model is further optimized by computational evaluation of the deformation energy of binding, i.e. the energy difference between bound and free states of the chemical entity.

Computer calculations may suggest more than one conformation similar in overall binding energy for a chemical entity. In these cases the deformation energy of binding is defined as the difference between the energy of the free entity and the average energy of the conformations observed when the inhibitor binds to the protein.

EXAMPLES

Examples are provided below to further illustrate different features of the present invention. The examples also illustrate useful methodology for practicing the invention. These examples do not limit the claimed invention.

Material and Methods

Expression and Purification of the cMet1 Kinase Domain

cDNA of full-length cMet purchased from Origen Technologies was used as template for PCR amplification. The DNA fragment encoding the kinase domain (1038-1346) was inserted into a Novagen vector pet28a between Nco1 and Sal1 sites. The primers were designed to contain a six-histidine tag to the N-terminus. In order to express dephosphorylated cMet kinase protein, a tyrosine phosphatase PTP1B (1-283) was sequentially ligated into the construct between SalI and NotI sites. A second ribosome binding site was incorporated in the PTP1B primer after the SalI site.

c-Met1 Protein Expression

The N-terminal His-tagged proteins were expressed in Circlegrow broth (Q-Biogen). The transformed E. Coli cell line BL21(DE3)RIL (Stratagene) was cultured to OD=0.8 at 37° C. and induced with 0.3 mM of IPTG for overnight at 12° C. The co-expressed protein was purified by metal-chelation chromatography followed by anion and cation columns. In a typical preparation 4 liters of cells were lysed by sonication in 140 ml buffer containing 20 mM MOPS pH 6.5, 200 mM NaCl, 7.5% glycerol, 0.1% Igepal, supplied with 1 mM PMSF. The supernatant was obtained by centrifugation at 50,000 g for 30 minutes and followed by incubation with 8 mL of Ni-NTA His Bind resin (Novagen) at 4° C. for one hour. A second step 50 ml wash buffer (with 100 mM NaCl and 5 mM imidazole) was applied after initial wash with the lysis buffer. Protein was eluted by 200 mM imidazole pH8.5, 100 mM NaCl and 7.5% glycerol and directly cleared by passing 10 ml QFF column. The salt concentration and the pH value of the protein flow through were adjusted to 50 mM and 7.5 by dilution, and then loaded to 1 ml SP FF column. The protein was further gel-filtered in an equilibrium buffer of 20 mM TrisHCl pH8.5, 150 mM NaCl, 7.5% glycerol and 2 mM DTT. The monomeric cMet protein was concentrated to 30 mg/ml for storage at −80° C.

c-Met1 Protein purification was performed as follows:

BL21(DE3)RIL cells were chilled on ice before being induced at 12° C. overnight at a density of OD600=1.

4-6 L cell pellets were then resuspended in 150 ml of 50 mM K₂HPO₄ pH 8.0, 200 mM NaCl, 7% Glycerol, 0.1% Igepal.=buffer A, +1.5 mM PMSF.

Cell suspensions were subsequently sonicated at 60% for 10 min, in cycles of 5 s on and 8 s off, and kept in ice.

Sonicated suspensions were centrifuged at 50,000×g for 30 min at 4° C. The resulting supernatants were transferred to 8 ml fresh nickle beads. This solution was rotated for 40 min at 4° C.

Supernatant liquid was allowed to drain off.

The nickel beads (which bound cMet1 protein) were resuspended twice with 50 ml of buffer A.

Nickel beads were then resuspended twice with 25 ml 50 mM K₂HPO₄, 100 mM NaCl, 7.5% Glycerol, 10 mM Imidazole (pH 8.5).

cMet1 protein was eluted from the nickel beads with 30 ml 200 mM Imidazole (pH8.5), 100 mM NaCl, 7.5% Glycerol.

The eluted flow-through directly drains to 10 ml QFF (in 100 mM NaCl).

(a) The first 2 ml of the flow through is not collected, but sent to waste.

(b) All remaining fractions are collected and concentrated down to ˜500 ul for Gelfiltration in 20 mM TrisHCl pH 8.5, 150 mM NaCl, 7.5% Glycerol, 1 mM DTT. Peak elutes around 16 ml from a 24 ml superdex 200.

c-Met1 Crystallization, Data Collection and Structure Determination

The c-Met protein was diluted to 10 mg/ml by a buffer of 20 mM TrisHCl 8.5, 100 mM NCl and 5% glycerol. The selective c-Met inhibitor was added to 1 mM from a 10 mM (50% DMSO) stock solution. 20 mM Li₂SO₄ was also included in the protein solution. Thin needle crystals were obtained at 4° C. by hanging drop methodology using 15% ethanol, 12% ethylene glycol, 100 mM imidazole pH8.5 as precipitant. Typically, 250 nL protein solution was mixed with an equal volume of reservoir solution and streak-seeding method was employed to reduce the crystal nucleus. The crystals were harvested after adding ethylene glycol to 30%. The triclinic crystal has unit cell dimension of a=53.22 Å, b=57.97 Å, c=64.93 Å, α=88.11°, β=67.97°, γ=85.58°. There are two copies of c-Met polypeptide chain per asymmetric unit and the solvent content is 45%.

Diffraction images were collected at Cornell High Energy Synchrotron Source beamline A1 at 100 K with CCD detector. Raw data were reduced with DENZO and scaled and merged by using SCALEPACK on CHESS site. The complex structure was solved by molecular replacement using the program MOLREP implemented in CCP4. The Initial mode was ligand free c-Met kinase crystal structure (PDB code 2G15) from 1060-1346, excluding 1222-1239 (activation loop). With data up to 3 Å, a unique solution was found with correlation coefficient 0.34 versus 0.19 for the next highest peak. Structure refinement consisted of iterative cycles of modeling building in Coot, following by simulated annealing, minimization, and restrained B-factor refinement in CNX. The N-terminal and the A-loop amino acids were revealed during the refinement and built back to the electron density with different conformation from the initial model. Water molecules were added based on Fo-Fc maps (3σ) with density recapitulated in 2Fo-Fc maps (1σ). All waters satisfy the hydrogen-bonding criteria as implemented in the CNX programs Waterpick and Waterdelete. Non-crystallographic symmetry was not employed for the refinement though the two subunits are almost identical. In both subunits, the inhibitor conformation was unambiguously defined in the electron density and included for the refinement at late stage. Final rounds of improvement were performed in REFAC5 with TLS protocols to 2 Å and no σ cutoff. The finished model has continuous electron density from 1047 to 1346 but missing 1038-1046, and also contains 500 water molecules with a crystallographic R-value of 20.9% (R_(free)=25.3%). The x-ray data and refinement statistics are summarized in Table 3.

TABLE 3 Data collection Space group P1 Cell dimensions a, b, c (Å) 53.22, 57.97, 64.93 Cell angles α, β, γ (deg) 88.11, 67.97, 85.58 Resolution (Å) 30.0-2.0 Unique reflections 38978 Completeness (2.07-2.00 Å) 84.8% (51.4%) R_(sym) (2.07-2.00 Å) 11.0% (26%)   Mean I/σ(I) 6.9 Redundancy 1.8 Refinement Intensity cutoff 0.0 R_(cryst) ^(a) 22.3% R_(free) ^(a) 24.6% rmsd in bond length (Å) 0.009 rmsd in bond angle (°) 1.77 Average B factor (Å²) 23.00 ^(a)R_(crys) and R_(free) = (Σ|Fobs − Fcalc|)/(Σ|Fobs|). R_(free) was calculated over a randomly selected 5% of the reflections not used in refinement. Parentheses indicate the outer resolution shell.

Example 1 The Structure of the c-Met1/Inhibitor Complex

The unphosphorylated c-Met kinase domain bound to the selective c-Met inhibitor follows the bi-lobal architecture with N-terminal domain mainly β-sheet connected through a hinge segment to the mainly α-helical C-terminal lobe. All of the residues of the kinase domain are well defined in the structure, including those from the activation loop and the nucleotide binding loop (P-loop). Residues of those loops have an average B-values less than 35 Å.

The selective c-Met inhibitor binds the interdomain cleft between the N- and C-lobes. The carbonyl group from the succinamide ring forms hydrogen bond with the backbone amide of M1160 and the N—H group forms hydrogen bonds with the backbone carbonyl of P1158. The indole ring is close to the ATP binding site opening while the tricyclic ring is bound deep inside the hydrophobic pocket. While the selective c-Met inhibitor binding mode is similar to the binding of many ATP competitive inhibitors, the kinase domain of c-Met bound to the selective c-Met inhibitor assumes an inactive conformation resembling that found in some receptor tyrosine kinases.

The activation loop is in the canonical, autoinhibitory conformation with a short anti-parallel strand observed in many inactive RTKs present in the structure. Two tyrosine residues Y1234 and Y1235 located in the A-loop of the kinase domain are responsible for c-Met catalytic activity. While Y1234 is exposed, Y1235 is sequestered into the active site occupying the site of the substrate tyrosine (FIG. 1). FIG. 1 shows the activation loop of the unphosphorylated c-Met bound to selective inhibitor AQ197 is shown in dark gray. The peptide substrate, as seen in the structure of the phosphorylated insulin receptor IRK in complex with ATP and a peptide (PDB entry 1IR3), is shown in lighter grey. FIG. 1 was generated by superimposing the catalytic segments of those two kinases. Similar orientation has been found for Y1162 in the inactive IRK (1IRK), Y842 of FLT3 (1RJB), Y823 in c-Kit (1T45), Y412 of c-Abl (2HYY) as well as Y823 of c-Kit (1T46) bound to Gleevec, and Y809 of cFMS bound to arylamides (2IOY) and quinolone (2IOV) series of inhibitors.

Y1235 of unphosphorylated c-Met bound to the selective c-Met inhibitor is held by a hydrogen bond network formed by catalytic loop (C-loop) N1204 and R1208, strictly conserved residues across the type III RTKs. Their hydrogen bond interactions correlate well with observed substrate preferences in active RTKs like IRK and c-Kit, where the corresponding Asp residue interacts with the attacking hydroxyl side chain of the substrate, while the arginine residue engages in hydrogen bonding interactions that orient asparagine (FIG. 2). FIG. 2 is a cartoon image of c-Met kinase domain. The activation loop is in the canonical, autoinhibitory conformation forming a typical short anti-parallel strand. This particular conformation has been observed in other inactive RTKs. While Y1235 is mimicking the substrate tyrosine residue Y1234 is exposed. Residues shown in sticks are labeled. Y1235 of c-Met bound to the selective c-Met inhibitor is sequestered by the hydrogen bond network formed by N1204 and R1208. These two residues are part of the catalytic loop (C-loop) and strictly conserved across the type III RTKs. The aromatic side chain of F1089 (sticks) stabilize the downfold of the loop by van de Waals contacts with the selective c-Met inhibitor. Similar specific conformations induced by small molecule fitting are present in the crystal structures of Abl bound to Gleevec and FGFR-1 bound to SU-5402 (PDB entry 1FGK). In the structure of the selective c-Met inhibitor bound to c-Met the conformation of the A-loop dramatically differs from those reported previously for the c-Met receptor kinase domain (Wang, W. et al. 2006. Proc. Natl. Acad. Sci. USA 103:3563-3568 (2006); Schiering, N. et al. 2003. Proc. Natl. Acad. Sci. USA 100:112654-12659). The wild type apo-c-Met reported by Wang et al. shows the activation loop in an open conformation, unsuitable for substrate binding, but does not block the ATP binding site. Y1234 is pulled closer to the N-terminal domain, making hydrogen bonds with E1127 an important catalytic residue as we explained above. The structure of mutant c-Met resolved by Schiering et al. was obtained from baculovirus cultures where the Y1194, Y1234 and Y1235 were mutated to prevent their phosphorylation during production. In this case the activation loop resembles the activated conformation.

Two different conformations of the DFG motif are known. In the activated kinases the DFG motif is in so-called ‘DFG-in’ conformation. This conformation permits Mg²⁺ ion ligation by asparagine residue and phenylalanine makes room for the ATP tucking itself away under the αC helix. In this case the kinase has the ability to bind the ATP productively. In the ‘DFG-out’ conformation which is exhibited by our structure the aspartic acid and the phenylalanine switched sides, with aspartic acid point away from where the ATP would bind and phenylalanine is situated in the approximated position of the ATP adenine moiety. Stabilization of this portion of the A-loop is provided in part by the tricyclic group of the selective c-Met inhibitor, which is making van der Waals interactions with phenylalanine residue from the DFG motif. This is why, although the hydroxyl group of the Y1235 is in position for phosphor-transfer, the DFG-out motif occludes the ATP binding site interfering with a possibility of cis-transfer.

The nucleotide binding loop, the P-loop is well ordered in the structure of c-Met bound to the selective c-Met inhibitor, where residues 11084 to G1087 form part of the β1 strand. In contrast, in the publicly available unbound c-Met these four residues are disordered. F1089 stabilizes the downfold of the loop by van de Waals contacts with the selective c-Met inhibitor (FIG. 2). Crystal structures of Abl and FGFR complexed with inhibitors STI-571 (2HYY) and SU-5402 (1FGI), respectively, adopt similar conformations induced by inhibitor fitting.

While there are common features shared by Gleevec bound to c-Abl and c-Met bound to the selective c-Met inhibitor, there is an important difference in the alignment of the lysine-glutamic acid pair. In phosphorylated kinases corresponding glutamic acid residue stabilizes the orientation of lysine residue after kinase activation. When Gleevec binds c-Abl the salt bridge is well preserved and forms part of the hydrogen bond network with the inhibitor. When the selective c-Met inhibitor binds c-Met, the ion pair is disrupted, residues K1110 and E1127 are 16 Å apart, accentuating the inactive nature of the c-Met kinase conformation in the presence of the selective c-Met inhibitor With respect to FIG. 4, strictly conserved Lys (β3) and Glu (αC) in active kinases form an ion pair necessary for stabilizing the phosphate group transfer. Unphosphorylated c-Met bound to AQ197 shows this salt bridge disrupted as a result of the conformational changes of the A-loop and the helix αC (magenta). In yellow, the αC structure of the active form of insuline receptor kinase. Catalytic important Glutamic acid residues are shown in sticks.

A similar situation to c-Abl is present in c-Kit bound to Gleevec, lysine-glutamic acid maintain salt bridge distance. c-Kit structure is remarkable in another way. The unphosphorylated apo-structure appears very similar to the structure in complex with Gleevec. This fact may confirm the overall belief that Gleevec recognizes and binds the canonical, autoinhibited kinase conformation.

Another receptor kinase cFMS bound to small molecule inhibitors is also in the canonical inactive conformation (Schubert, C. et al. 2007. J. Biol. Chem. 282:4094-4101). These inhibitors resemble the binding mode of Gleevec, but being small they do not reach the back pocket.

It is reasonable to suggest based on this description of the binding mode of the selective c-Met inhibitor bound to the non-phosphorylated form of c-Met, that the selective c-Met inhibitor binds a pre-existing pocket formed in the unphosphorylated c-Met, with the tricyclic moiety fitting perfectly between two phenylalanine residues F1089 from the P-loop and F1223 from the DFG motif. Both residues have their aromatic rings in van der Waals, hydrophobic contact with the selective c-Met inhibitor.

Example 1A The Construction of the c-Met2 Inhibition Model

The three dimensional electronic representation of the ligand bound to c-Met was used. Twenty three residues of c-Met at distances up to 6 Å from every atom of the ligand were selected. The coordinates of these twenty three residues constitute the inhibition model of c-Met.

The amino acids of the inhibition model of c-Met derived from the structure of c-Met2 kinase domain are described herein and are defined by a set of structure coordinates set forth in Table 4.

TABLE 4 (SEQ ID NO: 11) ATOM 1 N ILE 1084 −19.676 −14.451 −19.716 15.47 N ATOM 2 CA ILE 1084 −20.082 −15.696 −19.067 15.31 C ATOM 3 CB ILE 1084 −21.542 −15.681 −18.586 14.71 C ATOM 4 CG1 ILE 1084 −21.729 −14.619 −17.505 14.37 C ATOM 5 CD1 ILE 1084 −23.127 −14.461 −17.033 6.51 C ATOM 6 CG2 ILE 1084 −21.928 −17.056 −18.067 14.52 C ATOM 7 C ILE 1084 −19.802 −16.886 −19.998 14.64 C ATOM 8 O ILE 1084 −19.178 −17.865 −19.589 14.54 O ATOM 9 N GLY 1085 −20.235 −16.777 −21.247 14.55 N ATOM 10 CA GLY 1085 −19.946 −17.782 −22.243 13.94 C ATOM 11 C GLY 1085 −20.087 −17.158 −23.592 14.69 C ATOM 12 O GLY 1085 −20.694 −16.104 −23.725 13.22 O ATOM 13 N PHE 1089 −24.836 −18.883 −30.097 15.3 N ATOM 14 CA PHE 1089 −25.9 −18.001 −29.571 13.53 C ATOM 15 CB PHE 1089 −26.393 −18.453 −28.156 12.25 C ATOM 16 CG PHE 1089 −25.281 −18.681 −27.155 12.52 C ATOM 17 CD1 PHE 1089 −24.789 −19.972 −26.93 10.55 C ATOM 18 CE1 PHE 1089 −23.728 −20.182 −26.026 10.53 C ATOM 19 CZ PHE 1089 −23.173 −19.124 −25.36 10.12 C ATOM 20 CE2 PHE 1089 −23.625 −17.83 −25.583 9.89 C ATOM 21 CD2 PHE 1089 −24.694 −17.613 −26.476 12.9 C ATOM 22 C PHE 1089 −25.449 −16.545 −29.503 13.39 C ATOM 23 O PHE 1089 −26.284 −15.658 −29.406 14.08 O ATOM 24 N VAL 1092 −22.639 −13.849 −23.919 12.22 N ATOM 25 CA VAL 1092 −23.38 −13.53 −22.701 10.83 C ATOM 26 CB VAL 1092 −24.097 −14.78 −22.141 10.23 C ATOM 27 CG1 VAL 1092 −24.877 −14.441 −20.91 8.74 C ATOM 28 CG2 VAL 1092 −24.998 −15.332 −23.184 11.17 C ATOM 29 C VAL 1092 −22.393 −12.944 −21.691 10.92 C ATOM 30 O VAL 1092 −21.402 −13.605 −21.364 9.96 O ATOM 31 N ALA 1108 −26.911 −12.095 −15.851 8.12 N ATOM 32 CA ALA 1108 −26.39 −12.461 −17.121 8.23 C ATOM 33 CB ALA 1108 −26.701 −13.958 −17.42 7.36 C ATOM 34 C ALA 1108 −27.054 −11.581 −18.146 7.48 C ATOM 35 O ALA 1108 −28.294 −11.377 −18.103 6.23 O ATOM 36 N VAL 1109 −26.262 −11.022 −19.053 6.4 N ATOM 37 CA VAL 1109 −26.871 −10.086 −19.974 7.09 C ATOM 38 CB VAL 1109 −26.761 −8.561 −19.567 7.99 C ATOM 39 CG1 VAL 1109 −25.877 −8.259 −18.375 9.38 C ATOM 40 CG2 VAL 1109 −26.627 −7.612 −20.741 7.64 C ATOM 41 C VAL 1109 −26.574 −10.363 −21.435 8.01 C ATOM 42 O VAL 1109 −25.47 −10.729 −21.79 5.65 O ATOM 43 N LYS 1110 −27.587 −10.221 −22.269 7.51 N ATOM 44 CA LYS 1110 −27.256 −10.294 −23.664 9.65 C ATOM 45 CB LYS 1110 −27.073 −11.731 −24.086 10.89 C ATOM 46 CG LYS 1110 −28.259 −12.478 −24.304 12.06 C ATOM 47 CD LYS 1110 −28.291 −12.786 −25.777 14.94 C ATOM 48 CE LYS 1110 −26.923 −13.196 −26.354 15.05 C ATOM 49 NZ LYS 1110 −27.04 −13.161 −27.915 11.9 N ATOM 50 C LYS 1110 −28.105 −9.473 −24.577 9.23 C ATOM 51 O LYS 1110 −29.287 −9.193 −24.318 8.86 O ATOM 52 N LEU 1140 −37.463 −20.519 −16.111 8.72 N ATOM 53 CA LEU 1140 −36.55 −19.367 −16.142 11.04 C ATOM 54 CB LEU 1140 −35.314 −19.688 −17 10.97 C ATOM 55 CG LEU 1140 −34.23 −18.646 −17.065 9.46 C ATOM 56 CD1 LEU 1140 −33.609 −18.426 −15.69 8.34 C ATOM 57 CD2 LEU 1140 −33.188 −19.076 −18.042 11.77 C ATOM 58 C LEU 1140 −37.252 −18.13 −16.69 12.97 C ATOM 59 O LEU 1140 −37.803 −18.148 −17.804 12.64 O ATOM 60 N VAL 1155 −31.611 −8.495 −22.98 8.16 N ATOM 61 CA VAL 1155 −32.323 −9.277 −21.923 8.76 C ATOM 62 CB VAL 1155 −32.814 −10.693 −22.353 9.39 C ATOM 63 CG1 VAL 1155 −34.033 −10.582 −23.316 10.94 C ATOM 64 CG2 VAL 1155 −31.728 −11.492 −22.993 8.74 C ATOM 65 C VAL 1155 −31.427 −9.427 −20.73 8.02 C ATOM 66 O VAL 1155 −30.209 −9.527 −20.889 7.13 O ATOM 67 N LEU 1157 −30.843 −11.847 −17.422 7.79 N ATOM 68 CA LEU 1157 −31.27 −13.118 −16.786 7.81 C ATOM 69 CB LEU 1157 −30.902 −14.33 −17.682 9.69 C ATOM 70 CG LEU 1157 −32.066 −14.227 −18.65 11.62 C ATOM 71 CD1 LEU 1157 −31.674 −13.539 −19.933 11.32 C ATOM 72 CD2 LEU 1157 −32.851 −15.474 −18.797 10.57 C ATOM 73 C LEU 1157 −30.661 −13.291 −15.419 8.75 C ATOM 74 O LEU 1157 −29.588 −12.733 −15.162 7.63 O ATOM 75 N PRO 1158 −31.285 −14.129 −14.552 9.58 N ATOM 76 CA PRO 1158 −30.573 −14.427 −13.309 10.72 C ATOM 77 CB PRO 1158 −31.566 −15.292 −12.497 10.18 C ATOM 78 CG PRO 1158 −32.788 −15.258 −13.187 11.04 C ATOM 79 CD PRO 1158 −32.545 −14.873 −14.637 9.45 C ATOM 80 C PRO 1158 −29.342 −15.228 −13.655 11.46 C ATOM 81 O PRO 1158 −29.302 −15.934 −14.683 11.52 O ATOM 82 N TYR 1159 −28.326 −15.091 −12.828 12.18 N ATOM 83 CA TYR 1159 −27.094 −15.799 −13.05 13.78 C ATOM 84 CB TYR 1159 −25.976 −15.173 −12.234 13.95 C ATOM 85 CG TYR 1159 −24.668 −15.894 −12.374 15.44 C ATOM 86 CD1 TYR 1159 −23.973 −15.906 −13.604 15.19 C ATOM 87 CE1 TYR 1159 −22.762 −16.583 −13.73 15.55 C ATOM 88 CZ TYR 1159 −22.229 −17.235 −12.622 15.73 C ATOM 89 OH TYR 1159 −21.025 −17.924 −12.718 18.54 O ATOM 90 CE2 TYR 1159 −22.889 −17.225 −11.399 16.11 C ATOM 91 CD2 TYR 1159 −24.099 −16.548 −11.276 14.98 C ATOM 92 C TYR 1159 −27.328 −17.25 −12.659 14.12 C ATOM 93 O TYR 1159 −27.868 −17.544 −11.573 13.85 O ATOM 94 N MET 1160 −26.977 −18.141 −13.575 13.76 N ATOM 95 CA MET 1160 −27.199 −19.572 −13.403 14.48 C ATOM 96 CB MET 1160 −28.079 −20.159 −14.542 14.71 C ATOM 97 CG MET 1160 −29.48 −19.592 −14.597 15.91 C ATOM 98 SD MET 1160 −30.533 −20.154 −13.195 20.68 S ATOM 99 CE MET 1160 −31.401 −18.698 −12.74 20.48 C ATOM 100 C MET 1160 −25.816 −20.14 −13.382 14.64 C ATOM 101 O MET 1160 −25.182 −20.283 −14.417 15.02 O ATOM 102 N LYS 1161 −25.314 −20.346 −12.167 15.21 N ATOM 103 CA LYS 1161 −23.952 −20.771 −11.91 14.1 C ATOM 104 CB LYS 1161 −23.758 −21.08 −10.427 15.12 C ATOM 105 CG LYS 1161 −22.333 −21.497 −10.095 17.53 C ATOM 106 CD LYS 1161 −22.188 −21.839 −8.613 24.97 C ATOM 107 CE LYS 1161 −20.714 −21.982 −8.207 26.67 C ATOM 108 NZ LYS 1161 −20.549 −21.583 −6.789 32.02 N ATOM 109 C LYS 1161 −23.518 −21.98 −12.746 13.45 C ATOM 110 O LYS 1161 −22.404 −22.006 −13.258 12.16 O ATOM 111 N HIS 1162 −24.38 −22.987 −12.865 12.66 N ATOM 112 CA HIS 1162 −23.979 −24.201 −13.569 12.84 C ATOM 113 CB HIS 1162 −24.427 −25.452 −12.815 11.85 C ATOM 114 CG HIS 1162 −23.908 −25.504 −11.426 13.4 C ATOM 115 ND1 HIS 1162 −22.554 −25.561 −11.145 15.28 N ATOM 116 CE1 HIS 1162 −22.385 −25.595 −9.838 16.31 C ATOM 117 NE2 HIS 1162 −23.575 −25.537 −9.261 17.98 N ATOM 118 CD2 HIS 1162 −24.542 −25.471 −10.232 14.71 C ATOM 119 C HIS 1162 −24.36 −24.282 −15.038 13.45 C ATOM 120 O HIS 1162 −24.234 −25.367 −15.634 14.09 O ATOM 121 N GLY 1163 −24.807 −23.162 −15.62 12.39 N ATOM 122 CA GLY 1163 −25.108 −23.113 −17.056 11.81 C ATOM 123 C GLY 1163 −26.195 −24.111 −17.397 11.37 C ATOM 124 O GLY 1163 −27.052 −24.405 −16.541 12.27 O ATOM 125 N ASP 1164 −26.16 −24.657 −18.612 10.58 N ATOM 126 CA ASP 1164 −27.202 −25.57 −19.037 11.05 C ATOM 127 CB ASP 1164 −27.395 −25.576 −20.566 10.73 C ATOM 128 CG ASP 1164 −26.214 −26.22 −21.317 14.82 C ATOM 129 OD1 ASP 1164 −26.203 −27.447 −21.509 16.5 O ATOM 130 OD2 ASP 1164 −25.324 −25.485 −21.76 16.71 O ATOM 131 C ASP 1164 −26.958 −26.97 −18.481 10.14 C ATOM 132 O ASP 1164 −25.836 −27.355 −18.139 9.32 O ATOM 133 N ASP 1211 −31.568 −24.508 −17.398 11.25 N ATOM 134 CA ASP 1211 −30.407 −23.962 −16.703 12.07 C ATOM 135 CB ASP 1211 −30.29 −22.425 −16.878 13.35 C ATOM 136 CG ASP 1211 −29.946 −21.986 −18.38 15.72 C ATOM 137 OD1 ASP 1211 −28.869 −22.268 −19.063 3.34 O ATOM 138 OD2 ASP 1211 −30.838 −21.298 −18.869 22.8 O ATOM 139 C ASP 1211 −30.314 −24.43 −15.238 11.76 C ATOM 140 O ASP 1211 −31.303 −24.781 −14.626 11.98 O ATOM 141 N ALA 1221 −35.874 −22.995 −19.798 9.64 N ATOM 142 CA ALA 1221 −35.638 −21.759 −20.538 11.43 C ATOM 143 CB ALA 1221 −34.165 −21.475 −20.605 12.72 C ATOM 144 C ALA 1221 −36.215 −21.756 −21.953 12.59 C ATOM 145 O ALA 1221 −36.317 −22.801 −22.617 11.05 O ATOM 146 O ASP 1222 −36.499 −18.098 −24.227 17.5 O ATOM 147 N ASP 1222 −36.5 −20.634 −22.356 20 N ATOM 148 CA ASP 1222 −36.941 −20.406 −23.727 20 C ATOM 149 C ASP 1222 −36.151 −19.273 −24.377 20 C ATOM 150 CB ASP 1222 −38.437 −20.091 −23.763 20 C ATOM 151 CG ASP 1222 −38.824 −18.99 −22.796 20 C ATOM 152 OD1 ASP 1222 −37.994 −18.638 −21.932 20 O ATOM 153 OD2 ASP 1222 −39.935 −18.418 −22.824 20 O ATOM 154 N PHE 1223 −35.113 −19.54 −24.88 16.19 N ATOM 155 CA PHE 1223 −34.306 −18.466 −25.34 17.32 C ATOM 156 CB PHE 1223 −32.818 −18.714 −25.181 16 C ATOM 157 CG PHE 1223 −32.355 −18.541 −23.754 11.65 C ATOM 158 CD1 PHE 1223 −32.357 −17.286 −23.16 11.27 C ATOM 159 CE1 PHE 1223 −31.94 −17.128 −21.826 15.53 C ATOM 160 CZ PHE 1223 −31.549 −18.252 −21.091 14.31 C ATOM 161 CE2 PHE 1223 −31.558 −19.492 −21.689 14.38 C ATOM 162 CD2 PHE 1223 −31.98 −19.622 −23.01 14.35 C ATOM 163 C PHE 1223 −34.816 −18.009 −26.7 20.29 C ATOM 164 O PHE 1223 −35.386 −16.886 −26.787 22.15 O ATOM 165 N ALA 1226 −32.985 −15.014 −28.359 16.83 N ATOM 166 CA ALA 1226 −31.681 −14.627 −27.816 15.78 C ATOM 167 CB ALA 1226 −31.656 −14.803 −26.309 15.05 C ATOM 168 C ALA 1226 −30.512 −15.38 −28.432 15.33 C ATOM 169 O ALA 1226 −29.385 −14.922 −28.31 14.85 O ATOM 170 N ARG 1227 −30.768 −16.534 −29.062 14.69 N ATOM 171 CA ARG 1227 −29.719 −17.245 −29.776 13.62 C ATOM 172 CB ARG 1227 −30.066 −18.729 −29.985 14.18 C ATOM 173 CG ARG 1227 −30.303 −19.5 −28.711 12.15 C ATOM 174 CD ARG 1227 −30.765 −20.926 −28.952 14.86 C ATOM 175 NE ARG 1227 −30.801 −21.623 −27.669 17.43 N ATOM 176 CZ ARG 1227 −29.719 −22.054 −27.024 18.53 C ATOM 177 NH1 ARG 1227 −28.513 −21.933 −27.574 20.01 N ATOM 178 NH2 ARG 1227 −29.843 −22.65 −25.851 19.76 N ATOM 179 C ARG 1227 −29.535 −16.57 −31.118 13.93 C ATOM 180 O ARG 1227 −30.445 −16.603 −31.947 14.89 O

Example 2 The Construction of the c-Abl Inhibition Model

A 3-dimensional model for the inhibition of c-Abl was created using the process described below.

The sequence alignment of c-Abl kinase and the amino acid sequence of c-Met was performed using MOE alignment tools. Care was taken to make sure that known kinase motifs: DFG motif, the hinge residues and the salt bridge residues were superposed.

The identification of conserved amino acid residues between c-Met and c-Abl, generation of atomic coordinates of all conserved amino acids in c-Abl from the electronic representation of c-Met residues; rotamer search of the structurally variable and replacement of non-conserved residues of c-Met with residues from c-Abl sequence; building of side chain conformations; and final refinement and evaluation of the c-Abl structure were carried out in an automated fashion using MOE homology tools.

Example 3 The Similarity Assessment of c-Abl Inhibition Model

From Table 2, it can be determined that the similarity assessment value is less than 50% for c-Abl. Three residues show negative weights: T333 (L1157), N340 (D1164), and S403 (A1226). The inhibition model will have a significant change in polarity factor.

L1157 is located deep into the c-Met inhibition model. This residue is one of several which confers c-Met its mainly hydrophobic nature. In this position, c-Abl model shows a T333, a highly polar residue. Therefore, the chemical environment of an inhibitor has changed dramatically. The selective c-Met inhibitor does not have any atomic group to make favorable electrostatic interactions with T333. N340 and S403 also lack favorable electrostatic interactions with the selective c-Met inhibitor. Thus, the selective c-Met inhibitor is not predicted to inhibit c-Abl.

The amino acids of the inhibition model of c-Abl derived from the c-Met inhibition model are described herein and are defined by a set of structure coordinates set forth in Table 5.

TABLE 5 (SEQ ID NO: 8) ATOM N LEU 266 −19.916 −14.441 −18.273 N ATOM CA LEU 266 −20.814 −15.367 −18.929 C ATOM CB LEU 266 −22.191 −14.827 −19.221 C ATOM C LEU 266 −20.09 −16.157 −20.018 C ATOM O LEU 266 −19.184 −16.942 −19.745 O ATOM CG LEU 266 −23.209 −15.308 −18.209 C ATOM CD1 LEU 266 −22.892 −14.842 −16.81 C ATOM CD2 LEU 266 −24.581 −14.82 −18.593 C ATOM N GLY 267 −20.417 −15.864 −21.327 N ATOM CA GLY 267 −19.615 −16.503 −22.345 C ATOM C GLY 267 −20.218 −16.526 −23.733 C ATOM O GLY 267 −21.424 −16.638 −23.949 O ATOM N TYR 271 −24.397 −19.744 −29.694 N ATOM CA TYR 271 −25.559 −18.884 −29.522 C ATOM CB TYR 271 −26.283 −19.182 −28.204 C ATOM C TYR 271 −25.27 −17.375 −29.625 C ATOM O TYR 271 −26.133 −16.521 −29.392 O ATOM CG TYR 271 −25.398 −19.096 −26.995 C ATOM CD1 TYR 271 −24.792 −17.887 −26.648 C ATOM CD2 TYR 271 −25.102 −20.248 −26.264 C ATOM CE1 TYR 271 −23.869 −17.829 −25.616 C ATOM CE2 TYR 271 −24.179 −20.197 −25.219 C ATOM CZ TYR 271 −23.557 −18.989 −24.92 C ATOM OH TYR 271 −22.608 −18.958 −23.929 O ATOM N VAL 274 −23.294 −14.153 −24.61 N ATOM CA VAL 274 −24.16 −13.806 −23.491 C ATOM CB VAL 274 −25.02 −14.966 −23.017 C ATOM C VAL 274 −23.242 −13.359 −22.365 C ATOM O VAL 274 −22.23 −13.983 −22.045 O ATOM CG1 VAL 274 −26.029 −14.498 −21.991 C ATOM CG2 VAL 274 −25.781 −15.575 −24.163 C ATOM N ALA 287 −27.677 −12.533 −15.683 N ATOM CA ALA 287 −27.163 −12.605 −17.031 C ATOM CB ALA 287 −27.621 −13.873 −17.711 C ATOM C ALA 287 −27.733 −11.415 −17.791 C ATOM O ALA 287 −28.826 −10.907 −17.535 O ATOM N VAL 288 −26.977 −11.03 −18.871 N ATOM CA VAL 288 −27.516 −10.069 −19.803 C ATOM CB VAL 288 −26.987 −8.657 −19.576 C ATOM C VAL 288 −27.201 −10.557 −21.208 C ATOM O VAL 288 −26.124 −11.023 −21.58 O ATOM CG1 VAL 288 −27.658 −7.659 −20.495 C ATOM CG2 VAL 288 −27.21 −8.185 −18.157 C ATOM N LYS 289 −28.252 −10.312 −22.064 N ATOM CA LYS 289 −28.041 −10.491 −23.48 C ATOM CB LYS 289 −28.329 −11.881 −24.014 C ATOM C LYS 289 −28.817 −9.471 −24.288 C ATOM O LYS 289 −29.858 −8.937 −23.914 O ATOM CG LYS 289 −27.284 −12.24 −25.052 C ATOM CD LYS 289 −27.779 −13.297 −26.008 C ATOM CE LYS 289 −26.677 −13.676 −26.976 C ATOM NZ LYS 289 −27.262 −14.535 −28.044 N1+ ATOM N VAL 317 −36.3 −20.382 −15.116 N ATOM CA VAL 317 −35.436 −19.216 −15.287 C ATOM CB VAL 317 −34.28 −19.474 −16.244 C ATOM C VAL 317 −36.337 −18.127 −15.852 C ATOM O VAL 317 −37.128 −18.313 −16.773 O ATOM CG1 VAL 317 −33.439 −20.65 −15.809 C ATOM CG2 VAL 317 −33.373 −18.267 −16.334 C ATOM N ILE 331 −32.2 −7.875 −22.796 N ATOM CA ILE 331 −32.865 −8.817 −21.914 C ATOM CB ILE 331 −33.299 −10.061 −22.683 C ATOM C ILE 331 −31.906 −9.163 −20.783 C ATOM O ILE 331 −30.744 −9.528 −20.955 O ATOM CG1 ILE 331 −34.398 −9.745 −23.684 C ATOM CG2 ILE 331 −33.763 −11.172 −21.764 C ATOM CD1 ILE 331 −35.654 −9.209 −23.03 C ATOM N THR 333 −31.711 −11.403 −17.09 N ATOM CA THR 333 −32.291 −12.558 −16.398 C ATOM CB THR 333 −32.376 −13.8 −17.293 C ATOM C THR 333 −31.371 −12.885 −15.243 C ATOM O THR 333 −30.16 −12.687 −15.306 O ATOM OG1 THR 333 −31.099 −14.206 −17.797 O ATOM CG2 THR 333 −33.289 −13.577 −18.477 C ATOM N GLU 334 −31.929 −13.562 −14.194 N ATOM CA GLU 334 −31.049 −14.086 −13.162 C ATOM CB GLU 334 −31.793 −14.548 −11.918 C ATOM C GLU 334 −30.016 −15.113 −13.667 C ATOM O GLU 334 −30.153 −15.806 −14.674 O ATOM CG GLU 334 −32.718 −15.726 −12.155 C ATOM CD GLU 334 −33.907 −15.472 −13.064 C ATOM OE1 GLU 334 −34.471 −16.519 −13.499 O1− ATOM OE2 GLU 334 −34.185 −14.264 −13.348 O ATOM N PHE 335 −28.897 −15.174 −12.855 N ATOM CA PHE 335 −27.724 −15.967 −13.224 C ATOM CB PHE 335 −26.472 −15.304 −12.651 C ATOM C PHE 335 −27.822 −17.389 −12.673 C ATOM O PHE 335 −27.992 −17.648 −11.486 O ATOM CG PHE 335 −25.147 −15.936 −12.949 C ATOM CD1 PHE 335 −24.88 −16.583 −14.156 C ATOM CD2 PHE 335 −24.145 −15.864 −11.983 C ATOM CE1 PHE 335 −23.637 −17.166 −14.389 C ATOM CE2 PHE 335 −22.898 −16.44 −12.214 C ATOM CZ PHE 335 −22.645 −17.095 −13.416 C ATOM N MET 336 −27.676 −18.363 −13.637 N ATOM CA MET 336 −27.674 −19.773 −13.292 C ATOM CB MET 336 −28.489 −20.582 −14.273 C ATOM C MET 336 −26.24 −20.281 −13.223 C ATOM O MET 336 −25.533 −20.558 −14.187 O ATOM CG MET 336 −29.927 −20.877 −13.875 C ATOM SD MET 336 −30.643 −20.004 −12.452 S ATOM CE MET 336 −31.071 −18.464 −13.296 C ATOM N THR 337 −25.767 −20.22 −11.937 N ATOM CA THR 337 −24.346 −20.219 −11.611 C ATOM CB THR 337 −24.222 −20.086 −10.094 C ATOM C THR 337 −23.595 −21.487 −12.019 C ATOM O THR 337 −22.386 −21.482 −12.227 O ATOM OG1 THR 337 −25.449 −19.587 −9.527 O ATOM CG2 THR 337 −23.079 −19.169 −9.723 C ATOM N TYR 338 −24.343 −22.643 −11.985 N ATOM CA TYR 338 −23.729 −23.934 −12.217 C ATOM CB TYR 338 −24.416 −24.993 −11.379 C ATOM C TYR 338 −23.762 −24.378 −13.682 C ATOM O TYR 338 −23.383 −25.493 −14.026 O ATOM CG TYR 338 −23.568 −25.565 −10.292 C ATOM CD1 TYR 338 −22.236 −25.927 −10.513 C ATOM CD2 TYR 338 −24.147 −25.802 −9.046 C ATOM CE1 TYR 338 −21.497 −26.545 −9.507 C ATOM CE2 TYR 338 −23.411 −26.411 −8.034 C ATOM CZ TYR 338 −22.098 −26.795 −8.277 C ATOM OH TYR 338 −21.418 −27.465 −7.287 O ATOM N GLY 339 −24.173 −23.424 −14.591 N ATOM CA GLY 339 −24.111 −23.721 −16.01 C ATOM C GLY 339 −25.334 −24.505 −16.464 C ATOM O GLY 339 −26.443 −24.373 −15.942 O ATOM N ASN 340 −25.101 −25.257 −17.604 N ATOM CA ASN 340 −26.191 −26.036 −18.17 C ATOM CB ASN 340 −26.524 −25.799 −19.634 C ATOM C ASN 340 −26.198 −27.515 −17.8 C ATOM O ASN 340 −25.188 −28.131 −17.466 O ATOM CG ASN 340 −25.47 −26.41 −20.502 C ATOM OD1 ASN 340 −25.344 −27.622 −20.648 O ATOM ND2 ASN 340 −24.639 −25.481 −21.052 N ATOM N LEU 388 −30.765 −24.965 −17.173 N ATOM CA LEU 388 −29.637 −24.46 −16.404 C ATOM CB LEU 388 −29.54 −22.942 −16.453 C ATOM C LEU 388 −29.728 −24.852 −14.933 C ATOM O LEU 388 −30.785 −25.113 −14.356 O ATOM CG LEU 388 −29.205 −22.298 −17.782 C ATOM CD1 LEU 388 −28.098 −23.005 −18.523 C ATOM CD2 LEU 388 −30.424 −22.172 −18.658 C ATOM N ALA 398 −35.889 −22.88 −19.129 N ATOM CA ALA 398 −36.044 −21.552 −19.7 C ATOM CB ALA 398 −34.943 −20.618 −19.251 C ATOM C ALA 398 −36.046 −21.615 −21.211 C ATOM O ALA 398 −35.39 −22.427 −21.854 O ATOM N ASP 399 −36.893 −20.694 −21.784 N ATOM CA ASP 399 −36.858 −20.444 −23.21 C ATOM CB ASP 399 −38.239 −20.251 −23.829 C ATOM C ASP 399 −35.954 −19.212 −23.354 C ATOM O ASP 399 −35.733 −18.392 −22.468 O ATOM CG ASP 399 −38.247 −20.184 −25.363 C ATOM OD1 ASP 399 −37.116 −20.365 −25.93 O ATOM OD2 ASP 399 −39.369 −19.86 −25.882 O1− ATOM N PHE 400 −35.483 −19.083 −24.627 N ATOM CA PHE 400 −34.56 −18.038 −24.992 C ATOM CB PHE 400 −33.141 −18.571 −25.139 C ATOM C PHE 400 −34.97 −17.332 −26.27 C ATOM O PHE 400 −34.492 −16.233 −26.549 O ATOM CG PHE 400 −32.584 −19.079 −23.847 C ATOM CD1 PHE 400 −32.179 −20.407 −23.749 C ATOM CE1 PHE 400 −31.711 −20.913 −22.54 C ATOM CZ PHE 400 −31.651 −20.091 −21.42 C ATOM CE2 PHE 400 −32.052 −18.762 −21.512 C ATOM CD2 PHE 400 −32.512 −18.255 −22.723 C ATOM N GLY 401 −35.767 −18.029 −27.165 N ATOM CA GLY 401 −36.219 −17.353 −28.371 C ATOM C GLY 401 −35.078 −16.919 −29.288 C ATOM O GLY 401 −34.093 −17.609 −29.541 O ATOM N SER 403 −32.943 −14.891 −28.539 N ATOM CA SER 403 −31.691 −14.692 −27.847 C ATOM CB SER 403 −31.925 −14.71 −26.353 C ATOM C SER 403 −30.655 −15.749 −28.247 C ATOM O SER 403 −29.448 −15.589 −28.049 O ATOM OG SER 403 −31.052 −13.781 −25.724 O ATOM N ARG 404 −31.161 −16.939 −28.747 N ATOM CA ARG 404 −30.26 −17.923 −29.325 C ATOM C ARG 404 −30.241 −17.654 −30.824 C ATOM O ARG 404 −31.151 −17.963 −31.589 O ATOM CB ARG 404 −30.647 −19.349 −28.982 C ATOM CG ARG 404 −30.039 −19.673 −27.637 C ATOM CD ARG 404 −30.267 −21.085 −27.152 C ATOM NE ARG 404 −29.692 −21.2 −25.81 N1+ ATOM CZ ARG 404 −28.984 −22.31 −25.348 C ATOM NH1 ARG 404 −28.74 −23.394 −26.179 N ATOM NH2 ARG 404 −28.465 −22.29 −24.064 N

Example 4 The Use of c-Abl Inhibition Model in the Fitting and Optimization of a Small Molecular Template

N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)nicotinamide, which is known as a c-Abl inhibitor (Schindler et al, 2000) was placed inside the c-Abl inhibition model.

Docking and optimization against the c-Abl inhibition model was performed. The docking procedure was carried out using ICM software. A conformation in which the pyridine ring and the hinge residues were in close proximity was selected. Further optimization was carried out using MOE energy minimization tools

Hydrogen bonds between the pyridine and the critical amino group of the hinge from M336 and the compound's amino group and T333 were identified. The presence of these hydrogen bonds is in agreement with experimental X-ray crystallographic data for the complex c-Abl kinase/Gleevec.

The overall protein-ligand interaction energy was negative (−68 kcal/mol), as it is calculated using MOE energy calculation tools, indicating a high probability of interaction.

(−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione, the selective c-Met inhibitor, was also docked in the c-Abl inhibition model where the pyrrolidine carbonyl ring makes a hydrogen bonds with the amino group of M336.

Further energy optimization using MOE tools was carried out. Two hydrogen bonds where observed between the pyrrolidine ring and hinge residues M336 and E334. Although the overall interaction energy is negative (−50 kcal/mol), a lack of feature complementarity between the selective c-Met inhibitor and c-Abl inhibitor model is clearly observed.

The hydrophobic tricyclic ring is placed in a polar region of the c-Abl inhibition model. Additionally no interactions between the selective c-Met inhibitor and a critical residue in c-Abl T333 are observed. N340 and S403 will also lack favorable electrostatic interactions with the selective c-Met inhibitor. Taken together, it is expected that the selective c-Met inhibitor does not bind to the inactive form of c-Abl kinase. This conclusion is consistent with the observation that the selective c-Met inhibitor does not inhibit the activity of c-Abl effectively, while it inhibits the activity of c-Met effectively (WO 2006/086484 A1).

Example 5 The Construction of FGFR-2 Inhibition Model

A 3-dimensional inhibition model of FGFR-2 was created using the process.

The sequence alignment of FGFR-2 kinase and the amino acid sequence of c-Met were performed using MOE alignment tools. Known kinase motifs: the P-loop F492, the DFG motif (644-646), the hinge residue A567, the salt bridge K517-E534, and tyrosine residues Y656 and Y657 in the A-loop, residues which are phosphorylated upon activation, were superposed.

The identification of conserved amino acid residues between c-Met and FGFR-2; generation of atomic coordinates of all conserved amino acids in FGFR-2 from the electronic representation of c-Met residues; rotamer search of the structurally variable and replacement of non-conserved residues of c-Met with residues from FGFR-2 sequence; building of side chain conformations; and final refinement and evaluation of the FGFR-2 structure was carried out in an automated fashion using MOE homology tools.

Example 6 The Similarity Assessment of FGFR2 Inhibition Model

The FGFR-2 model is 78% similar to c-Met1 (Table 6). One residue shows negative weights: E565 (P1158). The inhibition model has no significant changes in polarity factor. The only differences are in size: I548 (L1140), gate keeper V564 (L1157), hinge residue A567 (M1160), and L633 (M1211).

Although, the FGFR-2 binding pocket is 78% similar, the presence of a smaller gate keeper residue V564, hinge residue (A567) and L633, results in a larger binding site.

TABLE 6 (SEQ ID NOs: 11 and 13, respectively) CMET FGFR-2 (SEQ ID NO: 11) weight (SEQ ID NO: 13) weight PROTEIN I_1084 2 L_487 1 G_1085 2 G_488 2 F_1089 2 F_492 2 V_1092 2 V_495 2 A_1108 1 A_515 1 V_1109b 0.5 V_516b 0.5 K_1110b 0.5 K_517 0.5 L_1140 1 I_548 0.5 V_1155 1 V_562 1 L_1157 1 V_564 0.5 P_1158 1 E_565 −1 Y_1159b 0.5 Y_566b 0.5 M_1160b 1 A_567 0.5 K_1161b 0.5 S_568 0.5 H_1162b 0.5 K_569 0.5 G_1163 0.5 G_570 0.5 D_1164 1 N_571 0.5 M_1211 1 L_633 0.5 A_1221 1 A_643 1 D_1222 1 D_644 1 F_1223 1 F_645 1 A_1226 1 A_648 1 R_1227 2 R_649 2 Similarity 25 19.5 assessmet value

The amino acids of the inhibition model of FGFR-2 derived from the c-Met inhibition model are described herein and are defined by a set of structure coordinates set forth in Table 7.

TABLE 7 (SEQ ID NO: 14) ATOM 1 N LEU 487 −15.283 −12.748 −21.3 N ATOM 2 CA LEU 487 −15.06 −13.48 −22.53 C ATOM 3 CB LEU 487 −13.576 −13.545 −22.839 C ATOM 4 C LEU 487 −15.629 −14.889 −22.364 C ATOM 5 O LEU 487 −15.735 −15.456 −21.281 O ATOM 6 CG LEU 487 −13.279 −13.768 −24.307 C ATOM 7 CD1 LEU 487 −13.885 −12.686 −25.169 C ATOM 8 CD2 LEU 487 −11.787 −13.812 −24.52 C ATOM 9 N GLY 488 −15.929 −15.472 −23.57 N ATOM 10 CA GLY 488 −16.524 −16.79 −23.653 C ATOM 11 C GLY 488 −16.466 −17.181 −25.116 C ATOM 12 O GLY 488 −15.582 −16.783 −25.867 O ATOM 13 N PHE 492 −23.749 −19.863 −29.63 N ATOM 14 CA PHE 492 −25.002 −19.22 −29.231 C ATOM 15 CB PHE 492 −25.587 −19.86 −27.979 C ATOM 16 C PHE 492 −25.001 −17.689 −29.085 C ATOM 17 O PHE 492 −26.019 −17.067 −28.781 O ATOM 18 CG PHE 492 −24.719 −19.956 −26.759 C ATOM 19 CD1 PHE 492 −24.804 −21.1 −25.968 C ATOM 20 CD2 PHE 492 −23.836 −18.942 −26.382 C ATOM 21 CE1 PHE 492 −24.02 −21.234 −24.825 C ATOM 22 CE2 PHE 492 −23.048 −19.07 −25.241 C ATOM 23 CZ PHE 492 −23.141 −20.219 −24.461 C ATOM 24 N GLY 493 −23.77 −17.113 −29.309 N ATOM 25 CA GLY 493 −23.455 −15.731 −29.017 C ATOM 26 C GLY 493 −22.503 −15.689 −27.832 C ATOM 27 O GLY 493 −21.708 −16.582 −27.563 O ATOM 28 N GLN 494 −22.526 −14.481 −27.17 N ATOM 29 CA GLN 494 −21.732 −14.296 −25.963 C ATOM 30 CB GLN 494 −21.048 −12.945 −26.027 C ATOM 31 C GLN 494 −22.718 −14.31 −24.793 C ATOM 32 O GLN 494 −23.886 −13.945 −24.911 O ATOM 33 CG GLN 494 −20.061 −12.71 −24.903 C ATOM 34 CD GLN 494 −19.703 −11.252 −24.848 C ATOM 35 OE1 GLN 494 −20.153 −10.395 −25.598 O ATOM 36 NE2 GLN 494 −18.807 −10.945 −23.868 N ATOM 37 N VAL 495 −22.162 −14.629 −23.575 N ATOM 38 CA VAL 495 −22.939 −14.409 −22.373 C ATOM 39 CB VAL 495 −22.86 −15.58 −21.402 C ATOM 40 C VAL 495 −22.459 −13.103 −21.75 C ATOM 41 O VAL 495 −21.278 −12.855 −21.519 O ATOM 42 CG1 VAL 495 −21.452 −15.945 −20.985 C ATOM 43 CG2 VAL 495 −23.702 −15.34 −20.173 C ATOM 44 N VAL 496 −23.484 −12.248 −21.413 N ATOM 45 CA VAL 496 −23.179 −11.07 −20.645 C ATOM 46 CB VAL 496 −22.851 −9.761 −21.324 C ATOM 47 C VAL 496 −23.249 −11.167 −19.14 C ATOM 48 O VAL 496 −24.216 −11.678 −18.581 O ATOM 49 CG1 VAL 496 −23.894 −9.375 −22.346 C ATOM 50 CG2 VAL 496 −21.48 −9.77 −21.952 C ATOM 51 N VAL 514 −25.883 −11.411 −12.079 N ATOM 52 CA VAL 514 −26.859 −11.989 −12.989 C ATOM 53 CB VAL 514 −28.229 −11.335 −12.845 C ATOM 54 C VAL 514 −26.37 −11.928 −14.442 C ATOM 55 O VAL 514 −25.251 −11.529 −14.762 O ATOM 56 CG1 VAL 514 −28.19 −9.827 −12.937 C ATOM 57 CG2 VAL 514 −28.95 −11.778 −11.595 C ATOM 58 N ALA 515 −27.267 −12.383 −15.386 N ATOM 59 CA ALA 515 −26.791 −12.451 −16.749 C ATOM 60 CB ALA 515 −26.728 −13.861 −17.274 C ATOM 61 C ALA 515 −27.514 −11.523 −17.703 C ATOM 62 O ALA 515 −28.703 −11.235 −17.586 O ATOM 63 N VAL 516 −26.711 −11.107 −18.744 N ATOM 64 CA VAL 516 −27.23 −10.248 −19.791 C ATOM 65 CB VAL 516 −26.383 −8.987 −19.971 C ATOM 66 C VAL 516 −27.215 −10.994 −21.123 C ATOM 67 O VAL 516 −26.31 −11.744 −21.483 O ATOM 68 CG1 VAL 516 −27.079 −7.964 −20.836 C ATOM 69 CG2 VAL 516 −26.019 −8.316 −18.674 C ATOM 70 N LYS 517 −28.253 −10.572 −21.928 N ATOM 71 CA LYS 517 −28.249 −10.726 −23.368 C ATOM 72 CB LYS 517 −27.776 −11.986 −24.071 C ATOM 73 C LYS 517 −28.797 −9.577 −24.194 C ATOM 74 O LYS 517 −29.796 −8.954 −23.846 O ATOM 75 CG LYS 517 −28.92 −12.668 −24.793 C ATOM 76 CD LYS 517 −28.518 −13.807 −25.713 C ATOM 77 CE LYS 517 −27.58 −13.411 −26.843 C ATOM 78 NZ LYS 517 −27.474 −14.567 −27.763 N1+ ATOM 79 N ILE 548 −36.281 −20.184 −15.458 N ATOM 80 CA ILE 548 −35.436 −19.031 −15.752 C ATOM 81 CB ILE 548 −34.664 −19.219 −17.06 C ATOM 82 C ILE 548 −36.408 −17.853 −15.822 C ATOM 83 O ILE 548 −37.458 −17.886 −16.452 O ATOM 84 CG1 ILE 548 −33.392 −20.028 −16.883 C ATOM 85 CG2 ILE 548 −34.252 −17.907 −17.69 C ATOM 86 CD1 ILE 548 −33.627 −21.413 −16.336 C ATOM 87 N VAL 562 −31.795 −7.739 −22.294 N ATOM 88 CA VAL 562 −32.342 −8.134 −21.014 C ATOM 89 CB VAL 562 −33.499 −9.124 −21.117 C ATOM 90 C VAL 562 −31.274 −8.662 −20.068 C ATOM 91 O VAL 562 −30.216 −9.164 −20.451 O ATOM 92 CG1 VAL 562 −34.749 −8.496 −21.679 C ATOM 93 CG2 VAL 562 −33.149 −10.372 −21.896 C ATOM 94 N VAL 564 −31.237 −11.518 −16.699 N ATOM 95 CA VAL 564 −31.896 −12.694 −16.127 C ATOM 96 CB VAL 564 −32.086 −13.727 −17.235 C ATOM 97 C VAL 564 −31.098 −13.219 −14.919 C ATOM 98 O VAL 564 −29.92 −12.905 −14.743 O ATOM 99 CG1 VAL 564 −32.973 −14.887 −16.875 C ATOM 100 CG2 VAL 564 −30.789 −14.232 −17.825 C ATOM 101 N GLU 565 −31.782 −14.111 −14.099 N ATOM 102 CA GLU 565 −31.085 −14.734 −12.973 C ATOM 103 CB GLU 565 −31.992 −15.005 −11.782 C ATOM 104 C GLU 565 −29.941 −15.717 −13.297 C ATOM 105 O GLU 565 −29.737 −16.147 −14.431 O ATOM 106 CG GLU 565 −32.392 −16.452 −11.541 C ATOM 107 CD GLU 565 −31.43 −17.186 −10.607 C ATOM 108 OE1 GLU 565 −31.684 −18.423 −10.464 O1− ATOM 109 OE2 GLU 565 −30.465 −16.501 −10.16 O ATOM 110 N TYR 566 −29.152 −16.054 −12.215 N ATOM 111 CA TYR 566 −27.823 −16.588 −12.406 C ATOM 112 CB TYR 566 −26.781 −15.718 −11.724 C ATOM 113 C TYR 566 −27.641 −18.044 −11.99 C ATOM 114 O TYR 566 −28.024 −18.531 −10.93 O ATOM 115 CG TYR 566 −25.444 −15.789 −12.391 C ATOM 116 CD1 TYR 566 −25.275 −15.305 −13.689 C ATOM 117 CE1 TYR 566 −24.024 −15.355 −14.299 C ATOM 118 CD2 TYR 566 −24.353 −16.321 −11.703 C ATOM 119 CE2 TYR 566 −23.098 −16.379 −12.308 C ATOM 120 CZ TYR 566 −22.945 −15.891 −13.6 C ATOM 121 OH TYR 566 −21.693 −15.924 −14.174 O ATOM 122 N ALA 567 −26.891 −18.744 −12.906 N ATOM 123 CA ALA 567 −26.494 −20.101 −12.647 C ATOM 124 CB ALA 567 −26.697 −20.945 −13.884 C ATOM 125 C ALA 567 −25.023 −20.106 −12.297 C ATOM 126 O ALA 567 −24.142 −19.656 −13.025 O ATOM 127 N SER 568 −24.777 −20.692 −11.076 N ATOM 128 CA SER 568 −23.392 −20.872 −10.669 C ATOM 129 CB SER 568 −23.287 −21.156 −9.18 C ATOM 130 C SER 568 −22.779 −22.049 −11.436 C ATOM 131 O SER 568 −21.589 −22.069 −11.739 O ATOM 132 OG SER 568 −23.589 −19.986 −8.424 O ATOM 133 N LYS 569 −23.612 −23.14 −11.637 N ATOM 134 CA LYS 569 −23.125 −24.243 −12.446 C ATOM 135 CB LYS 569 −23.916 −25.503 −12.162 C ATOM 136 C LYS 569 −23.157 −23.937 −13.939 C ATOM 137 O LYS 569 −22.249 −24.312 −14.674 O ATOM 138 CG LYS 569 −23.179 −26.423 −11.212 C ATOM 139 CD LYS 569 −21.753 −26.645 −11.661 C ATOM 140 CE LYS 569 −21.016 −27.517 −10.675 C ATOM 141 NZ LYS 569 −19.648 −27.708 −11.215 N1+ ATOM 142 N GLY 570 −24.319 −23.373 −14.413 N ATOM 143 CA GLY 570 −24.453 −23.038 −15.812 C ATOM 144 C GLY 570 −25.524 −23.921 −16.407 C ATOM 145 O GLY 570 −26.559 −24.245 −15.824 O ATOM 146 N ASN 571 −25.286 −24.249 −17.721 N ATOM 147 CA ASN 571 −26.274 −25.077 −18.386 C ATOM 148 CB ASN 571 −26.321 −24.743 −19.86 C ATOM 149 C ASN 571 −26.109 −26.524 −17.918 C ATOM 150 O ASN 571 −25.024 −27.043 −17.664 O ATOM 151 CG ASN 571 −25.797 −25.724 −20.862 C ATOM 152 OD1 ASN 571 −25.578 −26.912 −20.665 O ATOM 153 ND2 ASN 571 −25.585 −25.128 −22.072 N ATOM 154 N LEU 633 −31.139 −24.989 −17.022 N ATOM 155 CA LEU 633 −30.144 −24.369 −16.179 C ATOM 156 CB LEU 633 −30.509 −22.921 −15.923 C ATOM 157 C LEU 633 −29.959 −25.091 −14.857 C ATOM 158 O LEU 633 −30.903 −25.516 −14.191 O ATOM 159 CG LEU 633 −29.311 −21.997 −15.935 C ATOM 160 CD1 LEU 633 −28.592 −22.042 −17.263 C ATOM 161 CD2 LEU 633 −29.768 −20.585 −15.665 C ATOM 162 N ALA 643 −36.35 −23.324 −19.23 N ATOM 163 CA ALA 643 −36.544 −22.152 −20.052 C ATOM 164 CB ALA 643 −35.423 −21.153 −19.88 C ATOM 165 C ALA 643 −36.674 −22.565 −21.505 C ATOM 166 O ALA 643 −36.305 −23.66 −21.933 O ATOM 167 N ASP 644 −37.2 −21.581 −22.31 N ATOM 168 CA ASP 644 −37.014 −21.613 −23.75 C ATOM 169 C ASP 644 −35.623 −20.964 −23.979 C ATOM 170 O ASP 644 −34.857 −20.648 −23.073 O ATOM 171 CB ASP 644 −38.16 −20.848 −24.389 C ATOM 172 CG ASP 644 −38.22 −20.841 −25.905 C ATOM 173 OD1 ASP 644 −37.259 −21.446 −26.484 O ATOM 174 OD2 ASP 644 −39.176 −20.165 −26.375 O1− ATOM 175 N PHE 645 −35.297 −20.757 −25.29 N ATOM 176 CA PHE 645 −34.1 −20.044 −25.673 C ATOM 177 CB PHE 645 −32.96 −21.008 −25.921 C ATOM 178 C PHE 645 −34.416 −19.213 −26.908 C ATOM 179 O PHE 645 −34.014 −18.058 −27.023 O ATOM 180 CG PHE 645 −31.717 −20.552 −25.231 C ATOM 181 CD1 PHE 645 −31.097 −19.35 −25.573 C ATOM 182 CD2 PHE 645 −31.156 −21.354 −24.239 C ATOM 183 CE1 PHE 645 −29.924 −18.956 −24.935 C ATOM 184 CE2 PHE 645 −29.98 −20.965 −23.603 C ATOM 185 CZ PHE 645 −29.366 −19.766 −23.952 C ATOM 186 N GLY 646 −35.072 −19.861 −27.936 N ATOM 187 CA GLY 646 −35.65 −19.091 −29.017 C ATOM 188 C GLY 646 −34.659 −18.179 −29.727 C ATOM 189 O GLY 646 −33.522 −18.494 −30.065 O ATOM 190 N ALA 648 −33.161 −15.84 −28.383 N ATOM 191 CA ALA 648 −32.005 −15.478 −27.595 C ATOM 192 CB ALA 648 −32.175 −15.893 −26.152 C ATOM 193 C ALA 648 −30.73 −16.122 −28.147 C ATOM 194 O ALA 648 −29.621 −15.677 −27.855 O ATOM 195 N ARG 649 −30.876 −17.281 −28.889 N ATOM 196 CA ARG 649 −29.696 −17.894 −29.479 C ATOM 197 CB ARG 649 −29.859 −19.371 −29.767 C ATOM 198 C ARG 649 −29.344 −17.17 −30.777 C ATOM 199 O ARG 649 −30.151 −16.969 −31.678 O ATOM 200 CG ARG 649 −29.749 −20.201 −28.508 C ATOM 201 CD ARG 649 −29.878 −21.666 −28.861 C ATOM 202 NE ARG 649 −30.114 −22.502 −27.687 N1+ ATOM 203 CZ ARG 649 −29.201 −22.79 −26.717 C ATOM 204 NH1 ARG 649 −27.944 −22.278 −26.724 N ATOM 205 NH2 ARG 649 −29.564 −23.67 −25.761 N

Example 7 The Use of FGFR-2 Inhibition Model in the Fitting and Optimization of a Small Molecular Template

Virtual screening of ArQule's collection of kinase inhibitors was carried out using the described FGFR-2 inhibition model. Additional filters were applied for compound selection: molecular weight between 250 and 350, number of hetero atoms less or equal 5, number of hydrogen bonds donors less or equal 3, AlogP less than 5.

Docking and optimization against the FGFR-2 inhibition model was performed. The docking procedure was carried out using ICM software. Further optimization was carried out using MOE energy minimization tools.

ARQ13194808, a racemic mixture of two enantiomers, was identified from this virtual screening (MW 342, logP 4.17). Individual enantiomers were optimized in the model binding site. A single enantiomer was determined to have a preferential binding interaction.

Hydrogen bonds between the pyridine and the critical amino and carbonyl groups of the hinge residue A567 were identified. The fused benzene ring makes aromatic interactions with the F492 from the P-loop.

The overall protein-ligand interaction energy was negative (−40 kcal/mol) and the compounds energy was low (37 kcal/mol) just 3 kcal/mol above the energy minimum in the absence of the protein, as it is calculated using MOE energy calculation tools, indicating a high probability of interaction.

Based on the analysis of these results, ARQ13194808 could be selected as a starting point for designing a FGFR-2 kinase inhibitor.

(−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione, the selective c-Met inhibitor, was also docked in the FGFR-2 inhibition model. A docking pose, where the pyrrolidine carbonyl ring was making hydrogen bonds with the amino group of A567, was selected.

Further energy optimization using MOE tools was carried out. Two hydrogen bonds where observed between the pyrrolidine ring and hinge residue A567. The overall interaction energy is negative (−37 kcal/mol) and the compound's energy is equal to 51 kcal/mol, which is 5 kcal/mol above the energy minimum in the absence of the protein.

Example 8 Cloning, Expression and Purification of c-Met2

As used herein, the c-Met protein of Table 1A is related to the cMet1 protein. cMet1 contains a mutation at residue position 1166, a substitution of glutamine for arginine. Wild type cMet, which has the same sequence as cMet2 of the present application, contains an arginine residue at position 1166. cMet1 contains a glutamine residue at position 1166. Tables 1B and 4, relate to the cMet2 protein. Table 1B provides the complete sequence and atomic structure of the cMet2/the selective cMet inhibitor complex.

The DNA fragment encoding the kinase domain (1038-1346) of cMet was PCR amplified using full length human cDNA with primers designed to contain a non-cleavable N-terminus 6×His tag. The resulting DNA fragment was inserted into pET28a vector between NcoI and SalI sites. A bicistronic form of this vector was designed for co-expression with phosphatase by sequentially inserting the PTP1B gene (1-283) between Sal1 and Not1 sites. A second ribosome binding site was incorporated into the PTP1B primer after the Sal1 site. The construct generated initially contained a random mutation in cMet gene at position 1166 (Arginine to Glutamine), which was corrected to the wild-type form using site-directed mutagenesis kit (Stratagene). All constructs and mutants were verified by sequencing the entire coding region from both 5′ and 3′ directions.

Plasmids were transformed into E. Coli strain BL21 (DE3)-RILP cells. The culture was grown at 25° C. in 2×YT medium up to an A₆₀₀ of 0.6 when overexpression of cMet protein was induced with 0.25 mM IPTG at 12° C. The incubation continued at 12° C. for 16 h before harvesting. Frozen cell pastes suspended in lysis buffer (50 mM Tris pH 8.5, 150 mM NaCl, 0.01% 2-mercapto ethanol, 30 mM imidazole, 1 mM PMSF, 100 μg/ml lysozyme, 10 μg/ml DNAase-1) were lysed by using Branson 450D sonifier on ice at 60% power. The lysate was clarified by centrifugation at 30,000×g at 4° C. for 45 min, and the supernatant loaded onto a 10 ml Ni-Chelating Sepharose column (GE Healthcare). The column washed with 25 mM Tris pH 8.5, 100 mM NaCl, 0.01% 2-mercapto ethanol, 30 mM imidazole, pH 8.5 and the unphosphorylated cMet was eluted with 500 mM imidazole in the same buffer. cMet protein was further purified with an anion exchange column, Fast Trap QFF 5 ml column (GE Healthcare), after dialysis with 25 mM Tris pH 8.5 and 10% glycerol. Eluted protein was concentrated to 20 mg/ml and stored at −80° C. in buffer composed of 25 mM Tris pH 8.5, 100 mM NaCl, 0.1% 2-mercaptoethanol and 10% glycerol.

Crystallization of cMet2 in Complex with the Selective c-Met Inhibitor

Co-crystals of unphosphorylated cMet kinase domain and the selective c-Met inhibitor were grown by the hanging drop vapor diffusion method at 4° C. using a drop size of 1 μl from 12% ethanol, 14% ethylene glycol and 0.1M imidazole buffer, pH 8.5. For cMet/the selective c-Met inhibitor complex preparation, 10 mM the selective c-Met inhibitor solution was prepared in 50% DMSO/water, diluted to 1.2 mM with buffer solution (25 mM Tris pH 8.5, 100 mM NaCl), and immediately mixed in equal volumes with cMet (20 mg/ml). The complex was incubated on ice for 30 min and centrifuged at 13,000×g prior to crystallization. Large single crystals suitable for data collection were obtained after microseeding from thin needle-like clusters generated from initial screening. Crystals were harvested into a cryoprotected solution of 12% ethanol, 20% ethylene glycol, 10% glycerol and 0.1M imidazole buffer, pH 8.5, and flash-frozen in liquid nitrogen. X-ray diffraction data were collected at beamline X29 of the National Synchrotron Light Source (Brookhaven, N.Y.) on a CCD detector under cryogenic temperature. The diffraction data was integrated, processed and scaled using HKL2000 at NSLS site. The crystals belong to P1 space group with unit cell dimension of a=53.47 Å, b=58.67 Å, c=64.96 Å, α=88.41, β=68.10, γ=85.52, and contain two molecules of cMet in the asymmetric unit with solvent content of 46%.

The structure was determined by molecular replacement utilizing MOLREP as implemented in CCP4 package. The atomic coordinates of the published cMet structure 2G15 was used as search model and the activation and p-loop residues were deleted from the model. The initial electron density map for the selective c-Met inhibitor, P-loop and activation loop regions were well resolved, leaving no ambiguities for the binding mode of the inhibitor. Structure refinement consisted of iterative cycles of model building in Coot, followed by simulated annealing, B-factor minimization, and restrained B-factor refinement in CNX. The residues for activation loop, P-loop and the N-terminal regions different from the initial model were built during the refinement process. The selective c-Met inhibitor conformation was identical in both copies of cMet and was built during the final stages of refinement. Water molecules were added based on Fo-Fc maps (3σ) with density recapitulated in 2Fo-Fc maps (1σ). All waters satisfy the hydrogen-bonding criteria as implemented in the CNX programs Waterpick and Waterdelete. Final rounds of refinement were performed using REFMAC5 restrained refinement protocol. The final model consists of two copies of cMet with residues from 1046 to 1346, two selective c-Met inhibitor molecules and 600 hundred water molecules with crystallographic R value of 19.8% (R_(free)=25.9%). The data collection and refinement statistics are summarized in Table 8.

TABLE 8 Diffraction data and refinement statistics Data collection Space group P1 Cell dimensions a, b, c (Å) 53.47, 58.67, 64.96 Cell angles α, β, γ (deg) 88.41, 68.10, 85.52 Resolution (Å) 50.0-1.93 Unique reflections 47320 Completeness 93% (96%) R_(sym) 0.102 (0.28)  Mean I/σ(I) 6.9 Redundancy 2 Refinement R^(a) 0.198 R_(free) 0.259 RMSD Bond distance (Å) 0.018 RMSD Bond angle (deg) 1.951 ^(a)R and R_(free) = (Σ|Fobs − Fcalc|)/(Σ|Fobs|). R_(free) was calculated over randomly chosen 5% of the reflections not used in refinement. Parentheses indicate the outer resolution shell.

Other embodiments are within the following claims. While several embodiments have been shown and described, various modifications may be made without departing from the spirit and scope of the present invention. 

1. A method for generating a kinase inhibition model, comprising: a) performing sequence alignment between the amino acid sequences of the kinase and the c-Met kinase domain of SEQ ID NO: 2; b) identifying non-conserved amino acids between the kinase and the c-Met kinase domain; c) replacing in the crystal structure of the c-Met kinase domain the amino acids corresponding to the non-conserved amino acids with the amino acids of the kinase corresponding to the non-conserved amino acids; and d) refining the crystal structure with the amino acids of the kinase corresponding to the non-conserved amino acids.
 2. The method of claim 1, wherein the kinase is a tyrosine kinase.
 3. The method of claim 2, wherein the tyrosine kinase is a receptor tyrosine kinase.
 4. The method of claim 3, wherein the receptor tyrosine kinase is selected from the group consisting of EGFR, VEGFR, FGFR, PDGFR, HER2, Kit, IRK, RET, AXL, FLT-3, EphB4, c-Met homologs and c-Met mutants.
 5. The method of claim 3, wherein the receptor tyrosine kinase is FGFR-2.
 6. The method of claim 2, wherein the tyrosine kinase is a non-receptor tyrosine kinase.
 7. The method of claim 6, wherein the non-receptor tyrosine kinase is selected from the group consisting of c-Abl, Src, Fyn, Lyn and Yes.
 8. The method of claim 6, wherein the non-receptor tyrosine kinase is c-Abl.
 9. The method of claim 1, wherein the kinase is a serine/threonine kinase.
 10. The method of claim 9, wherein the serine/threonine kinase is selected from the group consisting of B-Raf, PIM, PAK, MEK, MAPK, AKT and Aurora.
 11. A kinase inhibition model generated according to the method of claim
 1. 12. The kinase inhibition model of claim 11, wherein the kinase inhibition model is a c-Abl inhibition model, comprising the crystallography coordinates of c-Abl amino acids L_(—)266, G_(—)267, Y_(—)271, V_(—)274, A_(—)287, V_(—)288, K_(—)289, V_(—)317, I_(—)331, T_(—)333, E_(—)334, F_(—)335, M_(—)336, T_(—)337, Y_(—)338, G_(—)339, N_(—)340, L_(—)388, A_(—)398, D_(—)399, F_(—)400, S_(—)403 and R_(—)404, wherein the crystallography coordinates are within about a root mean square deviation of not more than about 1.5 Å from the backbone atoms of the amino acids according to Table
 5. 13. The kinase inhibition model of claim 11, wherein the kinase inhibition model is a FGFR-2 inhibition model, comprising the crystallography coordinates of FGFR-2 amino acids L_(—)487, G_(—)488, F_(—)492, V_(—)495, A_(—)515, V_(—)516, K_(—)517, I_(—)548, V 562, V 564, E_(—)565, Y 566, A 567, S 568, K 569, G_(—)570, N_(—)571, L_(—)633, A_(—)643, D_(—)644, F_(—)645, A 648 and R_(—)649, wherein the crystallography coordinates are within about a root mean square deviation of not more than about 1.5 Å from the backbone atoms of the amino acids according to Table
 7. 14. A method comprising comparing the inhibition models of kinases generated according to the method of claim
 1. 15. The method of claim 14, comprising applying a weighting system.
 16. The method of claim 15, wherein the weighting system comprises positive scores for conserved residue substitutions, residues critical for ligand binding, residues with side chain lining the inhibition model, and residues which are part of backbone of the inhibition model; and negative scores for additions, deletions and changes in backbone flexibility, lack of residue alignment, dramatic changes in size and/or polarity inside the inhibition model, and lack of alignment of critical residues.
 17. The method of claim 16, wherein the positive score for residues critical for ligand binding is 2, the positive score for residues with side chain lining the inhibition model is 1, and the positive score for residues which are part of backbone of the inhibition model is 1; and the negative score for additions, deletions and changes in backbone flexibility or lack of residue alignment is −1, and the negative score for dramatic changes in size and/or polarity inside the inhibition model or lack of alignment of critical residues is −2.
 18. The method of claim 16, wherein the positive score for conserved residue substitutions is
 1. 19. A c-Abl inhibition model comprising the crystallography coordinates of c-Abl amino acids L_(—)266, G_(—)267, Y_(—)271, V_(—)274, A_(—)287, V_(—)288, K_(—)289, V_(—)317, I_(—)331, T_(—)333, E_(—)334, F_(—)335, M_(—)336, T_(—)337, Y_(—)338, G_(—)339, N_(—)340, L_(—)388, A_(—)398, D_(—)399, F_(—)400, S_(—)403, and R_(—)404 which are within about a root mean square deviation of not more than about 1.5 Å from the backbone atoms of said amino acids according to Table
 5. 20. An FGFR-2 inhibition model comprising the crystallography coordinates of FGFR-2 amino acids L_(—)487, G_(—)488, F_(—)492, V_(—)495, A_(—)515, V_(—)516, K_(—)517, I_(—)548, V 562, V 564, E_(—)565, Y 566, A 567, S 568, K 569, G_(—)570, N_(—)571, L_(—)633, A_(—)643, D_(—)644, F_(—)645, A 648, and R_(—)649 which are within about a root mean square deviation of not more than about 1.5 Å from the backbone atoms of said amino acids according to Table
 7. 